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P47929

- LEG7_HUMAN

UniProt

P47929 - LEG7_HUMAN

Protein

Galectin-7

Gene

LGALS7

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.1 Publication

    GO - Molecular functioni

    1. carbohydrate binding Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. heterophilic cell-cell adhesion Source: ProtInc

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-7
    Short name:
    Gal-7
    Alternative name(s):
    HKL-14
    PI7
    p53-induced gene 1 protein
    Gene namesi
    Name:LGALS7
    Synonyms:PIG1
    AND
    Name:LGALS7B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6568. LGALS7.
    HGNC:34447. LGALS7B.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Secreted Curated
    Note: May be secreted by a non-classical secretory pathway.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: ProtInc
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162393892.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 136136Galectin-7PRO_0000076940Add
    BLAST

    Proteomic databases

    MaxQBiP47929.
    PaxDbiP47929.
    PeptideAtlasiP47929.
    PRIDEiP47929.

    PTM databases

    PhosphoSiteiP47929.

    Expressioni

    Tissue specificityi

    Mainly expressed in stratified squamous epithelium.

    Inductioni

    By p53/TP53.

    Gene expression databases

    BgeeiP47929.
    CleanExiHS_LGALS7.
    GenevestigatoriP47929.

    Organism-specific databases

    HPAiCAB025100.
    CAB032606.
    HPA001549.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi110154. 13 interactions.
    575831. 1 interaction.
    IntActiP47929. 8 interactions.
    MINTiMINT-1154298.
    STRINGi9606.ENSP00000313571.

    Structurei

    Secondary structure

    1
    136
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 94
    Beta strandi16 – 2611
    Beta strandi32 – 4211
    Beta strandi47 – 548
    Turni55 – 584
    Beta strandi59 – 668
    Beta strandi85 – 939
    Beta strandi95 – 1028
    Beta strandi105 – 1117
    Helixi116 – 1183
    Beta strandi121 – 1277
    Beta strandi129 – 1357

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BKZX-ray1.90A/B2-136[»]
    2GALX-ray2.00A/B2-136[»]
    3GALX-ray1.90A/B2-136[»]
    3ZXEX-ray1.67A/B4-136[»]
    3ZXFX-ray1.38A/B1-136[»]
    4GALX-ray1.95A/B2-136[»]
    5GALX-ray2.00A/B2-136[»]
    ProteinModelPortaliP47929.
    SMRiP47929. Positions 4-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP47929.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 136131GalectinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 767Beta-galactoside bindingSequence Analysis

    Sequence similaritiesi

    Contains 1 galectin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG301549.
    HOGENOMiHOG000293279.
    HOVERGENiHBG006255.
    InParanoidiP47929.
    KOiK10092.
    OMAiRHRMPLA.
    OrthoDBiEOG7S7SFG.
    PhylomeDBiP47929.
    TreeFamiTF315551.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 1 hit.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 1 hit.
    SM00276. GLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS51304. GALECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47929-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH    50
    FNPRLDTSEV VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA 100
    VVGDAQYHHF RHRLPLARVR LVEVGGDVQL DSVRIF 136
    Length:136
    Mass (Da):15,075
    Last modified:January 23, 2007 - v2
    Checksum:iF613D3540331C13F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07769 mRNA. Translation: AAA67899.1.
    U06643 mRNA. Translation: AAA86820.1.
    CR456917 mRNA. Translation: CAG33198.1.
    CH471126 Genomic DNA. Translation: EAW56817.1.
    CH471126 Genomic DNA. Translation: EAW56818.1.
    BC042911 mRNA. Translation: AAH42911.2.
    BC061588 mRNA. Translation: AAH61588.1.
    BC073743 mRNA. Translation: AAH73743.1.
    CCDSiCCDS42565.1.
    PIRiI55469.
    RefSeqiNP_001035972.1. NM_001042507.3.
    NP_002298.1. NM_002307.3.
    UniGeneiHs.558355.
    Hs.702546.

    Genome annotation databases

    EnsembliENST00000314980; ENSP00000313571; ENSG00000178934.
    ENST00000378626; ENSP00000367891; ENSG00000205076.
    GeneIDi3963.
    653499.
    KEGGihsa:3963.
    hsa:653499.
    UCSCiuc002oje.3. human.

    Polymorphism databases

    DMDMi1346431.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Galectin-7

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07769 mRNA. Translation: AAA67899.1 .
    U06643 mRNA. Translation: AAA86820.1 .
    CR456917 mRNA. Translation: CAG33198.1 .
    CH471126 Genomic DNA. Translation: EAW56817.1 .
    CH471126 Genomic DNA. Translation: EAW56818.1 .
    BC042911 mRNA. Translation: AAH42911.2 .
    BC061588 mRNA. Translation: AAH61588.1 .
    BC073743 mRNA. Translation: AAH73743.1 .
    CCDSi CCDS42565.1.
    PIRi I55469.
    RefSeqi NP_001035972.1. NM_001042507.3.
    NP_002298.1. NM_002307.3.
    UniGenei Hs.558355.
    Hs.702546.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BKZ X-ray 1.90 A/B 2-136 [» ]
    2GAL X-ray 2.00 A/B 2-136 [» ]
    3GAL X-ray 1.90 A/B 2-136 [» ]
    3ZXE X-ray 1.67 A/B 4-136 [» ]
    3ZXF X-ray 1.38 A/B 1-136 [» ]
    4GAL X-ray 1.95 A/B 2-136 [» ]
    5GAL X-ray 2.00 A/B 2-136 [» ]
    ProteinModelPortali P47929.
    SMRi P47929. Positions 4-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110154. 13 interactions.
    575831. 1 interaction.
    IntActi P47929. 8 interactions.
    MINTi MINT-1154298.
    STRINGi 9606.ENSP00000313571.

    Chemistry

    BindingDBi P47929.
    ChEMBLi CHEMBL5008.

    PTM databases

    PhosphoSitei P47929.

    Polymorphism databases

    DMDMi 1346431.

    Proteomic databases

    MaxQBi P47929.
    PaxDbi P47929.
    PeptideAtlasi P47929.
    PRIDEi P47929.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314980 ; ENSP00000313571 ; ENSG00000178934 .
    ENST00000378626 ; ENSP00000367891 ; ENSG00000205076 .
    GeneIDi 3963.
    653499.
    KEGGi hsa:3963.
    hsa:653499.
    UCSCi uc002oje.3. human.

    Organism-specific databases

    CTDi 3963.
    653499.
    GeneCardsi GC19M039261.
    GC19P039279.
    HGNCi HGNC:6568. LGALS7.
    HGNC:34447. LGALS7B.
    HPAi CAB025100.
    CAB032606.
    HPA001549.
    MIMi 600615. gene.
    neXtProti NX_P47929.
    PharmGKBi PA162393892.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301549.
    HOGENOMi HOG000293279.
    HOVERGENi HBG006255.
    InParanoidi P47929.
    KOi K10092.
    OMAi RHRMPLA.
    OrthoDBi EOG7S7SFG.
    PhylomeDBi P47929.
    TreeFami TF315551.

    Miscellaneous databases

    EvolutionaryTracei P47929.
    GeneWikii LGALS7.
    NextBioi 15548.
    PROi P47929.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47929.
    CleanExi HS_LGALS7.
    Genevestigatori P47929.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 1 hit.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 1 hit.
    SM00276. GLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS51304. GALECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 8-20; 76-83; 112-118 AND 121-133.
      Tissue: Epidermis.
    2. "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid."
      Magnaldo T., Bernerd F., Darmon M.
      Dev. Biol. 168:259-271(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epidermis.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and PNS.
    6. "Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release."
      Kuwabara I., Kuwabara Y., Yang R.Y., Schuler M., Green D.R., Zuraw B.L., Hsu D.K., Liu F.T.
      J. Biol. Chem. 277:3487-3497(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Structural basis for the recognition of carbohydrates by human galectin-7."
      Leonidas D.D., Vatzaki E.H., Vorum H., Celis J.E., Madsen P., Acharya K.R.
      Biochemistry 37:13930-13940(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

    Entry informationi

    Entry nameiLEG7_HUMAN
    AccessioniPrimary (citable) accession number: P47929
    Secondary accession number(s): Q6IB87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3