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Protein

Eukaryotic translation initiation factor 1

Gene

Eif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • dosage compensation by inactivation of X chromosome Source: MGI
  • regulation of translational initiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1
Short name:
eIF1
Alternative name(s):
Protein translation factor SUI1 homolog
Gene namesi
Name:Eif1
Synonyms:Sui1, Sui1-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105125. Eif1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 113112Eukaryotic translation initiation factor 1PRO_0000130555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP48024.
PaxDbiP48024.
PRIDEiP48024.

PTM databases

iPTMnetiP48024.
PhosphoSiteiP48024.

Expressioni

Gene expression databases

BgeeiP48024.
CleanExiMM_EIF1.
ExpressionAtlasiP48024. baseline and differential.
GenevisibleiP48024. MM.

Interactioni

Subunit structurei

Interacts with RENT2.By similarity

Protein-protein interaction databases

IntActiP48024. 1 interaction.
MINTiMINT-4136107.
STRINGi10090.ENSMUSP00000041538.

Structurei

3D structure databases

ProteinModelPortaliP48024.
SMRiP48024. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiKOG1770. Eukaryota.
COG0023. LUCA.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiP48024.
KOiK03113.
OMAiNTANYLH.
OrthoDBiEOG76QFKK.
PhylomeDBiP48024.
TreeFamiTF314417.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLIEI
110
GLAKDDQLKV HGF
Length:113
Mass (Da):12,747
Last modified:May 30, 2000 - v2
Checksum:i4B6C7F9B53FFEB34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129888 mRNA. Translation: AAD31266.1.
BC003463 mRNA. Translation: AAH03463.1.
BC010791 mRNA. Translation: AAH10791.1.
BC081429 mRNA. Translation: AAH81429.1.
Z50159 mRNA. Translation: CAA90519.1.
CCDSiCCDS25417.1.
PIRiS58180.
RefSeqiNP_035638.1. NM_011508.2.
UniGeneiMm.13886.

Genome annotation databases

EnsembliENSMUST00000049385; ENSMUSP00000041538; ENSMUSG00000035530.
GeneIDi20918.
KEGGimmu:20918.
UCSCiuc007lkv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129888 mRNA. Translation: AAD31266.1.
BC003463 mRNA. Translation: AAH03463.1.
BC010791 mRNA. Translation: AAH10791.1.
BC081429 mRNA. Translation: AAH81429.1.
Z50159 mRNA. Translation: CAA90519.1.
CCDSiCCDS25417.1.
PIRiS58180.
RefSeqiNP_035638.1. NM_011508.2.
UniGeneiMm.13886.

3D structure databases

ProteinModelPortaliP48024.
SMRiP48024. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48024. 1 interaction.
MINTiMINT-4136107.
STRINGi10090.ENSMUSP00000041538.

PTM databases

iPTMnetiP48024.
PhosphoSiteiP48024.

Proteomic databases

EPDiP48024.
PaxDbiP48024.
PRIDEiP48024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049385; ENSMUSP00000041538; ENSMUSG00000035530.
GeneIDi20918.
KEGGimmu:20918.
UCSCiuc007lkv.1. mouse.

Organism-specific databases

CTDi10209.
MGIiMGI:105125. Eif1.

Phylogenomic databases

eggNOGiKOG1770. Eukaryota.
COG0023. LUCA.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiP48024.
KOiK03113.
OMAiNTANYLH.
OrthoDBiEOG76QFKK.
PhylomeDBiP48024.
TreeFamiTF314417.

Miscellaneous databases

ChiTaRSiEif1. mouse.
NextBioi299825.
PROiP48024.
SOURCEiSearch...

Gene expression databases

BgeeiP48024.
CleanExiMM_EIF1.
ExpressionAtlasiP48024. baseline and differential.
GenevisibleiP48024. MM.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differentially expressed genes in branching tubulogenesis."
    Li Z., Stuart R.O., Nigam S.K.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ureteric bud.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain, Colon and Mammary tumor.
  3. "Multiple translation initiation factor Sui1 related sequences in mammalian genomes."
    Purohit R., McCormick D., Dyson J.
    Mamm. Genome 7:79-80(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-113.
    Strain: DBA/2J.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiEIF1_MOUSE
AccessioniPrimary (citable) accession number: P48024
Secondary accession number(s): Q9WUD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.