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P47992

- XCL1_HUMAN

UniProt

P47992 - XCL1_HUMAN

Protein

Lymphotactin

Gene

XCL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

    GO - Molecular functioni

    1. chemokine activity Source: BHF-UCL
    2. chemokine receptor binding Source: BHF-UCL
    3. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. cell-cell signaling Source: BHF-UCL
    2. cellular response to interleukin-4 Source: BHF-UCL
    3. cellular response to transforming growth factor beta stimulus Source: BHF-UCL
    4. immune response Source: InterPro
    5. mature natural killer cell chemotaxis Source: BHF-UCL
    6. negative regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
    7. negative regulation of interferon-gamma production Source: BHF-UCL
    8. negative regulation of interleukin-2 production Source: BHF-UCL
    9. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    10. negative regulation of T cell cytokine production Source: BHF-UCL
    11. negative regulation of T-helper 1 cell activation Source: BHF-UCL
    12. negative regulation of T-helper 1 type immune response Source: BHF-UCL
    13. negative regulation of transcription, DNA-templated Source: BHF-UCL
    14. neutrophil chemotaxis Source: BHF-UCL
    15. positive regulation of B cell chemotaxis Source: BHF-UCL
    16. positive regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
    17. positive regulation of CD8-positive, alpha-beta T cell proliferation Source: BHF-UCL
    18. positive regulation of granzyme A production Source: BHF-UCL
    19. positive regulation of granzyme B production Source: BHF-UCL
    20. positive regulation of immunoglobulin production in mucosal tissue Source: BHF-UCL
    21. positive regulation of interleukin-10 production Source: BHF-UCL
    22. positive regulation of leukocyte chemotaxis Source: BHF-UCL
    23. positive regulation of natural killer cell chemotaxis Source: BHF-UCL
    24. positive regulation of neutrophil chemotaxis Source: BHF-UCL
    25. positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
    26. positive regulation of T cell chemotaxis Source: BHF-UCL
    27. positive regulation of T cell cytokine production Source: BHF-UCL
    28. positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
    29. positive regulation of T-helper 1 cell cytokine production Source: BHF-UCL
    30. positive regulation of T-helper 2 cell cytokine production Source: BHF-UCL
    31. positive regulation of thymocyte migration Source: BHF-UCL
    32. positive regulation of transforming growth factor beta production Source: BHF-UCL
    33. regulation of inflammatory response Source: BHF-UCL
    34. release of sequestered calcium ion into cytosol Source: BHF-UCL
    35. response to virus Source: BHF-UCL
    36. signal transduction Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lymphotactin
    Alternative name(s):
    ATAC
    C motif chemokine 1
    Cytokine SCM-1
    Lymphotaxin
    SCM-1-alpha
    Small-inducible cytokine C1
    XC chemokine ligand 1
    Gene namesi
    Name:XCL1
    Synonyms:LTN, SCYC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10645. XCL1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35575.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 11493LymphotactinPRO_0000005248Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 691 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP47992.
    PRIDEiP47992.

    Miscellaneous databases

    PMAP-CutDBP47992.

    Expressioni

    Tissue specificityi

    Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

    Gene expression databases

    BgeeiP47992.
    CleanExiHS_XCL1.
    GenevestigatoriP47992.

    Organism-specific databases

    HPAiHPA057725.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-29876N.
    MINTiMINT-1535585.
    STRINGi9606.ENSP00000356792.

    Structurei

    Secondary structure

    1
    114
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi33 – 353
    Helixi42 – 443
    Beta strandi45 – 506
    Beta strandi53 – 553
    Beta strandi57 – 626
    Beta strandi65 – 706
    Beta strandi72 – 743
    Helixi75 – 828
    Helixi85 – 873
    Turni88 – 914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J8INMR-A22-114[»]
    1J9ONMR-A22-114[»]
    2HDMNMR-A23-114[»]
    2JP1NMR-A/B22-114[»]
    2NYZX-ray2.60D/E22-114[»]
    ProteinModelPortaliP47992.
    SMRiP47992. Positions 22-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP47992.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the intercrine gamma family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47852.
    HOGENOMiHOG000036685.
    HOVERGENiHBG102118.
    InParanoidiP47992.
    KOiK05507.
    OMAiWVKKAVE.
    OrthoDBiEOG7RBZBM.
    PhylomeDBiP47992.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    IPR008105. Chemokine_XCL1.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR01731. LYMPHOTACTIN.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47992-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI    50
    TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT 100
    GTQQSTNTAV TLTG 114
    Length:114
    Mass (Da):12,517
    Last modified:February 1, 1996 - v1
    Checksum:iFABA16063C3FC165
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23772 mRNA. Translation: AAC50164.1.
    D43768 mRNA. Translation: BAA07825.1.
    X86474 mRNA. Translation: CAA60198.1.
    D63790 Genomic DNA. Translation: BAA09859.1.
    AL031736 Genomic DNA. Translation: CAB46691.1.
    BC069817 mRNA. Translation: AAH69817.1.
    BC070309 mRNA. Translation: AAH70309.1.
    CCDSiCCDS1274.1.
    PIRiS60650. ETHUL.
    RefSeqiNP_002986.1. NM_002995.2.
    UniGeneiHs.458346.
    Hs.546295.

