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P48023

- TNFL6_HUMAN

UniProt

P48023 - TNFL6_HUMAN

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Protein

Tumor necrosis factor ligand superfamily member 6

Gene

FASLG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.1 Publication
The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei81 – 822Cleavage; by SPPL2ACurated
Sitei129 – 1302Cleavage; by ADAM10Curated

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
  2. apoptotic process Source: Reactome
  3. apoptotic signaling pathway Source: BHF-UCL
  4. cell-cell signaling Source: ProtInc
  5. cellular chloride ion homeostasis Source: Ensembl
  6. endosomal lumen acidification Source: Ensembl
  7. extrinsic apoptotic signaling pathway Source: UniProtKB
  8. extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
  9. immune response Source: InterPro
  10. inflammatory cell apoptotic process Source: Ensembl
  11. necroptotic process Source: BHF-UCL
  12. necroptotic signaling pathway Source: BHF-UCL
  13. negative regulation of angiogenesis Source: BHF-UCL
  14. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  15. positive regulation of apoptotic process Source: UniProtKB
  16. positive regulation of cell proliferation Source: Ensembl
  17. positive regulation of endothelial cell apoptotic process Source: BHF-UCL
  18. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  19. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  20. positive regulation of neuron apoptotic process Source: Ensembl
  21. regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
  22. response to growth factor Source: Ensembl
  23. response to lipopolysaccharide Source: Ensembl
  24. retinal cell programmed cell death Source: Ensembl
  25. signal transduction Source: ProtInc
  26. T cell apoptotic process Source: UniProtKB
  27. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_900. FasL/ CD95L signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 6
Alternative name(s):
Apoptosis antigen ligand
Short name:
APTL
CD95 ligand
Short name:
CD95-L
Fas antigen ligand
Short name:
Fas ligand
Short name:
FasL
CD_antigen: CD178
Cleaved into the following 4 chains:
Alternative name(s):
Receptor-binding FasL ectodomain
Soluble Fas ligand
Short name:
sFasL
FasL intracellular domain
Short name:
FasL ICD
Alternative name(s):
SPPL2A-processed FasL form
Short name:
SPA
Gene namesi
Name:FASLG
Synonyms:APT1LG1, CD95L, FASL, TNFSF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11936. FASLG.

Subcellular locationi

Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen
Note: Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.
Chain Tumor necrosis factor ligand superfamily member 6, soluble form : Secreted By similarity
Note: May be released into the extracellular fluid, probably by cleavage form the cell surface.By similarity
Chain FasL intracellular domain : Nucleus
Note: The FasL ICD cytoplasmic form is translocated into the nucleus.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8080CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10222Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini103 – 281179ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. cytoplasmic membrane-bounded vesicle Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. extracellular region Source: Reactome
  5. extracellular space Source: BHF-UCL
  6. extracellular vesicular exosome Source: UniProtKB
  7. integral component of plasma membrane Source: ProtInc
  8. lysosome Source: UniProtKB-KW
  9. nucleus Source: UniProtKB
  10. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi206 – 2061P → D, F or R: Lowers binding to TNFRSF6 and reduces cytotoxicity more than 100-fold. 1 Publication
Mutagenesisi218 – 2181Y → F or R: Lowers binding to TNFRSF6 and abolishes cytotoxicity. 1 Publication
Mutagenesisi275 – 2751F → L: Abolishes binding to TNRFSF6 and cytotoxicity. 1 Publication

Organism-specific databases

MIMi601859. phenotype.
Orphaneti3261. Autoimmune lymphoproliferative syndrome.
PharmGKBiPA56.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Tumor necrosis factor ligand superfamily member 6, membrane formPRO_0000034500Add
BLAST
Chaini1 – 129129ADAM10-processed FasL formPRO_0000417152Add
BLAST
Chaini1 – 8181FasL intracellular domainPRO_0000416842Add
BLAST
Chaini130 – 281152Tumor necrosis factor ligand superfamily member 6, soluble formPRO_0000034501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi202 ↔ 233Sequence Analysis
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.2 Publications
N-glycosylated.
Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.1 Publication
Monoubiquitinated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP48023.
PRIDEiP48023.

Miscellaneous databases

PMAP-CutDBP48023.

Expressioni

Gene expression databases

BgeeiP48023.
CleanExiHS_FASLG.
ExpressionAtlasiP48023. baseline and differential.
GenevestigatoriP48023.

Organism-specific databases

HPAiCAB011435.

