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P47968 (RPIA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-5-phosphate isomerase
EC=5.3.1.6
Alternative name(s):
Phosphoriboisomerase
Gene names
Name:Rpia
Synonyms:Rpi
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-ribose 5-phosphate = D-ribulose 5-phosphate.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.

Tissue specificity

Found in the spleen, kidney, thymus, heart, brain and lung. Higher levels are found in testis. Ref.1

Sequence similarities

Belongs to the ribose 5-phosphate isomerase family.

Sequence caution

The sequence AAC42060.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE23281.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Ribose-5-phosphate isomerase
PRO_0000158522

Experimental info

Sequence conflict841E → D in BAE23281. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47968 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: F8535B80A9D823C8

FASTA30332,451
        10         20         30         40         50         60 
MQRPGPFSTL YGRVLAPLPG RAGGAASGGG GNNWGLSGSH VQLPGRAHSE TRGDKGGSSA 

        70         80         90        100        110        120 
GGPAPSTMSK AEEAKKLASH TAVENHVKNN QVLGIGSGST IVHAVQRIAE RVKQENLDLI 

       130        140        150        160        170        180 
CIPTSFQARQ LILQYGLTLS DLDQHPEIDL AIDGADEVDA ELNLIKGGGG CLTQEKIVAG 

       190        200        210        220        230        240 
YASRFIVIAD FRKDSKNLGD RWHKGIPIEV IPMAYVPVSR AVAQKFGGEV ELRMAVNKAG 

       250        260        270        280        290        300 
PVVTDNGNFI LDWKFDRVHK WSEVNTAIKM TPGVVDTGLF INMAERVYFG MQDGSVNVRE 


KPF

« Hide

References

« Hide 'large scale' references
[1]"The ribose 5-phosphate isomerase-encoding gene is located immediately downstream from that encoding murine immunoglobulin kappa."
Apel T.W., Scherer A., Adachi T., Auch D., Ayane M., Reth M.
Gene 156:191-197(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Pre-B cell.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-303.
Strain: C57BL/6J.
Tissue: Urinary bladder.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-303.
Strain: FVB/N-3.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L35034 mRNA. Translation: AAC42060.1. Different initiation.
AK137235 mRNA. Translation: BAE23281.1. Different initiation.
BC053526 mRNA. Translation: AAH53526.2.
IPIIPI00113408.
PIRI53951.
RefSeqNP_033101.2. NM_009075.2.
UniGeneMm.17905.

3D structure databases

ProteinModelPortalP47968.
SMRP47968. Positions 72-301.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000064158.

PTM databases

PhosphoSiteP47968.

Proteomic databases

PaxDbP47968.
PRIDEP47968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000066134; ENSMUSP00000064158; ENSMUSG00000053604.
GeneID19895.
KEGGmmu:19895.
UCSCuc009cfy.1. mouse.

Organism-specific databases

CTD22934.
MGIMGI:103254. Rpia.

Phylogenomic databases

eggNOGCOG0120.
GeneTreeENSGT00390000004352.
HOGENOMHOG000276369.
HOVERGENHBG017746.
InParanoidP47968.
KOK01807.
OMADDIDCID.
OrthoDBEOG4BVRV4.

Enzyme and pathway databases

UniPathwayUPA00115; UER00412.

Gene expression databases

BgeeP47968.
CleanExMM_RPIA.
GenevestigatorP47968.
GermOnlineENSMUSG00000053604. Mus musculus.

Family and domain databases

InterProIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERPTHR11934. PTHR11934. 1 hit.
PfamPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsTIGR00021. rpiA. 1 hit.
ProtoNetSearch...

Other

NextBio297424.
SOURCESearch...

Entry information

Entry nameRPIA_MOUSE
AccessionPrimary (citable) accession number: P47968
Secondary accession number(s): Q3UVI8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 24, 2007
Last modified: May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents