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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

rpc10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24ZincBy similarity1
Metal bindingi27ZincBy similarity1
Metal bindingi41ZincBy similarity1
Metal bindingi44ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 44C4-typeSequence analysisAdd BLAST21

GO - Molecular functioni

GO - Biological processi

  • transcription by RNA polymerase I Source: PomBase
  • transcription by RNA polymerase II Source: PomBase
  • transcription by RNA polymerase III Source: PomBase

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-113418 Formation of the Early Elongation Complex
R-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SPO-72086 mRNA Capping
R-SPO-72165 mRNA Splicing - Minor Pathway
R-SPO-73762 RNA Polymerase I Transcription Initiation
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SPO-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Short name:
RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
ABC10-alpha
Gene namesi
Name:rpc10
Synonyms:rpb12
ORF Names:SPBC19C2.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19C2.03
PomBaseiSPBC19C2.03 rpc10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597521 – 63DNA-directed RNA polymerases I, II, and III subunit RPABC4Add BLAST63

Proteomic databases

PaxDbiP48011
PRIDEiP48011

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi277312, 9 interactors
IntActiP48011, 1 interactor
STRINGi4896.SPBC19C2.03.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0GX-ray3.65L/X1-63[»]
5U0Selectron microscopy7.80l1-63[»]
ProteinModelPortaliP48011
SMRiP48011
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48011

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 44C4-typeSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000191755
InParanoidiP48011
KOiK03009
OMAiLMVYDAR
OrthoDBiEOG092C5YM4
PhylomeDBiP48011

Family and domain databases

InterProiView protein in InterPro
IPR006591 RNAP_P/RPABC4
IPR029040 RPABC4/Spt4
PfamiView protein in Pfam
PF03604 DNA_RNApol_7kD, 1 hit
SMARTiView protein in SMART
SM00659 RPOLCX, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit

Sequencei

Sequence statusi: Complete.

P48011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHPTSTGGT AFNPPRPATM IYLCADCGAR NTIQAKEVIR CRECGHRVMY
60
KMRTKRMVQF EAR
Length:63
Mass (Da):7,203
Last modified:July 15, 1998 - v2
Checksum:i97EBE50FAA95E884
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29A → R (PubMed:7651387).Curated1
Sequence conflicti29A → R (PubMed:9290054).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20867 mRNA Translation: AAA80487.1
U80217 mRNA Translation: AAC49841.1
AF027819 Genomic DNA Translation: AAC16896.1
D89634 Genomic DNA Translation: BAA22807.1
CU329671 Genomic DNA Translation: CAB52030.1
PIRiT43546
T52536
RefSeqiNP_595688.1, NM_001021585.2

Genome annotation databases

EnsemblFungiiSPBC19C2.03.1; SPBC19C2.03.1:pep; SPBC19C2.03
GeneIDi2540793
KEGGispo:SPBC19C2.03

Similar proteinsi

Entry informationi

Entry nameiRPAB4_SCHPO
AccessioniPrimary (citable) accession number: P48011
Secondary accession number(s): O14457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health