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Protein

Tristetraprolin

Gene

Zfp36

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 12429C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 16229C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tristetraprolin
Short name:
TTP
Alternative name(s):
Protein TIS11A
Short name:
TIS11
Zinc finger protein 36
Short name:
Zfp-36
Gene namesi
Name:Zfp36
Synonyms:Tis11a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620722. Zfp36.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320TristetraprolinPRO_0000089165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531Phosphoserine; by MAPKAPK2By similarity
Modified residuei59 – 591PhosphoserineBy similarity
Modified residuei81 – 811PhosphoserineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity
Modified residuei85 – 851PhosphothreonineBy similarity
Modified residuei86 – 861PhosphoserineBy similarity
Modified residuei179 – 1791Phosphoserine; by MAPKAPK2By similarity
Modified residuei190 – 1901PhosphoserineBy similarity
Modified residuei211 – 2111PhosphoserineBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity
Modified residuei251 – 2511PhosphothreonineBy similarity
Modified residuei270 – 2701PhosphoserineBy similarity
Modified residuei290 – 2901PhosphoserineBy similarity
Modified residuei317 – 3171PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP47973.
PRIDEiP47973.

PTM databases

PhosphoSiteiP47973.

Interactioni

Subunit structurei

Interacts with CNOT1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026661.

Structurei

3D structure databases

ProteinModelPortaliP47973.
SMRiP47973. Positions 94-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 685P-P-P-P-G
Repeati191 – 1955P-P-P-P-G
Repeati212 – 2165P-P-P-P-G

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni306 – 32015Interaction with CNOT1By similarityAdd
BLAST

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 12429C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 16229C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiP47973.
KOiK15308.
PhylomeDBiP47973.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSAIYESL MSMSHDLSPD HGGTESSGGL WNINSSDSIP SGVTSRLTGR
60 70 80 90 100
STSLVEGRSC SWVPPPPGFA PLAPRPGPEL SPSPTSPTAT PTTSSRYKTE
110 120 130 140 150
LCRTYSESGR CRYGAKCQFA HGPGELRQAN RHPKYKTELC HKFYLQGRCP
160 170 180 190 200
YGSRCHFIHN PTEDLALPGQ PHVLRQSISF SGLPSGRRTS PPPPGFSGPS
210 220 230 240 250
LSSCSFSPSS SPPPPGDLPL SPSAFSAAPG TPVSRRDPTP ACCPSCRRST
260 270 280 290 300
TPSTIWGPLG GLARSPSAHS LGSDPDDYAS SGSSLGGSDS PVFEAGVFGP
310 320
PQPPAPPRRL PIFNRISVSE
Length:320
Mass (Da):33,654
Last modified:October 1, 1996 - v1
Checksum:iCFC597F3C7E5CA76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63369 mRNA. Translation: CAA44970.1.
AB025017 Genomic DNA. Translation: BAB12432.1.
BC060308 mRNA. Translation: AAH60308.1.
PIRiJC1255.
RefSeqiNP_579824.2. NM_133290.3.
UniGeneiRn.82737.

Genome annotation databases

GeneIDi79426.
KEGGirno:79426.
UCSCiRGD:620722. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63369 mRNA. Translation: CAA44970.1.
AB025017 Genomic DNA. Translation: BAB12432.1.
BC060308 mRNA. Translation: AAH60308.1.
PIRiJC1255.
RefSeqiNP_579824.2. NM_133290.3.
UniGeneiRn.82737.

3D structure databases

ProteinModelPortaliP47973.
SMRiP47973. Positions 94-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026661.

PTM databases

PhosphoSiteiP47973.

Proteomic databases

PaxDbiP47973.
PRIDEiP47973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79426.
KEGGirno:79426.
UCSCiRGD:620722. rat.

Organism-specific databases

CTDi7538.
RGDi620722. Zfp36.

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiP47973.
KOiK15308.
PhylomeDBiP47973.

Miscellaneous databases

PROiP47973.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a rat TIS11 cDNA, an immediate early gene induced by growth factors and phorbol esters."
    Kaneda N., Oshima M., Chung S.Y., Guroff G.
    Gene 118:289-291(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of the rat TIS11 gene."
    Kaneda N., Murata T., Niimi Y., Minamiyama M.
    Mol. Cell. Biochem. 213:119-126(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiTTP_RAT
AccessioniPrimary (citable) accession number: P47973
Secondary accession number(s): Q54AH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.