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Protein

Metallothionein-4

Gene

Mt4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
Metal bindingi58 – 581Divalent metal cation; cluster ABy similarity
Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity
Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. metal ion binding Source: MGI

GO - Biological processi

  1. cellular metal ion homeostasis Source: MGI
  2. response to cadmium ion Source: MGI
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein-IV
Short name:
MT-IV
Gene namesi
Name:Mt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99692. Mt4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262Metallothionein-4PRO_0000197256Add
BLAST

Proteomic databases

PRIDEiP47945.

Expressioni

Tissue specificityi

Expressed exclusively in stratified squamous epithelia associated with oral epithelia, esophagus, upper stomach, tail, footpads and neonatal skin.

Gene expression databases

BgeeiP47945.
CleanExiMM_MT4.
ExpressionAtlasiP47945. baseline and differential.
GenevestigatoriP47945.

Structurei

3D structure databases

ProteinModelPortaliP47945.
SMRiP47945. Positions 32-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69278.
HOGENOMiHOG000236262.
HOVERGENiHBG094959.
InParanoidiP47945.
KOiK14741.
OMAiCTNCNCK.
OrthoDBiEOG7G7KSQ.
PhylomeDBiP47945.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGECTCMS GGICICGDNC KCTTCSCKTC RKSCCPCCPP GCAKCARGCI
60
CKGGSDKCSC CP
Length:62
Mass (Da):6,277
Last modified:February 1, 1996 - v1
Checksum:i8F78DA6D0744333A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07808 Genomic DNA. Translation: AAA20233.1.
CCDSiCCDS40435.1.
PIRiB53640.
RefSeqiNP_032657.1. NM_008631.2.
UniGeneiMm.1536.

Genome annotation databases

EnsembliENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757.
GeneIDi17752.
KEGGimmu:17752.
UCSCiuc009mvt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07808 Genomic DNA. Translation: AAA20233.1.
CCDSiCCDS40435.1.
PIRiB53640.
RefSeqiNP_032657.1. NM_008631.2.
UniGeneiMm.1536.

3D structure databases

ProteinModelPortaliP47945.
SMRiP47945. Positions 32-62.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP47945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757.
GeneIDi17752.
KEGGimmu:17752.
UCSCiuc009mvt.1. mouse.

Organism-specific databases

CTDi84560.
MGIiMGI:99692. Mt4.

Phylogenomic databases

eggNOGiNOG69278.
HOGENOMiHOG000236262.
HOVERGENiHBG094959.
InParanoidiP47945.
KOiK14741.
OMAiCTNCNCK.
OrthoDBiEOG7G7KSQ.
PhylomeDBiP47945.
TreeFamiTF336054.

Miscellaneous databases

NextBioi292419.
PROiP47945.
SOURCEiSearch...

Gene expression databases

BgeeiP47945.
CleanExiMM_MT4.
ExpressionAtlasiP47945. baseline and differential.
GenevestigatoriP47945.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia."
    Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D.
    Biochemistry 33:7250-7259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiMT4_MOUSE
AccessioniPrimary (citable) accession number: P47945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.