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P47929 (LEG7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 145. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-7

Short name=Gal-7
Alternative name(s):
HKL-14
PI7
p53-induced gene 1 protein
Gene names
Name:LGALS7
Synonyms:PIG1
AND
Name:LGALS7B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length136 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. Ref.6

Subunit structure

Monomer.

Subcellular location

Cytoplasm. Nucleus. Secreted Potential. Note: May be secreted by a non-classical secretory pathway. Ref.6

Tissue specificity

Mainly expressed in stratified squamous epithelium.

Induction

By p53/TP53.

Sequence similarities

Contains 1 galectin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 136136Galectin-7
PRO_0000076940

Regions

Domain6 – 136131Galectin
Region70 – 767Beta-galactoside binding Potential

Secondary structure

....................... 136
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P47929 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: F613D3540331C13F

FASTA13615,075
        10         20         30         40         50         60 
MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH FNPRLDTSEV 

        70         80         90        100        110        120 
VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA VVGDAQYHHF RHRLPLARVR 

       130 
LVEVGGDVQL DSVRIF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression, and chromosome mapping of human galectin-7."
Madsen P., Rasmussen H.H., Flint T., Gromov P., Kruse T.A., Honore B., Vorum H., Celis J.E.
J. Biol. Chem. 270:5823-5829(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 8-20; 76-83; 112-118 AND 121-133.
Tissue: Epidermis.
[2]"Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid."
Magnaldo T., Bernerd F., Darmon M.
Dev. Biol. 168:259-271(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epidermis.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and PNS.
[6]"Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release."
Kuwabara I., Kuwabara Y., Yang R.Y., Schuler M., Green D.R., Zuraw B.L., Hsu D.K., Liu F.T.
J. Biol. Chem. 277:3487-3497(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"Structural basis for the recognition of carbohydrates by human galectin-7."
Leonidas D.D., Vatzaki E.H., Vorum H., Celis J.E., Madsen P., Acharya K.R.
Biochemistry 37:13930-13940(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07769 mRNA. Translation: AAA67899.1.
U06643 mRNA. Translation: AAA86820.1.
CR456917 mRNA. Translation: CAG33198.1.
CH471126 Genomic DNA. Translation: EAW56817.1.
CH471126 Genomic DNA. Translation: EAW56818.1.
BC042911 mRNA. Translation: AAH42911.2.
BC061588 mRNA. Translation: AAH61588.1.
BC073743 mRNA. Translation: AAH73743.1.
CCDSCCDS42565.1.
PIRI55469.
RefSeqNP_001035972.1. NM_001042507.3.
NP_002298.1. NM_002307.3.
UniGeneHs.558355.
Hs.702546.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BKZX-ray1.90A/B2-136[»]
2GALX-ray2.00A/B2-136[»]
3GALX-ray1.90A/B2-136[»]
3ZXEX-ray1.67A/B4-136[»]
3ZXFX-ray1.38A/B1-136[»]
4GALX-ray1.95A/B2-136[»]
5GALX-ray2.00A/B2-136[»]
ProteinModelPortalP47929.
SMRP47929. Positions 4-136.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110154. 13 interactions.
575831. 1 interaction.
IntActP47929. 8 interactions.
MINTMINT-1154298.
STRING9606.ENSP00000313571.

Chemistry

BindingDBP47929.
ChEMBLCHEMBL5008.

PTM databases

PhosphoSiteP47929.

Polymorphism databases

DMDM1346431.

Proteomic databases

MaxQBP47929.
PaxDbP47929.
PeptideAtlasP47929.
PRIDEP47929.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314980; ENSP00000313571; ENSG00000178934.
ENST00000378626; ENSP00000367891; ENSG00000205076.
GeneID3963.
653499.
KEGGhsa:3963.
hsa:653499.
UCSCuc002oje.3. human.

Organism-specific databases

CTD3963.
653499.
GeneCardsGC19M039261.
GC19P039279.
HGNCHGNC:6568. LGALS7.
HGNC:34447. LGALS7B.
HPACAB025100.
CAB032606.
HPA001549.
MIM600615. gene.
neXtProtNX_P47929.
PharmGKBPA162393892.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301549.
HOGENOMHOG000293279.
HOVERGENHBG006255.
InParanoidP47929.
KOK10092.
OMARHRMPLA.
OrthoDBEOG7S7SFG.
PhylomeDBP47929.
TreeFamTF315551.

Gene expression databases

BgeeP47929.
CleanExHS_LGALS7.
GenevestigatorP47929.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP47929.
GeneWikiLGALS7.
NextBio15548.
PROP47929.
SOURCESearch...

Entry information

Entry nameLEG7_HUMAN
AccessionPrimary (citable) accession number: P47929
Secondary accession number(s): Q6IB87
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM