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Protein

Crk-like protein

Gene

Crkl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate the transduction of intracellular signals.

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • blood vessel development Source: MGI
  • heart development Source: MGI
  • parathyroid gland development Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of substrate adhesion-dependent cell spreading Source: MGI
  • thymus development Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-170968. Frs2-mediated activation.
R-MMU-186763. Downstream signal transduction.
R-MMU-8875555. MET activates RAP1 and RAC1.
R-MMU-8875656. MET receptor recycling.
R-MMU-912631. Regulation of signaling by CBL.

Names & Taxonomyi

Protein namesi
Recommended name:
Crk-like protein
Gene namesi
Name:Crkl
Synonyms:Crkol
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:104686. Crkl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793481 – 303Crk-like proteinAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphotyrosineBy similarity1
Modified residuei207PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine. Phosphorylation is prominent during early development, but decreases at later embryonic stages and in newborn mice.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP47941.
MaxQBiP47941.
PaxDbiP47941.
PRIDEiP47941.

2D gel databases

REPRODUCTION-2DPAGEIPI00113362.

PTM databases

iPTMnetiP47941.
PhosphoSitePlusiP47941.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006134.
ExpressionAtlasiP47941. baseline and differential.
GenevisibleiP47941. MM.

Interactioni

Subunit structurei

Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4 (By similarity). Interacts with INPP5D/SHIP1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198888. 14 interactors.
IntActiP47941. 5 interactors.
MINTiMINT-4092019.
STRINGi10090.ENSMUSP00000006293.

Structurei

3D structure databases

ProteinModelPortaliP47941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 102SH2PROSITE-ProRule annotationAdd BLAST89
Domaini123 – 183SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini235 – 296SH3 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the CRK family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
GeneTreeiENSGT00820000127055.
HOGENOMiHOG000236288.
HOVERGENiHBG105616.
InParanoidiP47941.
KOiK04438.
OMAiTRMNISG.
OrthoDBiEOG091G0JPQ.
PhylomeDBiP47941.
TreeFamiTF321436.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSARFDSSD RSAWYMGPVT RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL
60 70 80 90 100
SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE
110 120 130 140 150
PAPRYPSPPV GSVSAPNLPT AEENLEYVRT LYDFPGNDAE DLPFKKGELL
160 170 180 190 200
VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI
210 220 230 240 250
PEPAHAYAQP QTTTPLPTVA STPGAAINPL PSTQNGPVFA KAIQKRVPCA
260 270 280 290 300
YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD

DNE
Length:303
Mass (Da):33,830
Last modified:February 1, 2005 - v2
Checksum:iA8C801F78EF73573
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165N → T in CAA62220 (PubMed:7478571).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90648 mRNA. Translation: CAA62220.1.
AK048641 mRNA. Translation: BAC33406.1.
AK052315 mRNA. Translation: BAC34933.1.
AK163981 mRNA. Translation: BAE37567.1.
CCDSiCCDS28002.1.
PIRiS58352.
RefSeqiNP_001264160.1. NM_001277231.1.
NP_031790.2. NM_007764.5.
UniGeneiMm.21048.
Mm.451241.
Mm.486420.

Genome annotation databases

EnsembliENSMUST00000006293; ENSMUSP00000006293; ENSMUSG00000006134.
GeneIDi12929.
KEGGimmu:12929.
UCSCiuc007ykv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90648 mRNA. Translation: CAA62220.1.
AK048641 mRNA. Translation: BAC33406.1.
AK052315 mRNA. Translation: BAC34933.1.
AK163981 mRNA. Translation: BAE37567.1.
CCDSiCCDS28002.1.
PIRiS58352.
RefSeqiNP_001264160.1. NM_001277231.1.
NP_031790.2. NM_007764.5.
UniGeneiMm.21048.
Mm.451241.
Mm.486420.

3D structure databases

ProteinModelPortaliP47941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198888. 14 interactors.
IntActiP47941. 5 interactors.
MINTiMINT-4092019.
STRINGi10090.ENSMUSP00000006293.

PTM databases

iPTMnetiP47941.
PhosphoSitePlusiP47941.

2D gel databases

REPRODUCTION-2DPAGEIPI00113362.

Proteomic databases

EPDiP47941.
MaxQBiP47941.
PaxDbiP47941.
PRIDEiP47941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006293; ENSMUSP00000006293; ENSMUSG00000006134.
GeneIDi12929.
KEGGimmu:12929.
UCSCiuc007ykv.2. mouse.

Organism-specific databases

CTDi1399.
MGIiMGI:104686. Crkl.

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
GeneTreeiENSGT00820000127055.
HOGENOMiHOG000236288.
HOVERGENiHBG105616.
InParanoidiP47941.
KOiK04438.
OMAiTRMNISG.
OrthoDBiEOG091G0JPQ.
PhylomeDBiP47941.
TreeFamiTF321436.

Enzyme and pathway databases

ReactomeiR-MMU-170968. Frs2-mediated activation.
R-MMU-186763. Downstream signal transduction.
R-MMU-8875555. MET activates RAP1 and RAC1.
R-MMU-8875656. MET receptor recycling.
R-MMU-912631. Regulation of signaling by CBL.

Miscellaneous databases

PROiP47941.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006134.
ExpressionAtlasiP47941. baseline and differential.
GenevisibleiP47941. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRKL_MOUSE
AccessioniPrimary (citable) accession number: P47941
Secondary accession number(s): Q3TQ18, Q8BGC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.