Reviewed,
UniProtKB/Swiss-Prot P47945 (MT4_MOUSE)
Last modified
November 24, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (3) |
 Third-party data |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Metallothionein-4 Short name=MT-4 Alternative name(s): Metallothionein-IV Short name=MT-IV | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 62 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia. |
| Tissue specificity | Expressed exclusively in stratified squamous epithelia associated with oral epithelia, esophagus, upper stomach, tail, footpads and neonatal skin. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Copper Metal-binding Metal-thiolate cluster Zinc |
| Gene Ontology (GO) | |
| Biological process | cellular metal ion homeostasis Inferred from direct assay. Source: MGI |
| Molecular function | copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 62 | 62 | Metallothionein-4 | PRO_0000197256 | |||||
Sites | |||||||||
| Metal binding | 6 | 1 | Cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Cluster B By similarity | ||||||
| Metal binding | 30 | 1 | Cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Cluster A By similarity | ||||||
| Metal binding | 37 | 1 | Cluster A By similarity | ||||||
| Metal binding | 38 | 1 | Cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Cluster A By similarity | ||||||
| Metal binding | 45 | 1 | Cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Cluster A By similarity | ||||||
| Metal binding | 51 | 1 | Cluster A By similarity | ||||||
| Metal binding | 58 | 1 | Cluster A By similarity | ||||||
| Metal binding | 60 | 1 | Cluster A By similarity | ||||||
| Metal binding | 61 | 1 | Cluster A By similarity | ||||||
Sequences
References
| [1] | "Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia." Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D. Biochemistry 33:7250-7259(1994) [PubMed: 8003488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U07808 Genomic DNA. Translation: AAA20233.1. | |
| IPI | IPI00113365. |
| PIR | B53640. |
| RefSeq | NP_032657.1. |
| UniGene | Mm.1536 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P47945. |
Genome annotation databases | |
| Ensembl | ENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757; Mus musculus. [Genome view] |
| GeneID | 17752. |
| KEGG | mmu:17752. |
| UCSC | uc009mvt.1. mouse. |
Organism-specific databases | |
| CTD | 17752. |
| MGI | MGI:99692. Mt4. |
Phylogenomic databases | |
| HOVERGEN | P47945. |
| OMA | CQKSCCP |
| OrthoDB | EOG9W6RF9 |
Gene expression databases | |
| ArrayExpress | P47945. |
| Bgee | P47945. |
| CleanEx | MM_MT4. |
| Genevestigator | P47945. |
| GermOnline | ENSMUSG00000031757. Mus musculus. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 292419. |
| SOURCE | Search... |
Entry information
| Entry name | MT4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P47945 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
