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Protein

Lymphotactin

Gene

XCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

GO - Molecular functioni

  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotactin
Alternative name(s):
ATAC
C motif chemokine 1
Cytokine SCM-1
Lymphotaxin
SCM-1-alpha
Small-inducible cytokine C1
XC chemokine ligand 1
Gene namesi
Name:XCL1
Synonyms:LTN, SCYC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10645. XCL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35575.

Polymorphism and mutation databases

BioMutaiXCL1.
DMDMi1346471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11493LymphotactinPRO_0000005248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 691 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP47992.
PRIDEiP47992.

Miscellaneous databases

PMAP-CutDBP47992.

Expressioni

Tissue specificityi

Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

Gene expression databases

BgeeiP47992.
CleanExiHS_XCL1.
GenevisibleiP47992. HS.

Organism-specific databases

HPAiHPA057725.

Interactioni

Protein-protein interaction databases

BioGridi112277. 1 interaction.
DIPiDIP-29876N.
MINTiMINT-1535585.
STRINGi9606.ENSP00000356792.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353Combined sources
Helixi42 – 443Combined sources
Beta strandi45 – 506Combined sources
Beta strandi53 – 553Combined sources
Beta strandi57 – 626Combined sources
Beta strandi65 – 706Combined sources
Beta strandi72 – 743Combined sources
Helixi75 – 828Combined sources
Helixi85 – 873Combined sources
Turni88 – 914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J8INMR-A22-114[»]
1J9ONMR-A22-114[»]
2HDMNMR-A23-114[»]
2JP1NMR-A/B22-114[»]
2NYZX-ray2.60D/E22-114[»]
ProteinModelPortaliP47992.
SMRiP47992. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47992.

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47852.
GeneTreeiENSGT00390000005120.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiP47992.
KOiK05507.
OMAiWVKKAVE.
OrthoDBiEOG7RBZBM.
PhylomeDBiP47992.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PANTHERiPTHR12015:SF3. PTHR12015:SF3. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI
60 70 80 90 100
TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT
110
GTQQSTNTAV TLTG
Length:114
Mass (Da):12,517
Last modified:February 1, 1996 - v1
Checksum:iFABA16063C3FC165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23772 mRNA. Translation: AAC50164.1.
D43768 mRNA. Translation: BAA07825.1.
X86474 mRNA. Translation: CAA60198.1.
D63790 Genomic DNA. Translation: BAA09859.1.
AL031736 Genomic DNA. Translation: CAB46691.1.
BC069817 mRNA. Translation: AAH69817.1.
BC070309 mRNA. Translation: AAH70309.1.
CCDSiCCDS1274.1.
PIRiS60650. ETHUL.
RefSeqiNP_002986.1. NM_002995.2.
XP_011508167.1. XM_011509865.1.
UniGeneiHs.458346.
Hs.546295.

Genome annotation databases

EnsembliENST00000367818; ENSP00000356792; ENSG00000143184.
GeneIDi6375.
KEGGihsa:6375.
UCSCiuc001gfo.2. human.

Cross-referencesi

Web resourcesi

Wikipedia

XCL1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23772 mRNA. Translation: AAC50164.1.
D43768 mRNA. Translation: BAA07825.1.
X86474 mRNA. Translation: CAA60198.1.
D63790 Genomic DNA. Translation: BAA09859.1.
AL031736 Genomic DNA. Translation: CAB46691.1.
BC069817 mRNA. Translation: AAH69817.1.
BC070309 mRNA. Translation: AAH70309.1.
CCDSiCCDS1274.1.
PIRiS60650. ETHUL.
RefSeqiNP_002986.1. NM_002995.2.
XP_011508167.1. XM_011509865.1.
UniGeneiHs.458346.
Hs.546295.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J8INMR-A22-114[»]
1J9ONMR-A22-114[»]
2HDMNMR-A23-114[»]
2JP1NMR-A/B22-114[»]
2NYZX-ray2.60D/E22-114[»]
ProteinModelPortaliP47992.
SMRiP47992. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112277. 1 interaction.
DIPiDIP-29876N.
MINTiMINT-1535585.
STRINGi9606.ENSP00000356792.

Polymorphism and mutation databases

BioMutaiXCL1.
DMDMi1346471.

Proteomic databases

PaxDbiP47992.
PRIDEiP47992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367818; ENSP00000356792; ENSG00000143184.
GeneIDi6375.
KEGGihsa:6375.
UCSCiuc001gfo.2. human.

Organism-specific databases

CTDi6375.
GeneCardsiGC01P168545.
HGNCiHGNC:10645. XCL1.
HPAiHPA057725.
MIMi600250. gene.
neXtProtiNX_P47992.
PharmGKBiPA35575.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47852.
GeneTreeiENSGT00390000005120.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiP47992.
KOiK05507.
OMAiWVKKAVE.
OrthoDBiEOG7RBZBM.
PhylomeDBiP47992.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTraceiP47992.
GenomeRNAii6375.
NextBioi24768.
PMAP-CutDBP47992.
PROiP47992.
SOURCEiSearch...

Gene expression databases

BgeeiP47992.
CleanExiHS_XCL1.
GenevisibleiP47992. HS.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PANTHERiPTHR12015:SF3. PTHR12015:SF3. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of human lymphotactin."
    Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
    J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of a novel C or gamma type chemokine, SCM-1."
    Yoshida T., Imai T., Kakizaki M., Nishimura M., Yoshie O.
    FEBS Lett. 360:155-159(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood.
  3. "Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes."
    Mueller S., Dorner B., Korthauer U., Mages H.W., D'Apuzzo M., Senger G., Kroczek R.A.
    Eur. J. Immunol. 25:1744-1748(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood.
  4. "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin."
    Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O.
    FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  7. "Monomeric solution structure of the prototypical 'C' chemokine lymphotactin."
    Kuloglu E.S., McCaslin D.R., Kitabwalla M., Pauza C.D., Markley J.L., Volkman B.F.
    Biochemistry 40:12486-12496(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 22-114, DISULFIDE BOND.

Entry informationi

Entry nameiXCL1_HUMAN
AccessioniPrimary (citable) accession number: P47992
Secondary accession number(s): Q52MA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 22, 2015
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.