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Protein

Plasmolipin

Gene

Pllp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective.

GO - Biological processi

  • ion transport Source: RGD
  • myelination Source: RGD
  • response to wounding Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.64.1.1. the plasmolipin (plasmolipin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmolipin
Alternative name(s):
Plasma membrane proteolipid
Gene namesi
Name:Pllp
Synonyms:Pmlp, Tm4sf11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621478. Pllp.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 68ExtracellularSequence analysisAdd BLAST12
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 99CytoplasmicSequence analysis10
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 141ExtracellularSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 182CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • compact myelin Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568151 – 182PlasmolipinAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP47987.
PRIDEiP47987.

PTM databases

iPTMnetiP47987.
PhosphoSitePlusiP47987.

Expressioni

Tissue specificityi

Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tublar epithelia.

Developmental stagei

In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.

Gene expression databases

BgeeiENSRNOG00000016558.
GenevisibleiP47987. RN.

Interactioni

Subunit structurei

Hexamer arranged as a trimer of two plasmolipin subunits.

Protein-protein interaction databases

BioGridi249048. 1 interactor.
STRINGi10116.ENSRNOP00000022277.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 166MARVELPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiP47987.
OMAiVLMIFNV.
OrthoDBiEOG091G0RE7.
PhylomeDBiP47987.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFPSKVST RTSSPAQGVG ASVSAMRPDL GFVRSALGVL ALLQLVLGLL
60 70 80 90 100
VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW
110 120 130 140 150
PLVLLVFFVA ATVLYITAFV ACAAAVDLTS LRGSRPYNQR SAASFFACLV
160 170 180
MIAYGLSAFF SFQAWRGVGS NAATSQMAGG YS
Length:182
Mass (Da):19,834
Last modified:December 1, 2000 - v2
Checksum:i18F5844F9AA79F6E
GO

Sequence cautioni

The sequence AAA62133 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13617 mRNA. Translation: AAA62133.1. Different initiation.
Z49858 mRNA. Translation: CAA90017.1.
BC078823 mRNA. Translation: AAH78823.1.
PIRiA55046.
RefSeqiNP_071978.1. NM_022533.1.
UniGeneiRn.1721.

Genome annotation databases

EnsembliENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558.
GeneIDi64364.
KEGGirno:64364.
UCSCiRGD:621478. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13617 mRNA. Translation: AAA62133.1. Different initiation.
Z49858 mRNA. Translation: CAA90017.1.
BC078823 mRNA. Translation: AAH78823.1.
PIRiA55046.
RefSeqiNP_071978.1. NM_022533.1.
UniGeneiRn.1721.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249048. 1 interactor.
STRINGi10116.ENSRNOP00000022277.

Protein family/group databases

TCDBi1.A.64.1.1. the plasmolipin (plasmolipin) family.

PTM databases

iPTMnetiP47987.
PhosphoSitePlusiP47987.

Proteomic databases

PaxDbiP47987.
PRIDEiP47987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558.
GeneIDi64364.
KEGGirno:64364.
UCSCiRGD:621478. rat.

Organism-specific databases

CTDi51090.
RGDi621478. Pllp.

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiP47987.
OMAiVLMIFNV.
OrthoDBiEOG091G0RE7.
PhylomeDBiP47987.
TreeFamiTF316174.

Miscellaneous databases

PROiP47987.

Gene expression databases

BgeeiENSRNOG00000016558.
GenevisibleiP47987. RN.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLLP_RAT
AccessioniPrimary (citable) accession number: P47987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.