P47940 (RES18_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulated endocrine-specific protein 18

Cleaved into the following 2 chains:

1. Regulated endocrine-specific protein 18
2. Triskadecapeptide

Gene names

Name:

Resp18

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play an important regulatory role in corticotrophs.
Subcellular location	Secreted. Endoplasmic reticulum. Golgi apparatus. Note: Found in the lumen of dense core vesicles (DCV). Ref.3
Tissue specificity	Pituitary, hypothalamus and pancreas. Found in alpha, beta and delta cells in the pancreatic islets. Ref.3
Sequence similarities	Belongs to the RESP18 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Golgi apparatus Secreted
Domain	Signal
PTM	Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell perikaryon Inferred from direct assay PubMed 9283614. Source: RGD rough endoplasmic reticulum lumen Inferred from direct assay Ref.1. Source: RGD secretory granule Inferred from direct assay PubMed 9415067. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 175	146	Regulated endocrine-specific protein 18		PRO_0000022221
	Peptide	87 – 99	13	Triskadecapeptide Potential		PRO_0000022222
Natural variations
	Natural variant	67	1	I → V.

Sequences

	Sequence		Length	Mass (Da)
	P47940 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 51FABF35A936F49E	FASTA	175	19,480
	10 20 30 40 50 60 MQSSLKPAGS GVLQLLVCFL LLYSRPSSCS DINAHDGQGQ VGSEQLWTFQ GLVASVFQYL 70 80 90 100 110 120 QLLFHHIVPQ GMFWTDDIAY ELMTKKVEHL SRLHPQYPCR KEGKVVSPIA TTGVRGKQEE 130 140 150 160 170 KLRLLSPQKS PAVKVNRDRC FTTKVIPKAT KQEVTHPSKG FFGPFPTVGL NLVAD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RESP18, a novel endocrine secretory protein transcript, and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes." Bloomquist B.T., Darlington D.N., Mains R.E., Eipper B.A. J. Biol. Chem. 269:9113-9122(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Pituitary.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose." Zhang G., Hirai H., Cai T., Miura J., Yu P., Huang H., Schiller M.R., Swaim W.D., Leapman R.D., Notkins A.L. J. Endocrinol. 195:313-321(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25633 mRNA. Translation: AAB59694.1. BC058147 mRNA. Translation: AAH58147.1.
IPI	IPI00192033.
PIR	A53523.
RefSeq	NP_062151.1. NM_019278.1.
UniGene	Rn.66430.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000026753.
Proteomic databases
PaxDb	P47940.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000026753; ENSRNOP00000026753; ENSRNOG00000019704.
GeneID	50561.
KEGG	rno:50561.
UCSC	RGD:3555. rat.
Organism-specific databases
CTD	389075.
RGD	3555. Resp18.
Phylogenomic databases
eggNOG	NOG43609.
GeneTree	ENSGT00390000008124.
HOGENOM	HOG000154092.
HOVERGEN	HBG059433.
InParanoid	P47940.
OMA	DIAYELM.
OrthoDB	EOG451DRN.
Gene expression databases
Genevestigator	P47940.
GermOnline	ENSRNOG00000019704. Rattus norvegicus.
Family and domain databases
InterPro	IPR024833. RESP18. [Graphical view]
PANTHER	PTHR17314. PTHR17314. 1 hit.
ProtoNet	Search...
Other
NextBio	610386.

Entry information

Entry name

RES18_RAT

Accession

Primary (citable) accession number: P47940

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program