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Protein

Regulated endocrine-specific protein 18

Gene

Resp18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important regulatory role in corticotrophs.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulated endocrine-specific protein 18
Gene namesi
Name:Resp18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3555 Resp18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002222130 – 175Regulated endocrine-specific protein 18Add BLAST146

Proteomic databases

PaxDbiP47940

Expressioni

Tissue specificityi

Pituitary, hypothalamus and pancreas (PubMed:8132649). Found in alpha, beta and delta cells in the pancreatic islets (PubMed:17951542).2 Publications

Gene expression databases

BgeeiENSRNOG00000019704
ExpressionAtlasiP47940 baseline and differential
GenevisibleiP47940 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026753

Family & Domainsi

Sequence similaritiesi

Belongs to the RESP18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JD9M Eukaryota
ENOG41117TI LUCA
GeneTreeiENSGT00390000008124
HOGENOMiHOG000154092
HOVERGENiHBG059433
InParanoidiP47940
PhylomeDBiP47940
TreeFamiTF338242

Family and domain databases

InterProiView protein in InterPro
IPR024833 RESP18
IPR029403 RESP18_dom
PANTHERiPTHR17314 PTHR17314, 1 hit
PfamiView protein in Pfam
PF14948 RESP18, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSLKPAGS GVLQLLVCFL LLYSRPSSCS DINAHDGQGQ VGSEQLWTFQ
60 70 80 90 100
GLVASVFQYL QLLFHHIVPQ GMFWTDDIAY ELMTKKVEHL SRLHPQYPCR
110 120 130 140 150
KEGKVVSPIA TTGVRGKQEE KLRLLSPQKS PAVKVNRDRC FTTKVIPKAT
160 170
KQEVTHPSKG FFGPFPTVGL NLVAD
Length:175
Mass (Da):19,480
Last modified:February 1, 1996 - v1
Checksum:i51FABF35A936F49E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti67I → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25633 mRNA Translation: AAB59694.1
BC058147 mRNA Translation: AAH58147.1
PIRiA53523
RefSeqiNP_062151.1, NM_019278.1
UniGeneiRn.66430

Genome annotation databases

EnsembliENSRNOT00000026753; ENSRNOP00000026753; ENSRNOG00000019704
GeneIDi50561
KEGGirno:50561
UCSCiRGD:3555 rat

Similar proteinsi

Entry informationi

Entry nameiRES18_RAT
AccessioniPrimary (citable) accession number: P47940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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