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P48031

- GBX2_MOUSE

UniProt

P48031 - GBX2_MOUSE

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Protein

Homeobox protein GBX-2

Gene

Gbx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi247 – 30660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. autonomic nervous system development Source: MGI
  2. axon guidance Source: MGI
  3. cell proliferation Source: MGI
  4. cerebellar granule cell precursor proliferation Source: MGI
  5. cerebellum development Source: MGI
  6. forebrain neuron development Source: MGI
  7. hindbrain development Source: MGI
  8. inner ear morphogenesis Source: MGI
  9. midbrain-hindbrain boundary development Source: MGI
  10. midbrain-hindbrain boundary morphogenesis Source: MGI
  11. neural crest cell migration Source: MGI
  12. patterning of blood vessels Source: MGI
  13. regulation of transcription, DNA-templated Source: UniProtKB-KW
  14. rhombomere 2 development Source: MGI
  15. thalamus development Source: MGI
  16. transcription, DNA-templated Source: UniProtKB-KW
  17. tube morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Stimulated by retinoic acid gene 7 protein
Gene namesi
Name:Gbx2
Synonyms:Mmoxa, Stra7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:95668. Gbx2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Homeobox protein GBX-2PRO_0000048881Add
BLAST

Proteomic databases

PRIDEiP48031.

PTM databases

PhosphoSiteiP48031.

Expressioni

Tissue specificityi

Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis.

Developmental stagei

Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum.

Gene expression databases

BgeeiP48031.
CleanExiMM_GBX2.
ExpressionAtlasiP48031. baseline and differential.
GenevestigatoriP48031.

Structurei

3D structure databases

ProteinModelPortaliP48031.
SMRiP48031. Positions 245-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 638Poly-Pro
Compositional biasi121 – 1244Poly-Ala
Compositional biasi248 – 2514Poly-Arg

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG315879.
GeneTreeiENSGT00760000119211.
HOGENOMiHOG000060099.
HOVERGENiHBG003967.
InParanoidiP48031.
KOiK09321.
OMAiGQTAHKE.
OrthoDBiEOG7D2FDK.
PhylomeDBiP48031.
TreeFamiTF351530.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48031-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY
60 70 80 90 100
RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL
110 120 130 140 150
TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED
160 170 180 190 200
GKAFLAKEGS LLAFSAAEAV QASLVGAVRG QGKDESKVED DPKGKEESFS
210 220 230 240 250
LESDVDYSSD DNLPGQTAHK EEDPGHALEE TPQSGGAAGS TTSTGKNRRR
260 270 280 290 300
RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA
310 320 330 340
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
Length:348
Mass (Da):37,359
Last modified:February 1, 1996 - v1
Checksum:iCF8594653EA8295B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48800 mRNA. Translation: CAA88737.1.
U74300 Genomic DNA. Translation: AAC61877.1.
BC116965 mRNA. Translation: AAI16966.1.
BC120492 mRNA. Translation: AAI20493.1.
L39770 mRNA. Translation: AAA65185.1.
M81661 Genomic DNA. Translation: AAA63314.1.
CCDSiCCDS15150.1.
PIRiS52720.
RefSeqiNP_034392.1. NM_010262.3.
UniGeneiMm.204730.

Genome annotation databases

EnsembliENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486.
GeneIDi14472.
KEGGimmu:14472.
UCSCiuc007bzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48800 mRNA. Translation: CAA88737.1 .
U74300 Genomic DNA. Translation: AAC61877.1 .
BC116965 mRNA. Translation: AAI16966.1 .
BC120492 mRNA. Translation: AAI20493.1 .
L39770 mRNA. Translation: AAA65185.1 .
M81661 Genomic DNA. Translation: AAA63314.1 .
CCDSi CCDS15150.1.
PIRi S52720.
RefSeqi NP_034392.1. NM_010262.3.
UniGenei Mm.204730.

3D structure databases

ProteinModelPortali P48031.
SMRi P48031. Positions 245-311.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P48031.

Proteomic databases

PRIDEi P48031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036954 ; ENSMUSP00000048508 ; ENSMUSG00000034486 .
GeneIDi 14472.
KEGGi mmu:14472.
UCSCi uc007bzb.1. mouse.

Organism-specific databases

CTDi 2637.
MGIi MGI:95668. Gbx2.

Phylogenomic databases

eggNOGi NOG315879.
GeneTreei ENSGT00760000119211.
HOGENOMi HOG000060099.
HOVERGENi HBG003967.
InParanoidi P48031.
KOi K09321.
OMAi GQTAHKE.
OrthoDBi EOG7D2FDK.
PhylomeDBi P48031.
TreeFami TF351530.

Miscellaneous databases

NextBioi 286138.
PROi P48031.
SOURCEi Search...

Gene expression databases

Bgeei P48031.
CleanExi MM_GBX2.
ExpressionAtlasi P48031. baseline and differential.
Genevestigatori P48031.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells."
    Bouillet P., Chazaud C., Oulad Abdelghani M., Dolle P., Chambon P.
    Dev. Dyn. 204:372-382(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse homeobox gene, Gbx2: genomic organization and expression in pluripotent cells in vitro and in vivo."
    Chapman G., Remiszewski J.L., Webb G.C., Schulz T.C., Bottema C.D.K., Rathjen P.D.
    Genomics 46:223-233(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene."
    Chapman G., Rathjen P.D.
    FEBS Lett. 364:289-292(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-348.
    Strain: 129.
  5. "Detection of homeobox genes in development and evolution."
    Murtha M.T., Leckman J.F., Ruddle F.H.
    Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-292.
    Strain: C57BL/6.
    Tissue: Spleen.

Entry informationi

Entry nameiGBX2_MOUSE
AccessioniPrimary (citable) accession number: P48031
Secondary accession number(s): Q14A66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3