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Protein

Metallothionein-4

Gene

Mt4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi58Divalent metal cation; cluster ABy similarity1
Metal bindingi60Divalent metal cation; cluster ABy similarity1
Metal bindingi61Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

  • metal ion binding Source: MGI

GO - Biological processi

  • cellular metal ion homeostasis Source: MGI
  • response to cadmium ion Source: MGI
  • response to metal ion Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5661231. Metallothioneins bind metals.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein-IV
Short name:
MT-IV
Gene namesi
Name:Mt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99692. Mt4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972561 – 62Metallothionein-4Add BLAST62

Proteomic databases

PaxDbiP47945.
PRIDEiP47945.

Expressioni

Tissue specificityi

Expressed exclusively in stratified squamous epithelia associated with oral epithelia, esophagus, upper stomach, tail, footpads and neonatal skin.

Gene expression databases

BgeeiENSMUSG00000031757.
CleanExiMM_MT4.
ExpressionAtlasiP47945. baseline and differential.
GenevisibleiP47945. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034207.

Structurei

3D structure databases

ProteinModelPortaliP47945.
SMRiP47945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J3IA. Eukaryota.
ENOG4111C2K. LUCA.
GeneTreeiENSGT00730000111475.
HOGENOMiHOG000236262.
HOVERGENiHBG094959.
InParanoidiP47945.
KOiK14741.
OMAiTCMSGGT.
PhylomeDBiP47945.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGECTCMS GGICICGDNC KCTTCSCKTC RKSCCPCCPP GCAKCARGCI
60
CKGGSDKCSC CP
Length:62
Mass (Da):6,277
Last modified:February 1, 1996 - v1
Checksum:i8F78DA6D0744333A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07808 Genomic DNA. Translation: AAA20233.1.
CCDSiCCDS40435.1.
PIRiB53640.
RefSeqiNP_032657.1. NM_008631.2.
UniGeneiMm.1536.

Genome annotation databases

EnsembliENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757.
GeneIDi17752.
KEGGimmu:17752.
UCSCiuc009mvt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07808 Genomic DNA. Translation: AAA20233.1.
CCDSiCCDS40435.1.
PIRiB53640.
RefSeqiNP_032657.1. NM_008631.2.
UniGeneiMm.1536.

3D structure databases

ProteinModelPortaliP47945.
SMRiP47945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034207.

Proteomic databases

PaxDbiP47945.
PRIDEiP47945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757.
GeneIDi17752.
KEGGimmu:17752.
UCSCiuc009mvt.1. mouse.

Organism-specific databases

CTDi84560.
MGIiMGI:99692. Mt4.

Phylogenomic databases

eggNOGiENOG410J3IA. Eukaryota.
ENOG4111C2K. LUCA.
GeneTreeiENSGT00730000111475.
HOGENOMiHOG000236262.
HOVERGENiHBG094959.
InParanoidiP47945.
KOiK14741.
OMAiTCMSGGT.
PhylomeDBiP47945.
TreeFamiTF336054.

Enzyme and pathway databases

ReactomeiR-MMU-5661231. Metallothioneins bind metals.

Miscellaneous databases

PROiP47945.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031757.
CleanExiMM_MT4.
ExpressionAtlasiP47945. baseline and differential.
GenevisibleiP47945. MM.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT4_MOUSE
AccessioniPrimary (citable) accession number: P47945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.