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Protein

Annexin A5

Gene

Anxa5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name:
PP4
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
Gene namesi
Name:Anxa5
Synonyms:Anx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106008. Anxa5.

Subcellular locationi

GO - Cellular componenti

  • endothelial microparticle Source: BHF-UCL
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674882 – 319Annexin A5Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei35PhosphoserineCombined sources1
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei74N6-acetyllysineBy similarity1
Modified residuei77N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei99N6-acetyllysineBy similarity1
Modified residuei288N6-succinyllysineCombined sources1

Post-translational modificationi

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

EPDiP48036.
MaxQBiP48036.
PaxDbiP48036.
PeptideAtlasiP48036.
PRIDEiP48036.
TopDownProteomicsiP48036.

2D gel databases

COMPLUYEAST-2DPAGEiP48036.
REPRODUCTION-2DPAGEiIPI00317309.
SWISS-2DPAGEiP48036.

PTM databases

iPTMnetiP48036.
PhosphoSitePlusiP48036.
SwissPalmiP48036.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027712.
CleanExiMM_ANXA5.
ExpressionAtlasiP48036. baseline and differential.
GenevisibleiP48036. MM.

Interactioni

Subunit structurei

Monomer. Binds ATRX and EIF5B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084604EBI-1184119,EBI-1633915

Protein-protein interaction databases

BioGridi198111. 3 interactors.
IntActiP48036. 7 interactors.
MINTiMINT-1869281.
STRINGi10090.ENSMUSP00000029266.

Structurei

3D structure databases

ProteinModelPortaliP48036.
SMRiP48036.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 82Annexin 1Add BLAST61
Repeati94 – 154Annexin 2Add BLAST61
Repeati178 – 238Annexin 3Add BLAST61
Repeati253 – 313Annexin 4Add BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 318[IL]-x-C-x-x-[DE] motifBy similarity7

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.
The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.By similarity

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP48036.
KOiK16646.
OMAiFAETLYY.
OrthoDBiEOG091G0H6H.
PhylomeDBiP48036.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002392. ANX5.
PANTHERiPTHR10502:SF140. PTHR10502:SF140. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRGTVTDF PGFDGRADAE VLRKAMKGLG TDEDSILNLL TSRSNAQRQE
60 70 80 90 100
IAQEFKTLFG RDLVDDLKSE LTGKFEKLIV AMMKPSRLYD AYELKHALKG
110 120 130 140 150
AGTDEKVLTE IIASRTPEEL SAIKQVYEEE YGSNLEDDVV GDTSGYYQRM
160 170 180 190 200
LVVLLQANRD PDTAIDDAQV ELDAQALFQA GELKWGTDEE KFITIFGTRS
210 220 230 240 250
VSHLRRVFDK YMTISGFQIE ETIDRETSGN LEQLLLAVVK SIRSIPAYLA
260 270 280 290 300
ETLYYAMKGA GTDDHTLIRV VVSRSEIDLF NIRKEFRKNF ATSLYSMIKG
310
DTSGDYKKAL LLLCGGEDD
Length:319
Mass (Da):35,752
Last modified:February 1, 1996 - v1
Checksum:i55055BAF2E1C36B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142D → G in BAE28107 (PubMed:16141072).Curated1
Sequence conflicti157A → G in AAH03716 (PubMed:15489334).Curated1
Sequence conflicti284K → N in BAE31952 (PubMed:16141072).Curated1
Sequence conflicti300G → S in BAE32026 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29396 mRNA. Translation: AAC52530.1.
D63423 mRNA. Translation: BAA09728.1.
AJ230108
, AJ230110, AJ230111, AJ230114, AJ230116, AJ230118, AJ230119, AJ230120, AJ230121, AJ230122, AJ230123, AJ230124 Genomic DNA. Translation: CAA13092.1.
AK147740 mRNA. Translation: BAE28107.1.
AK152185 mRNA. Translation: BAE31016.1.
AK153388 mRNA. Translation: BAE31952.1.
AK153476 mRNA. Translation: BAE32026.1.
BC003716 mRNA. Translation: AAH03716.1.
CCDSiCCDS38416.1.
RefSeqiNP_033803.1. NM_009673.2.
UniGeneiMm.1620.

Genome annotation databases

EnsembliENSMUST00000029266; ENSMUSP00000029266; ENSMUSG00000027712.
GeneIDi11747.
KEGGimmu:11747.
UCSCiuc008ozj.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiANXA5_MOUSE
AccessioniPrimary (citable) accession number: P48036
Secondary accession number(s): Q3U5Q1
, Q3U5X4, Q3U8K1, Q3UGV0, Q99LA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 7, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families