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Protein

Septin homolog spn5

Gene

spn5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151GTPBy similarity1
Binding sitei177GTP; via amide nitrogenBy similarity1
Binding sitei304GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei319GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 132GTPBy similarity8
Nucleotide bindingi257 – 265GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

  • spore membrane bending pathway Source: PomBase

Keywordsi

Biological processMeiosis, Sporulation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin homolog spn5
Alternative name(s):
Mei4-dependent protein 9
Meiotic expression up-regulated protein 28
Gene namesi
Name:spn5
Synonyms:mde9, meu28
ORF Names:SPAC24C9.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC24C9.15c
PomBaseiSPAC24C9.15c spn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735071 – 464Septin homolog spn5Add BLAST464

Proteomic databases

PaxDbiP48010
PRIDEiP48010

Expressioni

Inductioni

Expressed during meiosis. Expression is under the control of the meiosis-specific transcription factor mei4.1 Publication

Interactioni

Subunit structurei

Component of the sporulation-specific septin complex composed of at least spn2, spn5, spn6 and spn7.1 Publication

Protein-protein interaction databases

BioGridi279095, 12 interactors
STRINGi4896.SPAC24C9.15c.1

Structurei

3D structure databases

ProteinModelPortaliP48010
SMRiP48010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 370Septin-type GPROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 132G1 motifPROSITE-ProRule annotation8
Regioni174 – 177G3 motifPROSITE-ProRule annotation4
Regioni256 – 259G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili396 – 453Sequence analysisAdd BLAST58

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP48010
OrthoDBiEOG092C3HL6
PhylomeDBiP48010

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequencei

Sequence statusi: Complete.

P48010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSNLSSSM PQEGQLKLTE EAIITIKQVD ESSAKRSVSN ESRKSKDVTR
60 70 80 90 100
KEQIASDQQG DDQCPQSDTA KDKKTEFKQD EVPNSNGKSI PTFHPCNNIG
110 120 130 140 150
INDFNHQHYS RVCRNGIDIN LIVVGESSLG KTTFVNSFLQ SNDTNFRPKK
160 170 180 190 200
TMDFVEHKAT LSDGDQKFNL TIVDTPGFGD KSDNSNCWRP IATNLLHRLN
210 220 230 240 250
AYFQNEVKMD RETSEIDSRI HGCLFFINPN GHRLQPLEIY IMKKIDQFVN
260 270 280 290 300
IIPVIGKADT MTSDELNHFK KRVIADMVRE KIRYFREPHN EKKAKIPIPF
310 320 330 340 350
AIVGAGAPIE HDGKCIRGRA YPWGLVDIDD PKQSDFCQLR NFLLYTHIEG
360 370 380 390 400
LKHKTHKLIY DTFRTEKLVA LNATPGSQFI SAEEMNQKYI SEQTQLVEEA
410 420 430 440 450
LTKVMKEKYR EKENNLELLE TNLKTHHKDY KHALKKRITA LEEEKNRLIK
460
EIGPEKVKKA GILA
Length:464
Mass (Da):53,104
Last modified:July 15, 1998 - v2
Checksum:iF7BE83DE827ECE1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29891 Genomic DNA Translation: AAB53688.2
CU329670 Genomic DNA Translation: CAB11273.1
AB054312 mRNA Translation: BAB60879.1
PIRiT38356
RefSeqiNP_594040.1, NM_001019465.2

Genome annotation databases

EnsemblFungiiSPAC24C9.15c.1; SPAC24C9.15c.1:pep; SPAC24C9.15c
GeneIDi2542641
KEGGispo:SPAC24C9.15c

Similar proteinsi

Entry informationi

Entry nameiSPN5_SCHPO
AccessioniPrimary (citable) accession number: P48010
Secondary accession number(s): O13975, Q96WR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health