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Protein

Metalloproteinase inhibitor 3

Gene

Timp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partnerBy similarity1
Sitei37Involved in metalloproteinase-bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • central nervous system development Source: RGD
  • negative regulation of catalytic activity Source: GO_Central
  • negative regulation of membrane protein ectodomain proteolysis Source: GO_Central
  • negative regulation of proteolysis Source: RGD
  • response to amino acid Source: RGD
  • response to estrogen Source: RGD
  • response to folic acid Source: RGD
  • response to hormone Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • tissue regeneration Source: RGD

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiI35.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloproteinase inhibitor 3
Alternative name(s):
Tissue inhibitor of metalloproteinases 3
Short name:
TIMP-3
Gene namesi
Name:Timp3
Synonyms:Timp-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3865. Timp3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003434524 – 211Metalloproteinase inhibitor 3Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 91PROSITE-ProRule annotation
Disulfide bondi26 ↔ 118PROSITE-ProRule annotation
Disulfide bondi36 ↔ 143PROSITE-ProRule annotation
Disulfide bondi145 ↔ 192PROSITE-ProRule annotation
Disulfide bondi150 ↔ 155PROSITE-ProRule annotation
Disulfide bondi163 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP48032.
PRIDEiP48032.

Interactioni

Subunit structurei

Interacts with EFEMP1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005746.

Chemistry databases

BindingDBiP48032.

Structurei

3D structure databases

ProteinModelPortaliP48032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 143NTRPROSITE-ProRule annotationAdd BLAST120

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 27Involved in metalloproteinase-bindingBy similarity4
Regioni88 – 89Involved in metalloproteinase-bindingBy similarity2
Regioni105 – 188Mediates interaction with EFEMP1By similarityAdd BLAST84

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4745. Eukaryota.
ENOG41103NU. LUCA.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.
InParanoidiP48032.
PhylomeDBiP48032.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiView protein in InterPro
IPR001134. Netrin_domain.
IPR001820. TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015612. TIMP3.
IPR027465. TIMP_C.
IPR030490. TIMP_CS.
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF30. PTHR11844:SF30. 1 hit.
PfamiView protein in Pfam
PF00965. TIMP. 1 hit.
SMARTiView protein in SMART
SM00206. NTR. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiView protein in PROSITE
PS50189. NTR. 1 hit.
PS00288. TIMP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPWLGLVVL LSCWSLGHWG TEACTCSPSH PQDAFCNSDI VIRAKVVGKK
60 70 80 90 100
LVKEGPFGTL VYTIKQMKMY RGFSKMPHVQ YIHTEASESL CGLKLEVNKY
110 120 130 140 150
QYLLTGRVYE GKMYTGLCNF VERWDHLTLS QRKGLNYRYH LGCNCKIKSC
160 170 180 190 200
YYLPCFVTSK KECLWTDMLS NFGYPGYQSK HYACIRQKGG YCSWYRGWAP
210
PDKSISNATD P
Length:211
Mass (Da):24,226
Last modified:February 1, 1996 - v1
Checksum:i142FD4EB4BA8791E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27201 mRNA. Translation: AAA75002.1.
PIRiJC4630.
UniGeneiRn.119634.

Genome annotation databases

UCSCiRGD:3865. rat.

Similar proteinsi

Entry informationi

Entry nameiTIMP3_RAT
AccessioniPrimary (citable) accession number: P48032
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families