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P48020 (HMDH1_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Short name=HMG-CoA reductase 1
Short name=HMGR
Short name=HMGR1
EC=1.1.1.34
Gene names
Name:HMG1
OrganismSolanum tuberosum (Potato)
Taxonomic identifier4113 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.

Catalytic activity

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in flower primordia and anthers.

Induction

Induced by wounding. This enhancement is greatly reduced by treatment with arachidonic acid or after innoculation with the fungal pathogen, P.infestans.

Sequence similarities

Belongs to the HMG-CoA reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5965963-hydroxy-3-methylglutaryl-coenzyme A reductase 1
PRO_0000114448

Regions

Transmembrane41 – 6121Helical; Potential
Transmembrane83 – 10321Helical; Potential
Region104 – 18380Linker By similarity
Region184 – 596413Catalytic By similarity

Sites

Active site2781Charge relay system By similarity
Active site4101Charge relay system By similarity
Active site4861Charge relay system By similarity
Active site5841Proton donor By similarity

Amino acid modifications

Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation5881N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P48020 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 4E7060D3ADC6EE60

FASTA59663,917
        10         20         30         40         50         60 
MDVRRRPVKP LYTSKDASAG EPLKQQEVSS PKASDALPLP LYLTNGLFFT MFFSVMYFLL 

        70         80         90        100        110        120 
VRWREKIRNS IPLHVVTLSE LLAMVSLIAS VIYLLGFFGI GFVQSFVSRS NSDSWDIEDE 

       130        140        150        160        170        180 
NAEQLIIEED SRRGPCAAAT TLGCVVPPPP VRKIAPMVPQ QPAKVALSQT EKPSPIIMPA 

       190        200        210        220        230        240 
LSEDDEEIIQ SVVQGKTPSY SLESKLGDCM RAASIRKEAL QRITGKSLEG LPLEGFDYSS 

       250        260        270        280        290        300 
ILGQCCEMPV GYVQIPVGIA GPLLLDGREY SVPMATTEGC LVASTNRGCK AIFVSGGADS 

       310        320        330        340        350        360 
VLLRDGMTRA PVVRFTTAKR AAELKFFVED PLNFETLSLM FNKSSRFARL QGIQCAIAGK 

       370        380        390        400        410        420 
NLYITFSCST GDAMGMNMVS KGVQNVLDYL QSEYPDMDVI GISGNFCSDK KPAAVNWIEG 

       430        440        450        460        470        480 
RGKSVVCEAI IKEEVVKKVL KTEVAALVEL NMLKNLTGSA MAGALGGFNA HASNIVSAVY 

       490        500        510        520        530        540 
LATGQDPAQN VESSHCITMM EAVNDGKDLH VSVTMPSIEV GTVGGGTQLA SQSACLNLLG 

       550        560        570        580        590 
VKGANRDAPG SNARLLATIV AGSVLAGELS LMSAISAGQL VKSHMKYNRS IKDISK 

« Hide

References

[1]"Differential induction and suppression of potato 3-hydroxy-3-methylglutaryl coenzyme A reductase genes in response to Phytophthora infestans and to its elicitor arachidonic acid."
Choi D., Ward B.L., Bostock R.M.
Plant Cell 4:1333-1344(1992) [PubMed: 1283354] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Kennebec.
Tissue: Tuber.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L01400 mRNA. Translation: AAA93498.1.
PIRS59944.

3D structure databases

ProteinModelPortalP48020.
SMRP48020. Positions 183-581.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR023282. HMG_CoA_Rdtase_N.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd.
IPR009029. HMG_CoA_Rdtase_sub-bd.
[Graphical view]
Gene3DG3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit.
G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
G3DSA:1.10.3270.10. HMG_CoA_Rdtase_N. 1 hit.
PANTHERPTHR10572. HMG-CoA_red. 1 hit.
PfamPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSPR00071. HMGCOARDTASE.
SUPFAMSSF55035. HMG_CoA_NAD_bind. 1 hit.
SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMsTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEPS00066. HMG_COA_REDUCTASE_1. False negative.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHMDH1_SOLTU
AccessionPrimary (citable) accession number: P48020
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 28, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families