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P47987 (PLLP_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Plasmolipin
Alternative name(s):
Plasma membrane proteolipid
Gene names
Name:Pllp
Synonyms:Pmlp, Tm4sf11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective.

Subunit structure

Hexamer arranged as a trimer of two plasmolipin subunits.

Subcellular location

Membrane; Multi-pass membrane protein Ref.2.

Tissue specificity

Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tublar epithelia.

Developmental stage

In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.

Sequence similarities

Belongs to the MAL family.

Contains 1 MARVEL domain.

Sequence caution

The sequence AAA62133.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Plasmolipin
PRO_0000156815

Regions

Topological domain1 – 3535Cytoplasmic Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 6812Extracellular Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 9910Cytoplasmic Potential
Transmembrane100 – 12021Helical; Potential
Topological domain121 – 14121Extracellular Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 18220Cytoplasmic Potential
Domain32 – 166135MARVEL

Sequences

Sequence LengthMass (Da)Tools
P47987 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 18F5844F9AA79F6E

FASTA18219,834
        10         20         30         40         50         60 
MAEFPSKVST RTSSPAQGVG ASVSAMRPDL GFVRSALGVL ALLQLVLGLL VWALIADTPY 

        70         80         90        100        110        120 
HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW PLVLLVFFVA ATVLYITAFV 

       130        140        150        160        170        180 
ACAAAVDLTS LRGSRPYNQR SAASFFACLV MIAYGLSAFF SFQAWRGVGS NAATSQMAGG 


YS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of plasmolipin. Characterization of a novel proteolipid restricted to brain and kidney."
Fischer I., Sapirstein V.S.
J. Biol. Chem. 269:24912-24919(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: Sprague-Dawley.
Tissue: Kidney.
[2]"Full-lenth cloning, expression and cellular localization of rat plasmolipin mRNA, a proteolipid of PNS and CNS."
Gillen C., Gleichmann M., Greiner-Petter R., Zoidl G., Kupfer S., Bosse F., Auer J., Mueller H.W.
Eur. J. Neurosci. 8:405-414(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
Strain: Wistar.
Tissue: Sciatic nerve.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13617 mRNA. Translation: AAA62133.1. Different initiation.
Z49858 mRNA. Translation: CAA90017.1.
BC078823 mRNA. Translation: AAH78823.1.
PIRA55046.
RefSeqNP_071978.1. NM_022533.1.
UniGeneRn.1721.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249048. 1 interaction.
STRING10116.ENSRNOP00000022277.

Protein family/group databases

TCDB1.A.64.1.1. the plasmolipin (plasmolipin) family.

Proteomic databases

PaxDbP47987.
PRIDEP47987.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558.
GeneID64364.
KEGGrno:64364.
UCSCRGD:621478. rat.

Organism-specific databases

CTD51090.
RGD621478. Pllp.

Phylogenomic databases

eggNOGNOG257983.
GeneTreeENSGT00730000110954.
HOGENOMHOG000247057.
HOVERGENHBG108271.
InParanoidP47987.
OMAVLMIFNV.
OrthoDBEOG74TX1B.
PhylomeDBP47987.
TreeFamTF316174.

Gene expression databases

GenevestigatorP47987.

Family and domain databases

InterProIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSPR01884. MALPROTEIN.
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio613080.
PROP47987.

Entry information

Entry namePLLP_RAT
AccessionPrimary (citable) accession number: P47987
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families