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P47940

- RES18_RAT

UniProt

P47940 - RES18_RAT

Protein

Regulated endocrine-specific protein 18

Gene

Resp18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    May play an important regulatory role in corticotrophs.

    GO - Biological processi

    1. in utero embryonic development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulated endocrine-specific protein 18
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Resp18
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi3555. Resp18.

    Subcellular locationi

    Secreted 1 Publication. Endoplasmic reticulum 1 Publication. Golgi apparatus 1 Publication
    Note: Found in the lumen of dense core vesicles (DCV).

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RGD
    2. extracellular region Source: UniProtKB-SubCell
    3. Golgi apparatus Source: UniProtKB-SubCell
    4. perikaryon Source: RGD
    5. rough endoplasmic reticulum lumen Source: RGD
    6. secretory granule Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 175146Regulated endocrine-specific protein 18PRO_0000022221Add
    BLAST
    Peptidei87 – 9913TriskadecapeptideSequence AnalysisPRO_0000022222Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP47940.

    Expressioni

    Tissue specificityi

    Pituitary, hypothalamus and pancreas. Found in alpha, beta and delta cells in the pancreatic islets.1 Publication

    Gene expression databases

    GenevestigatoriP47940.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026753.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RESP18 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43609.
    GeneTreeiENSGT00390000008124.
    HOGENOMiHOG000154092.
    HOVERGENiHBG059433.
    InParanoidiP47940.
    OMAiQDQVGVG.
    OrthoDBiEOG722JB2.
    PhylomeDBiP47940.
    TreeFamiTF338242.

    Family and domain databases

    InterProiIPR024833. RESP18.
    IPR029403. RESP18_dom.
    [Graphical view]
    PANTHERiPTHR17314. PTHR17314. 1 hit.
    PfamiPF14948. RESP18. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47940-1 [UniParc]FASTAAdd to Basket

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    MQSSLKPAGS GVLQLLVCFL LLYSRPSSCS DINAHDGQGQ VGSEQLWTFQ    50
    GLVASVFQYL QLLFHHIVPQ GMFWTDDIAY ELMTKKVEHL SRLHPQYPCR 100
    KEGKVVSPIA TTGVRGKQEE KLRLLSPQKS PAVKVNRDRC FTTKVIPKAT 150
    KQEVTHPSKG FFGPFPTVGL NLVAD 175
    Length:175
    Mass (Da):19,480
    Last modified:February 1, 1996 - v1
    Checksum:i51FABF35A936F49E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671I → V.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25633 mRNA. Translation: AAB59694.1.
    BC058147 mRNA. Translation: AAH58147.1.
    PIRiA53523.
    RefSeqiNP_062151.1. NM_019278.1.
    UniGeneiRn.66430.

    Genome annotation databases

    EnsembliENSRNOT00000026753; ENSRNOP00000026753; ENSRNOG00000019704.
    GeneIDi50561.
    KEGGirno:50561.
    UCSCiRGD:3555. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25633 mRNA. Translation: AAB59694.1 .
    BC058147 mRNA. Translation: AAH58147.1 .
    PIRi A53523.
    RefSeqi NP_062151.1. NM_019278.1.
    UniGenei Rn.66430.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026753.

    Proteomic databases

    PaxDbi P47940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026753 ; ENSRNOP00000026753 ; ENSRNOG00000019704 .
    GeneIDi 50561.
    KEGGi rno:50561.
    UCSCi RGD:3555. rat.

    Organism-specific databases

    CTDi 389075.
    RGDi 3555. Resp18.

    Phylogenomic databases

    eggNOGi NOG43609.
    GeneTreei ENSGT00390000008124.
    HOGENOMi HOG000154092.
    HOVERGENi HBG059433.
    InParanoidi P47940.
    OMAi QDQVGVG.
    OrthoDBi EOG722JB2.
    PhylomeDBi P47940.
    TreeFami TF338242.

    Miscellaneous databases

    NextBioi 610386.
    PROi P47940.

    Gene expression databases

    Genevestigatori P47940.

    Family and domain databases

    InterProi IPR024833. RESP18.
    IPR029403. RESP18_dom.
    [Graphical view ]
    PANTHERi PTHR17314. PTHR17314. 1 hit.
    Pfami PF14948. RESP18. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RESP18, a novel endocrine secretory protein transcript, and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes."
      Bloomquist B.T., Darlington D.N., Mains R.E., Eipper B.A.
      J. Biol. Chem. 269:9113-9122(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Pituitary.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    3. "RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose."
      Zhang G., Hirai H., Cai T., Miura J., Yu P., Huang H., Schiller M.R., Swaim W.D., Leapman R.D., Notkins A.L.
      J. Endocrinol. 195:313-321(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRES18_RAT
    AccessioniPrimary (citable) accession number: P47940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3