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P48032

- TIMP3_RAT

UniProt

P48032 - TIMP3_RAT

Protein

Metalloproteinase inhibitor 3

Gene

Timp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi24 – 241Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partnerBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. aging Source: RGD
    2. central nervous system development Source: RGD
    3. negative regulation of proteolysis Source: RGD
    4. response to amino acid Source: RGD
    5. response to estrogen Source: RGD
    6. response to folic acid Source: RGD
    7. response to hormone Source: RGD
    8. response to mechanical stimulus Source: RGD
    9. response to organic cyclic compound Source: RGD
    10. response to organic substance Source: RGD
    11. tissue regeneration Source: RGD

    Keywords - Molecular functioni

    Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiI35.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metalloproteinase inhibitor 3
    Alternative name(s):
    Tissue inhibitor of metalloproteinases 3
    Short name:
    TIMP-3
    Gene namesi
    Name:Timp3
    Synonyms:Timp-3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3865. Timp3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 211188Metalloproteinase inhibitor 3PRO_0000034345Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 91PROSITE-ProRule annotation
    Disulfide bondi26 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi36 ↔ 143PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 192PROSITE-ProRule annotation
    Disulfide bondi150 ↔ 155PROSITE-ProRule annotation
    Disulfide bondi163 ↔ 184PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP48032.

    Expressioni

    Gene expression databases

    GenevestigatoriP48032.

    Interactioni

    Subunit structurei

    Interacts with EFEMP1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005746.

    Structurei

    3D structure databases

    ProteinModelPortaliP48032.
    SMRiP48032. Positions 24-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 143120NTRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 285Involved in metalloproteinase-bindingBy similarity
    Regioni88 – 892Involved in metalloproteinase-bindingBy similarity
    Regioni105 – 18884Mediates interaction with EFEMP1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG250837.
    HOGENOMiHOG000285981.
    HOVERGENiHBG068749.
    InParanoidiP48032.
    PhylomeDBiP48032.

    Family and domain databases

    Gene3Di3.90.370.10. 1 hit.
    InterProiIPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR027465. TIMP_C_dom.
    IPR015612. Tissue_inhib_metalloprotease_3.
    [Graphical view]
    PANTHERiPTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF6. PTHR11844:SF6. 1 hit.
    PfamiPF00965. TIMP. 1 hit.
    [Graphical view]
    SMARTiSM00206. NTR. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    PROSITEiPS50189. NTR. 1 hit.
    PS00288. TIMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48032-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPWLGLVVL LSCWSLGHWG TEACTCSPSH PQDAFCNSDI VIRAKVVGKK    50
    LVKEGPFGTL VYTIKQMKMY RGFSKMPHVQ YIHTEASESL CGLKLEVNKY 100
    QYLLTGRVYE GKMYTGLCNF VERWDHLTLS QRKGLNYRYH LGCNCKIKSC 150
    YYLPCFVTSK KECLWTDMLS NFGYPGYQSK HYACIRQKGG YCSWYRGWAP 200
    PDKSISNATD P 211
    Length:211
    Mass (Da):24,226
    Last modified:February 1, 1996 - v1
    Checksum:i142FD4EB4BA8791E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27201 mRNA. Translation: AAA75002.1.
    PIRiJC4630.
    UniGeneiRn.119634.

    Genome annotation databases

    UCSCiRGD:3865. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27201 mRNA. Translation: AAA75002.1 .
    PIRi JC4630.
    UniGenei Rn.119634.

    3D structure databases

    ProteinModelPortali P48032.
    SMRi P48032. Positions 24-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005746.

    Chemistry

    BindingDBi P48032.
    ChEMBLi CHEMBL3881.

    Protein family/group databases

    MEROPSi I35.003.

    Proteomic databases

    PaxDbi P48032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3865. rat.

    Organism-specific databases

    RGDi 3865. Timp3.

    Phylogenomic databases

    eggNOGi NOG250837.
    HOGENOMi HOG000285981.
    HOVERGENi HBG068749.
    InParanoidi P48032.
    PhylomeDBi P48032.

    Miscellaneous databases

    PROi P48032.

    Gene expression databases

    Genevestigatori P48032.

    Family and domain databases

    Gene3Di 3.90.370.10. 1 hit.
    InterProi IPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR027465. TIMP_C_dom.
    IPR015612. Tissue_inhib_metalloprotease_3.
    [Graphical view ]
    PANTHERi PTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF6. PTHR11844:SF6. 1 hit.
    Pfami PF00965. TIMP. 1 hit.
    [Graphical view ]
    SMARTi SM00206. NTR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    PROSITEi PS50189. NTR. 1 hit.
    PS00288. TIMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the cDNA encoding rat tissue inhibitor of metalloproteinase 3 (TIMP-3)."
      Wu I., Moses M.A.
      Gene 168:243-246(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTIMP3_RAT
    AccessioniPrimary (citable) accession number: P48032
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3