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Protein

Follistatin

Gene

Fst

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • female gonad development Source: MGI
  • gamete generation Source: MGI
  • hair follicle morphogenesis Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • keratinocyte proliferation Source: MGI
  • negative regulation of activin receptor signaling pathway Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of hair follicle development Source: MGI
  • skeletal system development Source: MGI

Protein family/group databases

MEROPSiI01.966.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin
Short name:
FS
Alternative name(s):
Activin-binding protein
Gene namesi
Name:Fst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95586. Fst.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001010430 – 344FollistatinAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 55PROSITE-ProRule annotationBy similarity
Disulfide bondi42 ↔ 88PROSITE-ProRule annotationBy similarity
Disulfide bondi56 ↔ 91PROSITE-ProRule annotationBy similarity
Disulfide bondi95 ↔ 106By similarity
Disulfide bondi100 ↔ 116By similarity
Disulfide bondi118 ↔ 150By similarity
Disulfide bondi122 ↔ 143By similarity
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 164By similarity
Disulfide bondi168 ↔ 179By similarity
Disulfide bondi173 ↔ 189By similarity
Disulfide bondi192 ↔ 225By similarity
Disulfide bondi196 ↔ 218By similarity
Disulfide bondi207 ↔ 239By similarity
Disulfide bondi245 ↔ 256By similarity
Disulfide bondi250 ↔ 267By similarity
Disulfide bondi270 ↔ 302By similarity
Disulfide bondi274 ↔ 295By similarity
Disulfide bondi284 ↔ 316By similarity
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP47931.
PaxDbiP47931.
PeptideAtlasiP47931.
PRIDEiP47931.

Expressioni

Developmental stagei

Embryonic expression first occurs in the primitive streak, followed by expression in head mesoderm, somites, and specific rhombomeres of the hindbrain, and later in midbrain and diencephalon. No expression is seen in the node or notochord.

Gene expression databases

CleanExiMM_FST.

Interactioni

Subunit structurei

Monomer.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199751. 1 interactor.
STRINGi10090.ENSMUSP00000022287.

Structurei

3D structure databases

ProteinModelPortaliP47931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 103TBPROSITE-ProRule annotationAdd BLAST74
Domaini94 – 117Follistatin-like 1Add BLAST24
Domaini112 – 166Kazal-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini167 – 190Follistatin-like 2Add BLAST24
Domaini186 – 241Kazal-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini244 – 268Follistatin-like 3Add BLAST25
Domaini264 – 318Kazal-like 3PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 333Asp/Glu-rich (highly acidic)Add BLAST13

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0F. Eukaryota.
ENOG410YM8Q. LUCA.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiP47931.
KOiK04661.
PhylomeDBiP47931.
TreeFamiTF106409.

Family and domain databases

InterProiView protein in InterPro
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
PfamiView protein in Pfam
PF09289. FOLN. 1 hit.
PF07648. Kazal_2. 3 hits.
SMARTiView protein in SMART
SM00274. FOLN. 3 hits.
SM00280. KAZAL. 3 hits.
SUPFAMiSSF100895. SSF100895. 3 hits.
SSF57581. SSF57581. 1 hit.
PROSITEiView protein in PROSITE
PS51465. KAZAL_2. 3 hits.
PS51364. TB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELEVQY QGKCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPS
210 220 230 240 250
SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC
260 270 280 290 300
GGGKKCLWDS KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EETEEEEEEE DQDYSFPISS ILEW
Length:344
Mass (Da):37,866
Last modified:February 1, 1996 - v1
Checksum:i935B6CBB213176F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241 – 242KA → T in CAA82648 (PubMed:7600958).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29532 mRNA. Translation: CAA82648.1.
BC144926 mRNA. Translation: AAI44927.1.
BC145945 mRNA. Translation: AAI45946.1.
X83377 mRNA. Translation: CAA58291.1.
PIRiS45321.
RefSeqiNP_001288302.1. NM_001301373.1.
NP_001288304.1. NM_001301375.1.
NP_032072.1. NM_008046.3.
UniGeneiMm.4913.

Genome annotation databases

GeneIDi14313.
KEGGimmu:14313.
UCSCiuc007rxn.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiFST_MOUSE
AccessioniPrimary (citable) accession number: P47931
Secondary accession number(s): A6H6P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot