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P48031

- GBX2_MOUSE

UniProt

P48031 - GBX2_MOUSE

Protein

Homeobox protein GBX-2

Gene

Gbx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    May act as a transcription factor for cell pluripotency and differentiation in the embryo.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi247 – 30660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. autonomic nervous system development Source: MGI
    2. axon guidance Source: MGI
    3. cell proliferation Source: MGI
    4. cerebellar granule cell precursor proliferation Source: MGI
    5. cerebellum development Source: MGI
    6. forebrain neuron development Source: MGI
    7. hindbrain development Source: MGI
    8. inner ear morphogenesis Source: MGI
    9. midbrain-hindbrain boundary development Source: MGI
    10. midbrain-hindbrain boundary morphogenesis Source: MGI
    11. neural crest cell migration Source: MGI
    12. patterning of blood vessels Source: MGI
    13. rhombomere 2 development Source: MGI
    14. thalamus development Source: MGI
    15. transcription, DNA-templated Source: UniProtKB-KW
    16. tube morphogenesis Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein GBX-2
    Alternative name(s):
    Gastrulation and brain-specific homeobox protein 2
    Stimulated by retinoic acid gene 7 protein
    Gene namesi
    Name:Gbx2
    Synonyms:Mmoxa, Stra7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:95668. Gbx2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Homeobox protein GBX-2PRO_0000048881Add
    BLAST

    Proteomic databases

    PRIDEiP48031.

    PTM databases

    PhosphoSiteiP48031.

    Expressioni

    Tissue specificityi

    Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis.

    Developmental stagei

    Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum.

    Gene expression databases

    BgeeiP48031.
    CleanExiMM_GBX2.
    GenevestigatoriP48031.

    Structurei

    3D structure databases

    ProteinModelPortaliP48031.
    SMRiP48031. Positions 245-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 638Poly-Pro
    Compositional biasi121 – 1244Poly-Ala
    Compositional biasi248 – 2514Poly-Arg

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG315879.
    GeneTreeiENSGT00750000117598.
    HOGENOMiHOG000060099.
    HOVERGENiHBG003967.
    InParanoidiQ14A66.
    KOiK09321.
    OMAiGQTAHKE.
    OrthoDBiEOG7D2FDK.
    PhylomeDBiP48031.
    TreeFamiTF351530.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48031-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY    50
    RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL 100
    TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED 150
    GKAFLAKEGS LLAFSAAEAV QASLVGAVRG QGKDESKVED DPKGKEESFS 200
    LESDVDYSSD DNLPGQTAHK EEDPGHALEE TPQSGGAAGS TTSTGKNRRR 250
    RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA 300
    KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP 348
    Length:348
    Mass (Da):37,359
    Last modified:February 1, 1996 - v1
    Checksum:iCF8594653EA8295B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48800 mRNA. Translation: CAA88737.1.
    U74300 Genomic DNA. Translation: AAC61877.1.
    BC116965 mRNA. Translation: AAI16966.1.
    BC120492 mRNA. Translation: AAI20493.1.
    L39770 mRNA. Translation: AAA65185.1.
    M81661 Genomic DNA. Translation: AAA63314.1.
    CCDSiCCDS15150.1.
    PIRiS52720.
    RefSeqiNP_034392.1. NM_010262.3.
    UniGeneiMm.204730.

    Genome annotation databases

    EnsembliENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486.
    GeneIDi14472.
    KEGGimmu:14472.
    UCSCiuc007bzb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48800 mRNA. Translation: CAA88737.1 .
    U74300 Genomic DNA. Translation: AAC61877.1 .
    BC116965 mRNA. Translation: AAI16966.1 .
    BC120492 mRNA. Translation: AAI20493.1 .
    L39770 mRNA. Translation: AAA65185.1 .
    M81661 Genomic DNA. Translation: AAA63314.1 .
    CCDSi CCDS15150.1.
    PIRi S52720.
    RefSeqi NP_034392.1. NM_010262.3.
    UniGenei Mm.204730.

    3D structure databases

    ProteinModelPortali P48031.
    SMRi P48031. Positions 245-311.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P48031.

    Proteomic databases

    PRIDEi P48031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036954 ; ENSMUSP00000048508 ; ENSMUSG00000034486 .
    GeneIDi 14472.
    KEGGi mmu:14472.
    UCSCi uc007bzb.1. mouse.

    Organism-specific databases

    CTDi 2637.
    MGIi MGI:95668. Gbx2.

    Phylogenomic databases

    eggNOGi NOG315879.
    GeneTreei ENSGT00750000117598.
    HOGENOMi HOG000060099.
    HOVERGENi HBG003967.
    InParanoidi Q14A66.
    KOi K09321.
    OMAi GQTAHKE.
    OrthoDBi EOG7D2FDK.
    PhylomeDBi P48031.
    TreeFami TF351530.

    Miscellaneous databases

    NextBioi 286138.
    PROi P48031.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48031.
    CleanExi MM_GBX2.
    Genevestigatori P48031.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells."
      Bouillet P., Chazaud C., Oulad Abdelghani M., Dolle P., Chambon P.
      Dev. Dyn. 204:372-382(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The mouse homeobox gene, Gbx2: genomic organization and expression in pluripotent cells in vitro and in vivo."
      Chapman G., Remiszewski J.L., Webb G.C., Schulz T.C., Bottema C.D.K., Rathjen P.D.
      Genomics 46:223-233(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene."
      Chapman G., Rathjen P.D.
      FEBS Lett. 364:289-292(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-348.
      Strain: 129.
    5. "Detection of homeobox genes in development and evolution."
      Murtha M.T., Leckman J.F., Ruddle F.H.
      Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-292.
      Strain: C57BL/6.
      Tissue: Spleen.

    Entry informationi

    Entry nameiGBX2_MOUSE
    AccessioniPrimary (citable) accession number: P48031
    Secondary accession number(s): Q14A66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3