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P47928

- ID4_HUMAN

UniProt

P47928 - ID4_HUMAN

Protein

DNA-binding protein inhibitor ID-4

Gene

ID4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. cellular protein localization Source: Ensembl
    2. central nervous system myelination Source: Ensembl
    3. cerebral cortex neuron differentiation Source: Ensembl
    4. fat cell differentiation Source: Ensembl
    5. G1/S transition of mitotic cell cycle Source: Ensembl
    6. hippocampus development Source: Ensembl
    7. negative regulation of astrocyte differentiation Source: Ensembl
    8. negative regulation of fat cell differentiation Source: Ensembl
    9. negative regulation of neuron differentiation Source: Ensembl
    10. negative regulation of oligodendrocyte differentiation Source: Ensembl
    11. negative regulation of transcription, DNA-templated Source: GDB
    12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. neuroblast proliferation Source: Ensembl
    14. positive regulation of cell proliferation Source: Ensembl
    15. positive regulation of osteoblast differentiation Source: Ensembl
    16. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    17. regulation of transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-binding protein inhibitor ID-4
    Alternative name(s):
    Class B basic helix-loop-helix protein 27
    Short name:
    bHLHb27
    Inhibitor of DNA binding 4
    Inhibitor of differentiation 4
    Gene namesi
    Name:ID4
    Synonyms:BHLHB27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:5363. ID4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29611.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161DNA-binding protein inhibitor ID-4PRO_0000127250Add
    BLAST

    Proteomic databases

    MaxQBiP47928.
    PaxDbiP47928.
    PRIDEiP47928.

    Expressioni

    Gene expression databases

    BgeeiP47928.
    CleanExiHS_ID4.
    GenevestigatoriP47928.

    Organism-specific databases

    HPAiCAB022407.

    Interactioni

    Subunit structurei

    Heterodimer with other HLH proteins.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163333EBI-1754719,EBI-389883

    Protein-protein interaction databases

    BioGridi109626. 1 interaction.
    IntActiP47928. 6 interactions.
    MINTiMINT-7241891.
    STRINGi9606.ENSP00000367972.

    Structurei

    3D structure databases

    ProteinModelPortaliP47928.
    SMRiP47928. Positions 67-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 10453bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi39 – 4810Poly-Ala
    Compositional biasi118 – 1247Poly-Pro

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG74134.
    HOGENOMiHOG000234788.
    HOVERGENiHBG009009.
    InParanoidiP47928.
    KOiK17695.
    OMAiGACPVAP.
    OrthoDBiEOG7X9G8G.
    PhylomeDBiP47928.
    TreeFamiTF326217.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR026052. DNA-bd_prot-inh.
    [Graphical view]
    PANTHERiPTHR11723. PTHR11723. 1 hit.
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47928-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC    50
    KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY 100
    ILDLQLALET HPALLRQPPP PAPPHHPAGT CPAAPPRTPL TALNTDPAGA 150
    VNKQGDSILC R 161
    Length:161
    Mass (Da):16,622
    Last modified:February 1, 1996 - v1
    Checksum:i5B14847AE7337339
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 145SGRKA → RPLR in AAA82882. (PubMed:7665172)Curated
    Sequence conflicti39 – 402AA → Q in AAA82882. (PubMed:7665172)Curated
    Sequence conflicti77 – 793RLV → WL in AAA82882. (PubMed:7665172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28368 mRNA. Translation: AAA73923.1.
    Y07958 mRNA. Translation: CAA69255.1.
    U16153 mRNA. Translation: AAA82882.1.
    AL022726 Genomic DNA. Translation: CAA18779.1.
    BC014941 mRNA. Translation: AAH14941.1.
    CCDSiCCDS4544.1.
    PIRiG01855.
    JE0306.
    RefSeqiNP_001537.1. NM_001546.3.
    UniGeneiHs.519601.
    Hs.663469.

    Genome annotation databases

    EnsembliENST00000378700; ENSP00000367972; ENSG00000172201.
    GeneIDi3400.
    KEGGihsa:3400.
    UCSCiuc003ncw.4. human.

    Polymorphism databases

    DMDMi1352422.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28368 mRNA. Translation: AAA73923.1 .
    Y07958 mRNA. Translation: CAA69255.1 .
    U16153 mRNA. Translation: AAA82882.1 .
    AL022726 Genomic DNA. Translation: CAA18779.1 .
    BC014941 mRNA. Translation: AAH14941.1 .
    CCDSi CCDS4544.1.
    PIRi G01855.
    JE0306.
    RefSeqi NP_001537.1. NM_001546.3.
    UniGenei Hs.519601.
    Hs.663469.

    3D structure databases

    ProteinModelPortali P47928.
    SMRi P47928. Positions 67-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109626. 1 interaction.
    IntActi P47928. 6 interactions.
    MINTi MINT-7241891.
    STRINGi 9606.ENSP00000367972.

    Polymorphism databases

    DMDMi 1352422.

    Proteomic databases

    MaxQBi P47928.
    PaxDbi P47928.
    PRIDEi P47928.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378700 ; ENSP00000367972 ; ENSG00000172201 .
    GeneIDi 3400.
    KEGGi hsa:3400.
    UCSCi uc003ncw.4. human.

    Organism-specific databases

    CTDi 3400.
    GeneCardsi GC06P019837.
    HGNCi HGNC:5363. ID4.
    HPAi CAB022407.
    MIMi 600581. gene.
    neXtProti NX_P47928.
    PharmGKBi PA29611.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74134.
    HOGENOMi HOG000234788.
    HOVERGENi HBG009009.
    InParanoidi P47928.
    KOi K17695.
    OMAi GACPVAP.
    OrthoDBi EOG7X9G8G.
    PhylomeDBi P47928.
    TreeFami TF326217.

    Miscellaneous databases

    GeneWikii ID4.
    GenomeRNAii 3400.
    NextBioi 13436.
    PROi P47928.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47928.
    CleanExi HS_ID4.
    Genevestigatori P47928.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR026052. DNA-bd_prot-inh.
    [Graphical view ]
    PANTHERi PTHR11723. PTHR11723. 1 hit.
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kiesling T.L., Christy B.A.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Abdominal adipose tissue.
    2. "cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene."
      Rigolet M., Rich T., Gross-Morand M.S., Molina-Gomes D., Viegas-Pequignot E., Junien C.
      DNA Res. 5:309-313(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22."
      Pagliuca A., Bartoli P.C., Saccone S., Della Valle G., Lania L.
      Genomics 27:200-203(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiID4_HUMAN
    AccessioniPrimary (citable) accession number: P47928
    Secondary accession number(s): Q13005
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3