    Genome annotation databases

    EnsembliENST00000367818; ENSP00000356792; ENSG00000143184.
    GeneIDi6375.
    KEGGihsa:6375.
    UCSCiuc001gfo.2. human.

    Polymorphism databases

    DMDMi1346471.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    XCL1 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23772 mRNA. Translation: AAC50164.1 .
    D43768 mRNA. Translation: BAA07825.1 .
    X86474 mRNA. Translation: CAA60198.1 .
    D63790 Genomic DNA. Translation: BAA09859.1 .
    AL031736 Genomic DNA. Translation: CAB46691.1 .
    BC069817 mRNA. Translation: AAH69817.1 .
    BC070309 mRNA. Translation: AAH70309.1 .
    CCDSi CCDS1274.1.
    PIRi S60650. ETHUL.
    RefSeqi NP_002986.1. NM_002995.2.
    UniGenei Hs.458346.
    Hs.546295.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J8I NMR - A 22-114 [» ]
    1J9O NMR - A 22-114 [» ]
    2HDM NMR - A 23-114 [» ]
    2JP1 NMR - A/B 22-114 [» ]
    2NYZ X-ray 2.60 D/E 22-114 [» ]
    ProteinModelPortali P47992.
    SMRi P47992. Positions 22-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29876N.
    MINTi MINT-1535585.
    STRINGi 9606.ENSP00000356792.

    Polymorphism databases

    DMDMi 1346471.

    Proteomic databases

    PaxDbi P47992.
    PRIDEi P47992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367818 ; ENSP00000356792 ; ENSG00000143184 .
    GeneIDi 6375.
    KEGGi hsa:6375.
    UCSCi uc001gfo.2. human.

    Organism-specific databases

    CTDi 6375.
    GeneCardsi GC01P168545.
    HGNCi HGNC:10645. XCL1.
    HPAi HPA057725.
    MIMi 600250. gene.
    neXtProti NX_P47992.
    PharmGKBi PA35575.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47852.
    HOGENOMi HOG000036685.
    HOVERGENi HBG102118.
    InParanoidi P47992.
    KOi K05507.
    OMAi WVKKAVE.
    OrthoDBi EOG7RBZBM.
    PhylomeDBi P47992.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P47992.
    GenomeRNAii 6375.
    NextBioi 24768.
    PMAP-CutDB P47992.
    PROi P47992.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47992.
    CleanExi HS_XCL1.
    Genevestigatori P47992.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    IPR008105. Chemokine_XCL1.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR01731. LYMPHOTACTIN.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of human lymphotactin."
      Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
      J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of a novel C or gamma type chemokine, SCM-1."
      Yoshida T., Imai T., Kakizaki M., Nishimura M., Yoshie O.
      FEBS Lett. 360:155-159(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood.
    3. "Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes."
      Mueller S., Dorner B., Korthauer U., Mages H.W., D'Apuzzo M., Senger G., Kroczek R.A.
      Eur. J. Immunol. 25:1744-1748(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood.
    4. "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin."
      Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O.
      FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    7. "Monomeric solution structure of the prototypical 'C' chemokine lymphotactin."
      Kuloglu E.S., McCaslin D.R., Kitabwalla M., Pauza C.D., Markley J.L., Volkman B.F.
      Biochemistry 40:12486-12496(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 22-114, DISULFIDE BOND.

    Entry informationi

    Entry nameiXCL1_HUMAN
    AccessioniPrimary (citable) accession number: P47992
    Secondary accession number(s): Q52MA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3