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Protein

Neuronal pentraxin-1

Gene

Nptx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Calcium 1By similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2PROSITE-ProRule annotation1
Metal bindingi359Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi360Calcium 1By similarity1
Metal bindingi360Calcium 2PROSITE-ProRule annotation1
Metal bindingi370Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • cellular response to potassium ion Source: RGD
  • mitochondrial fragmentation involved in apoptotic process Source: RGD
  • mitochondrial transport Source: RGD

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
47 kDa taipoxin-binding protein
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:Nptx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628894 Nptx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002354923 – 432Neuronal pentraxin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 316PROSITE-ProRule annotation

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47971
PRIDEiP47971

PTM databases

UniCarbKBiP47971

Expressioni

Tissue specificityi

Cerebellum, hippocampus and cerebral cortex.

Gene expression databases

GenevisibleiP47971 RN

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).1 Publication

Protein-protein interaction databases

BioGridi251819, 2 interactors
CORUMiP47971
STRINGi10116.ENSRNOP00000005067

Structurei

3D structure databases

ProteinModelPortaliP47971
SMRiP47971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 428Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiP47971
OrthoDBiEOG091G0AHP
PhylomeDBiP47971
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAGRAARTC ALLALCLLGS RAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSNVLQ LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDAGPG
110 120 130 140 150
EARSGGGRKQ PGSGKNTMGD LSRTPASETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DDLERQVLSR VNTLEEGKGG PKNDTEERAK
210 220 230 240 250
IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK
410 420 430
ALSGNVIAWA ESQIEIFGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,216
Last modified:February 1, 1996 - v1
Checksum:i3071E3E40ACA3820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18772 mRNA Translation: AAA92685.1
RefSeqiNP_714957.1, NM_153735.2
UniGeneiRn.54707

Genome annotation databases

GeneIDi266777
KEGGirno:266777

Similar proteinsi

Entry informationi

Entry nameiNPTX1_RAT
AccessioniPrimary (citable) accession number: P47971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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