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Protein

Neuronal pentraxin-1

Gene

Nptx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Calcium 1By similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2By similarity1
Metal bindingi359Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi360Calcium 1By similarity1
Metal bindingi360Calcium 2By similarity1
Metal bindingi370Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • cellular response to potassium ion Source: RGD
  • mitochondrial fragmentation involved in apoptotic process Source: RGD
  • mitochondrial transport Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
47 kDa taipoxin-binding protein
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:Nptx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628894. Nptx1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • mitochondrion Source: RGD
  • neuron projection Source: RGD
  • plasma membrane Source: RGD
  • transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002354923 – 432Neuronal pentraxin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi256 ↔ 316By similarity

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47971.
PRIDEiP47971.

PTM databases

UniCarbKBiP47971.

Expressioni

Tissue specificityi

Cerebellum, hippocampus and cerebral cortex.

Gene expression databases

BgeeiENSRNOG00000003741.
GenevisibleiP47971. RN.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).1 Publication

Protein-protein interaction databases

BioGridi251819. 2 interactors.
STRINGi10116.ENSRNOP00000005067.

Structurei

3D structure databases

ProteinModelPortaliP47971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 432PentaxinAdd BLAST203

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiP47971.
OrthoDBiEOG091G0AHP.
PhylomeDBiP47971.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAGRAARTC ALLALCLLGS RAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSNVLQ LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDAGPG
110 120 130 140 150
EARSGGGRKQ PGSGKNTMGD LSRTPASETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DDLERQVLSR VNTLEEGKGG PKNDTEERAK
210 220 230 240 250
IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK
410 420 430
ALSGNVIAWA ESQIEIFGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,216
Last modified:February 1, 1996 - v1
Checksum:i3071E3E40ACA3820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18772 mRNA. Translation: AAA92685.1.
RefSeqiNP_714957.1. NM_153735.2.
UniGeneiRn.54707.

Genome annotation databases

GeneIDi266777.
KEGGirno:266777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18772 mRNA. Translation: AAA92685.1.
RefSeqiNP_714957.1. NM_153735.2.
UniGeneiRn.54707.

3D structure databases

ProteinModelPortaliP47971.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251819. 2 interactors.
STRINGi10116.ENSRNOP00000005067.

PTM databases

UniCarbKBiP47971.

Proteomic databases

PaxDbiP47971.
PRIDEiP47971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266777.
KEGGirno:266777.

Organism-specific databases

CTDi4884.
RGDi628894. Nptx1.

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiP47971.
OrthoDBiEOG091G0AHP.
PhylomeDBiP47971.
TreeFamiTF330208.

Miscellaneous databases

PROiP47971.

Gene expression databases

BgeeiENSRNOG00000003741.
GenevisibleiP47971. RN.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX1_RAT
AccessioniPrimary (citable) accession number: P47971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.