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Protein

Prorelaxin 1

Gene

Rln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • developmental growth Source: MGI
  • mammary gland morphogenesis Source: CACAO
  • nipple development Source: CACAO
  • prostate gland growth Source: MGI
  • regulation of apoptotic process Source: CACAO
  • regulation of nitric oxide mediated signal transduction Source: MGI
  • spermatogenesis Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Prorelaxin 1
Cleaved into the following 2 chains:
Gene namesi
Name:Rln1
Synonyms:Rln, Rlx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97931. Rln1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Peptidei23 – 5735Relaxin B chainBy similarityPRO_0000016103Add
BLAST
Propeptidei58 – 15699Connecting peptideBy similarityPRO_0000016104Add
BLAST
Peptidei161 – 18525Relaxin A chainBy similarityPRO_0000016105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 171Interchain (between B and A chains)1 Publication
Disulfide bondi48 ↔ 185Interchain (between B and A chains)1 Publication
Disulfide bondi170 ↔ 1751 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP47932.
PRIDEiP47932.

Expressioni

Gene expression databases

CleanExiMM_RLN1.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043376.

Structurei

3D structure databases

ProteinModelPortaliP47932.
SMRiP47932. Positions 27-53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP47932.
PhylomeDBiP47932.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRFLLQLL GFWLLLSQPC RTRVSEEWMD GFIRMCGREY ARELIKICGA
60 70 80 90 100
SVGRLALSQE EPALLARQAT EVVPSFINKD AEPFDTTLKC LPNLSEELKA
110 120 130 140 150
VLSEAQASLP ELQHAPVLSD SVVSLEGFKK TLHDRLGEAE DGSPPGLKYL
160 170 180
QSDTHSRKKR ESGGLMSQQC CHVGCSRRSI AKLYC
Length:185
Mass (Da):20,571
Last modified:February 1, 1996 - v1
Checksum:i2B9E753E8B85087B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27088 mRNA. Translation: CAA81611.1.
CCDSiCCDS29733.1.
PIRiS48082.
UniGeneiMm.5033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27088 mRNA. Translation: CAA81611.1.
CCDSiCCDS29733.1.
PIRiS48082.
UniGeneiMm.5033.

3D structure databases

ProteinModelPortaliP47932.
SMRiP47932. Positions 27-53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043376.

Proteomic databases

PaxDbiP47932.
PRIDEiP47932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97931. Rln1.

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP47932.
PhylomeDBiP47932.

Miscellaneous databases

PROiP47932.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RLN1.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiREL1_MOUSE
AccessioniPrimary (citable) accession number: P47932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.