P47928 (ID4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-binding protein inhibitor ID-4

Alternative name(s):
Class B basic helix-loop-helix protein 27
Short name=bHLHb27
Inhibitor of DNA binding 4

Gene names

Name:	ID4
Synonyms:	BHLHB27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
Subunit structure	Heterodimer with other HLH proteins.
Subcellular location	Nucleus.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred by curator. Source: UniProtKB
Molecular function	transcription corepressor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	3	EBI-1754719,EBI-389883

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	DNA-binding protein inhibitor ID-4		PRO_0000127250
Regions
	Domain	65 – 105	41	Helix-loop-helix motif
	Compositional bias	39 – 48	10	Poly-Ala
	Compositional bias	118 – 124	7	Poly-Pro
Experimental info
	Sequence conflict	10 – 14	5	SGRKA → RPLR in AAA82882. Ref.3
	Sequence conflict	39 – 40	2	AA → Q in AAA82882. Ref.3
	Sequence conflict	77 – 79	3	RLV → WL in AAA82882. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P47928 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 5B14847AE7337339	FASTA	161	16,622
	10 20 30 40 50 60 MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP 70 80 90 100 110 120 ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP 130 140 150 160 PAPPHHPAGT CPAAPPRTPL TALNTDPAGA VNKQGDSILC R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Kiesling T.L., Christy B.A. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Abdominal adipose tissue.
[2]	"cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene." Rigolet M., Rich T., Gross-Morand M.S., Molina-Gomes D., Viegas-Pequignot E., Junien C. DNA Res. 5:309-313(1998) [PubMed: 9872455] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22." Pagliuca A., Bartoli P.C., Saccone S., Della Valle G., Lania L. Genomics 27:200-203(1995) [PubMed: 7665172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	U28368 mRNA. Translation: AAA73923.1. Y07958 mRNA. Translation: CAA69255.1. U16153 mRNA. Translation: AAA82882.1. AL022726 Genomic DNA. Translation: CAA18779.1. BC014941 mRNA. Translation: AAH14941.1.
IPI	IPI00026864.
PIR	G01855. JE0306.
RefSeq	NP_001537.1. NM_001546.2.
UniGene	Hs.519601.
3D structure databases
ProteinModelPortal	P47928.
SMR	P47928. Positions 56-106.
ModBase	Search...
Protein-protein interaction databases
IntAct	P47928. 6 interactions.
MINT	MINT-7241891.
STRING	P47928.
Polymorphism databases
DMDM	1352422.
Proteomic databases
PRIDE	P47928.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378700; ENSP00000367972; ENSG00000172201.
GeneID	3400.
KEGG	hsa:3400.
UCSC	uc003ncw.1. human.
Organism-specific databases
CTD	3400.
GeneCards	GC06P019782.
H-InvDB	HIX0005610.
HGNC	HGNC:5363. ID4.
HPA	CAB022407.
MIM	600581. gene.
neXtProt	NX_P47928.
PharmGKB	PA29611.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20738.
GeneTree	ENSGT00390000000908.
HOGENOM	HBG713167.
HOVERGEN	HBG009009.
InParanoid	P47928.
OMA	GACPVAP.
PhylomeDB	P47928.
Gene expression databases
ArrayExpress	P47928.
Bgee	P47928.
CleanEx	HS_ID4.
Genevestigator	P47928.
GermOnline	ENSG00000172201. Homo sapiens.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
KO	K04680.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13436.
SOURCE	Search...

Entry information

Entry name

ID4_HUMAN

Accession

Primary (citable) accession number: P47928
Secondary accession number(s): Q13005

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.