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P47911

- RL6_MOUSE

UniProt

P47911 - RL6_MOUSE

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Protein

60S ribosomal protein L6

Gene

Rpl6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_231519. Eukaryotic Translation Termination.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_253640. Peptide chain elongation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
TAX-responsive enhancer element-binding protein 107
Short name:
TAXREB107
Gene namesi
Name:Rpl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:108057. Rpl6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleolus Source: MGI
  3. nucleus Source: MGI
  4. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 29629560S ribosomal protein L6PRO_0000171010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351PhosphoserineBy similarity
Modified residuei226 – 2261N6-acetyllysineBy similarity
Modified residuei247 – 2471N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP47911.
PaxDbiP47911.
PRIDEiP47911.

PTM databases

PhosphoSiteiP47911.

Expressioni

Gene expression databases

BgeeiP47911.
CleanExiMM_RPL6.
ExpressionAtlasiP47911. baseline and differential.
GenevestigatoriP47911.

Interactioni

Subunit structurei

May bind IPO9 with low affinity.

Protein-protein interaction databases

BioGridi202987. 11 interactions.
IntActiP47911. 7 interactions.
MINTiMINT-1857899.

Structurei

3D structure databases

ProteinModelPortaliP47911.
SMRiP47911. Positions 50-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

eggNOGiCOG2163.
HOGENOMiHOG000207317.
HOVERGENiHBG002565.
InParanoidiP47911.
KOiK02934.
OMAiYELTEQR.
OrthoDBiEOG78D7MH.
PhylomeDBiP47911.
TreeFamiTF300115.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47911-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGEKAPDTK EKKPAAKKAG SDAAASRPRA AKVAKKVHPK GKKPKKAKPH
60 70 80 90 100
CSRNPVLVRG IGRYSRSAMY SRKALYKRKY SAAKTKVEKK KKKEKVLATV
110 120 130 140 150
TKTVGGDKNG GTRVVKLRKM PRYYPTEDVP RKLLSHGKKP FSQHVRRLRS
160 170 180 190 200
SITPGTVLII LTGRHRGKRV VFLKQLDSGL LLVTGPLVIN RVPLRRTHQK
210 220 230 240 250
FVIATSTKVD ISDVKIPKHL TDAYFKKKQL RKPRHQEGEI FDTEKEKYEI
260 270 280 290
TEQRKADQKA VDLQILPKIK AVPQLQGYLR SQFSLTNGMY PHKLVF
Length:296
Mass (Da):33,510
Last modified:January 23, 2007 - v3
Checksum:iD65D5EF517660836
GO

Sequence cautioni

The sequence CAA57513.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51K → R(PubMed:7537974)Curated
Sequence conflicti10 – 101K → M in CAA57513. (PubMed:7537974)Curated
Sequence conflicti75 – 751L → F in AAH62880. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF374195 Genomic DNA. Translation: AAK56936.1.
BC062880 mRNA. Translation: AAH62880.1.
X81987 mRNA. Translation: CAA57513.1. Different initiation.
CCDSiCCDS19632.1.
PIRiS55922.
RefSeqiNP_035420.2. NM_011290.5.
XP_006530290.1. XM_006530227.1.
UniGeneiMm.262021.

Genome annotation databases

EnsembliENSMUST00000031617; ENSMUSP00000031617; ENSMUSG00000029614.
GeneIDi19988.
KEGGimmu:19988.
UCSCiuc008ziq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF374195 Genomic DNA. Translation: AAK56936.1 .
BC062880 mRNA. Translation: AAH62880.1 .
X81987 mRNA. Translation: CAA57513.1 . Different initiation.
CCDSi CCDS19632.1.
PIRi S55922.
RefSeqi NP_035420.2. NM_011290.5.
XP_006530290.1. XM_006530227.1.
UniGenei Mm.262021.

3D structure databases

ProteinModelPortali P47911.
SMRi P47911. Positions 50-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202987. 11 interactions.
IntActi P47911. 7 interactions.
MINTi MINT-1857899.

PTM databases

PhosphoSitei P47911.

Proteomic databases

MaxQBi P47911.
PaxDbi P47911.
PRIDEi P47911.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031617 ; ENSMUSP00000031617 ; ENSMUSG00000029614 .
GeneIDi 19988.
KEGGi mmu:19988.
UCSCi uc008ziq.3. mouse.

Organism-specific databases

CTDi 6128.
MGIi MGI:108057. Rpl6.

Phylogenomic databases

eggNOGi COG2163.
HOGENOMi HOG000207317.
HOVERGENi HBG002565.
InParanoidi P47911.
KOi K02934.
OMAi YELTEQR.
OrthoDBi EOG78D7MH.
PhylomeDBi P47911.
TreeFami TF300115.

Enzyme and pathway databases

Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_231519. Eukaryotic Translation Termination.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_253640. Peptide chain elongation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Miscellaneous databases

NextBioi 297499.
PROi P47911.
SOURCEi Search...

Gene expression databases

Bgeei P47911.
CleanExi MM_RPL6.
ExpressionAtlasi P47911. baseline and differential.
Genevestigatori P47911.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
InterProi IPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR10715. PTHR10715. 1 hit.
Pfami PF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
PROSITEi PS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Wang J.-S., Han H., Yang X., Li R., Zhou P.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The mouse homologue of the HTLV-I tax responsive element binding protein TAXREB107 is a highly conserved gene which may regulate some basal cellular functions."
    Nacken W., Klempt M., Sorg C.
    Biochim. Biophys. Acta 1261:432-434(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-296.
  4. "Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
    Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
    EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IPO9.

Entry informationi

Entry nameiRL6_MOUSE
AccessioniPrimary (citable) accession number: P47911
Secondary accession number(s): Q6P5I2, Q925C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3