P47987 (PLLP_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasmolipin

Alternative name(s):
Plasma membrane proteolipid

Gene names

Name:	Pllp
Synonyms:	Pmlp, Tm4sf11

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective.
Subunit structure	Hexamer arranged as a trimer of two plasmolipin subunits.
Subcellular location	Membrane; Multi-pass membrane protein Ref.2.
Tissue specificity	Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tublar epithelia.
Developmental stage	In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.
Sequence similarities	Belongs to the MAL family. Contains 1 MARVEL domain.
Sequence caution	The sequence AAA62133.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transport Inferred from direct assay Ref.1. Source: RGD myelination Inferred from expression pattern Ref.2. Source: RGD response to wounding Inferred from expression pattern Ref.2. Source: RGD
Cellular_component	compact myelin Inferred from direct assay PubMed 12871592. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from direct assay PubMed 12871592. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Plasmolipin		PRO_0000156815
Regions
	Topological domain	1 – 35	35	Cytoplasmic Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Topological domain	57 – 68	12	Extracellular Potential
	Transmembrane	69 – 89	21	Helical; Potential
	Topological domain	90 – 99	10	Cytoplasmic Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Topological domain	121 – 141	21	Extracellular Potential
	Transmembrane	142 – 162	21	Helical; Potential
	Topological domain	163 – 182	20	Cytoplasmic Potential
	Domain	32 – 166	135	MARVEL

Sequences

	Sequence		Length	Mass (Da)
	P47987 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 18F5844F9AA79F6E	FASTA	182	19,834
	10 20 30 40 50 60 MAEFPSKVST RTSSPAQGVG ASVSAMRPDL GFVRSALGVL ALLQLVLGLL VWALIADTPY 70 80 90 100 110 120 HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW PLVLLVFFVA ATVLYITAFV 130 140 150 160 170 180 ACAAAVDLTS LRGSRPYNQR SAASFFACLV MIAYGLSAFF SFQAWRGVGS NAATSQMAGG YS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of plasmolipin. Characterization of a novel proteolipid restricted to brain and kidney." Fischer I., Sapirstein V.S. J. Biol. Chem. 269:24912-24919(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Strain: Sprague-Dawley. Tissue: Kidney.
[2]	"Full-lenth cloning, expression and cellular localization of rat plasmolipin mRNA, a proteolipid of PNS and CNS." Gillen C., Gleichmann M., Greiner-Petter R., Zoidl G., Kupfer S., Bosse F., Auer J., Mueller H.W. Eur. J. Neurosci. 8:405-414(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION. Strain: Wistar. Tissue: Sciatic nerve.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U13617 mRNA. Translation: AAA62133.1. Different initiation. Z49858 mRNA. Translation: CAA90017.1. BC078823 mRNA. Translation: AAH78823.1.
IPI	IPI00192160.
PIR	A55046.
RefSeq	NP_071978.1. NM_022533.1.
UniGene	Rn.1721.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000022277.
Protein family/group databases
TCDB	1.A.64.1.1. plasmolipin family.
Proteomic databases
PaxDb	P47987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558.
GeneID	64364.
KEGG	rno:64364.
UCSC	RGD:621478. rat.
Organism-specific databases
CTD	51090.
RGD	621478. Pllp.
Phylogenomic databases
eggNOG	NOG257983.
GeneTree	ENSGT00530000062900.
HOGENOM	HOG000247057.
HOVERGEN	HBG108271.
InParanoid	P47987.
OMA	SAFFSYQ.
OrthoDB	EOG4WDDD0.
Gene expression databases
Genevestigator	P47987.
GermOnline	ENSRNOG00000016558. Rattus norvegicus.
Family and domain databases
InterPro	IPR013295. MAL. IPR008253. Marvel. IPR021128. MARVEL-like_dom. [Graphical view]
Pfam	PF01284. MARVEL. 1 hit. [Graphical view]
PRINTS	PR01884. MALPROTEIN.
PROSITE	PS51225. MARVEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	613080.

Entry information

Entry name

PLLP_RAT

Accession

Primary (citable) accession number: P47987

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program