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P48034 (ADO_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde oxidase
EC=1.2.3.1
Gene names
Name:AOX1
Synonyms:AO
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length1339 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

An aldehyde + H2O + O2 = a carboxylic acid + H2O2.

Cofactor

Binds 2 2Fe-2S clusters.

FAD.

Molybdopterin.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed at high levels in liver, lung and spleen.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the xanthine dehydrogenase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13391339Aldehyde oxidase
PRO_0000166103

Regions

Domain5 – 92882Fe-2S ferredoxin-type
Domain236 – 421186FAD-binding PCMH-type

Sites

Metal binding441Iron-sulfur (2Fe-2S) By similarity
Metal binding491Iron-sulfur (2Fe-2S) By similarity
Metal binding521Iron-sulfur (2Fe-2S) By similarity

Experimental info

Sequence conflict51S → A in AAI05266. Ref.2
Sequence conflict1851M → I in AAI05266. Ref.2
Sequence conflict8041V → I in AAI05266. Ref.2
Sequence conflict10601V → A in AAI05266. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P48034 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 3CA7FF9D2B06F655

FASTA1,339147,611
        10         20         30         40         50         60 
MEGGSELLFY VNGRKVTEKN VDPETMLLPY LRKKLRLTGT KYGCGGGGCG ACTVMISRYN 

        70         80         90        100        110        120 
PITKKIRHYP ANACLTPICS LYGAAVTTVE GIGSTKTRIH PVQERIAKCH GTQCGFCTPG 

       130        140        150        160        170        180 
MVMSLYTLLR NHPEPTLTQL NDALGGNLCR CTGYRPIINA CKTFCKTSGC CQSKENGVCC 

       190        200        210        220        230        240 
LDQGMNGLPE FEEGNETSLK LFSEEEFLPL DPTQELIFPP ELMTMAEKKT QKTRIFGSDR 

       250        260        270        280        290        300 
MTWISPVTLK ELLEAKVKYP QAPVVMGNTS VGPDMKFKGI FHPVIISPDR IEELSVVNYT 

       310        320        330        340        350        360 
DNGLTLGAAV SLAEVKDILA NVTRKLPEEK TQMYHALLKH LETLAGPQIR NMASLGGHIV 

       370        380        390        400        410        420 
SRHPDSDLNP LLAVGNCTLN LLSKEGRRQI PLNEQFLRKC PSADLKPEEI LISVNIPYSR 

       430        440        450        460        470        480 
KWEFVSAFRQ AQRQQNALAI VNSGMRVCFG KGDGIIRELS IAYGGVGPTT ILANNSCQKL 

       490        500        510        520        530        540 
IGRPWNEEML DAACRLILDE VSLPGSAPGG RVEFKRTLIV SFLFKFYLEV SQILKGMDLV 

       550        560        570        580        590        600 
HYPSLASKYE SALEDLHSRH YWSTLKYQNA DLKQLSQDPI GHPIMHLSGI KHATGEAIYC 

       610        620        630        640        650        660 
DDMPVVDREL FLTFVTSSRA HAKIVSIDVS AALSLPGVVD ILTGEHLPGI NTTFGFLTDA 

       670        680        690        700        710        720 
DQLLSTDEVS CVGQLVCAVI ADSEVQARRA AQQVKIVYQD LEPVILTIEE AIQNKSFFEP 

       730        740        750        760        770        780 
ERKLEYGNVD EAFKMVDQIL EGEIHMGGQE HFYMETQSML VVPKGEDREI DVYVSAQFPK 

       790        800        810        820        830        840 
YIQDITASVL KVSANKVMCH VKRVGGAFGG KVTKTGVLAA ITAFAANKHG RPVRCILERG 

       850        860        870        880        890        900 
EDILITGGRH PYLGKYKAGF MNDGRILALD MEHYNNAGAF LDESLFVIEM GLLKLENAYK 

