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Protein

Neuromedin-K receptor

Gene

Tacr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-K receptor
Short name:
NKR
Alternative name(s):
NK-3 receptor
Short name:
NK-3R
Neurokinin B receptor
Tachykinin receptor 3
Gene namesi
Name:Tacr3
Synonyms:Tac3r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:892968. Tacr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71ExtracellularSequence analysisAdd BLAST71
Transmembranei72 – 94Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini95 – 104CytoplasmicSequence analysis10
Transmembranei105 – 126Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini127 – 146ExtracellularSequence analysisAdd BLAST20
Transmembranei147 – 168Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini169 – 188CytoplasmicSequence analysisAdd BLAST20
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini210 – 232ExtracellularSequence analysisAdd BLAST23
Transmembranei233 – 257Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini258 – 286CytoplasmicSequence analysisAdd BLAST29
Transmembranei287 – 308Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini309 – 321ExtracellularSequence analysisAdd BLAST13
Transmembranei322 – 346Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini347 – 452CytoplasmicSequence analysisAdd BLAST106

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699001 – 452Neuromedin-K receptorAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi145 ↔ 220PROSITE-ProRule annotation
Lipidationi361S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47937.
PRIDEiP47937.

PTM databases

iPTMnetiP47937.
PhosphoSitePlusiP47937.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028172.
CleanExiMM_TACR3.
GenevisibleiP47937. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029822.

Chemistry databases

BindingDBiP47937.

Structurei

3D structure databases

ProteinModelPortaliP47937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP47937.
KOiK04224.
OMAiVMTFAIC.
OrthoDBiEOG091G0WYG.
PhylomeDBiP47937.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR001013. NK3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01026. NEUROKININ3R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVPTGENW TDGTAGVGSH TGNLSAALGI TEWLALQAGN FSSALGLPVT
60 70 80 90 100
SQAPSQVRAN LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH
110 120 130 140 150
KRMRTVTNYF LVNLAFSDAS VAAFNTLVNF IYGVHSEWYF GANYCRFQNF
160 170 180 190 200
FPITAVFASI YSMTAIAVDR YMAIIDPLKP RLSATATKIV IGSIWILAFL
210 220 230 240 250
LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII LVYCFPLLIM
260 270 280 290 300
GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL
310 320 330 340 350
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF
360 370 380 390 400
RAGFKRAFRW CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLY
410 420 430 440 450
DPSEGDPAKS SRKKRAVPRD PSANGCSHRE FKSASTTSSF ISSPYTSVDE

YS
Length:452
Mass (Da):51,026
Last modified:May 30, 2003 - v2
Checksum:i7A46D400AD7FC444
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59A → D in CAA61088 (Ref. 3) Curated1
Sequence conflicti198A → S in AAA17893 (PubMed:8120392).Curated1
Sequence conflicti267P → L in CAA61088 (Ref. 3) Curated1
Sequence conflicti385S → P in CAA61088 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233341 mRNA. Translation: AAF62517.1.
AK031898 mRNA. Translation: BAC27596.1.
AK046424 mRNA. Translation: BAC32723.1.
X87823 mRNA. Translation: CAA61088.1.
L27827 mRNA. Translation: AAA17893.1.
CCDSiCCDS17852.1.
PIRiS55524.
RefSeqiNP_067357.1. NM_021382.6.
UniGeneiMm.103810.

Genome annotation databases

EnsembliENSMUST00000029822; ENSMUSP00000029822; ENSMUSG00000028172.
GeneIDi21338.
KEGGimmu:21338.
UCSCiuc008rky.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233341 mRNA. Translation: AAF62517.1.
AK031898 mRNA. Translation: BAC27596.1.
AK046424 mRNA. Translation: BAC32723.1.
X87823 mRNA. Translation: CAA61088.1.
L27827 mRNA. Translation: AAA17893.1.
CCDSiCCDS17852.1.
PIRiS55524.
RefSeqiNP_067357.1. NM_021382.6.
UniGeneiMm.103810.

3D structure databases

ProteinModelPortaliP47937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029822.

Chemistry databases

BindingDBiP47937.
GuidetoPHARMACOLOGYi362.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47937.
PhosphoSitePlusiP47937.

Proteomic databases

PaxDbiP47937.
PRIDEiP47937.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029822; ENSMUSP00000029822; ENSMUSG00000028172.
GeneIDi21338.
KEGGimmu:21338.
UCSCiuc008rky.2. mouse.

Organism-specific databases

CTDi6870.
MGIiMGI:892968. Tacr3.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP47937.
KOiK04224.
OMAiVMTFAIC.
OrthoDBiEOG091G0WYG.
PhylomeDBiP47937.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP47937.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028172.
CleanExiMM_TACR3.
GenevisibleiP47937. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR001013. NK3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01026. NEUROKININ3R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNK3R_MOUSE
AccessioniPrimary (citable) accession number: P47937
Secondary accession number(s): Q61968, Q8BL44, Q9JKN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2003
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.