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P47940

- RES18_RAT

UniProt

P47940 - RES18_RAT

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Protein
Regulated endocrine-specific protein 18
Gene
Resp18
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May play an important regulatory role in corticotrophs.

GO - Biological processi

  1. in utero embryonic development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Regulated endocrine-specific protein 18
Cleaved into the following 2 chains:
Gene namesi
Name:Resp18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi3555. Resp18.

Subcellular locationi

Secreted. Endoplasmic reticulum. Golgi apparatus
Note: Found in the lumen of dense core vesicles (DCV).1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. endoplasmic reticulum Source: RGD
  3. extracellular region Source: UniProtKB-SubCell
  4. perikaryon Source: RGD
  5. rough endoplasmic reticulum lumen Source: RGD
  6. secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 175146Regulated endocrine-specific protein 18
PRO_0000022221Add
BLAST
Peptidei87 – 9913Triskadecapeptide Reviewed prediction
PRO_0000022222Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP47940.

Expressioni

Tissue specificityi

Pituitary, hypothalamus and pancreas. Found in alpha, beta and delta cells in the pancreatic islets.1 Publication

Gene expression databases

GenevestigatoriP47940.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026753.

Family & Domainsi

Sequence similaritiesi

Belongs to the RESP18 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43609.
GeneTreeiENSGT00390000008124.
HOGENOMiHOG000154092.
HOVERGENiHBG059433.
InParanoidiP47940.
OMAiQDQVGVG.
OrthoDBiEOG722JB2.
PhylomeDBiP47940.
TreeFamiTF338242.

Family and domain databases

InterProiIPR024833. RESP18.
IPR029403. RESP18_dom.
[Graphical view]
PANTHERiPTHR17314. PTHR17314. 1 hit.
PfamiPF14948. RESP18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47940-1 [UniParc]FASTAAdd to Basket

« Hide

MQSSLKPAGS GVLQLLVCFL LLYSRPSSCS DINAHDGQGQ VGSEQLWTFQ    50
GLVASVFQYL QLLFHHIVPQ GMFWTDDIAY ELMTKKVEHL SRLHPQYPCR 100
KEGKVVSPIA TTGVRGKQEE KLRLLSPQKS PAVKVNRDRC FTTKVIPKAT 150
KQEVTHPSKG FFGPFPTVGL NLVAD 175
Length:175
Mass (Da):19,480
Last modified:February 1, 1996 - v1
Checksum:i51FABF35A936F49E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671I → V.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25633 mRNA. Translation: AAB59694.1.
BC058147 mRNA. Translation: AAH58147.1.
PIRiA53523.
RefSeqiNP_062151.1. NM_019278.1.
UniGeneiRn.66430.

Genome annotation databases

EnsembliENSRNOT00000026753; ENSRNOP00000026753; ENSRNOG00000019704.
GeneIDi50561.
KEGGirno:50561.
UCSCiRGD:3555. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25633 mRNA. Translation: AAB59694.1 .
BC058147 mRNA. Translation: AAH58147.1 .
PIRi A53523.
RefSeqi NP_062151.1. NM_019278.1.
UniGenei Rn.66430.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026753.

Proteomic databases

PaxDbi P47940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026753 ; ENSRNOP00000026753 ; ENSRNOG00000019704 .
GeneIDi 50561.
KEGGi rno:50561.
UCSCi RGD:3555. rat.

Organism-specific databases

CTDi 389075.
RGDi 3555. Resp18.

Phylogenomic databases

eggNOGi NOG43609.
GeneTreei ENSGT00390000008124.
HOGENOMi HOG000154092.
HOVERGENi HBG059433.
InParanoidi P47940.
OMAi QDQVGVG.
OrthoDBi EOG722JB2.
PhylomeDBi P47940.
TreeFami TF338242.

Miscellaneous databases

NextBioi 610386.
PROi P47940.

Gene expression databases

Genevestigatori P47940.

Family and domain databases

InterProi IPR024833. RESP18.
IPR029403. RESP18_dom.
[Graphical view ]
PANTHERi PTHR17314. PTHR17314. 1 hit.
Pfami PF14948. RESP18. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RESP18, a novel endocrine secretory protein transcript, and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes."
    Bloomquist B.T., Darlington D.N., Mains R.E., Eipper B.A.
    J. Biol. Chem. 269:9113-9122(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose."
    Zhang G., Hirai H., Cai T., Miura J., Yu P., Huang H., Schiller M.R., Swaim W.D., Leapman R.D., Notkins A.L.
    J. Endocrinol. 195:313-321(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRES18_RAT
AccessioniPrimary (citable) accession number: P47940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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