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Protein

Metallothionein-4

Gene

MT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
Metal bindingi58 – 581Divalent metal cation; cluster ABy similarity
Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity
Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular metal ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein-IV
Short name:
MT-IV
Gene namesi
Name:MT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18705. MT4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262Metallothionein-4PRO_0000197255Add
BLAST

Proteomic databases

PRIDEiP47944.

Expressioni

Gene expression databases

BgeeiP47944.
CleanExiHS_MT4.
GenevestigatoriP47944.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000219162.

Structurei

3D structure databases

ProteinModelPortaliP47944.
SMRiP47944. Positions 32-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69278.
GeneTreeiENSGT00730000111475.
HOGENOMiHOG000236262.
InParanoidiP47944.
KOiK14741.
OMAiCTNCNCK.
OrthoDBiEOG7G7KSQ.
PhylomeDBiP47944.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

P47944-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPRECVCMS GGICMCGDNC KCTTCNCKTY WKSCCPCCPP GCAKCARGCI
60
CKGGSDKCSC CP
Length:62
Mass (Da):6,509
Last modified:February 9, 2010 - v2
Checksum:i55DA475A17BF28C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301Y → C.2 Publications
Corresponds to variant rs666636 [ dbSNP | Ensembl ].
VAR_034110
Natural varianti31 – 311W → R.2 Publications
Corresponds to variant rs666647 [ dbSNP | Ensembl ].
VAR_034111
Natural varianti48 – 481G → D.
Corresponds to variant rs11643815 [ dbSNP | Ensembl ].
VAR_034112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07807 Genomic DNA. Translation: AAA20232.1.
AC026461 mRNA. No translation available.
BC113442 mRNA. Translation: AAI13443.1.
BC113444 mRNA. Translation: AAI13445.1.
CCDSiCCDS42165.1.
PIRiA53640.
RefSeqiNP_116324.1. NM_032935.2.
UniGeneiHs.567624.

Genome annotation databases

EnsembliENST00000219162; ENSP00000219162; ENSG00000102891.
GeneIDi84560.
KEGGihsa:84560.
UCSCiuc002eje.1. human.

Polymorphism databases

DMDMi288558817.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07807 Genomic DNA. Translation: AAA20232.1.
AC026461 mRNA. No translation available.
BC113442 mRNA. Translation: AAI13443.1.
BC113444 mRNA. Translation: AAI13445.1.
CCDSiCCDS42165.1.
PIRiA53640.
RefSeqiNP_116324.1. NM_032935.2.
UniGeneiHs.567624.

3D structure databases

ProteinModelPortaliP47944.
SMRiP47944. Positions 32-62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000219162.

Polymorphism databases

DMDMi288558817.

Proteomic databases

PRIDEiP47944.

Protocols and materials databases

DNASUi84560.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219162; ENSP00000219162; ENSG00000102891.
GeneIDi84560.
KEGGihsa:84560.
UCSCiuc002eje.1. human.

Organism-specific databases

CTDi84560.
GeneCardsiGC16P056598.
HGNCiHGNC:18705. MT4.
MIMi606206. gene.
neXtProtiNX_P47944.
PharmGKBiPA38649.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG69278.
GeneTreeiENSGT00730000111475.
HOGENOMiHOG000236262.
InParanoidiP47944.
KOiK14741.
OMAiCTNCNCK.
OrthoDBiEOG7G7KSQ.
PhylomeDBiP47944.
TreeFamiTF336054.

Miscellaneous databases

ChiTaRSiMT4. human.
GenomeRNAii84560.
NextBioi74450.
PROiP47944.
SOURCEiSearch...

Gene expression databases

BgeeiP47944.
CleanExiHS_MT4.
GenevestigatoriP47944.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia."
    Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D.
    Biochemistry 33:7250-7259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-30 AND ARG-31.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-30 AND ARG-31.

Entry informationi

Entry nameiMT4_HUMAN
AccessioniPrimary (citable) accession number: P47944
Secondary accession number(s): Q14DA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 9, 2010
Last modified: January 7, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Metallothioneins
    Classification of metallothioneins and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.