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P48031 (GBX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Stimulated by retinoic acid gene 7 protein
Gene names
Name:Gbx2
Synonyms:Mmoxa, Stra7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis.

Developmental stage

Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processautonomic nervous system development

Inferred from mutant phenotype PubMed 15996652. Source: MGI

axon guidance

Inferred from mutant phenotype PubMed 11967891. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 16651541. Source: MGI

cerebellar granule cell precursor proliferation

Inferred from mutant phenotype PubMed 16651541. Source: MGI

cerebellum development

Inferred from mutant phenotype PubMed 16651541. Source: MGI

forebrain neuron development

Inferred from mutant phenotype PubMed 21048141. Source: MGI

hindbrain development

Inferred from mutant phenotype PubMed 15829521PubMed 16651541. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 15829521PubMed 15996652. Source: MGI

midbrain-hindbrain boundary development

Inferred from mutant phenotype PubMed 16651541. Source: MGI

midbrain-hindbrain boundary morphogenesis

Inferred from mutant phenotype PubMed 16651541. Source: MGI

neural crest cell migration

Inferred from mutant phenotype PubMed 15996652PubMed 19700621. Source: MGI

patterning of blood vessels

Inferred from mutant phenotype PubMed 15996652. Source: MGI

rhombomere 2 development

Inferred from mutant phenotype PubMed 16651541. Source: MGI

thalamus development

Inferred from mutant phenotype PubMed 19279136. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

tube morphogenesis

Inferred from mutant phenotype PubMed 15996652. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Homeobox protein GBX-2
PRO_0000048881

Regions

DNA binding247 – 30660Homeobox
Compositional bias56 – 638Poly-Pro
Compositional bias121 – 1244Poly-Ala
Compositional bias248 – 2514Poly-Arg

Sequences

Sequence LengthMass (Da)Tools
P48031 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: CF8594653EA8295B

FASTA34837,359
        10         20         30         40         50         60 
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP 

        70         80         90        100        110        120 
PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL TSTLMATLPG GFSASPQHQE 

       130        140        150        160        170        180 
AAAARKFAPQ PLPGGGNFDK AEALQADAED GKAFLAKEGS LLAFSAAEAV QASLVGAVRG 

       190        200        210        220        230        240 
QGKDESKVED DPKGKEESFS LESDVDYSSD DNLPGQTAHK EEDPGHALEE TPQSGGAAGS 

       250        260        270        280        290        300 
TTSTGKNRRR RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA 

       310        320        330        340 
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells."
Bouillet P., Chazaud C., Oulad Abdelghani M., Dolle P., Chambon P.
Dev. Dyn. 204:372-382(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The mouse homeobox gene, Gbx2: genomic organization and expression in pluripotent cells in vitro and in vivo."
Chapman G., Remiszewski J.L., Webb G.C., Schulz T.C., Bottema C.D.K., Rathjen P.D.
Genomics 46:223-233(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene."
Chapman G., Rathjen P.D.
FEBS Lett. 364:289-292(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-348.
Strain: 129.
[5]"Detection of homeobox genes in development and evolution."
Murtha M.T., Leckman J.F., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-292.
Strain: C57BL/6.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48800 mRNA. Translation: CAA88737.1.
U74300 Genomic DNA. Translation: AAC61877.1.
BC116965 mRNA. Translation: AAI16966.1.
BC120492 mRNA. Translation: AAI20493.1.
L39770 mRNA. Translation: AAA65185.1.
M81661 Genomic DNA. Translation: AAA63314.1.
CCDSCCDS15150.1.
PIRS52720.
RefSeqNP_034392.1. NM_010262.3.
UniGeneMm.204730.

3D structure databases

ProteinModelPortalP48031.
SMRP48031. Positions 245-311.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP48031.

Proteomic databases

PRIDEP48031.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486.
GeneID14472.
KEGGmmu:14472.
UCSCuc007bzb.1. mouse.

Organism-specific databases

CTD2637.
MGIMGI:95668. Gbx2.

Phylogenomic databases

eggNOGNOG315879.
GeneTreeENSGT00750000117598.
HOGENOMHOG000060099.
HOVERGENHBG003967.
InParanoidQ14A66.
KOK09321.
OMAGQTAHKE.
OrthoDBEOG7D2FDK.
PhylomeDBP48031.
TreeFamTF351530.

Gene expression databases

BgeeP48031.
CleanExMM_GBX2.
GenevestigatorP48031.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286138.
PROP48031.
SOURCESearch...

Entry information

Entry nameGBX2_MOUSE
AccessionPrimary (citable) accession number: P48031
Secondary accession number(s): Q14A66
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot