##gff-version 3 P48025 UniProtKB Chain 1 629 . . . ID=PRO_0000088166;Note=Tyrosine-protein kinase SYK P48025 UniProtKB Domain 14 106 . . . Note=SH2 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 P48025 UniProtKB Domain 167 258 . . . Note=SH2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 P48025 UniProtKB Domain 365 625 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P48025 UniProtKB Region 107 166 . . . Note=Interdomain A P48025 UniProtKB Region 259 364 . . . Note=Interdomain B P48025 UniProtKB Region 293 328 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48025 UniProtKB Active site 488 488 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 P48025 UniProtKB Binding site 371 379 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P48025 UniProtKB Binding site 396 396 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P48025 UniProtKB Modified residue 27 27 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 43 43 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 46 46 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 130 130 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 201 201 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 255 255 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 270 270 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P48025 UniProtKB Modified residue 289 289 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 290 290 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 291 291 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 310 310 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P48025 UniProtKB Modified residue 311 311 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 313 313 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P48025 UniProtKB Modified residue 317 317 . . . Note=Phosphotyrosine%3B by LYN;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:12077122,ECO:0007744|PubMed:17947660;Dbxref=PMID:12077122,PMID:17947660 P48025 UniProtKB Modified residue 339 339 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 342 342 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:11672534,ECO:0000269|PubMed:12077122,ECO:0007744|PubMed:17947660;Dbxref=PMID:11672534,PMID:12077122,PMID:17947660 P48025 UniProtKB Modified residue 344 344 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 346 346 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:12077122,ECO:0007744|PubMed:17947660;Dbxref=PMID:12077122,PMID:17947660 P48025 UniProtKB Modified residue 358 358 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 373 373 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 378 378 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 478 478 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 501 501 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 519 519 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:11672534,ECO:0007744|PubMed:17947660;Dbxref=PMID:11672534,PMID:17947660 P48025 UniProtKB Modified residue 520 520 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:11672534,ECO:0007744|PubMed:17947660;Dbxref=PMID:11672534,PMID:17947660 P48025 UniProtKB Modified residue 524 524 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 540 540 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P48025 UniProtKB Modified residue 573 573 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 576 576 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Modified residue 623 623 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P48025 UniProtKB Modified residue 624 624 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P48025 UniProtKB Modified residue 625 625 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P43405 P48025 UniProtKB Mutagenesis 41 41 . . . Note=Loss of interaction with FCER1G and TYROBP%3B when associated with A-194. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17086186;Dbxref=PMID:17086186 P48025 UniProtKB Mutagenesis 194 194 . . . Note=Loss of interaction with FCER1G and TYROBP%3B when associated with A-41. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17086186;Dbxref=PMID:17086186 P48025 UniProtKB Mutagenesis 544 544 . . . Note=Constitutively active protein tyrosine kinase activity. Causes an immune dysregulation disorder. Treatment with SYK-specific inhibitor ameliorates the disease phenotype. S->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33782605;Dbxref=PMID:33782605 P48025 UniProtKB Sequence conflict 326 326 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P48025 UniProtKB Sequence conflict 446 447 . . . Note=EL->DV;Ontology_term=ECO:0000305;evidence=ECO:0000305 P48025 UniProtKB Beta strand 346 348 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LCT