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P47969

- PENK_CAVPO

UniProt

P47969 - PENK_CAVPO

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Protein

Proenkephalin-A

Gene

PENK

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 8 chains:
Gene namesi
Name:PENK
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Peptidei25 – 9773SynenkephalinPRO_0000008219Add
BLAST
Peptidei100 – 1045Met-enkephalinPRO_0000008220
Peptidei107 – 1115Met-enkephalinPRO_0000008221
Peptidei114 – 13320PENK(114-133)By similarityPRO_0000377685Add
BLAST
Peptidei136 – 1405Met-enkephalinPRO_0000008223
Peptidei143 – 18442PENK(143-184)By similarityPRO_0000377686Add
BLAST
Peptidei187 – 1948Met-enkephalin-Arg-Gly-LeuPRO_0000008225
Propeptidei197 – 20812PRO_0000008226Add
BLAST
Peptidei211 – 2155Met-enkephalinPRO_0000008227
Propeptidei218 – 22811PRO_0000008228Add
BLAST
Peptidei231 – 2355Leu-enkephalinPRO_0000008229
Peptidei238 – 25922PENK(238-259)By similarityPRO_0000377687Add
BLAST
Peptidei262 – 2687Met-enkephalin-Arg-PhePRO_0000008231

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48By similarity
Disulfide bondi30 ↔ 52By similarity
Disulfide bondi33 ↔ 65By similarity

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011497.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40630.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP47969.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47969-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARLLRLCTW LVALGPGLLA TVQAECSQDC AACSYRLVRP GDLNFLACTL
60 70 80 90 100
ECEGQLPSLK IWETCKDLLQ VSKQELPQEG ASSLRESGKQ DESHLLSKKY
110 120 130 140 150
GGFMKRYGGF MKKVDELYPV EPEEEANGGE ILTKRYGGFM KKDAEDGDAL
160 170 180 190 200
ANSSDLLKEL LGTGDDRDRE NHHQEGGDSD EGVSKRYGGF MRGLKRSPQV
210 220 230 240 250
EDEAKELQKR YGGFMRRVGR PEWWMDYQKR YGGFLKRFAE FLPSDEEGES
260
YSKEVPEMEK RYGGFMRF
Length:268
Mass (Da):30,436
Last modified:February 1, 1996 - v1
Checksum:i64C85EE9F480F238
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16138 Genomic DNA. Translation: AAA87900.1.
PIRiA18864.
RefSeqiNP_001166888.1. NM_001173417.1.

Genome annotation databases

GeneIDi100379621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16138 Genomic DNA. Translation: AAA87900.1 .
PIRi A18864.
RefSeqi NP_001166888.1. NM_001173417.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000011497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100379621.

Organism-specific databases

CTDi 110182.

Phylogenomic databases

eggNOGi NOG40630.
HOGENOMi HOG000013003.
HOVERGENi HBG000063.
InParanoidi P47969.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of the guinea pig preproenkephalin gene: site-specific cleavage in the 3' untranslated region yields truncated mRNA transcripts in specific brain regions."
    Laforge K.S., Unterwald E.M., Kreek M.J.
    Mol. Cell. Biol. 15:2080-2089(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hartley.
  2. "A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence."
    Kilpatrick D.L., Taniguchi T., Jones B.N., Stern A.S., Shively J.E., Hullihan J., Kimura S., Stein S., Udenfriend S.
    Proc. Natl. Acad. Sci. U.S.A. 78:3265-3268(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 211-235, POSSIBLE BIOLOGICAL FUNCTION.

Entry informationi

Entry nameiPENK_CAVPO
AccessioniPrimary (citable) accession number: P47969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3