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Protein

Galectin-7

Gene

LGALS7

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: ProtInc

Keywordsi

Biological processApoptosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Alternative name(s):
HKL-14
PI7
p53-induced gene 1 protein
Gene namesi
Name:LGALS7
Synonyms:PIG1
AND
Name:LGALS7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6568. LGALS7.
HGNC:34447. LGALS7B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: ProtInc
  • nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3963.
653499.
OpenTargetsiENSG00000178934.
ENSG00000205076.
PharmGKBiPA162393892.

Chemistry databases

ChEMBLiCHEMBL5008.
DrugBankiDB02678. 2-Deoxy-2-Aminogalactose.
DB02379. Beta-D-Glucose.

Polymorphism and mutation databases

BioMutaiLGALS7.
DMDMi1346431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769401 – 136Galectin-7Add BLAST136

Proteomic databases

EPDiP47929.
MaxQBiP47929.
PaxDbiP47929.
PeptideAtlasiP47929.
PRIDEiP47929.

PTM databases

iPTMnetiP47929.
PhosphoSitePlusiP47929.
SwissPalmiP47929.

Expressioni

Tissue specificityi

Mainly expressed in stratified squamous epithelium.

Inductioni

By p53/TP53.

Gene expression databases

BgeeiENSG00000178934.
CleanExiHS_LGALS7.
ExpressionAtlasiP47929. baseline and differential.
GenevisibleiP47929. HS.

Organism-specific databases

HPAiCAB025100.
CAB032606.
HPA001549.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi110154. 48 interactors.
575831. 10 interactors.
IntActiP47929. 15 interactors.
MINTiMINT-1154298.
STRINGi9606.ENSP00000367891.

Chemistry databases

BindingDBiP47929.

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi16 – 26Combined sources11
Beta strandi32 – 42Combined sources11
Beta strandi47 – 54Combined sources8
Turni55 – 58Combined sources4
Beta strandi59 – 66Combined sources8
Beta strandi85 – 93Combined sources9
Beta strandi95 – 102Combined sources8
Beta strandi105 – 111Combined sources7
Helixi116 – 118Combined sources3
Beta strandi121 – 127Combined sources7
Beta strandi129 – 135Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BKZX-ray1.90A/B2-136[»]
2GALX-ray2.00A/B2-136[»]
3GALX-ray1.90A/B2-136[»]
3ZXEX-ray1.67A/B4-136[»]
3ZXFX-ray1.38A/B1-136[»]
4GALX-ray1.95A/B2-136[»]
4UW3X-ray1.48A/B1-136[»]
4UW4X-ray1.77A/B1-136[»]
4UW5X-ray2.04A/B/C/D/E/F1-136[»]
4UW6X-ray1.79A/B1-136[»]
4XBQX-ray2.23A/B1-136[»]
4Y26X-ray2.61A/B4-136[»]
5GALX-ray2.00A/B2-136[»]
5H9QX-ray1.93A/B1-136[»]
5H9SX-ray1.82A/B1-136[»]
ProteinModelPortaliP47929.
SMRiP47929.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47929.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 136GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 76Beta-galactoside bindingSequence analysis7

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiP47929.
KOiK10092.
OMAiHSAHVSH.
OrthoDBiEOG09370HGL.
PhylomeDBiP47929.
TreeFamiTF315551.

Family and domain databases

InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
PANTHERiPTHR11346:SF118. PTHR11346:SF118. 1 hit.
PfamiView protein in Pfam
PF00337. Gal-bind_lectin. 1 hit.
SMARTiView protein in SMART
SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51304. GALECTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P47929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH
60 70 80 90 100
FNPRLDTSEV VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA
110 120 130
VVGDAQYHHF RHRLPLARVR LVEVGGDVQL DSVRIF
Length:136
Mass (Da):15,075
Last modified:January 23, 2007 - v2
Checksum:iF613D3540331C13F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07769 mRNA. Translation: AAA67899.1.
U06643 mRNA. Translation: AAA86820.1.
CR456917 mRNA. Translation: CAG33198.1.
CH471126 Genomic DNA. Translation: EAW56817.1.
CH471126 Genomic DNA. Translation: EAW56818.1.
BC042911 mRNA. Translation: AAH42911.2.
BC061588 mRNA. Translation: AAH61588.1.
BC073743 mRNA. Translation: AAH73743.1.
CCDSiCCDS42565.1.
PIRiI55469.
RefSeqiNP_001035972.1. NM_001042507.3.
NP_002298.1. NM_002307.3.
UniGeneiHs.558355.
Hs.702546.

Genome annotation databases

EnsembliENST00000314980; ENSP00000313571; ENSG00000178934.
ENST00000378626; ENSP00000367891; ENSG00000205076.
ENST00000634448; ENSP00000489395; ENSG00000282902.
ENST00000634800; ENSP00000489582; ENSG00000283082.
GeneIDi3963.
653499.
KEGGihsa:3963.
hsa:653499.
UCSCiuc002oje.4. human.

Similar proteinsi

Entry informationi

Entry nameiLEG7_HUMAN
AccessioniPrimary (citable) accession number: P47929
Secondary accession number(s): Q6IB87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references