       910        920        930        940        950        960 
FPNLRCRGWA CRTNLPSNTA LRGFGFPQAG LITEACITEV AAKCGLPPEK VRMINMYKEI 

       970        980        990       1000       1010       1020 
DQTPYKQEIN TKNLTQCWKE CMATSSYTLR KAAVEKFNSE NYWKKKGLAM VPLKYPIGLG 

      1030       1040       1050       1060       1070       1080 
SVAAGQAAAL VHIYLDGSVL VTHGGIEMGQ GVHTKMIQVV SRELRMPLSS IHLRGTSTET 

      1090       1100       1110       1120       1130       1140 
IPNTNPSGGS VVADLNGLAV KDACQTLLKR LKPIISKNPK GTWKDWAQAA FNESISLSAT 

      1150       1160       1170       1180       1190       1200 
GYFRGYESNI NWETGEGHPF EYFVYGAACS EVEIDCLTGA HKNIRTDIVM DVGYSINPAL 

      1210       1220       1230       1240       1250       1260 
DVGQIEGAFI QGMGLYTIEE LNYSPQGVLY TRGPNQYKIP AICDIPMELH ISFLPPSENS 

      1270       1280       1290       1300       1310       1320 
NTLYSSKGLG ESGIFLGCSV FFAIHDAIRA ARQERGLPGP LRLNSPLTPE KIRMACEDKF 

      1330 
TKMIPRDEPG SYVPWSVPI

« Hide

References

« Hide 'large scale' references
[1]"Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase."
Calzi M.L., Raviolo C., Ghibaudi E., de Gioia L., Salmona M., Cazzaniga G., Kurosaki M., Terao M., Garattini E.
J. Biol. Chem. 270:31037-31045(1995) [PubMed: 8537361] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 43-48; 187-218 AND 538-573.
Tissue: Liver.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X87251 mRNA. Translation: CAA60701.1.
BC105265 mRNA. Translation: AAI05266.1.
IPIIPI00705186.
PIRS46980.
RefSeqNP_788841.1. NM_176668.2.
UniGeneBt.45005.

3D structure databases

ProteinModelPortalP48034.
SMRP48034. Positions 6-166.
ModBaseSearch...

Protein-protein interaction databases

STRINGP48034.

Proteomic databases

PRIDEP48034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID338074.
KEGGbta:338074.

Organism-specific databases

CTD316.

Phylogenomic databases

eggNOGmaNOG15194.
GeneTreeENSGT00390000003772.
HOVERGENHBG004182.
InParanoidP48034.
OrthoDBEOG4DNF3N.
PhylomeDBP48034.

Family and domain databases

InterProIPR002888. 2Fe-2S-bd.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR014313. Aldehyde_oxidase.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_ferredoxin-type.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR001041. Ferredoxin.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
Gene3DG3DSA:1.10.150.120. 2Fe-2S-bd. 1 hit.
G3DSA:3.30.365.10. Ald_xan_DH_mo_bd. 6 hits.
G3DSA:3.90.1170.50. Aldxan_DH_hamm. 1 hit.
G3DSA:3.30.390.50. CO_DH_flav_C. 1 hit.
G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
KOK00157.
PANTHERPTHR11908:SF10. PTHR11908:SF10. 1 hit.
PfamPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFPIRSF000127. Xanthine_DH. 1 hit.
SMARTSM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF47741. 2Fe-2S_bind. 1 hit.
SSF56003. Ald_xan_DH_mo_bd. 1 hit.
SSF54665. Aldxan_dh_hamm. 1 hit.
SSF55447. CO_deh_flav_C. 1 hit.
SSF56176. FAD-binding_2. 1 hit.
SSF54292. Ferredoxin. 1 hit.
TIGRFAMsTIGR02969. Mam_aldehyde_ox. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADO_BOVIN
AccessionPrimary (citable) accession number: P48034
Secondary accession number(s): Q3MHE7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents