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Protein

DNA-binding protein inhibitor ID-4

Gene

ID4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).By similarity

GO - Molecular functioni

  • transcription corepressor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-4
Alternative name(s):
Class B basic helix-loop-helix protein 27
Short name:
bHLHb27
Inhibitor of DNA binding 4
Inhibitor of differentiation 4
Gene namesi
Name:ID4
Synonyms:BHLHB27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:5363. ID4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3400.
OpenTargetsiENSG00000172201.
PharmGKBiPA29611.

Polymorphism and mutation databases

BioMutaiID4.
DMDMi1352422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272501 – 161DNA-binding protein inhibitor ID-4Add BLAST161

Proteomic databases

EPDiP47928.
MaxQBiP47928.
PaxDbiP47928.
PeptideAtlasiP47928.
PRIDEiP47928.

PTM databases

iPTMnetiP47928.
PhosphoSitePlusiP47928.

Expressioni

Gene expression databases

BgeeiENSG00000172201.
CleanExiHS_ID4.
GenevisibleiP47928. HS.

Organism-specific databases

HPAiCAB022407.
HPA045710.
HPA060800.

Interactioni

Subunit structurei

Heterodimer with other HLH proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1754719,EBI-389883

Protein-protein interaction databases

BioGridi109626. 7 interactors.
IntActiP47928. 7 interactors.
MINTiMINT-7241891.
STRINGi9606.ENSP00000367972.

Structurei

3D structure databases

ProteinModelPortaliP47928.
SMRiP47928.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 104bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 48Poly-Ala10
Compositional biasi118 – 124Poly-Pro7

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVMK. Eukaryota.
ENOG4111QS6. LUCA.
GeneTreeiENSGT00390000000908.
HOGENOMiHOG000234788.
HOVERGENiHBG009009.
InParanoidiP47928.
KOiK17695.
OMAiDPAGSVN.
OrthoDBiEOG091G0VHR.
PhylomeDBiP47928.
TreeFamiTF326217.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC
60 70 80 90 100
KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY
110 120 130 140 150
ILDLQLALET HPALLRQPPP PAPPHHPAGT CPAAPPRTPL TALNTDPAGA
160
VNKQGDSILC R
Length:161
Mass (Da):16,622
Last modified:February 1, 1996 - v1
Checksum:i5B14847AE7337339
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 14SGRKA → RPLR in AAA82882 (PubMed:7665172).Curated5
Sequence conflicti39 – 40AA → Q in AAA82882 (PubMed:7665172).Curated2
Sequence conflicti77 – 79RLV → WL in AAA82882 (PubMed:7665172).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28368 mRNA. Translation: AAA73923.1.
Y07958 mRNA. Translation: CAA69255.1.
U16153 mRNA. Translation: AAA82882.1.
AL022726 Genomic DNA. Translation: CAA18779.1.
BC014941 mRNA. Translation: AAH14941.1.
CCDSiCCDS4544.1.
PIRiG01855.
JE0306.
RefSeqiNP_001537.1. NM_001546.3.
UniGeneiHs.519601.
Hs.663469.

Genome annotation databases

EnsembliENST00000378700; ENSP00000367972; ENSG00000172201.
GeneIDi3400.
KEGGihsa:3400.
UCSCiuc003ncw.5. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28368 mRNA. Translation: AAA73923.1.
Y07958 mRNA. Translation: CAA69255.1.
U16153 mRNA. Translation: AAA82882.1.
AL022726 Genomic DNA. Translation: CAA18779.1.
BC014941 mRNA. Translation: AAH14941.1.
CCDSiCCDS4544.1.
PIRiG01855.
JE0306.
RefSeqiNP_001537.1. NM_001546.3.
UniGeneiHs.519601.
Hs.663469.

3D structure databases

ProteinModelPortaliP47928.
SMRiP47928.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109626. 7 interactors.
IntActiP47928. 7 interactors.
MINTiMINT-7241891.
STRINGi9606.ENSP00000367972.

PTM databases

iPTMnetiP47928.
PhosphoSitePlusiP47928.

Polymorphism and mutation databases

BioMutaiID4.
DMDMi1352422.

Proteomic databases

EPDiP47928.
MaxQBiP47928.
PaxDbiP47928.
PeptideAtlasiP47928.
PRIDEiP47928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378700; ENSP00000367972; ENSG00000172201.
GeneIDi3400.
KEGGihsa:3400.
UCSCiuc003ncw.5. human.

Organism-specific databases

CTDi3400.
DisGeNETi3400.
GeneCardsiID4.
HGNCiHGNC:5363. ID4.
HPAiCAB022407.
HPA045710.
HPA060800.
MIMi600581. gene.
neXtProtiNX_P47928.
OpenTargetsiENSG00000172201.
PharmGKBiPA29611.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVMK. Eukaryota.
ENOG4111QS6. LUCA.
GeneTreeiENSGT00390000000908.
HOGENOMiHOG000234788.
HOVERGENiHBG009009.
InParanoidiP47928.
KOiK17695.
OMAiDPAGSVN.
OrthoDBiEOG091G0VHR.
PhylomeDBiP47928.
TreeFamiTF326217.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172201-MONOMER.

Miscellaneous databases

GeneWikiiID4.
GenomeRNAii3400.
PROiP47928.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172201.
CleanExiHS_ID4.
GenevisibleiP47928. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiID4_HUMAN
AccessioniPrimary (citable) accession number: P47928
Secondary accession number(s): Q13005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.