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Protein

Neuronal pentraxin-2

Gene

NPTX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi277 – 2771Calcium 1By similarity
Metal bindingi355 – 3551Calcium 1By similarity
Metal bindingi355 – 3551Calcium 2By similarity
Metal bindingi356 – 3561Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi357 – 3571Calcium 1By similarity
Metal bindingi357 – 3571Calcium 2By similarity
Metal bindingi367 – 3671Calcium 2By similarity

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: Ensembl
  • chemical synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-2
Short name:
NP2
Alternative name(s):
Neuronal pentraxin II
Short name:
NP-II
Gene namesi
Name:NPTX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7953. NPTX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31739.

Polymorphism and mutation databases

BioMutaiNPTX2.
DMDMi20981708.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 431416Neuronal pentraxin-2PRO_0000023551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi253 ↔ 313By similarity
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP47972.
PaxDbiP47972.
PeptideAtlasiP47972.
PRIDEiP47972.

PTM databases

iPTMnetiP47972.
PhosphoSiteiP47972.

Expressioni

Tissue specificityi

Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.

Gene expression databases

BgeeiENSG00000106236.
CleanExiHS_NPTX2.
GenevisibleiP47972. HS.

Organism-specific databases

HPAiCAB020801.
HPA049799.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).1 Publication

Protein-protein interaction databases

BioGridi110945. 5 interactions.
IntActiP47972. 1 interaction.
STRINGi9606.ENSP00000265634.

Structurei

3D structure databases

ProteinModelPortaliP47972.
SMRiP47972. Positions 233-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini227 – 431205PentaxinAdd
BLAST

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiP47972.
OMAiCSTNMAG.
OrthoDBiEOG091G0AHP.
PhylomeDBiP47972.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLAASVA LAVAAGAQDS PAPGSRFVCT ALPPEAVHAG CPLPAMPMQG
60 70 80 90 100
GAQSPEEELR AAVLQLRETV VQQKETLGAQ REAIRELTGK LARCEGLAGG
110 120 130 140 150
KARGAGATGK DTMGDLPRDP GHVVEQLSRS LQTLKDRLES LEHQLRANVS
160 170 180 190 200
NAGLPGDFRE VLQQRLGELE RQLLRKVAEL EDEKSLLHNE TSAHRQKTES
210 220 230 240 250
TLNALLQRVT ELERGNSAFK SPDAFKVSLP LRTNYLYGKI KKTLPELYAF
260 270 280 290 300
TICLWLRSSA SPGIGTPFSY AVPGQANEIV LIEWGNNPIE LLINDKVAQL
310 320 330 340 350
PLFVSDGKWH HICVTWTTRD GMWEAFQDGE KLGTGENLAP WHPIKPGGVL
360 370 380 390 400
ILGQEQDTVG GRFDATQAFV GELSQFNIWD RVLRAQEIVN IANCSTNMPG
410 420 430
NIIPWVDNNV DVFGGASKWP VETCEERLLD L
Length:431
Mass (Da):47,042
Last modified:May 15, 2002 - v2
Checksum:i87B7BF9BA1049AC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 825GAQRE → ASAR in AAA68980 (PubMed:8530029).Curated
Sequence conflicti78 – 825GAQRE → ASAR in AAA92296 (PubMed:8530029).Curated
Sequence conflicti280 – 2801V → L in AAA68980 (PubMed:8530029).Curated
Sequence conflicti280 – 2801V → L in AAA92296 (PubMed:8530029).Curated
Sequence conflicti427 – 4271R → A in AAA68980 (PubMed:8530029).Curated
Sequence conflicti427 – 4271R → A in AAA92296 (PubMed:8530029).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29195
, U29191, U29192, U29193, U29194 Genomic DNA. Translation: AAA68980.2.
U26662 mRNA. Translation: AAA92296.1.
AC074121 Genomic DNA. Translation: AAQ93363.1.
CH236956 Genomic DNA. Translation: EAL23889.1.
CH471091 Genomic DNA. Translation: EAW76705.1.
BC009924 mRNA. Translation: AAH09924.1.
BC034781 mRNA. Translation: AAH34781.1.
BC035339 mRNA. Translation: AAH35339.1.
BC048275 mRNA. Translation: AAH48275.2.
CCDSiCCDS5657.1.
RefSeqiNP_002514.1. NM_002523.2.
UniGeneiHs.3281.

Genome annotation databases

EnsembliENST00000265634; ENSP00000265634; ENSG00000106236.
GeneIDi4885.
KEGGihsa:4885.
UCSCiuc003upl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29195
, U29191, U29192, U29193, U29194 Genomic DNA. Translation: AAA68980.2.
U26662 mRNA. Translation: AAA92296.1.
AC074121 Genomic DNA. Translation: AAQ93363.1.
CH236956 Genomic DNA. Translation: EAL23889.1.
CH471091 Genomic DNA. Translation: EAW76705.1.
BC009924 mRNA. Translation: AAH09924.1.
BC034781 mRNA. Translation: AAH34781.1.
BC035339 mRNA. Translation: AAH35339.1.
BC048275 mRNA. Translation: AAH48275.2.
CCDSiCCDS5657.1.
RefSeqiNP_002514.1. NM_002523.2.
UniGeneiHs.3281.

3D structure databases

ProteinModelPortaliP47972.
SMRiP47972. Positions 233-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110945. 5 interactions.
IntActiP47972. 1 interaction.
STRINGi9606.ENSP00000265634.

PTM databases

iPTMnetiP47972.
PhosphoSiteiP47972.

Polymorphism and mutation databases

BioMutaiNPTX2.
DMDMi20981708.

Proteomic databases

EPDiP47972.
PaxDbiP47972.
PeptideAtlasiP47972.
PRIDEiP47972.

Protocols and materials databases

DNASUi4885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265634; ENSP00000265634; ENSG00000106236.
GeneIDi4885.
KEGGihsa:4885.
UCSCiuc003upl.3. human.

Organism-specific databases

CTDi4885.
GeneCardsiNPTX2.
HGNCiHGNC:7953. NPTX2.
HPAiCAB020801.
HPA049799.
MIMi600750. gene.
neXtProtiNX_P47972.
PharmGKBiPA31739.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiP47972.
OMAiCSTNMAG.
OrthoDBiEOG091G0AHP.
PhylomeDBiP47972.
TreeFamiTF330208.

Miscellaneous databases

GeneWikiiNPTX2.
GenomeRNAii4885.
PROiP47972.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106236.
CleanExiHS_NPTX2.
GenevisibleiP47972. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX2_HUMAN
AccessioniPrimary (citable) accession number: P47972
Secondary accession number(s): A4D267, Q86XV7, Q96G70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 15, 2002
Last modified: September 7, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.