Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P47987

- PLLP_RAT

UniProt

P47987 - PLLP_RAT

Protein

Plasmolipin

Gene

Pllp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective.

    GO - Biological processi

    1. ion transport Source: RGD
    2. myelination Source: RGD
    3. response to wounding Source: RGD

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi1.A.64.1.1. the plasmolipin (plasmolipin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasmolipin
    Alternative name(s):
    Plasma membrane proteolipid
    Gene namesi
    Name:Pllp
    Synonyms:Pmlp, Tm4sf11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi621478. Pllp.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. compact myelin Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182PlasmolipinPRO_0000156815Add
    BLAST

    Proteomic databases

    PaxDbiP47987.
    PRIDEiP47987.

    Expressioni

    Tissue specificityi

    Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tublar epithelia.

    Developmental stagei

    In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.

    Gene expression databases

    GenevestigatoriP47987.

    Interactioni

    Subunit structurei

    Hexamer arranged as a trimer of two plasmolipin subunits.

    Protein-protein interaction databases

    BioGridi249048. 1 interaction.
    STRINGi10116.ENSRNOP00000022277.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini57 – 6812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini90 – 9910CytoplasmicSequence Analysis
    Topological domaini121 – 14121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini163 – 18220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 166135MARVELPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MAL family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257983.
    GeneTreeiENSGT00730000110954.
    HOGENOMiHOG000247057.
    HOVERGENiHBG108271.
    InParanoidiP47987.
    OMAiVLMIFNV.
    OrthoDBiEOG74TX1B.
    PhylomeDBiP47987.
    TreeFamiTF316174.

    Family and domain databases

    InterProiIPR013295. MAL.
    IPR008253. Marvel.
    [Graphical view]
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PRINTSiPR01884. MALPROTEIN.
    PROSITEiPS51225. MARVEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47987-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEFPSKVST RTSSPAQGVG ASVSAMRPDL GFVRSALGVL ALLQLVLGLL    50
    VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW 100
    PLVLLVFFVA ATVLYITAFV ACAAAVDLTS LRGSRPYNQR SAASFFACLV 150
    MIAYGLSAFF SFQAWRGVGS NAATSQMAGG YS 182
    Length:182
    Mass (Da):19,834
    Last modified:December 1, 2000 - v2
    Checksum:i18F5844F9AA79F6E
    GO

    Sequence cautioni

    The sequence AAA62133.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13617 mRNA. Translation: AAA62133.1. Different initiation.
    Z49858 mRNA. Translation: CAA90017.1.
    BC078823 mRNA. Translation: AAH78823.1.
    PIRiA55046.
    RefSeqiNP_071978.1. NM_022533.1.
    UniGeneiRn.1721.

    Genome annotation databases

    EnsembliENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558.
    GeneIDi64364.
    KEGGirno:64364.
    UCSCiRGD:621478. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13617 mRNA. Translation: AAA62133.1 . Different initiation.
    Z49858 mRNA. Translation: CAA90017.1 .
    BC078823 mRNA. Translation: AAH78823.1 .
    PIRi A55046.
    RefSeqi NP_071978.1. NM_022533.1.
    UniGenei Rn.1721.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249048. 1 interaction.
    STRINGi 10116.ENSRNOP00000022277.

    Protein family/group databases

    TCDBi 1.A.64.1.1. the plasmolipin (plasmolipin) family.

    Proteomic databases

    PaxDbi P47987.
    PRIDEi P47987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022277 ; ENSRNOP00000022277 ; ENSRNOG00000016558 .
    GeneIDi 64364.
    KEGGi rno:64364.
    UCSCi RGD:621478. rat.

    Organism-specific databases

    CTDi 51090.
    RGDi 621478. Pllp.

    Phylogenomic databases

    eggNOGi NOG257983.
    GeneTreei ENSGT00730000110954.
    HOGENOMi HOG000247057.
    HOVERGENi HBG108271.
    InParanoidi P47987.
    OMAi VLMIFNV.
    OrthoDBi EOG74TX1B.
    PhylomeDBi P47987.
    TreeFami TF316174.

    Miscellaneous databases

    NextBioi 613080.
    PROi P47987.

    Gene expression databases

    Genevestigatori P47987.

    Family and domain databases

    InterProi IPR013295. MAL.
    IPR008253. Marvel.
    [Graphical view ]
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PRINTSi PR01884. MALPROTEIN.
    PROSITEi PS51225. MARVEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of plasmolipin. Characterization of a novel proteolipid restricted to brain and kidney."
      Fischer I., Sapirstein V.S.
      J. Biol. Chem. 269:24912-24919(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: Sprague-Dawley.
      Tissue: Kidney.
    2. "Full-lenth cloning, expression and cellular localization of rat plasmolipin mRNA, a proteolipid of PNS and CNS."
      Gillen C., Gleichmann M., Greiner-Petter R., Zoidl G., Kupfer S., Bosse F., Auer J., Mueller H.W.
      Eur. J. Neurosci. 8:405-414(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Strain: Wistar.
      Tissue: Sciatic nerve.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiPLLP_RAT
    AccessioniPrimary (citable) accession number: P47987
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3