Reviewed, UniProtKB/Swiss-Prot P47949 (TNNC3_DROME)

Names and origin

Protein names

Recommended name:
    Troponin C, isoform 3

Gene names

Name:	TpnC73F
Synonyms:	TnC73F
ORF Names:	CG7930

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Present in both larval and adult muscles.
Sequence similarities	Belongs to the troponin C family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium
Molecular function	Muscle protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ciliary or flagellar motility Inferred from electronic annotation. Source: InterPro
Cellular component	flagellin-based flagellum Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 155	155	Troponin C, isoform 3		PRO_0000073688
Regions
	Domain	11 – 46	36	EF-hand 1
	Domain	47 – 82	36	EF-hand 2
	Domain	87 – 122	36	EF-hand 3
	Domain	123 – 155	33	EF-hand 4
	Calcium binding	60 – 71	12	1 Potential
	Calcium binding	136 – 147	12	2 Potential
Experimental info
	Sequence conflict	93	1	R → A in CAA53627. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P47949-1 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: F45FCF78438C4D0B	FASTA	155	17,696
	10 20 30 40 50 60 MSSVDEDLTP EQIAVLQKAF NSFDHQKTGS IPTEMVADIL RLMGQPFDKK ILEELIEEVD 70 80 90 100 110 120 EDKSGRLEFG EFVQLAAKFI VEEDAEAMQK ELREAFRLYD KQGNGFIPTT CLKEILKELD 130 140 150 DQLTEQELDI MIEEIDSDGS GTVDFDEFME MMTGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Drosophila melanogaster genes encoding three troponin-C isoforms and a calmodulin-related protein." Fyrberg C., Parker H., Hutchison B., Fyrberg E.A. Biochem. Genet. 32:119-135(1994) [PubMed: 7980384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76042 mRNA. Translation: CAA53627.1. AE014296 Genomic DNA. Translation: AAF49371.1.
PIR	S38878.
RefSeq	NP_524122.2.
UniGene	Dm.2656
3D structure databases
HSSP	HSSP built from PDB template 1CDM based on UniProtKB P02593.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:23693N.
IntAct	P47949. 2 interactions.
Genome annotation databases
Ensembl	FBgn0010424. Drosophila melanogaster. [Contig view]
GeneID	39916.
KEGG	dme:Dmel_CG7930.
NMPDR	fig|7227.3.peg.10279.
Organism-specific databases
FlyBase	FBgn0010424. TpnC73F.
Phylogenomic databases
HOGENOM	P47949.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-017083-MON.
Gene expression databases
ArrayExpress	P47949.
GermOnline	CG7930. Drosophila melanogaster.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR018248. EF_hand. IPR018247. EF_HAND_1. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF00036. efhand. 3 hits. [Graphical view]
ProDom	PD000012. EF-hand. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	816066.

Entry information

Entry name

TNNC3_DROME

Accession

Primary (citable) accession number: P47949
Secondary accession number(s): Q9VVE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project