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P47944

- MT4_HUMAN

UniProt

P47944 - MT4_HUMAN

Protein

Metallothionein-4

Gene

MT4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
    Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
    Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
    Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
    Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
    Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
    Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
    Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
    Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
    Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
    Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
    Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
    Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
    Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
    Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
    Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
    Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
    Metal bindingi58 – 581Divalent metal cation; cluster ABy similarity
    Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity
    Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular metal ion homeostasis Source: Ensembl

    Keywords - Ligandi

    Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-4
    Short name:
    MT-4
    Alternative name(s):
    Metallothionein-IV
    Short name:
    MT-IV
    Gene namesi
    Name:MT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:18705. MT4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38649.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6262Metallothionein-4PRO_0000197255Add
    BLAST

    Proteomic databases

    PRIDEiP47944.

    Expressioni

    Gene expression databases

    BgeeiP47944.
    CleanExiHS_MT4.
    GenevestigatoriP47944.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000219162.

    Structurei

    3D structure databases

    ProteinModelPortaliP47944.
    SMRiP47944. Positions 1-62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG69278.
    HOGENOMiHOG000236262.
    InParanoidiP47944.
    KOiK14741.
    OMAiCICKGSS.
    OrthoDBiEOG7G7KSQ.
    PhylomeDBiP47944.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47944-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPRECVCMS GGICMCGDNC KCTTCNCKTY WKSCCPCCPP GCAKCARGCI   50
    CKGGSDKCSC CP 62
    Length:62
    Mass (Da):6,509
    Last modified:February 9, 2010 - v2
    Checksum:i55DA475A17BF28C9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301Y → C.2 Publications
    Corresponds to variant rs666636 [ dbSNP | Ensembl ].
    VAR_034110
    Natural varianti31 – 311W → R.2 Publications
    Corresponds to variant rs666647 [ dbSNP | Ensembl ].
    VAR_034111
    Natural varianti48 – 481G → D.
    Corresponds to variant rs11643815 [ dbSNP | Ensembl ].
    VAR_034112

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07807 Genomic DNA. Translation: AAA20232.1.
    AC026461 mRNA. No translation available.
    BC113442 mRNA. Translation: AAI13443.1.
    BC113444 mRNA. Translation: AAI13445.1.
    CCDSiCCDS42165.1.
    PIRiA53640.
    RefSeqiNP_116324.1. NM_032935.2.
    UniGeneiHs.567624.

    Genome annotation databases

    EnsembliENST00000219162; ENSP00000219162; ENSG00000102891.
    GeneIDi84560.
    KEGGihsa:84560.
    UCSCiuc002eje.1. human.

    Polymorphism databases

    DMDMi288558817.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07807 Genomic DNA. Translation: AAA20232.1 .
    AC026461 mRNA. No translation available.
    BC113442 mRNA. Translation: AAI13443.1 .
    BC113444 mRNA. Translation: AAI13445.1 .
    CCDSi CCDS42165.1.
    PIRi A53640.
    RefSeqi NP_116324.1. NM_032935.2.
    UniGenei Hs.567624.

    3D structure databases

    ProteinModelPortali P47944.
    SMRi P47944. Positions 1-62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000219162.

    Polymorphism databases

    DMDMi 288558817.

    Proteomic databases

    PRIDEi P47944.

    Protocols and materials databases

    DNASUi 84560.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219162 ; ENSP00000219162 ; ENSG00000102891 .
    GeneIDi 84560.
    KEGGi hsa:84560.
    UCSCi uc002eje.1. human.

    Organism-specific databases

    CTDi 84560.
    GeneCardsi GC16P056598.
    HGNCi HGNC:18705. MT4.
    MIMi 606206. gene.
    neXtProti NX_P47944.
    PharmGKBi PA38649.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69278.
    HOGENOMi HOG000236262.
    InParanoidi P47944.
    KOi K14741.
    OMAi CICKGSS.
    OrthoDBi EOG7G7KSQ.
    PhylomeDBi P47944.
    TreeFami TF336054.

    Miscellaneous databases

    GenomeRNAii 84560.
    NextBioi 74450.
    PROi P47944.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47944.
    CleanExi HS_MT4.
    Genevestigatori P47944.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia."
      Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D.
      Biochemistry 33:7250-7259(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-30 AND ARG-31.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-30 AND ARG-31.

    Entry informationi

    Entry nameiMT4_HUMAN
    AccessioniPrimary (citable) accession number: P47944
    Secondary accession number(s): Q14DA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Metallothioneins
      Classification of metallothioneins and list of entries
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3