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Protein

Follistatin

Gene

Fst

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • female gonad development Source: MGI
  • gamete generation Source: MGI
  • hair follicle morphogenesis Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • keratinocyte proliferation Source: MGI
  • negative regulation of activin receptor signaling pathway Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of hair follicle development Source: MGI
  • skeletal system development Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiI01.966.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin
Short name:
FS
Alternative name(s):
Activin-binding protein
Gene namesi
Name:Fst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95586. Fst.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001010430 – 344FollistatinAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 55PROSITE-ProRule annotation
Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
Disulfide bondi56 ↔ 91PROSITE-ProRule annotation
Disulfide bondi95 ↔ 106PROSITE-ProRule annotation
Disulfide bondi100 ↔ 116PROSITE-ProRule annotation
Disulfide bondi118 ↔ 150PROSITE-ProRule annotation
Disulfide bondi122 ↔ 143PROSITE-ProRule annotation
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi132 ↔ 164PROSITE-ProRule annotation
Disulfide bondi192 ↔ 225PROSITE-ProRule annotation
Disulfide bondi196 ↔ 218PROSITE-ProRule annotation
Disulfide bondi207 ↔ 239PROSITE-ProRule annotation
Disulfide bondi270 ↔ 302PROSITE-ProRule annotation
Disulfide bondi274 ↔ 295PROSITE-ProRule annotation
Disulfide bondi284 ↔ 316PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47931.
PeptideAtlasiP47931.
PRIDEiP47931.

Expressioni

Developmental stagei

Embryonic expression first occurs in the primitive streak, followed by expression in head mesoderm, somites, and specific rhombomeres of the hindbrain, and later in midbrain and diencephalon. No expression is seen in the node or notochord.

Gene expression databases

BgeeiENSMUSG00000021765.
CleanExiMM_FST.

Interactioni

Subunit structurei

Monomer.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199751. 1 interactor.
STRINGi10090.ENSMUSP00000022287.

Structurei

3D structure databases

ProteinModelPortaliP47931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 103TBPROSITE-ProRule annotationAdd BLAST74
Domaini94 – 117Follistatin-like 1Add BLAST24
Domaini112 – 166Kazal-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini167 – 190Follistatin-like 2Add BLAST24
Domaini186 – 241Kazal-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini244 – 268Follistatin-like 3Add BLAST25
Domaini264 – 318Kazal-like 3PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 333Asp/Glu-rich (highly acidic)Add BLAST13

Sequence similaritiesi

Contains 3 follistatin-like domains.Curated
Contains 3 Kazal-like domains.PROSITE-ProRule annotation
Contains 1 TB (TGF-beta binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0F. Eukaryota.
ENOG410YM8Q. LUCA.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiP47931.
KOiK04661.
PhylomeDBiP47931.
TreeFamiTF106409.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 3 hits.
[Graphical view]
SMARTiSM00274. FOLN. 3 hits.
SM00280. KAZAL. 3 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 3 hits.
PS51364. TB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELEVQY QGKCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPS
210 220 230 240 250
SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC
260 270 280 290 300
GGGKKCLWDS KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EETEEEEEEE DQDYSFPISS ILEW
Length:344
Mass (Da):37,866
Last modified:February 1, 1996 - v1
Checksum:i935B6CBB213176F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241 – 242KA → T in CAA82648 (PubMed:7600958).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29532 mRNA. Translation: CAA82648.1.
BC144926 mRNA. Translation: AAI44927.1.
BC145945 mRNA. Translation: AAI45946.1.
X83377 mRNA. Translation: CAA58291.1.
PIRiS45321.
RefSeqiNP_001288302.1. NM_001301373.1.
NP_001288304.1. NM_001301375.1.
NP_032072.1. NM_008046.3.
UniGeneiMm.4913.

Genome annotation databases

GeneIDi14313.
KEGGimmu:14313.
UCSCiuc007rxn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29532 mRNA. Translation: CAA82648.1.
BC144926 mRNA. Translation: AAI44927.1.
BC145945 mRNA. Translation: AAI45946.1.
X83377 mRNA. Translation: CAA58291.1.
PIRiS45321.
RefSeqiNP_001288302.1. NM_001301373.1.
NP_001288304.1. NM_001301375.1.
NP_032072.1. NM_008046.3.
UniGeneiMm.4913.

3D structure databases

ProteinModelPortaliP47931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199751. 1 interactor.
STRINGi10090.ENSMUSP00000022287.

Protein family/group databases

MEROPSiI01.966.

Proteomic databases

PaxDbiP47931.
PeptideAtlasiP47931.
PRIDEiP47931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14313.
KEGGimmu:14313.
UCSCiuc007rxn.2. mouse.

Organism-specific databases

CTDi10468.
MGIiMGI:95586. Fst.

Phylogenomic databases

eggNOGiENOG410IP0F. Eukaryota.
ENOG410YM8Q. LUCA.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiP47931.
KOiK04661.
PhylomeDBiP47931.
TreeFamiTF106409.

Miscellaneous databases

PROiP47931.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021765.
CleanExiMM_FST.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 3 hits.
[Graphical view]
SMARTiSM00274. FOLN. 3 hits.
SM00280. KAZAL. 3 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 3 hits.
PS51364. TB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFST_MOUSE
AccessioniPrimary (citable) accession number: P47931
Secondary accession number(s): A6H6P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.