Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P48036 (ANXA5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name=CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name=PP4
Placental anticoagulant protein I
Short name=PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name=VAC-alpha
Gene names
Name:Anxa5
Synonyms:Anx5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Subunit structure

Monomer. Binds ATRX and EIF5B By similarity.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Kcnma1Q084604EBI-1184119,EBI-1633915

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 319318Annexin A5
PRO_0000067488

Regions

Repeat22 – 8261Annexin 1
Repeat94 – 15461Annexin 2
Repeat178 – 23861Annexin 3
Repeat253 – 31361Annexin 4

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue681N6-acetyllysine Ref.7
Modified residue741N6-acetyllysine By similarity
Modified residue771N6-acetyllysine By similarity
Modified residue951N6-acetyllysine Ref.7
Modified residue991N6-acetyllysine By similarity
Modified residue2881N6-succinyllysine Ref.7

Experimental info

Sequence conflict1421D → G in BAE28107. Ref.4
Sequence conflict1571A → G in AAH03716. Ref.5
Sequence conflict2841K → N in BAE31952. Ref.4
Sequence conflict3001G → S in BAE32026. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P48036 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 55055BAF2E1C36B7

FASTA31935,752
        10         20         30         40         50         60 
MATRGTVTDF PGFDGRADAE VLRKAMKGLG TDEDSILNLL TSRSNAQRQE IAQEFKTLFG 

        70         80         90        100        110        120 
RDLVDDLKSE LTGKFEKLIV AMMKPSRLYD AYELKHALKG AGTDEKVLTE IIASRTPEEL 

       130        140        150        160        170        180 
SAIKQVYEEE YGSNLEDDVV GDTSGYYQRM LVVLLQANRD PDTAIDDAQV ELDAQALFQA 

       190        200        210        220        230        240 
GELKWGTDEE KFITIFGTRS VSHLRRVFDK YMTISGFQIE ETIDRETSGN LEQLLLAVVK 

       250        260        270        280        290        300 
SIRSIPAYLA ETLYYAMKGA GTDDHTLIRV VVSRSEIDLF NIRKEFRKNF ATSLYSMIKG 

       310 
DTSGDYKKAL LLLCGGEDD 

« Hide

References

« Hide 'large scale' references
[1]"Mouse annexin V chromosomal localization, cDNA sequence conservation, and molecular evolution."
Rodriguez-Garcia M.I., Kozak C.A., Morgan R.O., Fernandez M.-P.
Genomics 31:151-157(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peritoneal cavity.
[2]Adachi T., Kojima K., Fukuoka S., Ogawa H., Matsumoto I.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Mouse annexin V genomic organization includes an endogenous retrovirus."
Rodriguez-Garcia M.I., Morgan R.O., Fernandez M.R., Bances P., Fernandez M.-P.
Biochem. J. 337:125-131(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
Tissue: Liver.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[6]Lubec G., Klug S., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 28-43; 62-74; 116-124; 192-199; 226-240 AND 275-283, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain and Hippocampus.
[7]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68 AND LYS-95, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29396 mRNA. Translation: AAC52530.1.
D63423 mRNA. Translation: BAA09728.1.
AJ230108 expand/collapse EMBL AC list , AJ230110, AJ230111, AJ230114, AJ230116, AJ230118, AJ230119, AJ230120, AJ230121, AJ230122, AJ230123, AJ230124 Genomic DNA. Translation: CAA13092.1.
AK147740 mRNA. Translation: BAE28107.1.
AK152185 mRNA. Translation: BAE31016.1.
AK153388 mRNA. Translation: BAE31952.1.
AK153476 mRNA. Translation: BAE32026.1.
BC003716 mRNA. Translation: AAH03716.1.
RefSeqNP_033803.1. NM_009673.2.
XP_006535439.1. XM_006535376.1.
UniGeneMm.1620.

3D structure databases

ProteinModelPortalP48036.
SMRP48036. Positions 2-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198111. 1 interaction.
IntActP48036. 6 interactions.
MINTMINT-1869281.

PTM databases

PhosphoSiteP48036.

2D gel databases

COMPLUYEAST-2DPAGEP48036.
REPRODUCTION-2DPAGEIPI00317309.
SWISS-2DPAGEP48036.

Proteomic databases

PaxDbP48036.
PRIDEP48036.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029266; ENSMUSP00000029266; ENSMUSG00000027712.
GeneID11747.
KEGGmmu:11747.
UCSCuc008ozj.2. mouse.

Organism-specific databases

CTD308.
MGIMGI:106008. Anxa5.

Phylogenomic databases

eggNOGNOG281174.
GeneTreeENSGT00740000115434.
HOGENOMHOG000158803.
HOVERGENHBG061815.
InParanoidP48036.
KOK16646.
OMAKVFDAYM.
OrthoDBEOG74XS72.
PhylomeDBP48036.
TreeFamTF105452.

Gene expression databases

BgeeP48036.
CleanExMM_ANXA5.
GenevestigatorP48036.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio279485.
PROP48036.
SOURCESearch...

Entry information

Entry nameANXA5_MOUSE
AccessionPrimary (citable) accession number: P48036
Secondary accession number(s): Q3U5Q1 expand/collapse secondary AC list , Q3U5X4, Q3U8K1, Q3UGV0, Q99LA1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot