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Protein

Galectin-7

Gene

LGALS7

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Alternative name(s):
HKL-14
PI7
p53-induced gene 1 protein
Gene namesi
Name:LGALS7
Synonyms:PIG1
AND
Name:LGALS7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6568. LGALS7.
HGNC:34447. LGALS7B.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication. Secreted Curated
Note: May be secreted by a non-classical secretory pathway.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: ProtInc
  3. extracellular vesicular exosome Source: UniProtKB
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Galectin-7PRO_0000076940Add
BLAST

Proteomic databases

MaxQBiP47929.
PaxDbiP47929.
PeptideAtlasiP47929.
PRIDEiP47929.

PTM databases

PhosphoSiteiP47929.

Expressioni

Tissue specificityi

Mainly expressed in stratified squamous epithelium.

Inductioni

By p53/TP53.

Gene expression databases

BgeeiP47929.
CleanExiHS_LGALS7.
ExpressionAtlasiP47929. baseline.
GenevestigatoriP47929.

Organism-specific databases

HPAiCAB025100.
CAB032606.
HPA001549.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi110154. 14 interactions.
575831. 2 interactions.
IntActiP47929. 8 interactions.
MINTiMINT-1154298.
STRINGi9606.ENSP00000313571.

Structurei

Secondary structure

1
136
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94Combined sources
Beta strandi16 – 2611Combined sources
Beta strandi32 – 4211Combined sources
Beta strandi47 – 548Combined sources
Turni55 – 584Combined sources
Beta strandi59 – 668Combined sources
Beta strandi85 – 939Combined sources
Beta strandi95 – 1028Combined sources
Beta strandi105 – 1117Combined sources
Helixi116 – 1183Combined sources
Beta strandi121 – 1277Combined sources
Beta strandi129 – 1357Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BKZX-ray1.90A/B2-136[»]
2GALX-ray2.00A/B2-136[»]
3GALX-ray1.90A/B2-136[»]
3ZXEX-ray1.67A/B4-136[»]
3ZXFX-ray1.38A/B1-136[»]
4GALX-ray1.95A/B2-136[»]
4UW3X-ray1.48A/B1-136[»]
4UW4X-ray1.77A/B1-136[»]
4UW5X-ray2.04A/B/C/D/E/F1-136[»]
4UW6X-ray1.79A/B1-136[»]
5GALX-ray2.00A/B2-136[»]
ProteinModelPortaliP47929.
SMRiP47929. Positions 4-136.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47929.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 136131GalectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 767Beta-galactoside bindingSequence Analysis

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG301549.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiP47929.
KOiK10092.
OMAiRHRMPLA.
OrthoDBiEOG7S7SFG.
PhylomeDBiP47929.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH
60 70 80 90 100
FNPRLDTSEV VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA
110 120 130
VVGDAQYHHF RHRLPLARVR LVEVGGDVQL DSVRIF
Length:136
Mass (Da):15,075
Last modified:January 23, 2007 - v2
Checksum:iF613D3540331C13F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07769 mRNA. Translation: AAA67899.1.
U06643 mRNA. Translation: AAA86820.1.
CR456917 mRNA. Translation: CAG33198.1.
CH471126 Genomic DNA. Translation: EAW56817.1.
CH471126 Genomic DNA. Translation: EAW56818.1.
BC042911 mRNA. Translation: AAH42911.2.
BC061588 mRNA. Translation: AAH61588.1.
BC073743 mRNA. Translation: AAH73743.1.
CCDSiCCDS42565.1.
PIRiI55469.
RefSeqiNP_001035972.1. NM_001042507.3.
NP_002298.1. NM_002307.3.
UniGeneiHs.558355.
Hs.702546.

Genome annotation databases

EnsembliENST00000314980; ENSP00000313571; ENSG00000178934.
ENST00000378626; ENSP00000367891; ENSG00000205076.
GeneIDi3963.
653499.
KEGGihsa:3963.
hsa:653499.
UCSCiuc002oje.3. human.

