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P47928

- ID4_HUMAN

UniProt

P47928 - ID4_HUMAN

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Protein

DNA-binding protein inhibitor ID-4

Gene

ID4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).By similarity

GO - Molecular functioni

  1. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. cellular protein localization Source: Ensembl
  2. central nervous system myelination Source: Ensembl
  3. cerebral cortex neuron differentiation Source: Ensembl
  4. fat cell differentiation Source: Ensembl
  5. G1/S transition of mitotic cell cycle Source: Ensembl
  6. hippocampus development Source: Ensembl
  7. negative regulation of astrocyte differentiation Source: Ensembl
  8. negative regulation of fat cell differentiation Source: Ensembl
  9. negative regulation of neuron differentiation Source: Ensembl
  10. negative regulation of oligodendrocyte differentiation Source: Ensembl
  11. negative regulation of transcription, DNA-templated Source: GDB
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. neuroblast proliferation Source: Ensembl
  14. positive regulation of cell proliferation Source: Ensembl
  15. positive regulation of osteoblast differentiation Source: Ensembl
  16. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  17. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  18. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-4
Alternative name(s):
Class B basic helix-loop-helix protein 27
Short name:
bHLHb27
Inhibitor of DNA binding 4
Inhibitor of differentiation 4
Gene namesi
Name:ID4
Synonyms:BHLHB27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:5363. ID4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161DNA-binding protein inhibitor ID-4PRO_0000127250Add
BLAST

Proteomic databases

MaxQBiP47928.
PaxDbiP47928.
PRIDEiP47928.

Expressioni

Gene expression databases

BgeeiP47928.
CleanExiHS_ID4.
GenevestigatoriP47928.

Organism-specific databases

HPAiCAB022407.

Interactioni

Subunit structurei

Heterodimer with other HLH proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1754719,EBI-389883

Protein-protein interaction databases

BioGridi109626. 1 interaction.
IntActiP47928. 6 interactions.
MINTiMINT-7241891.
STRINGi9606.ENSP00000367972.

Structurei

3D structure databases

ProteinModelPortaliP47928.
SMRiP47928. Positions 67-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 10453bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 4810Poly-Ala
Compositional biasi118 – 1247Poly-Pro

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG74134.
GeneTreeiENSGT00390000000908.
HOGENOMiHOG000234788.
HOVERGENiHBG009009.
InParanoidiP47928.
KOiK17695.
OMAiGACPVAP.
OrthoDBiEOG7X9G8G.
PhylomeDBiP47928.
TreeFamiTF326217.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47928-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC
60 70 80 90 100
KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY
110 120 130 140 150
ILDLQLALET HPALLRQPPP PAPPHHPAGT CPAAPPRTPL TALNTDPAGA
160
VNKQGDSILC R
Length:161
Mass (Da):16,622
Last modified:February 1, 1996 - v1
Checksum:i5B14847AE7337339
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 145SGRKA → RPLR in AAA82882. (PubMed:7665172)Curated
Sequence conflicti39 – 402AA → Q in AAA82882. (PubMed:7665172)Curated
Sequence conflicti77 – 793RLV → WL in AAA82882. (PubMed:7665172)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28368 mRNA. Translation: AAA73923.1.
Y07958 mRNA. Translation: CAA69255.1.
U16153 mRNA. Translation: AAA82882.1.
AL022726 Genomic DNA. Translation: CAA18779.1.
BC014941 mRNA. Translation: AAH14941.1.
CCDSiCCDS4544.1.
PIRiG01855.
JE0306.
RefSeqiNP_001537.1. NM_001546.3.
UniGeneiHs.519601.
Hs.663469.

Genome annotation databases

EnsembliENST00000378700; ENSP00000367972; ENSG00000172201.
GeneIDi3400.
KEGGihsa:3400.
UCSCiuc003ncw.4. human.

Polymorphism databases

DMDMi1352422.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28368 mRNA. Translation: AAA73923.1 .
Y07958 mRNA. Translation: CAA69255.1 .
U16153 mRNA. Translation: AAA82882.1 .
AL022726 Genomic DNA. Translation: CAA18779.1 .
BC014941 mRNA. Translation: AAH14941.1 .
CCDSi CCDS4544.1.
PIRi G01855.
JE0306.
RefSeqi NP_001537.1. NM_001546.3.
UniGenei Hs.519601.
Hs.663469.

3D structure databases

ProteinModelPortali P47928.
SMRi P47928. Positions 67-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109626. 1 interaction.
IntActi P47928. 6 interactions.
MINTi MINT-7241891.
STRINGi 9606.ENSP00000367972.

Polymorphism databases

DMDMi 1352422.

Proteomic databases

MaxQBi P47928.
PaxDbi P47928.
PRIDEi P47928.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378700 ; ENSP00000367972 ; ENSG00000172201 .
GeneIDi 3400.
KEGGi hsa:3400.
UCSCi uc003ncw.4. human.

Organism-specific databases

CTDi 3400.
GeneCardsi GC06P019837.
HGNCi HGNC:5363. ID4.
HPAi CAB022407.
MIMi 600581. gene.
neXtProti NX_P47928.
PharmGKBi PA29611.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74134.
GeneTreei ENSGT00390000000908.
HOGENOMi HOG000234788.
HOVERGENi HBG009009.
InParanoidi P47928.
KOi K17695.
OMAi GACPVAP.
OrthoDBi EOG7X9G8G.
PhylomeDBi P47928.
TreeFami TF326217.

Miscellaneous databases

GeneWikii ID4.
GenomeRNAii 3400.
NextBioi 13436.
PROi P47928.
SOURCEi Search...

Gene expression databases

Bgeei P47928.
CleanExi HS_ID4.
Genevestigatori P47928.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view ]
PANTHERi PTHR11723. PTHR11723. 1 hit.
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kiesling T.L., Christy B.A.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Abdominal adipose tissue.
  2. "cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene."
    Rigolet M., Rich T., Gross-Morand M.S., Molina-Gomes D., Viegas-Pequignot E., Junien C.
    DNA Res. 5:309-313(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22."
    Pagliuca A., Bartoli P.C., Saccone S., Della Valle G., Lania L.
    Genomics 27:200-203(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiID4_HUMAN
AccessioniPrimary (citable) accession number: P47928
Secondary accession number(s): Q13005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3