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Protein

Homeobox protein knotted-1-like 5

Gene

KNAT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi302 – 36564Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cellular response to ethylene stimulus Source: TAIR
  • detection of ethylene stimulus Source: TAIR
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein knotted-1-like 5
Alternative name(s):
Homeodomain-containing protein 1
Protein KNAT5
Gene namesi
Name:KNAT5
Synonyms:ATH1
Ordered Locus Names:At4g32040
ORF Names:F10N7.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G32040.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Homeobox protein knotted-1-like 5PRO_0000048961Add
BLAST

Proteomic databases

PaxDbiP48002.
PRIDEiP48002.

Expressioni

Gene expression databases

GenevisibleiP48002. AT.

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/BELL protein BEL1, BLH1 and BLH2. Interacts with OFP1, OFP2, OFP3 and OFP4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BEL1Q388973EBI-1153922,EBI-1153783

Protein-protein interaction databases

BioGridi14621. 19 interactions.
IntActiP48002. 18 interactions.
STRINGi3702.AT4G32040.1.

Structurei

3D structure databases

ProteinModelPortaliP48002.
SMRiP48002. Positions 311-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini281 – 30121ELKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TALE/KNOX homeobox family.PROSITE-ProRule annotation
Contains 1 ELK domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000272741.
InParanoidiP48002.
OMAiCVHAMEA.
PhylomeDBiP48002.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005539. ELK_dom.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR005540. KNOX1.
IPR005541. KNOX2.
[Graphical view]
PfamiPF03789. ELK. 1 hit.
PF05920. Homeobox_KN. 1 hit.
PF03790. KNOX1. 1 hit.
PF03791. KNOX2. 1 hit.
[Graphical view]
SMARTiSM01188. ELK. 1 hit.
SM00389. HOX. 1 hit.
SM01255. KNOX1. 1 hit.
SM01256. KNOX2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51213. ELK. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNSSHLLP PQEDLPLRHF TDQSQQPPPQ RHFSETPSLV TASFLNLPTT
60 70 80 90 100
LTTADSDLAP PHRNGDNSVA DTNPRWLSFH SEMQNTGEVR SEVIDGVNAD
110 120 130 140 150
GETILGVVGG EDWRSASYKA AILRHPMYEQ LLAAHVACLR VATPVDQIPR
160 170 180 190 200
IDAQLSQLHT VAAKYSTLGV VVDNKELDHF MSHYVVLLCS FKEQLQHHVC
210 220 230 240 250
VHAMEAITAC WEIEQSLQSL TGVSPSESNG KTMSDDEDDN QVESEVNMFD
260 270 280 290 300
GSLDGSDCLM GFGPLVPTER ERSLMERVKK ELKHELKQGF KEKIVDIREE
310 320 330 340 350
IMRKRRAGKL PGDTTSVLKE WWRTHSKWPY PTEEDKAKLV QETGLQLKQI
360 370 380
NNWFINQRKR NWNSNSSTSS TLTKNKRKRT GKS
Length:383
Mass (Da):43,284
Last modified:December 1, 2000 - v2
Checksum:iD9B91F16F088E10F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306661 mRNA. Translation: AAL37042.1.
D43962 mRNA. Translation: BAA22602.1.
AL021636 Genomic DNA. Translation: CAA16585.1.
AL161580 Genomic DNA. Translation: CAB79922.1.
CP002687 Genomic DNA. Translation: AEE85997.1.
BT026033 mRNA. Translation: ABG48389.1.
X92394 mRNA. Translation: CAA63132.1.
PIRiT04641.
RefSeqiNP_194932.1. NM_119356.3.
UniGeneiAt.20704.

Genome annotation databases

EnsemblPlantsiAT4G32040.1; AT4G32040.1; AT4G32040.
GeneIDi829335.
GrameneiAT4G32040.1; AT4G32040.1; AT4G32040.
KEGGiath:AT4G32040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306661 mRNA. Translation: AAL37042.1.
D43962 mRNA. Translation: BAA22602.1.
AL021636 Genomic DNA. Translation: CAA16585.1.
AL161580 Genomic DNA. Translation: CAB79922.1.
CP002687 Genomic DNA. Translation: AEE85997.1.
BT026033 mRNA. Translation: ABG48389.1.
X92394 mRNA. Translation: CAA63132.1.
PIRiT04641.
RefSeqiNP_194932.1. NM_119356.3.
UniGeneiAt.20704.

3D structure databases

ProteinModelPortaliP48002.
SMRiP48002. Positions 311-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14621. 19 interactions.
IntActiP48002. 18 interactions.
STRINGi3702.AT4G32040.1.

Proteomic databases

PaxDbiP48002.
PRIDEiP48002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G32040.1; AT4G32040.1; AT4G32040.
GeneIDi829335.
GrameneiAT4G32040.1; AT4G32040.1; AT4G32040.
KEGGiath:AT4G32040.

Organism-specific databases

TAIRiAT4G32040.

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000272741.
InParanoidiP48002.
OMAiCVHAMEA.
PhylomeDBiP48002.

Miscellaneous databases

PROiP48002.

Gene expression databases

GenevisibleiP48002. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005539. ELK_dom.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR005540. KNOX1.
IPR005541. KNOX2.
[Graphical view]
PfamiPF03789. ELK. 1 hit.
PF05920. Homeobox_KN. 1 hit.
PF03790. KNOX1. 1 hit.
PF03791. KNOX2. 1 hit.
[Graphical view]
SMARTiSM01188. ELK. 1 hit.
SM00389. HOX. 1 hit.
SM01255. KNOX1. 1 hit.
SM01256. KNOX2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51213. ELK. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis BELL1 and KNOX TALE homeodomain proteins interact through a domain conserved between plants and animals."
    Bellaoui M., Pidkowich M.S., Samach A., Kushalappa K., Kohalmi S.E., Modrusan Z., Crosby W.L., Haughn G.W.
    Plant Cell 13:2455-2470(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH BEL1.
    Strain: cv. Columbia.
  2. "A novel homeobox-containing gene with enriched expression in leaves of Arabidopsis thaliana."
    Koganeya T., Fujisawa T., Tasaka M.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
    Tissue: Leaf.
  3. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Arabidopsis ORF clone."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 280-383.
  7. "A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins."
    Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.
    Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OFP1; OFP2; OFP3 AND OFP4.
  8. "The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins."
    Kumar R., Kushalappa K., Godt D., Pidkowich M.S., Pastorelli S., Hepworth S.R., Haughn G.W.
    Plant Cell 19:2719-2735(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BEL1; BLH1 AND BLH2.

Entry informationi

Entry nameiKNAT5_ARATH
AccessioniPrimary (citable) accession number: P48002
Secondary accession number(s): O49387, Q548P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: May 11, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.