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Protein

Septin homolog spn4

Gene

spn4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701GTPBy similarity
Binding sitei96 – 961GTP; via amide nitrogenBy similarity
Binding sitei231 – 2311GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei247 – 2471GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 428GTPBy similarity
Nucleotide bindingi175 – 1839GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: PomBase
  • mitotic cytokinesis Source: PomBase
  • mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin homolog spn4
Gene namesi
Name:spn4
ORF Names:SPAC9G1.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC9G1.11c.
PomBaseiSPAC9G1.11c. spn4.

Subcellular locationi

  • Cytoplasmcell cortex 1 Publication

  • Note: Localizes to the medial ring at the cell cortex of dividing cells.

GO - Cellular componenti

  • cell division site Source: PomBase
  • cytosol Source: PomBase
  • septin complex Source: PomBase
  • septin ring Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Septin homolog spn4PRO_0000173506Add
BLAST

Proteomic databases

MaxQBiP48009.

Interactioni

Subunit structurei

Component of the septin complex composed of two copies of each spn1, spn2, spn3 and spn4.1 Publication

Protein-protein interaction databases

BioGridi278668. 26 interactions.
MINTiMINT-4690454.

Structurei

3D structure databases

ProteinModelPortaliP48009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 298274Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233586.
InParanoidiP48009.
KOiK16948.
OMAiFKQRIVS.
OrthoDBiEOG76HQBH.
PhylomeDBiP48009.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEETNFVG IADLPNQRHK IVSRNGVAFT LMLCGESGLG KTTFCNTLFS
60 70 80 90 100
TTIKSHMGPE KVRAKHAEKT VEIEITKAEL EEKNFHLRLT VIDTPGFGDF
110 120 130 140 150
INNSGCWESV VEFIEDQHES YMRQDQQPDR RKIIDMRIHA CLYFLRPVRN
160 170 180 190 200
GVRPMDLEAM KHISKRVNLI PVIAKADMYT RRDLALYKTR ISQVLEYHQV
210 220 230 240 250
NVYKPNMDEG DPVFHRQIQG IINCMPFAIV GSEDDIRTPD GRVVKGREYP
260 270 280 290 300
WGIVEIENEE HCDFKQLRNI LIRSCMLDLI QTTEEKLYEQ YRQEQMKVRQ
310 320 330 340 350
YGEPKLRTID NAKFKEEEEN LRKRFTEQVR VEETRFRQWE QRLIAERDSL
360 370 380
NKDLEAQHVQ IKQIELEIER LKAATSSRKR
Length:380
Mass (Da):44,773
Last modified:February 1, 1996 - v1
Checksum:iBFE92A3F784DE9B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29890 mRNA. Translation: AAB53689.1.
CU329670 Genomic DNA. Translation: CAB11495.1.
PIRiT39234.
RefSeqiNP_593566.1. NM_001018999.2.

Genome annotation databases

EnsemblFungiiSPAC9G1.11c.1; SPAC9G1.11c.1:pep; SPAC9G1.11c.
GeneIDi2542193.
KEGGispo:SPAC9G1.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29890 mRNA. Translation: AAB53689.1.
CU329670 Genomic DNA. Translation: CAB11495.1.
PIRiT39234.
RefSeqiNP_593566.1. NM_001018999.2.

3D structure databases

ProteinModelPortaliP48009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278668. 26 interactions.
MINTiMINT-4690454.

Proteomic databases

MaxQBiP48009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC9G1.11c.1; SPAC9G1.11c.1:pep; SPAC9G1.11c.
GeneIDi2542193.
KEGGispo:SPAC9G1.11c.

Organism-specific databases

EuPathDBiFungiDB:SPAC9G1.11c.
PomBaseiSPAC9G1.11c. spn4.

Phylogenomic databases

HOGENOMiHOG000233586.
InParanoidiP48009.
KOiK16948.
OMAiFKQRIVS.
OrthoDBiEOG76HQBH.
PhylomeDBiP48009.

Miscellaneous databases

PROiP48009.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Al-Awar O.S., Pugh T.A., Kim H.B., Valencik M.L., Pringle J.R.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Requirements of fission yeast septins for complex formation, localization, and function."
    An H., Morrell J.L., Jennings J.L., Link A.J., Gould K.L.
    Mol. Biol. Cell 15:5551-5564(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SEPTIN COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSPN4_SCHPO
AccessioniPrimary (citable) accession number: P48009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.