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Protein

Histone H2A.Z

Gene

pht1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis. Plays an important role in maintaining a silenced chromatin state at centromeres and in the architecture of anaphase chromosomes.3 Publications

GO - Molecular functioni

GO - Biological processi

  • chromatin organization Source: PomBase
  • chromatin remodeling Source: PomBase
  • chromatin silencing Source: GO_Central
  • histone exchange Source: PomBase
  • negative regulation of CENP-A containing nucleosome assembly Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-2299718 Condensation of Prophase Chromosomes
R-SPO-2559580 Oxidative Stress Induced Senescence
R-SPO-427359 SIRT1 negatively regulates rRNA expression
R-SPO-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.Z
Gene namesi
Name:pht1
ORF Names:pi001, SPBC11B10.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC11B10.10c
PomBaseiSPBC11B10.10c pht1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553371 – 139Histone H2A.ZAdd BLAST139

Post-translational modificationi

Acetylated at the N-terminus. N-terminal acetylation is essential for function.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP48003
PaxDbiP48003
PRIDEiP48003

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. Component of the SWR1 and INO80 chromatin-remodeling complexes.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cnd2Q9Y7R32EBI-15929575,EBI-1149594

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276223, 227 interactors
DIPiDIP-59185N
IntActiP48003, 2 interactors
STRINGi4896.SPBC11B10.10c.1

Structurei

3D structure databases

SMRiP48003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

HOGENOMiHOG000234652
InParanoidiP48003
KOiK11251
OMAiKQRTQHN
OrthoDBiEOG092C5QJX

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

P48003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGGKGKHV GGKGGSKIGE RGQMSHSARA GLQFPVGRVR RFLKAKTQNN
60 70 80 90 100
MRVGAKSAVY SAAVLEYLTA EVLELAGNAA KDLKVKRITP RHLQLAIRGD
110 120 130
EELDTLIRAT IAGGGVLPHI NKQLLIRTKE KYPEEEEII
Length:139
Mass (Da):15,025
Last modified:July 11, 2012 - v3
Checksum:i6D88B7ADABAD7E83
GO

Sequence cautioni

The sequence AAB32938 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA21378 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74633 Genomic DNA Translation: AAB32938.1 Different initiation.
AB004534 Genomic DNA Translation: BAA21378.1 Different initiation.
CU329671 Genomic DNA Translation: CAC37514.3
PIRiS52560
RefSeqiNP_595630.3, NM_001021524.3

Genome annotation databases

EnsemblFungiiSPBC11B10.10c.1; SPBC11B10.10c.1:pep; SPBC11B10.10c
GeneIDi2539668
KEGGispo:SPBC11B10.10c

Similar proteinsi

Entry informationi

Entry nameiH2AZ_SCHPO
AccessioniPrimary (citable) accession number: P48003
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 11, 2012
Last modified: May 23, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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