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P47940 (RES18_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulated endocrine-specific protein 18
Gene names
Name:Resp18
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important regulatory role in corticotrophs.

Subcellular location

Secreted. Endoplasmic reticulum. Golgi apparatus. Note: Found in the lumen of dense core vesicles (DCV). Ref.3

Tissue specificity

Pituitary, hypothalamus and pancreas. Found in alpha, beta and delta cells in the pancreatic islets. Ref.3

Sequence similarities

Belongs to the RESP18 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 175146Regulated endocrine-specific protein 18
PRO_0000022221
Peptide87 – 9913Triskadecapeptide Potential
PRO_0000022222

Natural variations

Natural variant671I → V.

Sequences

Sequence LengthMass (Da)Tools
P47940 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 51FABF35A936F49E

FASTA17519,480
        10         20         30         40         50         60 
MQSSLKPAGS GVLQLLVCFL LLYSRPSSCS DINAHDGQGQ VGSEQLWTFQ GLVASVFQYL 

        70         80         90        100        110        120 
QLLFHHIVPQ GMFWTDDIAY ELMTKKVEHL SRLHPQYPCR KEGKVVSPIA TTGVRGKQEE 

       130        140        150        160        170 
KLRLLSPQKS PAVKVNRDRC FTTKVIPKAT KQEVTHPSKG FFGPFPTVGL NLVAD 

« Hide

References

« Hide 'large scale' references
[1]"RESP18, a novel endocrine secretory protein transcript, and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes."
Bloomquist B.T., Darlington D.N., Mains R.E., Eipper B.A.
J. Biol. Chem. 269:9113-9122(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Pituitary.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[3]"RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose."
Zhang G., Hirai H., Cai T., Miura J., Yu P., Huang H., Schiller M.R., Swaim W.D., Leapman R.D., Notkins A.L.
J. Endocrinol. 195:313-321(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L25633 mRNA. Translation: AAB59694.1.
BC058147 mRNA. Translation: AAH58147.1.
PIRA53523.
RefSeqNP_062151.1. NM_019278.1.
UniGeneRn.66430.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000026753.

Proteomic databases

PaxDbP47940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026753; ENSRNOP00000026753; ENSRNOG00000019704.
GeneID50561.
KEGGrno:50561.
UCSCRGD:3555. rat.

Organism-specific databases

CTD389075.
RGD3555. Resp18.

Phylogenomic databases

eggNOGNOG43609.
GeneTreeENSGT00390000008124.
HOGENOMHOG000154092.
HOVERGENHBG059433.
InParanoidP47940.
OMAQDQVGVG.
OrthoDBEOG722JB2.
PhylomeDBP47940.
TreeFamTF338242.

Gene expression databases

GenevestigatorP47940.

Family and domain databases

InterProIPR024833. RESP18.
IPR029403. RESP18_dom.
[Graphical view]
PANTHERPTHR17314. PTHR17314. 1 hit.
PfamPF14948. RESP18. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610386.
PROP47940.

Entry information

Entry nameRES18_RAT
AccessionPrimary (citable) accession number: P47940
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families