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P47941

- CRKL_MOUSE

UniProt

P47941 - CRKL_MOUSE

Protein

Crk-like protein

Gene

Crkl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    May mediate the transduction of intracellular signals.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. blood vessel development Source: MGI
    3. heart development Source: MGI
    4. organ morphogenesis Source: MGI
    5. parathyroid gland development Source: MGI
    6. pattern specification process Source: MGI
    7. thymus development Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198634. Regulation of signaling by CBL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crk-like protein
    Gene namesi
    Name:Crkl
    Synonyms:Crkol
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:104686. Crkl.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Crk-like proteinPRO_0000079348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei127 – 1271PhosphotyrosineBy similarity
    Modified residuei207 – 2071PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine. Phosphorylation is prominent during early development, but decreases at later embryonic stages and in newborn mice.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP47941.
    PaxDbiP47941.
    PRIDEiP47941.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00113362.

    PTM databases

    PhosphoSiteiP47941.

    Expressioni

    Gene expression databases

    BgeeiP47941.
    GenevestigatoriP47941.

    Interactioni

    Subunit structurei

    Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4 By similarity. Interacts with INPP5D/SHIP1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi198888. 16 interactions.
    IntActiP47941. 5 interactions.
    MINTiMINT-4092019.
    STRINGi10090.ENSMUSP00000006293.

    Structurei

    3D structure databases

    ProteinModelPortaliP47941.
    SMRiP47941. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 10289SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini123 – 18361SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini235 – 29662SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRK family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG292767.
    GeneTreeiENSGT00390000001475.
    HOGENOMiHOG000236288.
    HOVERGENiHBG105616.
    InParanoidiP47941.
    KOiK04438.
    OMAiRTLYDFT.
    OrthoDBiEOG7NW69P.
    PhylomeDBiP47941.
    TreeFamiTF321436.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47941-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSARFDSSD RSAWYMGPVT RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL    50
    SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE 100
    PAPRYPSPPV GSVSAPNLPT AEENLEYVRT LYDFPGNDAE DLPFKKGELL 150
    VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI 200
    PEPAHAYAQP QTTTPLPTVA STPGAAINPL PSTQNGPVFA KAIQKRVPCA 250
    YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD 300
    DNE 303
    Length:303
    Mass (Da):33,830
    Last modified:February 1, 2005 - v2
    Checksum:iA8C801F78EF73573
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651N → T in CAA62220. (PubMed:7478571)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90648 mRNA. Translation: CAA62220.1.
    AK048641 mRNA. Translation: BAC33406.1.
    AK052315 mRNA. Translation: BAC34933.1.
    AK163981 mRNA. Translation: BAE37567.1.
    CCDSiCCDS28002.1.
    PIRiS58352.
    RefSeqiNP_001264160.1. NM_001277231.1.
    NP_031790.2. NM_007764.5.
    UniGeneiMm.21048.
    Mm.451241.
    Mm.486420.

    Genome annotation databases

    EnsembliENSMUST00000006293; ENSMUSP00000006293; ENSMUSG00000006134.
    GeneIDi12929.
    KEGGimmu:12929.
    UCSCiuc007ykv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90648 mRNA. Translation: CAA62220.1 .
    AK048641 mRNA. Translation: BAC33406.1 .
    AK052315 mRNA. Translation: BAC34933.1 .
    AK163981 mRNA. Translation: BAE37567.1 .
    CCDSi CCDS28002.1.
    PIRi S58352.
    RefSeqi NP_001264160.1. NM_001277231.1.
    NP_031790.2. NM_007764.5.
    UniGenei Mm.21048.
    Mm.451241.
    Mm.486420.

    3D structure databases

    ProteinModelPortali P47941.
    SMRi P47941. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198888. 16 interactions.
    IntActi P47941. 5 interactions.
    MINTi MINT-4092019.
    STRINGi 10090.ENSMUSP00000006293.

    PTM databases

    PhosphoSitei P47941.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00113362.

    Proteomic databases

    MaxQBi P47941.
    PaxDbi P47941.
    PRIDEi P47941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006293 ; ENSMUSP00000006293 ; ENSMUSG00000006134 .
    GeneIDi 12929.
    KEGGi mmu:12929.
    UCSCi uc007ykv.1. mouse.

    Organism-specific databases

    CTDi 1399.
    MGIi MGI:104686. Crkl.

    Phylogenomic databases

    eggNOGi NOG292767.
    GeneTreei ENSGT00390000001475.
    HOGENOMi HOG000236288.
    HOVERGENi HBG105616.
    InParanoidi P47941.
    KOi K04438.
    OMAi RTLYDFT.
    OrthoDBi EOG7NW69P.
    PhylomeDBi P47941.
    TreeFami TF321436.

    Enzyme and pathway databases

    Reactomei REACT_198634. Regulation of signaling by CBL.

    Miscellaneous databases

    NextBioi 282596.
    PROi P47941.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47941.
    Genevestigatori P47941.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tyrosine phosphorylation of murine Crkl."
      de Jong R.L., Haataja L., Voncken J.W., Heisterkamp N., Groffen J.
      Oncogene 11:1469-1474(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL X CBA.
      Tissue: Placenta.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head and Embryonic heart.
    3. "SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL."
      Sattler M., Verma S., Pride Y.B., Salgia R., Rohrschneider L.R., Griffin J.D.
      J. Biol. Chem. 276:2451-2458(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INPP5D.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    5. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiCRKL_MOUSE
    AccessioniPrimary (citable) accession number: P47941
    Secondary accession number(s): Q3TQ18, Q8BGC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3