Interactioni

Subunit structurei

Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.2 PublicationsCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
Ap2b1Q9DBG32EBI-495538,EBI-775229From a different organism.
CASP8Q147904EBI-495538,EBI-78060
FADDQ131583EBI-495538,EBI-494804
FASP254454EBI-495538,EBI-494743
FNBP1Q96RU34EBI-495538,EBI-1111248
FYNP062412EBI-495538,EBI-515315
ITKQ088813EBI-495538,EBI-968552
PACSIN1Q9BY114EBI-495538,EBI-721769
PACSIN2Q9UNF04EBI-495538,EBI-742503
PACSIN3Q9UKS64EBI-495538,EBI-77926
PIK3R1P279862EBI-495538,EBI-79464
PSTPIP1O435865EBI-495538,EBI-1050964
Snx18Q91ZR24EBI-495538,EBI-6879954From a different organism.
SNX33Q8WV412EBI-495538,EBI-2481535
SNX9Q9Y5X12EBI-495538,EBI-77848
SRGAP2O750442EBI-495538,EBI-1051034
TRIP10Q156424EBI-495538,EBI-739936

Protein-protein interaction databases

BioGridi106852. 81 interactions.
DIPiDIP-2997N.
IntActiP48023. 65 interactions.
MINTiMINT-238167.
STRINGi9606.ENSP00000356694.

Structurei

Secondary structure

1
281
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi146 – 1516Combined sources
Beta strandi157 – 1593Combined sources
Beta strandi165 – 1684Combined sources
Beta strandi170 – 1778Combined sources
Beta strandi180 – 1823Combined sources
Beta strandi187 – 20115Combined sources
Beta strandi207 – 2148Combined sources
Beta strandi218 – 2203Combined sources
Beta strandi222 – 2298Combined sources
Beta strandi239 – 25113Combined sources
Beta strandi256 – 2627Combined sources
Helixi264 – 2663Combined sources
Turni271 – 2733Combined sources
Beta strandi274 – 2807Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BZImodel-B/C1-281[»]
4MSVX-ray2.50A130-281[»]
ProteinModelPortaliP48023.
SMRiP48023. Positions 143-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 7067Pro-richAdd
BLAST
Compositional biasi45 – 6521Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42315.
GeneTreeiENSGT00530000062992.
HOGENOMiHOG000290680.
HOVERGENiHBG055128.
InParanoidiP48023.
KOiK04389.
OMAiHLTGKPN.
OrthoDBiEOG7V4B0Q.
PhylomeDBiP48023.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR028326. FASL.
IPR006053. TNF.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01681. FASLIGAND.
PR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P48023-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP
60 70 80 90 100
PPPLPPPPPP PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG
110 120 130 140 150
MFQLFHLQKE LAELRESTSQ MHTASSLEKQ IGHPSPPPEK KELRKVAHLT
160 170 180 190 200
GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG LVINETGLYF VYSKVYFRGQ
210 220 230 240 250
SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA RSSYLGAVFN
260 270 280
LTSADHLYVN VSELSLVNFE ESQTFFGLYK L
Length:281
Mass (Da):31,485
Last modified:February 1, 1996 - v1
Checksum:iA8A6EB358246E9BB
GO
Isoform 2 (identifier: P48023-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-127: STSQMHTASSL → ATPVHPLKKRS
     128-281: Missing.

Show »
Length:127
Mass (Da):14,006
Checksum:iF617D96B26B8E3BA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891Y → S.
Corresponds to variant rs12079514 [ dbSNP | Ensembl ].
VAR_052583

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 12711STSQMHTASSL → ATPVHPLKKRS in isoform 2. 1 PublicationVSP_006443Add
BLAST
Alternative sequencei128 – 281154Missing in isoform 2. 1 PublicationVSP_006444Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08137 mRNA. Translation: AAC50071.1.
U11821 mRNA. Translation: AAC50124.1.
X89102 mRNA. Translation: CAA61474.1.
D38122 mRNA. Translation: BAA07320.1.
AF288573 mRNA. Translation: AAG60017.1.
Z96050 Genomic DNA. Translation: CAB09424.1.
BC017502 mRNA. Translation: AAH17502.1.
AB013303 Genomic DNA. Translation: BAA32542.1.
CCDSiCCDS1304.1. [P48023-1]
PIRiI38707.
RefSeqiNP_000630.1. NM_000639.1. [P48023-1]
UniGeneiHs.2007.

Genome annotation databases

EnsembliENST00000340030; ENSP00000344739; ENSG00000117560. [P48023-2]
ENST00000367721; ENSP00000356694; ENSG00000117560. [P48023-1]
GeneIDi356.
KEGGihsa:356.
UCSCiuc001gis.3. human. [P48023-1]
uc001git.3. human. [P48023-2]

Polymorphism databases

DMDMi1345957.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

FASLGbase

FASLG mutation db

Wikipedia

FAS-ligand entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08137 mRNA. Translation: AAC50071.1 .
U11821 mRNA. Translation: AAC50124.1 .
X89102 mRNA. Translation: CAA61474.1 .
D38122 mRNA. Translation: BAA07320.1 .
AF288573 mRNA. Translation: AAG60017.1 .
Z96050 Genomic DNA. Translation: CAB09424.1 .
BC017502 mRNA. Translation: AAH17502.1 .
AB013303 Genomic DNA. Translation: BAA32542.1 .
CCDSi CCDS1304.1. [P48023-1 ]
PIRi I38707.
RefSeqi NP_000630.1. NM_000639.1. [P48023-1 ]
UniGenei Hs.2007.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BZI model - B/C 1-281 [» ]
4MSV X-ray 2.50 A 130-281 [» ]
ProteinModelPortali P48023.
SMRi P48023. Positions 143-281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106852. 81 interactions.
DIPi DIP-2997N.
IntActi P48023. 65 interactions.
MINTi MINT-238167.
STRINGi 9606.ENSP00000356694.

