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P47945

- MT4_MOUSE

UniProt

P47945 - MT4_MOUSE

Protein

Metallothionein-4

Gene

Mt4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
    Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
    Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
    Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
    Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
    Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
    Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
    Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
    Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
    Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
    Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
    Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
    Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
    Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
    Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
    Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
    Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
    Metal bindingi58 – 581Divalent metal cation; cluster ABy similarity
    Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity
    Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. metal ion binding Source: MGI

    GO - Biological processi

    1. cellular metal ion homeostasis Source: MGI
    2. response to cadmium ion Source: MGI

    Keywords - Ligandi

    Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-4
    Short name:
    MT-4
    Alternative name(s):
    Metallothionein-IV
    Short name:
    MT-IV
    Gene namesi
    Name:Mt4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:99692. Mt4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6262Metallothionein-4PRO_0000197256Add
    BLAST

    Proteomic databases

    PRIDEiP47945.

    Expressioni

    Tissue specificityi

    Expressed exclusively in stratified squamous epithelia associated with oral epithelia, esophagus, upper stomach, tail, footpads and neonatal skin.

    Gene expression databases

    BgeeiP47945.
    CleanExiMM_MT4.
    GenevestigatoriP47945.

    Structurei

    3D structure databases

    ProteinModelPortaliP47945.
    SMRiP47945. Positions 1-62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG69278.
    HOGENOMiHOG000236262.
    HOVERGENiHBG094959.
    InParanoidiP47945.
    KOiK14741.
    OMAiCICKGSS.
    OrthoDBiEOG7G7KSQ.
    PhylomeDBiP47945.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPGECTCMS GGICICGDNC KCTTCSCKTC RKSCCPCCPP GCAKCARGCI   50
    CKGGSDKCSC CP 62
    Length:62
    Mass (Da):6,277
    Last modified:February 1, 1996 - v1
    Checksum:i8F78DA6D0744333A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07808 Genomic DNA. Translation: AAA20233.1.
    CCDSiCCDS40435.1.
    PIRiB53640.
    RefSeqiNP_032657.1. NM_008631.2.
    UniGeneiMm.1536.

    Genome annotation databases

    EnsembliENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757.
    GeneIDi17752.
    KEGGimmu:17752.
    UCSCiuc009mvt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07808 Genomic DNA. Translation: AAA20233.1 .
    CCDSi CCDS40435.1.
    PIRi B53640.
    RefSeqi NP_032657.1. NM_008631.2.
    UniGenei Mm.1536.

    3D structure databases

    ProteinModelPortali P47945.
    SMRi P47945. Positions 1-62.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P47945.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034207 ; ENSMUSP00000034207 ; ENSMUSG00000031757 .
    GeneIDi 17752.
    KEGGi mmu:17752.
    UCSCi uc009mvt.1. mouse.

    Organism-specific databases

    CTDi 84560.
    MGIi MGI:99692. Mt4.

    Phylogenomic databases

    eggNOGi NOG69278.
    HOGENOMi HOG000236262.
    HOVERGENi HBG094959.
    InParanoidi P47945.
    KOi K14741.
    OMAi CICKGSS.
    OrthoDBi EOG7G7KSQ.
    PhylomeDBi P47945.
    TreeFami TF336054.

    Miscellaneous databases

    NextBioi 292419.
    PROi P47945.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47945.
    CleanExi MM_MT4.
    Genevestigatori P47945.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia."
      Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D.
      Biochemistry 33:7250-7259(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiMT4_MOUSE
    AccessioniPrimary (citable) accession number: P47945
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3