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P47992

- XCL1_HUMAN

UniProt

P47992 - XCL1_HUMAN

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Protein

Lymphotactin

Gene
XCL1, LTN, SCYC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

GO - Molecular functioni

  1. chemokine activity Source: BHF-UCL
  2. chemokine receptor binding Source: BHF-UCL
  3. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. cell-cell signaling Source: BHF-UCL
  2. cellular response to interleukin-4 Source: BHF-UCL
  3. cellular response to transforming growth factor beta stimulus Source: BHF-UCL
  4. immune response Source: InterPro
  5. mature natural killer cell chemotaxis Source: BHF-UCL
  6. negative regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
  7. negative regulation of interferon-gamma production Source: BHF-UCL
  8. negative regulation of interleukin-2 production Source: BHF-UCL
  9. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  10. negative regulation of T cell cytokine production Source: BHF-UCL
  11. negative regulation of T-helper 1 cell activation Source: BHF-UCL
  12. negative regulation of T-helper 1 type immune response Source: BHF-UCL
  13. negative regulation of transcription, DNA-templated Source: BHF-UCL
  14. neutrophil chemotaxis Source: BHF-UCL
  15. positive regulation of B cell chemotaxis Source: BHF-UCL
  16. positive regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
  17. positive regulation of CD8-positive, alpha-beta T cell proliferation Source: BHF-UCL
  18. positive regulation of granzyme A production Source: BHF-UCL
  19. positive regulation of granzyme B production Source: BHF-UCL
  20. positive regulation of immunoglobulin production in mucosal tissue Source: BHF-UCL
  21. positive regulation of interleukin-10 production Source: BHF-UCL
  22. positive regulation of leukocyte chemotaxis Source: BHF-UCL
  23. positive regulation of natural killer cell chemotaxis Source: BHF-UCL
  24. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  25. positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
  26. positive regulation of T cell chemotaxis Source: BHF-UCL
  27. positive regulation of T cell cytokine production Source: BHF-UCL
  28. positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
  29. positive regulation of T-helper 1 cell cytokine production Source: BHF-UCL
  30. positive regulation of T-helper 2 cell cytokine production Source: BHF-UCL
  31. positive regulation of thymocyte migration Source: BHF-UCL
  32. positive regulation of transforming growth factor beta production Source: BHF-UCL
  33. regulation of inflammatory response Source: BHF-UCL
  34. release of sequestered calcium ion into cytosol Source: BHF-UCL
  35. response to virus Source: BHF-UCL
  36. signal transduction Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotactin
Alternative name(s):
ATAC
C motif chemokine 1
Cytokine SCM-1
Lymphotaxin
SCM-1-alpha
Small-inducible cytokine C1
XC chemokine ligand 1
Gene namesi
Name:XCL1
Synonyms:LTN, SCYC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10645. XCL1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 11493LymphotactinPRO_0000005248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 691 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP47992.
PRIDEiP47992.

Miscellaneous databases

PMAP-CutDBP47992.

Expressioni

Tissue specificityi

Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

Gene expression databases

BgeeiP47992.
CleanExiHS_XCL1.
GenevestigatoriP47992.

Organism-specific databases

HPAiHPA057725.

Interactioni

Protein-protein interaction databases

DIPiDIP-29876N.
MINTiMINT-1535585.
STRINGi9606.ENSP00000356792.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353
Helixi42 – 443
Beta strandi45 – 506
Beta strandi53 – 553
Beta strandi57 – 626
Beta strandi65 – 706
Beta strandi72 – 743
Helixi75 – 828
Helixi85 – 873
Turni88 – 914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J8INMR-A22-114[»]
1J9ONMR-A22-114[»]
2HDMNMR-A23-114[»]
2JP1NMR-A/B22-114[»]
2NYZX-ray2.60D/E22-114[»]
ProteinModelPortaliP47992.
SMRiP47992. Positions 22-114.

Miscellaneous databases

EvolutionaryTraceiP47992.

