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Protein

Regulated endocrine-specific protein 18

Gene

Resp18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important regulatory role in corticotrophs.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Regulated endocrine-specific protein 18
Cleaved into the following 2 chains:
Gene namesi
Name:Resp18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3555. Resp18.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: RGD
  • extracellular region Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • perikaryon Source: RGD
  • rough endoplasmic reticulum lumen Source: RGD
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 175146Regulated endocrine-specific protein 18PRO_0000022221Add
BLAST
Peptidei87 – 9913TriskadecapeptideSequence AnalysisPRO_0000022222Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP47940.

Expressioni

Tissue specificityi

Pituitary, hypothalamus and pancreas. Found in alpha, beta and delta cells in the pancreatic islets.1 Publication

Gene expression databases

GenevestigatoriP47940.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026753.

Family & Domainsi

Sequence similaritiesi

Belongs to the RESP18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43609.
GeneTreeiENSGT00390000008124.
HOGENOMiHOG000154092.
HOVERGENiHBG059433.
InParanoidiP47940.
OMAiPTVGHNL.
OrthoDBiEOG722JB2.
PhylomeDBiP47940.
TreeFamiTF338242.

Family and domain databases

InterProiIPR024833. RESP18.
IPR029403. RESP18_dom.
[Graphical view]
PANTHERiPTHR17314. PTHR17314. 1 hit.
PfamiPF14948. RESP18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSLKPAGS GVLQLLVCFL LLYSRPSSCS DINAHDGQGQ VGSEQLWTFQ
60 70 80 90 100
GLVASVFQYL QLLFHHIVPQ GMFWTDDIAY ELMTKKVEHL SRLHPQYPCR
110 120 130 140 150
KEGKVVSPIA TTGVRGKQEE KLRLLSPQKS PAVKVNRDRC FTTKVIPKAT
160 170
KQEVTHPSKG FFGPFPTVGL NLVAD
Length:175
Mass (Da):19,480
Last modified:February 1, 1996 - v1
Checksum:i51FABF35A936F49E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671I → V.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25633 mRNA. Translation: AAB59694.1.
BC058147 mRNA. Translation: AAH58147.1.
PIRiA53523.
RefSeqiNP_062151.1. NM_019278.1.
UniGeneiRn.66430.

Genome annotation databases

EnsembliENSRNOT00000026753; ENSRNOP00000026753; ENSRNOG00000019704.
GeneIDi50561.
KEGGirno:50561.
UCSCiRGD:3555. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25633 mRNA. Translation: AAB59694.1.
BC058147 mRNA. Translation: AAH58147.1.
PIRiA53523.
RefSeqiNP_062151.1. NM_019278.1.
UniGeneiRn.66430.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026753.

Proteomic databases

PaxDbiP47940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026753; ENSRNOP00000026753; ENSRNOG00000019704.
GeneIDi50561.
KEGGirno:50561.
UCSCiRGD:3555. rat.

Organism-specific databases

CTDi389075.
RGDi3555. Resp18.

Phylogenomic databases

eggNOGiNOG43609.
GeneTreeiENSGT00390000008124.
HOGENOMiHOG000154092.
HOVERGENiHBG059433.
InParanoidiP47940.
OMAiPTVGHNL.
OrthoDBiEOG722JB2.
PhylomeDBiP47940.
TreeFamiTF338242.

Miscellaneous databases

NextBioi610386.
PROiP47940.

Gene expression databases

GenevestigatoriP47940.

Family and domain databases

InterProiIPR024833. RESP18.
IPR029403. RESP18_dom.
[Graphical view]
PANTHERiPTHR17314. PTHR17314. 1 hit.
PfamiPF14948. RESP18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RESP18, a novel endocrine secretory protein transcript, and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes."
    Bloomquist B.T., Darlington D.N., Mains R.E., Eipper B.A.
    J. Biol. Chem. 269:9113-9122(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose."
    Zhang G., Hirai H., Cai T., Miura J., Yu P., Huang H., Schiller M.R., Swaim W.D., Leapman R.D., Notkins A.L.
    J. Endocrinol. 195:313-321(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRES18_RAT
AccessioniPrimary (citable) accession number: P47940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.