Chemistry

ChEMBLi CHEMBL5714.

Polymorphism databases

DMDMi 1345957.

Proteomic databases

PaxDbi P48023.
PRIDEi P48023.

Protocols and materials databases

DNASUi 356.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340030 ; ENSP00000344739 ; ENSG00000117560 . [P48023-2 ]
ENST00000367721 ; ENSP00000356694 ; ENSG00000117560 . [P48023-1 ]
GeneIDi 356.
KEGGi hsa:356.
UCSCi uc001gis.3. human. [P48023-1 ]
uc001git.3. human. [P48023-2 ]

Organism-specific databases

CTDi 356.
GeneCardsi GC01P172628.
GeneReviewsi FASLG.
HGNCi HGNC:11936. FASLG.
HPAi CAB011435.
MIMi 134638. gene.
601859. phenotype.
neXtProti NX_P48023.
Orphaneti 3261. Autoimmune lymphoproliferative syndrome.
PharmGKBi PA56.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42315.
GeneTreei ENSGT00530000062992.
HOGENOMi HOG000290680.
HOVERGENi HBG055128.
InParanoidi P48023.
KOi K04389.
OMAi HLTGKPN.
OrthoDBi EOG7V4B0Q.
PhylomeDBi P48023.
TreeFami TF332169.

Enzyme and pathway databases

Reactomei REACT_900. FasL/ CD95L signaling.

Miscellaneous databases

GeneWikii Fas_ligand.
GenomeRNAii 356.
NextBioi 1489.
PMAP-CutDB P48023.
PROi P48023.
SOURCEi Search...

Gene expression databases

Bgeei P48023.
CleanExi HS_FASLG.
ExpressionAtlasi P48023. baseline and differential.
Genevestigatori P48023.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR028326. FASL.
IPR006053. TNF.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01681. FASLIGAND.
PR01234. TNECROSISFCT.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fas ligand mediates activation-induced cell death in human T lymphocytes."
    Alderson M.
    J. Exp. Med. 181:71-77(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human Fas ligand: gene structure, chromosomal location and species specificity."
    Takahashi T., Tanaka M., Inazawa J., Abe T., Suda T., Nagata S.
    Int. Immunol. 6:1567-1574(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Schaetzlein C.E., Poehlmann R., Philippsen P., Eibel H.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Isolation and characterization of a new naturally occurring variant of human Fas ligand that is expressed only in membrane bound form."
    Zeytun A., Nagarkatti M., Nagarkatti P.S.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Leukocyte.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Blood.
  8. Matsumura M., Nakanishi Y., Ohba Y.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.
    Tissue: Blood.
  9. "Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease."
    Wu J., Wilson J., He J., Xiang L., Schur P.H., Mountz J.D.
    J. Clin. Invest. 98:1107-1113(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ALPS1B.
  10. Cited for: CHARACTERIZATION, MUTAGENESIS OF PRO-206; TYR-218 AND PHE-275.
  11. "Downregulation of Fas ligand by shedding."
    Tanaka M., Itai T., Adachi M., Nagata S.
    Nat. Med. 4:31-36(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  12. Cited for: FUNCTION OF FASL INTRACELLULAR DOMAIN, CLEAVAGE BY ADAM10 AND SPPL2A, SUBCELLULAR LOCATION.
  13. "Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation."
    Zuccato E., Blott E.J., Holt O., Sigismund S., Shaw M., Bossi G., Griffiths G.M.
    J. Cell Sci. 120:191-199(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, PHOSPHORYLATION, INTERACTION WITH FGR; FYN AND LYN, SUBCELLULAR LOCATION.
  14. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGAP9; BAIAP2L1; BTK; CACNB3; CACNB4; CRK; DLG2; DNMBP; DOCK4; EPS8L3; FYB; FYN; HCK; ITK; ITSN2; KALRN; LYN; MACC1; MIA; MPP4; MYO15A; NCF1; NCK1; NCK2; NCKIPSD; OSTF1; PIK3R1; PSTPIP1; RIMBP3C; SAMSN1; SH3GL3; SH3PXD2B; SH3PXD2A; SH3RF2; SKAP2; SNX33; SNX9; SORBS3; SPTA1; SRC; SRGAP1; SRGAP2; SRGAP3; TEC; TJP3 AND YES1.

Entry informationi

Entry nameiTNFL6_HUMAN
AccessioniPrimary (citable) accession number: P48023
Secondary accession number(s): Q9BZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3