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P48023

- TNFL6_HUMAN

UniProt

P48023 - TNFL6_HUMAN

Protein

Tumor necrosis factor ligand superfamily member 6

Gene

FASLG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.1 Publication
    The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei81 – 822Cleavage; by SPPL2ACurated
    Sitei129 – 1302Cleavage; by ADAM10Curated

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor binding Source: ProtInc

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
    2. apoptotic process Source: Reactome
    3. apoptotic signaling pathway Source: BHF-UCL
    4. cell-cell signaling Source: ProtInc
    5. cellular chloride ion homeostasis Source: Ensembl
    6. endosomal lumen acidification Source: Ensembl
    7. extrinsic apoptotic signaling pathway Source: UniProtKB
    8. extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
    9. immune response Source: InterPro
    10. inflammatory cell apoptotic process Source: Ensembl
    11. necroptotic process Source: BHF-UCL
    12. necroptotic signaling pathway Source: BHF-UCL
    13. negative regulation of angiogenesis Source: BHF-UCL
    14. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    15. positive regulation of apoptotic process Source: UniProtKB
    16. positive regulation of cell proliferation Source: Ensembl
    17. positive regulation of endothelial cell apoptotic process Source: BHF-UCL
    18. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    19. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    20. positive regulation of neuron apoptotic process Source: Ensembl
    21. regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
    22. response to growth factor Source: Ensembl
    23. response to lipopolysaccharide Source: Ensembl
    24. retinal cell programmed cell death Source: Ensembl
    25. signal transduction Source: ProtInc
    26. T cell apoptotic process Source: UniProtKB
    27. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine, Repressor

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_900. FasL/ CD95L signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 6
    Alternative name(s):
    Apoptosis antigen ligand
    Short name:
    APTL
    CD95 ligand
    Short name:
    CD95-L
    Fas antigen ligand
    Short name:
    Fas ligand
    Short name:
    FasL
    CD_antigen: CD178
    Cleaved into the following 4 chains:
    Alternative name(s):
    Receptor-binding FasL ectodomain
    Soluble Fas ligand
    Short name:
    sFasL
    FasL intracellular domain
    Short name:
    FasL ICD
    Alternative name(s):
    SPPL2A-processed FasL form
    Short name:
    SPA
    Gene namesi
    Name:FASLG
    Synonyms:APT1LG1, CD95L, FASL, TNFSF6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11936. FASLG.

    Subcellular locationi

    Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen
    Note: Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.
    Chain Tumor necrosis factor ligand superfamily member 6, soluble form : Secreted By similarity
    Note: May be released into the extracellular fluid, probably by cleavage form the cell surface.By similarity
    Chain FasL intracellular domain : Nucleus
    Note: The FasL ICD cytoplasmic form is translocated into the nucleus.

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
    3. external side of plasma membrane Source: Ensembl
    4. extracellular region Source: Reactome
    5. extracellular space Source: BHF-UCL
    6. extracellular vesicular exosome Source: UniProtKB
    7. integral component of plasma membrane Source: ProtInc
    8. lysosomal lumen Source: UniProtKB-SubCell
    9. nucleus Source: UniProtKB
    10. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Nucleus, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi206 – 2061P → D, F or R: Lowers binding to TNFRSF6 and reduces cytotoxicity more than 100-fold. 1 Publication
    Mutagenesisi218 – 2181Y → F or R: Lowers binding to TNFRSF6 and abolishes cytotoxicity. 1 Publication
    Mutagenesisi275 – 2751F → L: Abolishes binding to TNRFSF6 and cytotoxicity. 1 Publication

    Organism-specific databases

    MIMi601859. phenotype.
    Orphaneti3261. Autoimmune lymphoproliferative syndrome.
    PharmGKBiPA56.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Tumor necrosis factor ligand superfamily member 6, membrane formPRO_0000034500Add
    BLAST
    Chaini1 – 129129ADAM10-processed FasL formPRO_0000417152Add
    BLAST
    Chaini1 – 8181FasL intracellular domainPRO_0000416842Add
    BLAST
    Chaini130 – 281152Tumor necrosis factor ligand superfamily member 6, soluble formPRO_0000034501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi202 ↔ 233Sequence Analysis
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.2 Publications
    N-glycosylated.
    Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.1 Publication
    Monoubiquitinated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP48023.
    PRIDEiP48023.

    Miscellaneous databases

    PMAP-CutDBP48023.

    Expressioni

    Gene expression databases

    ArrayExpressiP48023.
    BgeeiP48023.
    CleanExiHS_FASLG.
    GenevestigatoriP48023.

    Organism-specific databases

    HPAiCAB011435.

