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P47944 (MT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-4

Short name=MT-4
Alternative name(s):
Metallothionein-IV
Short name=MT-IV
Gene names
Name:MT4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length62 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   LigandCopper
Metal-binding
Metal-thiolate cluster
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular metal ion homeostasis

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6262Metallothionein-4
PRO_0000197255

Sites

Metal binding61Divalent metal cation; cluster B By similarity
Metal binding81Divalent metal cation; cluster B By similarity
Metal binding141Divalent metal cation; cluster B By similarity
Metal binding161Divalent metal cation; cluster B By similarity
Metal binding201Divalent metal cation; cluster B By similarity
Metal binding221Divalent metal cation; cluster B By similarity
Metal binding251Divalent metal cation; cluster B By similarity
Metal binding271Divalent metal cation; cluster B By similarity
Metal binding301Divalent metal cation; cluster B By similarity
Metal binding341Divalent metal cation; cluster A By similarity
Metal binding351Divalent metal cation; cluster A By similarity
Metal binding371Divalent metal cation; cluster A By similarity
Metal binding381Divalent metal cation; cluster A By similarity
Metal binding421Divalent metal cation; cluster A By similarity
Metal binding451Divalent metal cation; cluster A By similarity
Metal binding491Divalent metal cation; cluster A By similarity
Metal binding511Divalent metal cation; cluster A By similarity
Metal binding581Divalent metal cation; cluster A By similarity
Metal binding601Divalent metal cation; cluster A By similarity
Metal binding611Divalent metal cation; cluster A By similarity

Natural variations

Natural variant301Y → C. Ref.1 Ref.3
Corresponds to variant rs666636 [ dbSNP | Ensembl ].
VAR_034110
Natural variant311W → R. Ref.1 Ref.3
Corresponds to variant rs666647 [ dbSNP | Ensembl ].
VAR_034111
Natural variant481G → D.
Corresponds to variant rs11643815 [ dbSNP | Ensembl ].
VAR_034112

Sequences

Sequence LengthMass (Da)Tools
P47944 [UniParc].

Last modified February 9, 2010. Version 2.
Checksum: 55DA475A17BF28C9

FASTA626,509
        10         20         30         40         50         60 
MDPRECVCMS GGICMCGDNC KCTTCNCKTY WKSCCPCCPP GCAKCARGCI CKGGSDKCSC 


CP 

« Hide

References

« Hide 'large scale' references
[1]"Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia."
Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D.
Biochemistry 33:7250-7259(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-30 AND ARG-31.
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-30 AND ARG-31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U07807 Genomic DNA. Translation: AAA20232.1.
AC026461 mRNA. No translation available.
BC113442 mRNA. Translation: AAI13443.1.
BC113444 mRNA. Translation: AAI13445.1.
PIRA53640.
RefSeqNP_116324.1. NM_032935.2.
UniGeneHs.567624.

3D structure databases

ProteinModelPortalP47944.
SMRP47944. Positions 1-62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000219162.

Polymorphism databases

DMDM288558817.

Proteomic databases

PRIDEP47944.

Protocols and materials databases

DNASU84560.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000219162; ENSP00000219162; ENSG00000102891.
GeneID84560.
KEGGhsa:84560.
UCSCuc002eje.1. human.

Organism-specific databases

CTD84560.
GeneCardsGC16P056598.
HGNCHGNC:18705. MT4.
MIM606206. gene.
neXtProtNX_P47944.
PharmGKBPA38649.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69278.
HOGENOMHOG000236262.
InParanoidP47944.
KOK14741.
OMACTNCNCK.
OrthoDBEOG7G7KSQ.
PhylomeDBP47944.
TreeFamTF336054.

Gene expression databases

BgeeP47944.
CleanExHS_MT4.
GenevestigatorP47944.

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi84560.
NextBio74450.
PROP47944.
SOURCESearch...

Entry information

Entry nameMT4_HUMAN
AccessionPrimary (citable) accession number: P47944
Secondary accession number(s): Q14DA1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 9, 2010
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Metallothioneins

Classification of metallothioneins and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM