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P47918 (COX2_CYBMR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismCyberlindnera mrakii (Yeast) (Williopsis mrakii)
Taxonomic identifier1004253 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Cytochrome c oxidase subunit 2
PRO_0000006045

Regions

Topological domain12 – 3827Mitochondrial intermembrane Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 7819Mitochondrial matrix Potential
Transmembrane79 – 10123Helical; Potential
Topological domain102 – 247146Mitochondrial intermembrane Potential

Sites

Metal binding1821Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P47918 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 98EF8346730B6ECA

FASTA24727,941
        10         20         30         40         50         60 
MLLLINNLIL NDVPTPWGLY FQDSSTPNQE GIIELHDNIM FYLVLILCTV SWLLFSIVKD 

        70         80         90        100        110        120 
SSKNPLPHKY LVHGQTIEII WTILPAVVLL IIAFPSFILL YLCDEVISPA MTIKAIGLQW 

       130        140        150        160        170        180 
YWRYEYSDFI NDSGETIEFE SYVIPEDLLE DGQLRLLDTD TSVVCPVNTH IRFIVSAADV 

       190        200        210        220        230        240 
IHDFAIPSLG IKVDACPGRL NQVSALIQRE GVYYGMCSET CGVAHSAMPI KIEVVSTKEF 


LTWLNEQ 

« Hide

References

[1]"Genes of the linear mitochondrial DNA of Williopsis mrakii: coding sequences for a maturase-like protein, a ribosomal protein VAR1 homologue, cytochrome oxidase subunit 2 and methionyl tRNA."
Drissi R., Sor F., Fukuhara H.
Yeast 10:391-398(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10743 / CBS 1707 / JCM 3614 / NBRC 0897 / NRRL Y-1364 / VKM Y-173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66595 Genomic DNA. Translation: CAA47160.1.
PIRS42736.

3D structure databases

ProteinModelPortalP47918.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CYBMR
AccessionPrimary (citable) accession number: P47918
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families