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Protein

Eukaryotic translation initiation factor 1

Gene

Eif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • dosage compensation by inactivation of X chromosome Source: MGI

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1
Short name:
eIF1
Alternative name(s):
Protein translation factor SUI1 homolog
Gene namesi
Name:Eif1
Synonyms:Sui1, Sui1-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105125 Eif1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001305552 – 113Eukaryotic translation initiation factor 1Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP48024
PaxDbiP48024
PeptideAtlasiP48024
PRIDEiP48024

PTM databases

iPTMnetiP48024
PhosphoSitePlusiP48024

Expressioni

Gene expression databases

BgeeiENSMUSG00000035530
CleanExiMM_EIF1
ExpressionAtlasiP48024 baseline and differential
GenevisibleiP48024 MM

Interactioni

Subunit structurei

Interacts with RENT2.By similarity

Protein-protein interaction databases

IntActiP48024, 1 interactor
MINTiP48024
STRINGi10090.ENSMUSP00000041538

Structurei

3D structure databases

ProteinModelPortaliP48024
SMRiP48024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiKOG1770 Eukaryota
COG0023 LUCA
GeneTreeiENSGT00390000015789
HOGENOMiHOG000279813
HOVERGENiHBG000295
InParanoidiP48024
KOiK03113
OMAiVGSQQNY
OrthoDBiEOG091G10OC
PhylomeDBiP48024
TreeFamiTF314417

Family and domain databases

CDDicd11566 eIF1_SUI1, 1 hit
InterProiView protein in InterPro
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR005874 SUI1_euk
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
PIRSFiPIRSF004499 SUI1_euk, 1 hit
SUPFAMiSSF55159 SSF55159, 1 hit
TIGRFAMsiTIGR01160 SUI1_MOF2, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLIEI
110
GLAKDDQLKV HGF
Length:113
Mass (Da):12,747
Last modified:May 30, 2000 - v2
Checksum:i4B6C7F9B53FFEB34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129888 mRNA Translation: AAD31266.1
BC003463 mRNA Translation: AAH03463.1
BC010791 mRNA Translation: AAH10791.1
BC081429 mRNA Translation: AAH81429.1
Z50159 mRNA Translation: CAA90519.1
CCDSiCCDS25417.1
PIRiS58180
RefSeqiNP_035638.1, NM_011508.2
UniGeneiMm.13886

Genome annotation databases

EnsembliENSMUST00000049385; ENSMUSP00000041538; ENSMUSG00000035530
GeneIDi20918
KEGGimmu:20918
UCSCiuc007lkv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiEIF1_MOUSE
AccessioniPrimary (citable) accession number: P48024
Secondary accession number(s): Q9WUD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: April 25, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health