P47990 (XDH_CHICK) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 95.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Xanthine dehydrogenase/oxidase Including the following 2 domains:
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| Gene names |
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| Organism | Gallus gallus (Chicken) [Reference proteome] | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus![]() |
Protein attributes
| Sequence length | 1358 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species By similarity. |
| Catalytic activity | Xanthine + NAD+ + H2O = urate + NADH. Ref.1 Ref.2 |
| Cofactor | Binds 2 2Fe-2S clusters By similarity. FAD By similarity. Binds 1 molybdenum ion (molybdopterin) per subunit By similarity. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Peroxisome By similarity. Cytoplasm Ref.2. |
| Tissue specificity | Detected in liver (at protein level). Ref.2 |
| Sequence similarities | Belongs to the xanthine dehydrogenase family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 FAD-binding PCMH-type domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1358 | 1358 | Xanthine dehydrogenase/oxidase | PRO_0000166083 | |||||
Regions | |||||||||
| Domain | 8 – 95 | 88 | 2Fe-2S ferredoxin-type | ||||||
| Domain | 255 – 440 | 186 | FAD-binding PCMH-type | ||||||
| Nucleotide binding | 283 – 290 | 8 | FAD By similarity | ||||||
| Nucleotide binding | 373 – 377 | 5 | FAD By similarity | ||||||
Sites | |||||||||
| Active site | 1290 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 47 | 1 | Iron-sulfur 1 By similarity | ||||||
| Metal binding | 52 | 1 | Iron-sulfur 1 By similarity | ||||||
| Metal binding | 55 | 1 | Iron-sulfur 1 By similarity | ||||||
| Metal binding | 77 | 1 | Iron-sulfur 1 By similarity | ||||||
| Metal binding | 117 | 1 | Iron-sulfur 2 By similarity | ||||||
| Metal binding | 120 | 1 | Iron-sulfur 2 By similarity | ||||||
| Metal binding | 152 | 1 | Iron-sulfur 2 By similarity | ||||||
| Metal binding | 154 | 1 | Iron-sulfur 2 By similarity | ||||||
| Metal binding | 796 | 1 | Molybdenum By similarity | ||||||
| Metal binding | 827 | 1 | Molybdenum; via carbonyl oxygen By similarity | ||||||
| Metal binding | 941 | 1 | Molybdenum; via amide nitrogen By similarity | ||||||
| Metal binding | 1108 | 1 | Molybdenum; via amide nitrogen By similarity | ||||||
| Binding site | 363 | 1 | FAD By similarity | ||||||
| Binding site | 386 | 1 | FAD By similarity | ||||||
| Binding site | 430 | 1 | FAD; via amide nitrogen and carbonyl oxygen By similarity | ||||||
| Binding site | 448 | 1 | FAD By similarity | ||||||
| Binding site | 831 | 1 | Substrate By similarity | ||||||
| Binding site | 909 | 1 | Substrate By similarity | ||||||
| Binding site | 943 | 1 | Substrate By similarity | ||||||
| Binding site | 1039 | 1 | Substrate; via amide nitrogen By similarity | ||||||
Sequences
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References
| [1] | "The structure of chicken liver xanthine dehydrogenase. cDNA cloning and the domain structure." Satoh A., Amaya Y., Noda K., Nishino T. J. Biol. Chem. 270:2818-2826(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CATALYTIC ACTIVITY. Tissue: Liver. |
| [2] | "Subcellular localization of chicken liver xanthine dehydrogenase. A possible source of cytoplasmic reducing equivalents." Coolbear K.P., Herzberg G.R., Brosnan J.T. Biochem. J. 202:555-558(1982) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, CATALYTIC ACTIVITY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D13221 mRNA. Translation: BAA02502.1. |
| IPI | IPI00589946. |
| PIR | XOCHDH. A55711. |
| RefSeq | NP_990458.1. NM_205127.1. |
| UniGene | Gga.2494. |
3D structure databases | |
| ProteinModelPortal | P47990. |
| SMR | P47990. Positions 600-1343. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9031.ENSGALP00000014144. |
Proteomic databases | |
| PaxDb | P47990. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 396025. |
| KEGG | gga:396025. |
Organism-specific databases | |
| CTD | 7498. |
Phylogenomic databases | |
| eggNOG | COG4630. |
| HOGENOM | HOG000191197. |
| HOVERGEN | HBG004182. |
| InParanoid | P47990. |
| KO | K00106. |
Enzyme and pathway databases | |
| Reactome | REACT_115655. Metabolism. |
Family and domain databases | |
| Gene3D | 1.10.150.120. 1 hit. 3.10.20.30. 1 hit. 3.30.365.10. 6 hits. 3.30.43.10. 1 hit. 3.30.465.10. 1 hit. 3.90.1170.50. 1 hit. |
| InterPro | IPR002888. 2Fe-2S-bd. IPR001041. 2Fe-2S_ferredoxin-type. IPR006058. 2Fe2S_fd_BS. IPR000674. Ald_Oxase/Xan_DH_a/b. IPR016208. Ald_Oxase/xanthine_DH. IPR008274. AldOxase/xan_DH_Mopterin-bd. IPR012675. Beta-grasp_dom. IPR005107. CO_DH_flav_C. IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR002346. Mopterin_DH_FAD-bd. IPR022407. OxRdtase_Mopterin_BS. IPR014309. Xanthine_DH_Mopterin-bd_su. IPR014307. Xanthine_DH_ssu. [Graphical view] |
| Pfam | PF01315. Ald_Xan_dh_C. 1 hit. PF02738. Ald_Xan_dh_C2. 1 hit. PF03450. CO_deh_flav_C. 1 hit. PF00941. FAD_binding_5. 1 hit. PF00111. Fer2. 1 hit. PF01799. Fer2_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000127. Xanthine_DH. 1 hit. |
| SMART | SM01008. Ald_Xan_dh_C. 1 hit. SM01092. CO_deh_flav_C. 1 hit. [Graphical view] |
| SUPFAM | SSF47741. 2Fe-2S_bind. 1 hit. SSF56003. Ald_xan_DH_mo_bd. 1 hit. SSF54665. Aldxan_dh_hamm. 1 hit. SSF55447. CO_deh_flav_C. 1 hit. SSF56176. FAD-binding_2. 1 hit. SSF54292. Ferredoxin. 1 hit. |
| TIGRFAMs | TIGR02963. xanthine_xdhA. 1 hit. TIGR02965. xanthine_xdhB. 1 hit. |
| PROSITE | PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS51387. FAD_PCMH. 1 hit. PS00559. MOLYBDOPTERIN_EUK. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20816087. |
Entry information
| Entry name | XDH_CHICK | ||||||||
| Accession | Primary (citable) accession number: P47990 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
