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Protein

Septin homolog spn4

Gene

spn4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei70GTPBy similarity1
Binding sitei96GTP; via amide nitrogenBy similarity1
Binding sitei231GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei247GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 42GTPBy similarity8
Nucleotide bindingi175 – 183GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

  • mitotic cytokinesis Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin homolog spn4
Gene namesi
Name:spn4
ORF Names:SPAC9G1.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC9G1.11c
PomBaseiSPAC9G1.11c spn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735061 – 380Septin homolog spn4Add BLAST380

Proteomic databases

MaxQBiP48009
PaxDbiP48009
PRIDEiP48009

Interactioni

Subunit structurei

Component of the septin complex composed of two copies of each spn1, spn2, spn3 and spn4.1 Publication

Protein-protein interaction databases

BioGridi278668, 27 interactors
STRINGi4896.SPAC9G1.11c.1

Structurei

3D structure databases

ProteinModelPortaliP48009
SMRiP48009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 298Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 42G1 motifPROSITE-ProRule annotation8
Regioni93 – 96G3 motifPROSITE-ProRule annotation4
Regioni174 – 177G4 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233586
InParanoidiP48009
KOiK16948
OMAiQWEQHLI
OrthoDBiEOG092C3HL6
PhylomeDBiP48009

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequencei

Sequence statusi: Complete.

P48009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEETNFVG IADLPNQRHK IVSRNGVAFT LMLCGESGLG KTTFCNTLFS
60 70 80 90 100
TTIKSHMGPE KVRAKHAEKT VEIEITKAEL EEKNFHLRLT VIDTPGFGDF
110 120 130 140 150
INNSGCWESV VEFIEDQHES YMRQDQQPDR RKIIDMRIHA CLYFLRPVRN
160 170 180 190 200
GVRPMDLEAM KHISKRVNLI PVIAKADMYT RRDLALYKTR ISQVLEYHQV
210 220 230 240 250
NVYKPNMDEG DPVFHRQIQG IINCMPFAIV GSEDDIRTPD GRVVKGREYP
260 270 280 290 300
WGIVEIENEE HCDFKQLRNI LIRSCMLDLI QTTEEKLYEQ YRQEQMKVRQ
310 320 330 340 350
YGEPKLRTID NAKFKEEEEN LRKRFTEQVR VEETRFRQWE QRLIAERDSL
360 370 380
NKDLEAQHVQ IKQIELEIER LKAATSSRKR
Length:380
Mass (Da):44,773
Last modified:February 1, 1996 - v1
Checksum:iBFE92A3F784DE9B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29890 mRNA Translation: AAB53689.1
CU329670 Genomic DNA Translation: CAB11495.1
PIRiT39234
RefSeqiNP_593566.1, NM_001018999.2

Genome annotation databases

EnsemblFungiiSPAC9G1.11c.1; SPAC9G1.11c.1:pep; SPAC9G1.11c
KEGGispo:SPAC9G1.11c

Similar proteinsi

Entry informationi

Entry nameiSPN4_SCHPO
AccessioniPrimary (citable) accession number: P48009
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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