Polymorphism databases

DMDMi1346431.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07769 mRNA. Translation: AAA67899.1.
U06643 mRNA. Translation: AAA86820.1.
CR456917 mRNA. Translation: CAG33198.1.
CH471126 Genomic DNA. Translation: EAW56817.1.
CH471126 Genomic DNA. Translation: EAW56818.1.
BC042911 mRNA. Translation: AAH42911.2.
BC061588 mRNA. Translation: AAH61588.1.
BC073743 mRNA. Translation: AAH73743.1.
CCDSiCCDS42565.1.
PIRiI55469.
RefSeqiNP_001035972.1. NM_001042507.3.
NP_002298.1. NM_002307.3.
UniGeneiHs.558355.
Hs.702546.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BKZX-ray1.90A/B2-136[»]
2GALX-ray2.00A/B2-136[»]
3GALX-ray1.90A/B2-136[»]
3ZXEX-ray1.67A/B4-136[»]
3ZXFX-ray1.38A/B1-136[»]
4GALX-ray1.95A/B2-136[»]
4UW3X-ray1.48A/B1-136[»]
4UW4X-ray1.77A/B1-136[»]
4UW5X-ray2.04A/B/C/D/E/F1-136[»]
4UW6X-ray1.79A/B1-136[»]
5GALX-ray2.00A/B2-136[»]
ProteinModelPortaliP47929.
SMRiP47929. Positions 4-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110154. 14 interactions.
575831. 2 interactions.
IntActiP47929. 8 interactions.
MINTiMINT-1154298.
STRINGi9606.ENSP00000313571.

Chemistry

BindingDBiP47929.
ChEMBLiCHEMBL5008.

PTM databases

PhosphoSiteiP47929.

Polymorphism databases

DMDMi1346431.

Proteomic databases

MaxQBiP47929.
PaxDbiP47929.
PeptideAtlasiP47929.
PRIDEiP47929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314980; ENSP00000313571; ENSG00000178934.
ENST00000378626; ENSP00000367891; ENSG00000205076.
GeneIDi3963.
653499.
KEGGihsa:3963.
hsa:653499.
UCSCiuc002oje.3. human.

Organism-specific databases

CTDi3963.
653499.
GeneCardsiGC19M039261.
GC19P039279.
HGNCiHGNC:6568. LGALS7.
HGNC:34447. LGALS7B.
HPAiCAB025100.
CAB032606.
HPA001549.
MIMi600615. gene.
neXtProtiNX_P47929.
PharmGKBiPA162393892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG301549.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiP47929.
KOiK10092.
OMAiRHRMPLA.
OrthoDBiEOG7S7SFG.
PhylomeDBiP47929.
TreeFamiTF315551.

Miscellaneous databases

EvolutionaryTraceiP47929.
GeneWikiiLGALS7.
NextBioi15548.
PROiP47929.
SOURCEiSearch...

Gene expression databases

BgeeiP47929.
CleanExiHS_LGALS7.
ExpressionAtlasiP47929. baseline.
GenevestigatoriP47929.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 8-20; 76-83; 112-118 AND 121-133.
    Tissue: Epidermis.
  2. "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid."
    Magnaldo T., Bernerd F., Darmon M.
    Dev. Biol. 168:259-271(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epidermis.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and PNS.
  6. "Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release."
    Kuwabara I., Kuwabara Y., Yang R.Y., Schuler M., Green D.R., Zuraw B.L., Hsu D.K., Liu F.T.
    J. Biol. Chem. 277:3487-3497(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Structural basis for the recognition of carbohydrates by human galectin-7."
    Leonidas D.D., Vatzaki E.H., Vorum H., Celis J.E., Madsen P., Acharya K.R.
    Biochemistry 37:13930-13940(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

Entry informationi

Entry nameiLEG7_HUMAN
AccessioniPrimary (citable) accession number: P47929
Secondary accession number(s): Q6IB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.