P47944 (MT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metallothionein-4
Short name=MT-4

Alternative name(s):
Metallothionein-IV
Short name=MT-IV

Gene names

Name:

MT4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	62 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Copper Metal-binding Metal-thiolate cluster Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular metal ion homeostasis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Non-traceable author statement. Source: UniProtKB
Molecular_function	copper ion binding Non-traceable author statement. Source: UniProtKB zinc ion binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 62	62	Metallothionein-4		PRO_0000197255
Sites
	Metal binding	6	1	Divalent metal cation; cluster B By similarity
	Metal binding	8	1	Divalent metal cation; cluster B By similarity
	Metal binding	14	1	Divalent metal cation; cluster B By similarity
	Metal binding	16	1	Divalent metal cation; cluster B By similarity
	Metal binding	20	1	Divalent metal cation; cluster B By similarity
	Metal binding	22	1	Divalent metal cation; cluster B By similarity
	Metal binding	25	1	Divalent metal cation; cluster B By similarity
	Metal binding	27	1	Divalent metal cation; cluster B By similarity
	Metal binding	30	1	Divalent metal cation; cluster B By similarity
	Metal binding	34	1	Divalent metal cation; cluster A By similarity
	Metal binding	35	1	Divalent metal cation; cluster A By similarity
	Metal binding	37	1	Divalent metal cation; cluster A By similarity
	Metal binding	38	1	Divalent metal cation; cluster A By similarity
	Metal binding	42	1	Divalent metal cation; cluster A By similarity
	Metal binding	45	1	Divalent metal cation; cluster A By similarity
	Metal binding	49	1	Divalent metal cation; cluster A By similarity
	Metal binding	51	1	Divalent metal cation; cluster A By similarity
	Metal binding	58	1	Divalent metal cation; cluster A By similarity
	Metal binding	60	1	Divalent metal cation; cluster A By similarity
	Metal binding	61	1	Divalent metal cation; cluster A By similarity
Natural variations
	Natural variant	30	1	Y → C. Ref.1 Ref.3 Corresponds to variant rs666636 [ dbSNP | Ensembl ].		VAR_034110
	Natural variant	31	1	W → R. Ref.1 Ref.3 Corresponds to variant rs666647 [ dbSNP | Ensembl ].		VAR_034111
	Natural variant	48	1	G → D. Corresponds to variant rs11643815 [ dbSNP | Ensembl ].		VAR_034112

Sequences

	Sequence		Length	Mass (Da)
	P47944 [UniParc]. Last modified February 9, 2010. Version 2. Checksum: 55DA475A17BF28C9	FASTA	62	6,509
	10 20 30 40 50 60 MDPRECVCMS GGICMCGDNC KCTTCNCKTY WKSCCPCCPP GCAKCARGCI CKGGSDKCSC CP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia." Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D. Biochemistry 33:7250-7259(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-30 AND ARG-31.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-30 AND ARG-31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07807 Genomic DNA. Translation: AAA20232.1. AC026461 mRNA. No translation available. BC113442 mRNA. Translation: AAI13443.1. BC113444 mRNA. Translation: AAI13445.1.
IPI	IPI00026892.
PIR	A53640.
RefSeq	NP_116324.1. NM_032935.2.
UniGene	Hs.567624.
3D structure databases
ProteinModelPortal	P47944.
SMR	P47944. Positions 32-62.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000219162.
Polymorphism databases
DMDM	288558817.
Proteomic databases
PRIDE	P47944.
Protocols and materials databases
DNASU	84560.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000219162; ENSP00000219162; ENSG00000102891.
GeneID	84560.
KEGG	hsa:84560.
UCSC	uc002eje.1. human.
Organism-specific databases
CTD	84560.
GeneCards	GC16P056598.
HGNC	HGNC:18705. MT4.
MIM	606206. gene.
neXtProt	NX_P47944.
PharmGKB	PA38649.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG69278.
HOGENOM	HOG000236262.
InParanoid	P47944.
KO	K14741.
OMA	CTNCNCK.
OrthoDB	EOG4M91T8.
Gene expression databases
Bgee	P47944.
CleanEx	HS_MT4.
Genevestigator	P47944.
GermOnline	ENSG00000102891. Homo sapiens.
Family and domain databases
Gene3D	4.10.10.10. 1 hit.
InterPro	IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. [Graphical view]
PANTHER	PTHR23299. PTHR23299. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
SUPFAM	SSF57868. Metallothionein_sfam. 1 hit.
PROSITE	PS00203. METALLOTHIONEIN_VRT. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84560.
NextBio	74450.
SOURCE	Search...

Entry information

Entry name

MT4_HUMAN

Accession

Primary (citable) accession number: P47944
Secondary accession number(s): Q14DA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 9, 2010
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.