Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein GBX-2

Gene

Gbx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi247 – 306HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • autonomic nervous system development Source: MGI
  • axon guidance Source: MGI
  • cell proliferation Source: MGI
  • cerebellar granule cell precursor proliferation Source: MGI
  • cerebellum development Source: MGI
  • forebrain neuron development Source: MGI
  • hindbrain development Source: MGI
  • inner ear morphogenesis Source: MGI
  • midbrain-hindbrain boundary development Source: MGI
  • midbrain-hindbrain boundary morphogenesis Source: MGI
  • neural crest cell migration Source: MGI
  • patterning of blood vessels Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • rhombomere 2 development Source: MGI
  • thalamus development Source: MGI
  • tube morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Stimulated by retinoic acid gene 7 protein
Gene namesi
Name:Gbx2
Synonyms:Mmoxa, Stra7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95668. Gbx2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488811 – 348Homeobox protein GBX-2Add BLAST348

Proteomic databases

PaxDbiP48031.
PRIDEiP48031.

PTM databases

iPTMnetiP48031.
PhosphoSitePlusiP48031.

Expressioni

Tissue specificityi

Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis.

Developmental stagei

Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum.

Gene expression databases

BgeeiENSMUSG00000034486.
CleanExiMM_GBX2.
GenevisibleiP48031. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048508.

Structurei

3D structure databases

ProteinModelPortaliP48031.
SMRiP48031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 63Poly-Pro8
Compositional biasi121 – 124Poly-Ala4
Compositional biasi248 – 251Poly-Arg4

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000060099.
HOVERGENiHBG003967.
InParanoidiP48031.
KOiK09321.
OMAiLIGGPPQ.
OrthoDBiEOG091G0SCQ.
PhylomeDBiP48031.
TreeFamiTF351530.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR031250. GBX-2.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PANTHERiPTHR24334:SF3. PTHR24334:SF3. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY
60 70 80 90 100
RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL
110 120 130 140 150
TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED
160 170 180 190 200
GKAFLAKEGS LLAFSAAEAV QASLVGAVRG QGKDESKVED DPKGKEESFS
210 220 230 240 250
LESDVDYSSD DNLPGQTAHK EEDPGHALEE TPQSGGAAGS TTSTGKNRRR
260 270 280 290 300
RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA
310 320 330 340
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
Length:348
Mass (Da):37,359
Last modified:February 1, 1996 - v1
Checksum:iCF8594653EA8295B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48800 mRNA. Translation: CAA88737.1.
U74300 Genomic DNA. Translation: AAC61877.1.
BC116965 mRNA. Translation: AAI16966.1.
BC120492 mRNA. Translation: AAI20493.1.
L39770 mRNA. Translation: AAA65185.1.
M81661 Genomic DNA. Translation: AAA63314.1.
CCDSiCCDS15150.1.
PIRiS52720.
RefSeqiNP_034392.1. NM_010262.3.
UniGeneiMm.204730.

Genome annotation databases

EnsembliENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486.
GeneIDi14472.
KEGGimmu:14472.
UCSCiuc007bzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48800 mRNA. Translation: CAA88737.1.
U74300 Genomic DNA. Translation: AAC61877.1.
BC116965 mRNA. Translation: AAI16966.1.
BC120492 mRNA. Translation: AAI20493.1.
L39770 mRNA. Translation: AAA65185.1.
M81661 Genomic DNA. Translation: AAA63314.1.
CCDSiCCDS15150.1.
PIRiS52720.
RefSeqiNP_034392.1. NM_010262.3.
UniGeneiMm.204730.

3D structure databases

ProteinModelPortaliP48031.
SMRiP48031.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048508.

PTM databases

iPTMnetiP48031.
PhosphoSitePlusiP48031.

Proteomic databases

PaxDbiP48031.
PRIDEiP48031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486.
GeneIDi14472.
KEGGimmu:14472.
UCSCiuc007bzb.1. mouse.

Organism-specific databases

CTDi2637.
MGIiMGI:95668. Gbx2.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000060099.
HOVERGENiHBG003967.
InParanoidiP48031.
KOiK09321.
OMAiLIGGPPQ.
OrthoDBiEOG091G0SCQ.
PhylomeDBiP48031.
TreeFamiTF351530.

Miscellaneous databases

PROiP48031.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034486.
CleanExiMM_GBX2.
GenevisibleiP48031. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR031250. GBX-2.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PANTHERiPTHR24334:SF3. PTHR24334:SF3. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBX2_MOUSE
AccessioniPrimary (citable) accession number: P48031
Secondary accession number(s): Q14A66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.