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P47987

- PLLP_RAT

UniProt

P47987 - PLLP_RAT

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Protein

Plasmolipin

Gene

Pllp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective.

GO - Biological processi

  1. ion transport Source: RGD
  2. myelination Source: RGD
  3. response to wounding Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.64.1.1. the plasmolipin (plasmolipin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmolipin
Alternative name(s):
Plasma membrane proteolipid
Gene namesi
Name:Pllp
Synonyms:Pmlp, Tm4sf11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi621478. Pllp.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. compact myelin Source: RGD
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane raft Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182PlasmolipinPRO_0000156815Add
BLAST

Proteomic databases

PaxDbiP47987.
PRIDEiP47987.

Expressioni

Tissue specificityi

Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tublar epithelia.

Developmental stagei

In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.

Gene expression databases

GenevestigatoriP47987.

Interactioni

Subunit structurei

Hexamer arranged as a trimer of two plasmolipin subunits.

Protein-protein interaction databases

BioGridi249048. 1 interaction.
STRINGi10116.ENSRNOP00000022277.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini57 – 6812ExtracellularSequence AnalysisAdd
BLAST
Topological domaini90 – 9910CytoplasmicSequence Analysis
Topological domaini121 – 14121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini163 – 18220CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 166135MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257983.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiP47987.
OMAiVLMIFNV.
OrthoDBiEOG74TX1B.
PhylomeDBiP47987.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47987-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEFPSKVST RTSSPAQGVG ASVSAMRPDL GFVRSALGVL ALLQLVLGLL
60 70 80 90 100
VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW
110 120 130 140 150
PLVLLVFFVA ATVLYITAFV ACAAAVDLTS LRGSRPYNQR SAASFFACLV
160 170 180
MIAYGLSAFF SFQAWRGVGS NAATSQMAGG YS
Length:182
Mass (Da):19,834
Last modified:December 1, 2000 - v2
Checksum:i18F5844F9AA79F6E
GO

Sequence cautioni

The sequence AAA62133.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13617 mRNA. Translation: AAA62133.1. Different initiation.
Z49858 mRNA. Translation: CAA90017.1.
BC078823 mRNA. Translation: AAH78823.1.
PIRiA55046.
RefSeqiNP_071978.1. NM_022533.1.
UniGeneiRn.1721.

Genome annotation databases

EnsembliENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558.
GeneIDi64364.
KEGGirno:64364.
UCSCiRGD:621478. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13617 mRNA. Translation: AAA62133.1 . Different initiation.
Z49858 mRNA. Translation: CAA90017.1 .
BC078823 mRNA. Translation: AAH78823.1 .
PIRi A55046.
RefSeqi NP_071978.1. NM_022533.1.
UniGenei Rn.1721.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249048. 1 interaction.
STRINGi 10116.ENSRNOP00000022277.

Protein family/group databases

TCDBi 1.A.64.1.1. the plasmolipin (plasmolipin) family.

Proteomic databases

PaxDbi P47987.
PRIDEi P47987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022277 ; ENSRNOP00000022277 ; ENSRNOG00000016558 .
GeneIDi 64364.
KEGGi rno:64364.
UCSCi RGD:621478. rat.

Organism-specific databases

CTDi 51090.
RGDi 621478. Pllp.

Phylogenomic databases

eggNOGi NOG257983.
GeneTreei ENSGT00730000110954.
HOGENOMi HOG000247057.
HOVERGENi HBG108271.
InParanoidi P47987.
OMAi VLMIFNV.
OrthoDBi EOG74TX1B.
PhylomeDBi P47987.
TreeFami TF316174.

Miscellaneous databases

NextBioi 613080.
PROi P47987.

Gene expression databases

Genevestigatori P47987.

Family and domain databases

InterProi IPR013295. MAL.
IPR008253. Marvel.
[Graphical view ]
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PRINTSi PR01884. MALPROTEIN.
PROSITEi PS51225. MARVEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of plasmolipin. Characterization of a novel proteolipid restricted to brain and kidney."
    Fischer I., Sapirstein V.S.
    J. Biol. Chem. 269:24912-24919(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. "Full-lenth cloning, expression and cellular localization of rat plasmolipin mRNA, a proteolipid of PNS and CNS."
    Gillen C., Gleichmann M., Greiner-Petter R., Zoidl G., Kupfer S., Bosse F., Auer J., Mueller H.W.
    Eur. J. Neurosci. 8:405-414(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: Wistar.
    Tissue: Sciatic nerve.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPLLP_RAT
AccessioniPrimary (citable) accession number: P47987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3