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Protein

60S ribosomal protein L29

Gene

RPL29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • heparin binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-9010553. Regulation of expression of SLITs and ROBOs.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SignaLinkiP47914.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L29
Alternative name(s):
Cell surface heparin-binding protein HIP
Large ribosomal subunit protein eL291 Publication
Gene namesi
Name:RPL29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000162244.10.
HGNCiHGNC:10331. RPL29.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6159.
OpenTargetsiENSG00000162244.
PharmGKBiPA34711.

Polymorphism and mutation databases

BioMutaiRPL29.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002191342 – 15960S ribosomal protein L29Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-methyllysineCombined sources1 Publication1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33N6-acetyllysineCombined sources1
Modified residuei142PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP47914.
MaxQBiP47914.
PaxDbiP47914.
PeptideAtlasiP47914.
PRIDEiP47914.
TopDownProteomicsiP47914.

PTM databases

iPTMnetiP47914.
PhosphoSitePlusiP47914.
SwissPalmiP47914.

Expressioni

Gene expression databases

BgeeiENSG00000162244.
CleanExiHS_RPL29.
ExpressionAtlasiP47914. baseline and differential.
GenevisibleiP47914. HS.

Organism-specific databases

HPAiHPA069064.

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112078. 69 interactors.
CORUMiP47914.
IntActiP47914. 15 interactors.
MINTiMINT-1375294.
STRINGi9606.ENSP00000294189.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lb1-159[»]
4V6Xelectron microscopy5.00Cb1-159[»]
5AJ0electron microscopy3.50Ab1-159[»]
5T2Celectron microscopy3.60V1-159[»]
ProteinModelPortaliP47914.
SMRiP47914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3504. Eukaryota.
ENOG4112428. LUCA.
GeneTreeiENSGT00390000007084.
HOVERGENiHBG000386.
InParanoidiP47914.
KOiK02905.
OMAiCRPKSQA.
OrthoDBiEOG091G15LL.
PhylomeDBiP47914.
TreeFamiTF313858.

Family and domain databases

InterProiView protein in InterPro
IPR002673. Ribosomal_L29e.
PANTHERiPTHR12884. PTHR12884. 1 hit.
PfamiView protein in Pfam
PF01779. Ribosomal_L29e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010314. Ribosomal_L29e. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSKNHTTH NQSRKWHRNG IKKPRSQRYE SLKGVDPKFL RNMRFAKKHN
60 70 80 90 100
KKGLKKMQAN NAKAMSARAE AIKALVKPKE VKPKIPKGVS RKLDRLAYIA
110 120 130 140 150
HPKLGKRARA RIAKGLRLCR PKAKAKAKAK DQTKAQAAAP ASVPAQAPKR

TQAPTKASE
Length:159
Mass (Da):17,752
Last modified:January 23, 2007 - v2
Checksum:i2A0C31984EF4FF95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → R in BAF82227 (PubMed:14702039).Curated1
Sequence conflicti120R → A in CAA89008 (PubMed:8597591).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10248 mRNA. Translation: AAC50499.1.
Z49148 mRNA. Translation: CAA89008.1.
U49083 mRNA. Translation: AAC50647.1.
AK289538 mRNA. Translation: BAF82227.1.
AK311884 mRNA. Translation: BAG34825.1.
BC008926 mRNA. Translation: AAH08926.1.
BC070190 mRNA. Translation: AAH70190.1.
BC070481 mRNA. Translation: AAH70481.1.
BC071663 mRNA. Translation: AAH71663.1.
CCDSiCCDS2845.1.
PIRiS65784.
RefSeqiNP_000983.1. NM_000992.2.
UniGeneiHs.425125.

Genome annotation databases

EnsembliENST00000294189; ENSP00000294189; ENSG00000162244.
ENST00000466397; ENSP00000418868; ENSG00000162244.
ENST00000475248; ENSP00000417048; ENSG00000162244.
ENST00000479017; ENSP00000418153; ENSG00000162244.
ENST00000492277; ENSP00000418346; ENSG00000162244.
ENST00000495383; ENSP00000420673; ENSG00000162244.
GeneIDi6159.
KEGGihsa:6159.
UCSCiuc003dcs.4. human.

Similar proteinsi

Entry informationi

Entry nameiRL29_HUMAN
AccessioniPrimary (citable) accession number: P47914
Secondary accession number(s): A8K0H3, B2R4M8, Q6IPY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families