    Interactioni

    Subunit structurei

    Homotrimer Probable. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.2 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ap2b1Q9DBG32EBI-495538,EBI-775229From a different organism.
    CASP8Q147904EBI-495538,EBI-78060
    FADDQ131583EBI-495538,EBI-494804
    FASP254454EBI-495538,EBI-494743
    FNBP1Q96RU34EBI-495538,EBI-1111248
    FYNP062412EBI-495538,EBI-515315
    ITKQ088813EBI-495538,EBI-968552
    PACSIN1Q9BY114EBI-495538,EBI-721769
    PACSIN2Q9UNF04EBI-495538,EBI-742503
    PACSIN3Q9UKS64EBI-495538,EBI-77926
    PIK3R1P279862EBI-495538,EBI-79464
    PSTPIP1O435865EBI-495538,EBI-1050964
    Snx18Q91ZR24EBI-495538,EBI-6879954From a different organism.
    SNX33Q8WV412EBI-495538,EBI-2481535
    SNX9Q9Y5X12EBI-495538,EBI-77848
    SRGAP2O750442EBI-495538,EBI-1051034
    TRIP10Q156424EBI-495538,EBI-739936

    Protein-protein interaction databases

    BioGridi106852. 75 interactions.
    DIPiDIP-2997N.
    IntActiP48023. 65 interactions.
    MINTiMINT-238167.
    STRINGi9606.ENSP00000356694.

    Structurei

    Secondary structure

    1
    281
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi146 – 1516
    Beta strandi157 – 1593
    Beta strandi165 – 1684
    Beta strandi170 – 1778
    Beta strandi180 – 1823
    Beta strandi187 – 20115
    Beta strandi207 – 2148
    Beta strandi218 – 2203
    Beta strandi222 – 2298
    Beta strandi239 – 25113
    Beta strandi256 – 2627
    Helixi264 – 2663
    Turni271 – 2733
    Beta strandi274 – 2807

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BZImodel-B/C1-281[»]
    4MSVX-ray2.50A130-281[»]
    ProteinModelPortaliP48023.
    SMRiP48023. Positions 143-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8080CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 281179ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10222Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 7067Pro-richAdd
    BLAST
    Compositional biasi45 – 6521Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42315.
    HOGENOMiHOG000290680.
    HOVERGENiHBG055128.
    InParanoidiP48023.
    KOiK04389.
    OMAiHLTGKPN.
    OrthoDBiEOG7V4B0Q.
    PhylomeDBiP48023.
    TreeFamiTF332169.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR028326. FASL.
    IPR006053. TNF.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01681. FASLIGAND.
    PR01234. TNECROSISFCT.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48023-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP    50
    PPPLPPPPPP PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG 100
    MFQLFHLQKE LAELRESTSQ MHTASSLEKQ IGHPSPPPEK KELRKVAHLT 150
    GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG LVINETGLYF VYSKVYFRGQ 200
    SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA RSSYLGAVFN 250
    LTSADHLYVN VSELSLVNFE ESQTFFGLYK L 281
    Length:281
    Mass (Da):31,485
    Last modified:February 1, 1996 - v1
    Checksum:iA8A6EB358246E9BB
    GO
    Isoform 2 (identifier: P48023-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         117-127: STSQMHTASSL → ATPVHPLKKRS
         128-281: Missing.

    Show »
    Length:127
    Mass (Da):14,006
    Checksum:iF617D96B26B8E3BA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti189 – 1891Y → S.
    Corresponds to variant rs12079514 [ dbSNP | Ensembl ].
    VAR_052583

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei117 – 12711STSQMHTASSL → ATPVHPLKKRS in isoform 2. 1 PublicationVSP_006443Add
    BLAST
    Alternative sequencei128 – 281154Missing in isoform 2. 1 PublicationVSP_006444Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08137 mRNA. Translation: AAC50071.1.
    U11821 mRNA. Translation: AAC50124.1.
    X89102 mRNA. Translation: CAA61474.1.
    D38122 mRNA. Translation: BAA07320.1.
    AF288573 mRNA. Translation: AAG60017.1.
    Z96050 Genomic DNA. Translation: CAB09424.1.
    BC017502 mRNA. Translation: AAH17502.1.
    AB013303 Genomic DNA. Translation: BAA32542.1.
    CCDSiCCDS1304.1. [P48023-1]
    PIRiI38707.
    RefSeqiNP_000630.1. NM_000639.1. [P48023-1]
    UniGeneiHs.2007.

    Genome annotation databases

    EnsembliENST00000340030; ENSP00000344739; ENSG00000117560. [P48023-2]
    ENST00000367721; ENSP00000356694; ENSG00000117560. [P48023-1]
    GeneIDi356.
    KEGGihsa:356.
    UCSCiuc001gis.3. human. [P48023-1]
    uc001git.3. human. [P48023-2]

    Polymorphism databases

    DMDMi1345957.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    FASLGbase

    FASLG mutation db

    Wikipedia

    FAS-ligand entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08137 mRNA. Translation: AAC50071.1 .
    U11821 mRNA. Translation: AAC50124.1 .
    X89102 mRNA. Translation: CAA61474.1 .
    D38122 mRNA. Translation: BAA07320.1 .
    AF288573 mRNA. Translation: AAG60017.1 .
    Z96050 Genomic DNA. Translation: CAB09424.1 .
    BC017502 mRNA. Translation: AAH17502.1 .
    AB013303 Genomic DNA. Translation: BAA32542.1 .
    CCDSi CCDS1304.1. [P48023-1 ]
    PIRi I38707.
    RefSeqi NP_000630.1. NM_000639.1. [P48023-1 ]
    UniGenei Hs.2007.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BZI model - B/C 1-281 [» ]
    4MSV X-ray 2.50 A 130-281 [» ]
    ProteinModelPortali P48023.
    SMRi P48023. Positions 143-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106852. 75 interactions.
    DIPi DIP-2997N.
    IntActi P48023. 65 interactions.
    MINTi MINT-238167.
    STRINGi 9606.ENSP00000356694.

