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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

rpc10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24ZincBy similarity1
Metal bindingi27ZincBy similarity1
Metal bindingi41ZincBy similarity1
Metal bindingi44ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 44C4-typeSequence analysisAdd BLAST21

GO - Molecular functioni

GO - Biological processi

  • transcription from RNA polymerase III promoter Source: PomBase
  • transcription from RNA polymerase II promoter Source: PomBase
  • transcription from RNA polymerase I promoter Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-1834949. Cytosolic sensors of pathogen-associated DNA.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-72086. mRNA Capping.
R-SPO-72165. mRNA Splicing - Minor Pathway.
R-SPO-73762. RNA Polymerase I Transcription Initiation.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Short name:
RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
ABC10-alpha
Gene namesi
Name:rpc10
Synonyms:rpb12
ORF Names:SPBC19C2.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19C2.03.
PomBaseiSPBC19C2.03. rpc10.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • DNA-directed RNA polymerase I complex Source: PomBase
  • DNA-directed RNA polymerase II, core complex Source: PomBase
  • DNA-directed RNA polymerase III complex Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597521 – 63DNA-directed RNA polymerases I, II, and III subunit RPABC4Add BLAST63

Proteomic databases

PRIDEiP48011.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi277312. 9 interactors.
IntActiP48011. 1 interactor.
MINTiMINT-1214266.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0GX-ray3.65L/X1-63[»]
ProteinModelPortaliP48011.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48011.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 44C4-typeSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000191755.
InParanoidiP48011.
KOiK03009.
OMAiCGAENQL.
OrthoDBiEOG092C5YM4.
PhylomeDBiP48011.

Family and domain databases

Gene3Di2.20.28.30. 1 hit.
InterProiIPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
[Graphical view]
PfamiPF03604. DNA_RNApol_7kD. 1 hit.
[Graphical view]
SMARTiSM00659. RPOLCX. 1 hit.
[Graphical view]
SUPFAMiSSF63393. SSF63393. 1 hit.

Sequencei

Sequence statusi: Complete.

P48011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHPTSTGGT AFNPPRPATM IYLCADCGAR NTIQAKEVIR CRECGHRVMY
60
KMRTKRMVQF EAR
Length:63
Mass (Da):7,203
Last modified:July 15, 1998 - v2
Checksum:i97EBE50FAA95E884
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29A → R (PubMed:7651387).Curated1
Sequence conflicti29A → R (PubMed:9290054).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20867 mRNA. Translation: AAA80487.1.
U80217 mRNA. Translation: AAC49841.1.
AF027819 Genomic DNA. Translation: AAC16896.1.
D89634 Genomic DNA. Translation: BAA22807.1.
CU329671 Genomic DNA. Translation: CAB52030.1.
PIRiT43546.
T52536.
RefSeqiNP_595688.1. NM_001021585.2.

Genome annotation databases

EnsemblFungiiSPBC19C2.03.1; SPBC19C2.03.1:pep; SPBC19C2.03.
GeneIDi2540793.
KEGGispo:SPBC19C2.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20867 mRNA. Translation: AAA80487.1.
U80217 mRNA. Translation: AAC49841.1.
AF027819 Genomic DNA. Translation: AAC16896.1.
D89634 Genomic DNA. Translation: BAA22807.1.
CU329671 Genomic DNA. Translation: CAB52030.1.
PIRiT43546.
T52536.
RefSeqiNP_595688.1. NM_001021585.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0GX-ray3.65L/X1-63[»]
ProteinModelPortaliP48011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277312. 9 interactors.
IntActiP48011. 1 interactor.
MINTiMINT-1214266.

Proteomic databases

PRIDEiP48011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC19C2.03.1; SPBC19C2.03.1:pep; SPBC19C2.03.
GeneIDi2540793.
KEGGispo:SPBC19C2.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC19C2.03.
PomBaseiSPBC19C2.03. rpc10.

Phylogenomic databases

HOGENOMiHOG000191755.
InParanoidiP48011.
KOiK03009.
OMAiCGAENQL.
OrthoDBiEOG092C5YM4.
PhylomeDBiP48011.

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-1834949. Cytosolic sensors of pathogen-associated DNA.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-72086. mRNA Capping.
R-SPO-72165. mRNA Splicing - Minor Pathway.
R-SPO-73762. RNA Polymerase I Transcription Initiation.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

EvolutionaryTraceiP48011.
PROiP48011.

Family and domain databases

Gene3Di2.20.28.30. 1 hit.
InterProiIPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
[Graphical view]
PfamiPF03604. DNA_RNApol_7kD. 1 hit.
[Graphical view]
SMARTiSM00659. RPOLCX. 1 hit.
[Graphical view]
SUPFAMiSSF63393. SSF63393. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPAB4_SCHPO
AccessioniPrimary (citable) accession number: P48011
Secondary accession number(s): O14457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.