ID   ID4_HUMAN               Reviewed;         161 AA.
AC   P47928; Q13005;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   14-DEC-2011, entry version 106.
DE   RecName: Full=DNA-binding protein inhibitor ID-4;
DE   AltName: Full=Class B basic helix-loop-helix protein 27;
DE            Short=bHLHb27;
DE   AltName: Full=Inhibitor of DNA binding 4;
GN   Name=ID4; Synonyms=BHLHB27;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Abdominal adipose tissue;
RA   Kiesling T.L., Christy B.A.;
RL   Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=99087490; PubMed=9872455; DOI=10.1093/dnares/5.5.309;
RA   Rigolet M., Rich T., Gross-Morand M.S., Molina-Gomes D.,
RA   Viegas-Pequignot E., Junien C.;
RT   "cDNA cloning, tissue distribution and chromosomal localization of the
RT   human ID4 gene.";
RL   DNA Res. 5:309-313(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=95394461; PubMed=7665172; DOI=10.1006/geno.1995.1026;
RA   Pagliuca A., Bartoli P.C., Saccone S., Della Valle G., Lania L.;
RT   "Molecular cloning of ID4, a novel dominant negative helix-loop-helix
RT   human gene on chromosome 6p21.3-p22.";
RL   Genomics 27:200-203(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: ID (inhibitor of DNA binding) HLH proteins lack a basic
CC       DNA-binding domain but are able to form heterodimers with other
CC       HLH proteins, thereby inhibiting DNA binding.
CC   -!- SUBUNIT: Heterodimer with other HLH proteins.
CC   -!- INTERACTION:
CC       P16333:NCK1; NbExp=3; IntAct=EBI-1754719, EBI-389883;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/ID4ID40916ch6p22.html";
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DR   EMBL; U28368; AAA73923.1; -; mRNA.
DR   EMBL; Y07958; CAA69255.1; -; mRNA.
DR   EMBL; U16153; AAA82882.1; -; mRNA.
DR   EMBL; AL022726; CAA18779.1; -; Genomic_DNA.
DR   EMBL; BC014941; AAH14941.1; -; mRNA.
DR   IPI; IPI00026864; -.
DR   PIR; G01855; G01855.
DR   PIR; JE0306; JE0306.
DR   RefSeq; NP_001537.1; NM_001546.2.
DR   UniGene; Hs.519601; -.
DR   ProteinModelPortal; P47928; -.
DR   SMR; P47928; 56-106.
DR   IntAct; P47928; 6.
DR   MINT; MINT-7241891; -.
DR   STRING; P47928; -.
DR   DMDM; 1352422; -.
DR   PRIDE; P47928; -.
DR   Ensembl; ENST00000378700; ENSP00000367972; ENSG00000172201.
DR   GeneID; 3400; -.
DR   KEGG; hsa:3400; -.
DR   UCSC; uc003ncw.1; human.
DR   CTD; 3400; -.
DR   GeneCards; GC06P019782; -.
DR   H-InvDB; HIX0005610; -.
DR   HGNC; HGNC:5363; ID4.
DR   HPA; CAB022407; -.
DR   MIM; 600581; gene.
DR   neXtProt; NX_P47928; -.
DR   PharmGKB; PA29611; -.
DR   eggNOG; prNOG20738; -.
DR   GeneTree; ENSGT00390000000908; -.
DR   HOGENOM; HBG713167; -.
DR   HOVERGEN; HBG009009; -.
DR   InParanoid; P47928; -.
DR   OMA; GACPVAP; -.
DR   PhylomeDB; P47928; -.
DR   NextBio; 13436; -.
DR   ArrayExpress; P47928; -.
DR   Bgee; P47928; -.
DR   CleanEx; HS_ID4; -.
DR   Genevestigator; P47928; -.
DR   GermOnline; ENSG00000172201; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR   GO; GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
DR   InterPro; IPR011598; HLH_DNA-bd.
DR   Gene3D; G3DSA:4.10.280.10; HLH_DNA_bd; 1.
DR   KO; K04680; -.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH_basic; 1.
DR   PROSITE; PS50888; HLH; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Nucleus; Reference proteome.
FT   CHAIN         1    161       DNA-binding protein inhibitor ID-4.
FT                                /FTId=PRO_0000127250.
FT   DOMAIN       65    105       Helix-loop-helix motif.
FT   COMPBIAS     39     48       Poly-Ala.
FT   COMPBIAS    118    124       Poly-Pro.
FT   CONFLICT     10     14       SGRKA -> RPLR (in Ref. 3; AAA82882).
FT   CONFLICT     39     40       AA -> Q (in Ref. 3; AAA82882).
FT   CONFLICT     77     79       RLV -> WL (in Ref. 3; AAA82882).
SQ   SEQUENCE   161 AA;  16622 MW;  5B14847AE7337339 CRC64;
     MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP
     ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP
     PAPPHHPAGT CPAAPPRTPL TALNTDPAGA VNKQGDSILC R
//