Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lymphotactin

Gene

Xcl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotactin
Alternative name(s):
C motif chemokine 1
Cytokine SCM-1
Lymphotaxin
Small-inducible cytokine C1
Gene namesi
Name:Xcl1
Synonyms:Lptn, Ltn, Scyc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104593. Xcl1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: BHF-UCL
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 11493LymphotactinPRO_0000005249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 69Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP47993.
PRIDEiP47993.

PTM databases

iPTMnetiP47993.

Expressioni

Gene expression databases

BgeeiP47993.
CleanExiMM_XCL1.
ExpressionAtlasiP47993. baseline and differential.
GenevisibleiP47993. MM.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

IntActiP47993. 1 interaction.
STRINGi10090.ENSMUSP00000027860.

Structurei

3D structure databases

ProteinModelPortaliP47993.
SMRiP47993. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ5E. Eukaryota.
ENOG4111C3M. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiP47993.
KOiK05507.
OMAiWVKKAVE.
OrthoDBiEOG7RBZBM.
PhylomeDBiP47993.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLLLTFLG VCCLTPWVVE GVGTEVLEES SCVNLQTQRL PVQKIKTYII
60 70 80 90 100
WEGAMRAVIF VTKRGLKICA DPEAKWVKAA IKTVDGRAST RKNMAETVPT
110
GAQRSTSTAI TLTG
Length:114
Mass (Da):12,467
Last modified:February 1, 1996 - v1
Checksum:i04B51A5FCC61763B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101I → V in AAA56752 (PubMed:7973732).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15607 mRNA. Translation: AAA56752.1.
D43769 mRNA. Translation: BAA07826.1.
U28493, U28491, U28492 Genomic DNA. Translation: AAA69801.1.
BC062249 mRNA. Translation: AAH62249.1.
CCDSiCCDS15438.1.
PIRiA55248. ETMSL.
RefSeqiNP_032536.1. NM_008510.1.
UniGeneiMm.190.

Genome annotation databases

EnsembliENSMUST00000027860; ENSMUSP00000027860; ENSMUSG00000026573.
GeneIDi16963.
KEGGimmu:16963.
UCSCiuc007dis.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15607 mRNA. Translation: AAA56752.1.
D43769 mRNA. Translation: BAA07826.1.
U28493, U28491, U28492 Genomic DNA. Translation: AAA69801.1.
BC062249 mRNA. Translation: AAH62249.1.
CCDSiCCDS15438.1.
PIRiA55248. ETMSL.
RefSeqiNP_032536.1. NM_008510.1.
UniGeneiMm.190.

3D structure databases

ProteinModelPortaliP47993.
SMRiP47993. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47993. 1 interaction.
STRINGi10090.ENSMUSP00000027860.

PTM databases

iPTMnetiP47993.

Proteomic databases

PaxDbiP47993.
PRIDEiP47993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027860; ENSMUSP00000027860; ENSMUSG00000026573.
GeneIDi16963.
KEGGimmu:16963.
UCSCiuc007dis.1. mouse.

Organism-specific databases

CTDi6375.
MGIiMGI:104593. Xcl1.

Phylogenomic databases

eggNOGiENOG410IZ5E. Eukaryota.
ENOG4111C3M. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiP47993.
KOiK05507.
OMAiWVKKAVE.
OrthoDBiEOG7RBZBM.
PhylomeDBiP47993.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP47993.
SOURCEiSearch...

Gene expression databases

BgeeiP47993.
CleanExiMM_XCL1.
ExpressionAtlasiP47993. baseline and differential.
GenevisibleiP47993. MM.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Lymphotactin: a cytokine that represents a new class of chemokine."
    Kelner G.S., Zlotnik A.
    Science 266:1395-1399(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Thymus.
  2. "Molecular cloning of a novel C or gamma type chemokine, SCM-1."
    Yoshida T., Imai T., Kakizaki M., Nishimura M., Yoshie O.
    FEBS Lett. 360:155-159(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Spleen.
  3. "Murine lymphotactin: gene structure, post-translational modification and inhibition of expression by CD28 costimulation."
    Hautamaa D., Merica R., Chen Z., Jenkins M.K.
    Cytokine 9:375-382(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiXCL1_MOUSE
AccessioniPrimary (citable) accession number: P47993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.