Reviewed,
UniProtKB/Swiss-Prot P47944 (MT4_HUMAN)
Last modified
November 24, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (6) |
 Third-party data |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Metallothionein-4 Short name=MT-4 Alternative name(s): Metallothionein-IV Short name=MT-IV | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 62 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Ligand | Copper Metal-binding Metal-thiolate cluster Zinc |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Non-traceable author statement. Source: UniProtKB |
| Molecular function | copper ion binding Non-traceable author statement. Source: UniProtKB zinc ion bindingNon-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 62 | 62 | Metallothionein-4 | PRO_0000197255 | |||||
Sites | |||||||||
| Metal binding | 6 | 1 | Cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Cluster B By similarity | ||||||
| Metal binding | 30 | 1 | Cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Cluster A By similarity | ||||||
| Metal binding | 37 | 1 | Cluster A By similarity | ||||||
| Metal binding | 38 | 1 | Cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Cluster A By similarity | ||||||
| Metal binding | 45 | 1 | Cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Cluster A By similarity | ||||||
| Metal binding | 51 | 1 | Cluster A By similarity | ||||||
| Metal binding | 58 | 1 | Cluster A By similarity | ||||||
| Metal binding | 60 | 1 | Cluster A By similarity | ||||||
| Metal binding | 61 | 1 | Cluster A By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 30 | 1 | C → Y: dbSNP rs666636. Ref.2 | VAR_034110 | |||||
| Natural variant | 31 | 1 | R → W: dbSNP rs666647. Ref.2 | VAR_034111 | |||||
| Natural variant | 48 | 1 | G → D: dbSNP rs11643815. | VAR_034112 | |||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia." Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D. Biochemistry 33:7250-7259(1994) [PubMed: 8003488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.  Pennacchio L.A.Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS TYR-30 AND TRP-31. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| U07807 Genomic DNA. Translation: AAA20232.1. AC026461 mRNA. No translation available. BC113442 mRNA. Translation: AAI13443.1. BC113444 mRNA. Translation: AAI13445.1. | |
| IPI | IPI00026892. |
| PIR | A53640. |
| RefSeq | NP_116324.1. |
| UniGene | Hs.567624 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P47944. |
Proteomic databases | |
| PRIDE | P47944. |
Genome annotation databases | |
| Ensembl | ENST00000219162; ENSP00000219162; ENSG00000102891; Homo sapiens. [Genome view] |
| GeneID | 84560. |
| KEGG | hsa:84560. |
| UCSC | uc002eje.1. human. |
Organism-specific databases | |
| CTD | 84560. |
| GeneCards | GC16P055156. |
| H-InvDB | HIX0038647. |
| HGNC | HGNC:18705. MT4. |
| MIM | 606206. gene. |
| PharmGKB | PA38649. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P47944. |
| OrthoDB | EOG9W6RF9 |
Gene expression databases | |
| ArrayExpress | P47944. |
| Bgee | P47944. |
| CleanEx | HS_MT4. |
| Genevestigator | P47944. |
| GermOnline | ENSG00000102891. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 74450. |
| SOURCE | Search... |
Entry information
| Entry name | MT4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P47944 Secondary accession number(s): Q14DA1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| Metallothioneins Classification of metallothioneins and list of entries |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
