Annexin A5 - Mus musculus (Mouse)

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P48036 (ANXA5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Annexin A5

Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name=CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name=PP4
Placental anticoagulant protein I
Short name=PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name=VAC-alpha

Gene names

Name:	Anxa5
Synonyms:	Anx5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Subunit structure	Monomer. Binds ATRX and EIF5B By similarity.
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.

Ontologies

Keywords
Biological process	Blood coagulation Hemostasis
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of coagulation Inferred from electronic annotation. Source: InterPro response to organic substance Inferred from direct assay PubMed 16455971. Source: MGI
Cellular_component	endothelial microparticle Inferred from direct assay PubMed 20978343. Source: BHF-UCL external side of plasma membrane Inferred from direct assay PubMed 17082577 PubMed 19623612 PubMed 19934022 PubMed 21508411. Source: MGI intracellular Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent phospholipid binding Inferred from electronic annotation. Source: UniProtKB-KW eukaryotic cell surface binding Inferred from direct assay PubMed 18097031. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Kcnma1	Q08460	4	EBI-1184119,EBI-1633915

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 319

318

Annexin A5

PRO_0000067488

Regions

Repeat

22 – 82

Annexin 1

Repeat

94 – 154

Annexin 2

Repeat

178 – 238

Annexin 3

Repeat

253 – 313

Annexin 4

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Experimental info

Sequence conflict

142

D → G in BAE28107. Ref.4

Sequence conflict

157

A → G in AAH03716. Ref.5

Sequence conflict

284

K → N in BAE31952. Ref.4

Sequence conflict

300

G → S in BAE32026. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P48036 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 55055BAF2E1C36B7
Show »

FASTA

319

35,752

        10         20         30         40         50         60 
MATRGTVTDF PGFDGRADAE VLRKAMKGLG TDEDSILNLL TSRSNAQRQE IAQEFKTLFG 

        70         80         90        100        110        120 
RDLVDDLKSE LTGKFEKLIV AMMKPSRLYD AYELKHALKG AGTDEKVLTE IIASRTPEEL 

       130        140        150        160        170        180 
SAIKQVYEEE YGSNLEDDVV GDTSGYYQRM LVVLLQANRD PDTAIDDAQV ELDAQALFQA 

       190        200        210        220        230        240 
GELKWGTDEE KFITIFGTRS VSHLRRVFDK YMTISGFQIE ETIDRETSGN LEQLLLAVVK 

       250        260        270        280        290        300 
SIRSIPAYLA ETLYYAMKGA GTDDHTLIRV VVSRSEIDLF NIRKEFRKNF ATSLYSMIKG 

       310 
DTSGDYKKAL LLLCGGEDD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse annexin V chromosomal localization, cDNA sequence conservation, and molecular evolution." Rodriguez-Garcia M.I., Kozak C.A., Morgan R.O., Fernandez M.-P. Genomics 31:151-157(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peritoneal cavity.
[2]	Adachi T., Kojima K., Fukuoka S., Ogawa H., Matsumoto I. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Mouse annexin V genomic organization includes an endogenous retrovirus." Rodriguez-Garcia M.I., Morgan R.O., Fernandez M.R., Bances P., Fernandez M.-P. Biochem. J. 337:125-131(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Liver.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone marrow.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[6]	Lubec G., Klug S., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 28-43; 62-74; 116-124; 192-199; 226-240 AND 275-283, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain and Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U29396 mRNA. Translation: AAC52530.1. D63423 mRNA. Translation: BAA09728.1. AJ230108 AJ230124 Genomic DNA. Translation: CAA13092.1. AK147740 mRNA. Translation: BAE28107.1. AK152185 mRNA. Translation: BAE31016.1. AK153388 mRNA. Translation: BAE31952.1. AK153476 mRNA. Translation: BAE32026.1. BC003716 mRNA. Translation: AAH03716.1.
IPI	IPI00317309.
RefSeq	NP_033803.1. NM_009673.2.
UniGene	Mm.1620.
3D structure databases
ProteinModelPortal	P48036.
SMR	P48036. Positions 2-319.
ModBase	Search...
Protein-protein interaction databases
IntAct	P48036. 4 interactions.
PTM databases
PhosphoSite	P48036.
2D gel databases
COMPLUYEAST-2DPAGE	P48036.
REPRODUCTION-2DPAGE	IPI00317309.
SWISS-2DPAGE	P48036.
Proteomic databases
PaxDb	P48036.
PRIDE	P48036.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029266; ENSMUSP00000029266; ENSMUSG00000027712.
GeneID	11747.
KEGG	mmu:11747.
UCSC	uc008ozj.2. mouse.
Organism-specific databases
CTD	308.
MGI	MGI:106008. Anxa5.
Phylogenomic databases
eggNOG	NOG281174.
GeneTree	ENSGT00700000104433.
HOGENOM	HOG000158803.
HOVERGEN	HBG061815.
InParanoid	P48036.
KO	K16646.
OMA	RGTVTAF.
OrthoDB	EOG4W9J4D.
Gene expression databases
Bgee	P48036.
CleanEx	MM_ANXA5.
Genevestigator	P48036.
GermOnline	ENSMUSG00000027712. Mus musculus.
Family and domain databases
Gene3D	1.10.220.10. 4 hits.
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR015473. Annexins_V. IPR002392. AnnexinV. [Graphical view]
PANTHER	PTHR10502. PTHR10502. 1 hit. PTHR10502:SF26. PTHR10502:SF26. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR00201. ANNEXINV.
SMART	SM00335. ANX. 4 hits. [Graphical view]
SUPFAM	SSF47874. Annexin. 1 hit.
PROSITE	PS00223. ANNEXIN. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	279485.
SOURCE	Search...

Entry information

Entry name

ANXA5_MOUSE

Accession

Primary (citable) accession number: P48036
Secondary accession number(s): Q3U5Q1

Q99LA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents