P48017 (CHS_SAPMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chitin synthase
EC=2.4.1.16

Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase

Gene names

Name:

CHS

Organism

Saprolegnia monoica

Taxonomic identifier

37553 [NCBI]

Taxonomic lineage

Eukaryota › stramenopiles › Oomycetes › Saprolegniales › Saprolegniaceae › Saprolegnia

Protein attributes

Sequence length	886 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in cell wall biogenesis.
Catalytic activity	UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the chitin synthase family.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW chitin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chitin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 886	886	Chitin synthase		PRO_0000193714
Regions
	Transmembrane	534 – 554	21	Helical; Potential
	Transmembrane	578 – 598	21	Helical; Potential
	Transmembrane	605 – 625	21	Helical; Potential
	Transmembrane	636 – 656	21	Helical; Potential
	Transmembrane	672 – 692	21	Helical; Potential
	Transmembrane	695 – 715	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P48017 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 74E347C4B941FE0C	FASTA	886	98,570
	10 20 30 40 50 60 MSDQLDLAAR LRALREGNAA PADPETATHT AWPAPQYHPH CRRCIHKSRS SWEGRMPRAA 70 80 90 100 110 120 PCAEAEGSYS QVPVWKDSKE TRRSYLDDEP TPQPQSLINM ANTLVQRQRR INLPAAAYSE 130 140 150 160 170 180 LPTAAQHRRG ASGRQANTAT QVLQLTCTWT LARRSSKSAE ELGTWMNTVA EEARKAALPP 190 200 210 220 230 240 QLKIARTNVP TVEQAWKGRT PPFHDADEFR LMRYTAVATK DPIQFSNDGY VLRVHQLHRR 250 260 270 280 290 300 IKVFITITMY NEEGSEILGT LTGLAKGLGY MCKEYGQDFW QEVAVAIVSD GRTKASKTCL 310 320 330 340 350 360 EYLNGLGAFD EEIMTVTSLG VDTPAGENQT FENYFPPLQV IYALKENNGG KLNSHLWFFN 370 380 390 400 410 420 AFSEQLNPKY TVLVDVGTIP AETSVFRLIR SMERNYQIGG VAGEIAVEAP NYFNPVIAAQ 430 440 450 460 470 480 HFEYKISNIM DKSLESVFGF ISVLPGAFSA YRYEAIRAVK GVGPLPEYFK SLTSTTKELG 490 500 510 520 530 540 PFQGNMYLAE DRILCFELLA RKHKQWTMHY VKDAIARTDV PETLVDLIKQ ARRWLNGSFF 550 560 570 580 590 600 AGLFAIGTLA VWSQSSHTMS RKLVFTFQFF YLALQNLLSW FLLSNLFLTF YFVLTLAFTD 610 620 630 640 650 660 SAPALLQAML TLYLAIVGGL IVFALGNKPE PRTASFYLFS CLYMGIIMML VTGISIYGLV 670 680 690 700 710 720 GKGTSAVKDP RVITGPLATV LSLKGSLSVV SSPRLGLIFL SAFVHGEFSI LLSVIQYFFM 730 740 750 760 770 780 LPTFVQFAHL SWGTKGLESG GRHGPTKTGG GKVKEVVEQQ KKLEAQRQAA AKEKEDVDNS 790 800 810 820 830 840 FRAFRSTLLA VVAHDQRHLA LRCDGLHVER VLLEGPQLVV GFFNVIVSRA ALYLLSCASL 850 860 870 880 SYSALTAVQW GPPTIPMSAT CRPTGRLITM YRTKATVGLW LPVQRA

References

[1]	Mort-Bontemps F. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19946 Genomic DNA. Translation: AAC49743.1.
3D structure databases
ProteinModelPortal	P48017.
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004834. Chitin_synth. IPR013616. Chitin_synth_N. [Graphical view]
Pfam	PF01644. Chitin_synth_1. 1 hit. PF08407. Chitin_synth_1N. 1 hit. [Graphical view]
ProDom	PD002998. Chitin_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

CHS_SAPMO

Accession

Primary (citable) accession number: P48017

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 31, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)