    Chemistry

    ChEMBLi CHEMBL5714.

    Polymorphism databases

    DMDMi 1345957.

    Proteomic databases

    PaxDbi P48023.
    PRIDEi P48023.

    Protocols and materials databases

    DNASUi 356.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340030 ; ENSP00000344739 ; ENSG00000117560 . [P48023-2 ]
    ENST00000367721 ; ENSP00000356694 ; ENSG00000117560 . [P48023-1 ]
    GeneIDi 356.
    KEGGi hsa:356.
    UCSCi uc001gis.3. human. [P48023-1 ]
    uc001git.3. human. [P48023-2 ]

    Organism-specific databases

    CTDi 356.
    GeneCardsi GC01P172628.
    GeneReviewsi FASLG.
    HGNCi HGNC:11936. FASLG.
    HPAi CAB011435.
    MIMi 134638. gene.
    601859. phenotype.
    neXtProti NX_P48023.
    Orphaneti 3261. Autoimmune lymphoproliferative syndrome.
    PharmGKBi PA56.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42315.
    HOGENOMi HOG000290680.
    HOVERGENi HBG055128.
    InParanoidi P48023.
    KOi K04389.
    OMAi HLTGKPN.
    OrthoDBi EOG7V4B0Q.
    PhylomeDBi P48023.
    TreeFami TF332169.

    Enzyme and pathway databases

    Reactomei REACT_900. FasL/ CD95L signaling.

    Miscellaneous databases

    GeneWikii Fas_ligand.
    GenomeRNAii 356.
    NextBioi 1489.
    PMAP-CutDB P48023.
    PROi P48023.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48023.
    Bgeei P48023.
    CleanExi HS_FASLG.
    Genevestigatori P48023.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR028326. FASL.
    IPR006053. TNF.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01681. FASLIGAND.
    PR01234. TNECROSISFCT.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fas ligand mediates activation-induced cell death in human T lymphocytes."
      Alderson M.
      J. Exp. Med. 181:71-77(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Human Fas ligand: gene structure, chromosomal location and species specificity."
      Takahashi T., Tanaka M., Inazawa J., Abe T., Suda T., Nagata S.
      Int. Immunol. 6:1567-1574(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Schaetzlein C.E., Poehlmann R., Philippsen P., Eibel H.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Isolation and characterization of a new naturally occurring variant of human Fas ligand that is expressed only in membrane bound form."
      Zeytun A., Nagarkatti M., Nagarkatti P.S.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Leukocyte.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Blood.
    8. Matsumura M., Nakanishi Y., Ohba Y.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.
      Tissue: Blood.
    9. "Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease."
      Wu J., Wilson J., He J., Xiang L., Schur P.H., Mountz J.D.
      J. Clin. Invest. 98:1107-1113(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN ALPS1B.
    10. Cited for: CHARACTERIZATION, MUTAGENESIS OF PRO-206; TYR-218 AND PHE-275.
    11. "Downregulation of Fas ligand by shedding."
      Tanaka M., Itai T., Adachi M., Nagata S.
      Nat. Med. 4:31-36(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    12. Cited for: FUNCTION OF FASL INTRACELLULAR DOMAIN, CLEAVAGE BY ADAM10 AND SPPL2A, SUBCELLULAR LOCATION.
    13. "Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation."
      Zuccato E., Blott E.J., Holt O., Sigismund S., Shaw M., Bossi G., Griffiths G.M.
      J. Cell Sci. 120:191-199(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, PHOSPHORYLATION, INTERACTION WITH FGR; FYN AND LYN, SUBCELLULAR LOCATION.
    14. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARHGAP9; BAIAP2L1; BTK; CACNB3; CACNB4; CRK; DLG2; DNMBP; DOCK4; EPS8L3; FYB; FYN; HCK; ITK; ITSN2; KALRN; LYN; MACC1; MIA; MPP4; MYO15A; NCF1; NCK1; NCK2; NCKIPSD; OSTF1; PIK3R1; PSTPIP1; RIMBP3C; SAMSN1; SH3GL3; SH3PXD2B; SH3PXD2A; SH3RF2; SKAP2; SNX33; SNX9; SORBS3; SPTA1; SRC; SRGAP1; SRGAP2; SRGAP3; TEC; TJP3 AND YES1.

    Entry informationi

    Entry nameiTNFL6_HUMAN
    AccessioniPrimary (citable) accession number: P48023
    Secondary accession number(s): Q9BZP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 164 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3