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Protein

60S ribosomal protein L6

Gene

rpl-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: GO_Central
  • determination of adult lifespan Source: WormBase
  • ribosomal large subunit assembly Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Gene namesi
Name:rpl-6
ORF Names:R151.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR151.3; CE00744; WBGene00004417; rpl-6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21721760S ribosomal protein L6PRO_0000171013Add
BLAST

Proteomic databases

EPDiP47991.
PaxDbiP47991.
PRIDEiP47991.

PTM databases

iPTMnetiP47991.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
let-756Q111843EBI-316106,EBI-3843983

Protein-protein interaction databases

BioGridi41227. 8 interactions.
DIPiDIP-26565N.
IntActiP47991. 1 interaction.
MINTiMINT-1063990.
STRINGi6239.R151.3.1.

Structurei

3D structure databases

ProteinModelPortaliP47991.
SMRiP47991. Positions 29-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
InParanoidiP47991.
KOiK02934.
OMAiDEQFGAS.
OrthoDBiEOG78D7MH.
PhylomeDBiP47991.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47991-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGKRNLPVI SRNFDLSPGV LRFSASRLRL KKGEKKPKFT KDTSAKLPKL
60 70 80 90 100
QRNGTKFALG HSKTVTLRKT LTPGTVLIVL AGRHKGKRVV FLKQLPQSGL
110 120 130 140 150
LLVTGPHKIN GFPLRRIGQA FVIATSLKVN VSGVKIPEHI NDEYFKRKST
160 170 180 190 200
AQKTGKNIFA SGKTEYTVSE QRKKDIKTVD APILAAIKKH PEHKFLFGYL
210
GTRFSLGKNQ YPHKMQF
Length:217
Mass (Da):24,313
Last modified:February 1, 1996 - v1
Checksum:i5BA7FE473B1C239B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081317 Genomic DNA. Translation: CCD70755.1.
PIRiT16762.
RefSeqiNP_498584.1. NM_066183.3.
UniGeneiCel.8890.

Genome annotation databases

EnsemblMetazoaiR151.3.1; R151.3.1; WBGene00004417.
R151.3.2; R151.3.2; WBGene00004417.
R151.3.3; R151.3.3; WBGene00004417.
GeneIDi176015.
KEGGicel:CELE_R151.3.
UCSCiR151.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081317 Genomic DNA. Translation: CCD70755.1.
PIRiT16762.
RefSeqiNP_498584.1. NM_066183.3.
UniGeneiCel.8890.

3D structure databases

ProteinModelPortaliP47991.
SMRiP47991. Positions 29-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41227. 8 interactions.
DIPiDIP-26565N.
IntActiP47991. 1 interaction.
MINTiMINT-1063990.
STRINGi6239.R151.3.1.

PTM databases

iPTMnetiP47991.

Proteomic databases

EPDiP47991.
PaxDbiP47991.
PRIDEiP47991.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR151.3.1; R151.3.1; WBGene00004417.
R151.3.2; R151.3.2; WBGene00004417.
R151.3.3; R151.3.3; WBGene00004417.
GeneIDi176015.
KEGGicel:CELE_R151.3.
UCSCiR151.3.1. c. elegans.

Organism-specific databases

CTDi176015.
WormBaseiR151.3; CE00744; WBGene00004417; rpl-6.

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
InParanoidiP47991.
KOiK02934.
OMAiDEQFGAS.
OrthoDBiEOG78D7MH.
PhylomeDBiP47991.

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP47991.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiRL6_CAEEL
AccessioniPrimary (citable) accession number: P47991
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.