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47852.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiP47992.
KOiK05507.
OMAiWVKKAVE.
OrthoDBiEOG7RBZBM.
PhylomeDBiP47992.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47992-1 [UniParc]FASTAAdd to Basket

« Hide

MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI    50
TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT 100
GTQQSTNTAV TLTG 114
Length:114
Mass (Da):12,517
Last modified:February 1, 1996 - v1
Checksum:iFABA16063C3FC165
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23772 mRNA. Translation: AAC50164.1.
D43768 mRNA. Translation: BAA07825.1.
X86474 mRNA. Translation: CAA60198.1.
D63790 Genomic DNA. Translation: BAA09859.1.
AL031736 Genomic DNA. Translation: CAB46691.1.
BC069817 mRNA. Translation: AAH69817.1.
BC070309 mRNA. Translation: AAH70309.1.
CCDSiCCDS1274.1.
PIRiS60650. ETHUL.
RefSeqiNP_002986.1. NM_002995.2.
UniGeneiHs.458346.
Hs.546295.

Genome annotation databases

EnsembliENST00000367818; ENSP00000356792; ENSG00000143184.
GeneIDi6375.
KEGGihsa:6375.
UCSCiuc001gfo.2. human.

Polymorphism databases

DMDMi1346471.

Cross-referencesi

Web resourcesi

Wikipedia

XCL1 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23772 mRNA. Translation: AAC50164.1 .
D43768 mRNA. Translation: BAA07825.1 .
X86474 mRNA. Translation: CAA60198.1 .
D63790 Genomic DNA. Translation: BAA09859.1 .
AL031736 Genomic DNA. Translation: CAB46691.1 .
BC069817 mRNA. Translation: AAH69817.1 .
BC070309 mRNA. Translation: AAH70309.1 .
CCDSi CCDS1274.1.
PIRi S60650. ETHUL.
RefSeqi NP_002986.1. NM_002995.2.
UniGenei Hs.458346.
Hs.546295.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J8I NMR - A 22-114 [» ]
1J9O NMR - A 22-114 [» ]
2HDM NMR - A 23-114 [» ]
2JP1 NMR - A/B 22-114 [» ]
2NYZ X-ray 2.60 D/E 22-114 [» ]
ProteinModelPortali P47992.
SMRi P47992. Positions 22-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29876N.
MINTi MINT-1535585.
STRINGi 9606.ENSP00000356792.

Polymorphism databases

DMDMi 1346471.

Proteomic databases

PaxDbi P47992.
PRIDEi P47992.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367818 ; ENSP00000356792 ; ENSG00000143184 .
GeneIDi 6375.
KEGGi hsa:6375.
UCSCi uc001gfo.2. human.

Organism-specific databases

CTDi 6375.
GeneCardsi GC01P168545.
HGNCi HGNC:10645. XCL1.
HPAi HPA057725.
MIMi 600250. gene.
neXtProti NX_P47992.
PharmGKBi PA35575.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47852.
HOGENOMi HOG000036685.
HOVERGENi HBG102118.
InParanoidi P47992.
KOi K05507.
OMAi WVKKAVE.
OrthoDBi EOG7RBZBM.
PhylomeDBi P47992.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P47992.
GenomeRNAii 6375.
NextBioi 24768.
PMAP-CutDB P47992.
PROi P47992.
SOURCEi Search...

Gene expression databases

Bgeei P47992.
CleanExi HS_XCL1.
Genevestigatori P47992.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR01731. LYMPHOTACTIN.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of human lymphotactin."
    Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
    J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of a novel C or gamma type chemokine, SCM-1."
    Yoshida T., Imai T., Kakizaki M., Nishimura M., Yoshie O.
    FEBS Lett. 360:155-159(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood.
  3. "Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes."
    Mueller S., Dorner B., Korthauer U., Mages H.W., D'Apuzzo M., Senger G., Kroczek R.A.
    Eur. J. Immunol. 25:1744-1748(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood.
  4. "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin."
    Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O.
    FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  7. "Monomeric solution structure of the prototypical 'C' chemokine lymphotactin."
    Kuloglu E.S., McCaslin D.R., Kitabwalla M., Pauza C.D., Markley J.L., Volkman B.F.
    Biochemistry 40:12486-12496(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 22-114, DISULFIDE BOND.

Entry informationi

Entry nameiXCL1_HUMAN
AccessioniPrimary (citable) accession number: P47992
Secondary accession number(s): Q52MA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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