Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cannabinoid receptor 2

Gene

Cnr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.8 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 2
Short name:
CB-2
Short name:
CB2
Short name:
mCB2
Gene namesi
Name:Cnr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104650. Cnr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 59Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 104ExtracellularSequence analysisAdd BLAST12
Transmembranei105 – 129Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 188ExtracellularSequence analysisAdd BLAST16
Transmembranei189 – 214Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini215 – 246CytoplasmicSequence analysisAdd BLAST32
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 279ExtracellularSequence analysisAdd BLAST12
Transmembranei280 – 301Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini302 – 347CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are responsive to the psychotropic effects of cannabinoid but not to the cannabinoid-induced immunomodulation. They also show accelerated age-related trabecular bone loss and cortical expansion.1 Publication

Chemistry databases

ChEMBLiCHEMBL5373.
GuidetoPHARMACOLOGYi57.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693241 – 347Cannabinoid receptor 2Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei338PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP47936.
PaxDbiP47936.
PRIDEiP47936.

PTM databases

iPTMnetiP47936.
PhosphoSitePlusiP47936.

Expressioni

Tissue specificityi

Expressed by cells of hematopoietic origin. Expressed in skin in suprabasal layers and hair follicles, in brain by neurons and glial cells and by osteoblasts, osteocytes, osteoclasts (at protein level).5 Publications

Gene expression databases

BgeeiENSMUSG00000062585.
CleanExiMM_CNR2.
GenevisibleiP47936. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069957.

Chemistry databases

BindingDBiP47936.

Structurei

3D structure databases

ProteinModelPortaliP47936.
SMRiP47936.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiP47936.
KOiK04278.
OMAiLAHWKKC.
OrthoDBiEOG091G05O3.
PhylomeDBiP47936.
TreeFamiTF330052.

Family and domain databases

InterProiIPR001551. Canbinoid_rcpt_2.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00523. CANABINOID2R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGCRETEVT NGSNGGLEFN PMKEYMILSS GQQIAVAVLC TLMGLLSALE
60 70 80 90 100
NMAVLYIILS SRRLRRKPSY LFISSLAGAD FLASVIFACN FVIFHVFHGV
110 120 130 140 150
DSNAIFLLKI GSVTMTFTAS VGSLLLTAVD RYLCLCYPPT YKALVTRGRA
160 170 180 190 200
LVALCVMWVL SALISYLPLM GWTCCPSPCS ELFPLIPNDY LLGWLLFIAI
210 220 230 240 250
LFSGIIYTYG YVLWKAHRHV ATLAEHQDRQ VPGIARMRLD VRLAKTLGLV
260 270 280 290 300
LAVLLICWFP ALALMGHSLV TTLSDQVKEA FAFCSMLCLV NSMVNPIIYA
310 320 330 340
LRSGEIRSAA QHCLIGWKKY LQGLGPEGKE EGPRSSVTET EADVKTT
Length:347
Mass (Da):38,213
Last modified:February 1, 1996 - v1
Checksum:i10747611D41FF442
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64L → V in CAA63655 (PubMed:9261404).Curated1
Sequence conflicti126L → V in CAA63655 (PubMed:9261404).Curated1
Sequence conflicti272T → M in AAA63757 (Ref. 3) Curated1
Sequence conflicti332G → A in AAA63757 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86405 mRNA. Translation: CAA60159.1.
X93168 mRNA. Translation: CAA63655.1.
U21681 Genomic DNA. Translation: AAA63757.1.
AK036658 mRNA. Translation: BAC29520.1.
AK037898 mRNA. Translation: BAC29894.1.
AK134109 mRNA. Translation: BAE22017.1.
AL672076 Genomic DNA. Translation: CAM15899.1.
CH466552 Genomic DNA. Translation: EDL29965.1.
BC024052 mRNA. Translation: AAH24052.1.
CCDSiCCDS18793.1.
PIRiS70364.
RefSeqiNP_001292207.1. NM_001305278.1.
NP_034054.3. NM_009924.4.
UniGeneiMm.297251.

Genome annotation databases

EnsembliENSMUST00000068830; ENSMUSP00000069957; ENSMUSG00000062585.
ENSMUST00000097843; ENSMUSP00000095454; ENSMUSG00000062585.
GeneIDi12802.
KEGGimmu:12802.
UCSCiuc008vhh.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86405 mRNA. Translation: CAA60159.1.
X93168 mRNA. Translation: CAA63655.1.
U21681 Genomic DNA. Translation: AAA63757.1.
AK036658 mRNA. Translation: BAC29520.1.
AK037898 mRNA. Translation: BAC29894.1.
AK134109 mRNA. Translation: BAE22017.1.
AL672076 Genomic DNA. Translation: CAM15899.1.
CH466552 Genomic DNA. Translation: EDL29965.1.
BC024052 mRNA. Translation: AAH24052.1.
CCDSiCCDS18793.1.
PIRiS70364.
RefSeqiNP_001292207.1. NM_001305278.1.
NP_034054.3. NM_009924.4.
UniGeneiMm.297251.

3D structure databases

ProteinModelPortaliP47936.
SMRiP47936.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069957.

Chemistry databases

BindingDBiP47936.
ChEMBLiCHEMBL5373.
GuidetoPHARMACOLOGYi57.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47936.
PhosphoSitePlusiP47936.

Proteomic databases

MaxQBiP47936.
PaxDbiP47936.
PRIDEiP47936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068830; ENSMUSP00000069957; ENSMUSG00000062585.
ENSMUST00000097843; ENSMUSP00000095454; ENSMUSG00000062585.
GeneIDi12802.
KEGGimmu:12802.
UCSCiuc008vhh.3. mouse.

Organism-specific databases

CTDi1269.
MGIiMGI:104650. Cnr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiP47936.
KOiK04278.
OMAiLAHWKKC.
OrthoDBiEOG091G05O3.
PhylomeDBiP47936.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP47936.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062585.
CleanExiMM_CNR2.
GenevisibleiP47936. MM.

Family and domain databases

InterProiIPR001551. Canbinoid_rcpt_2.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00523. CANABINOID2R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNR2_MOUSE
AccessioniPrimary (citable) accession number: P47936
Secondary accession number(s): Q544H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.