P47911 (RL6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L6

Alternative name(s):
TAX-responsive enhancer element-binding protein 107
Short name=TAXREB107

Gene names

Name:

Rpl6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	May bind IPO9 with low affinity.
Sequence similarities	Belongs to the ribosomal protein L6e family.
Sequence caution	The sequence CAA57513.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from sequence alignment PubMed 11707324. Source: MGI nucleolus Inferred from sequence alignment PubMed 11707324. Source: MGI ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 296	295	60S ribosomal protein L6		PRO_0000171010
Amino acid modifications
	Modified residue	135	1	Phosphoserine By similarity
	Modified residue	226	1	N6-acetyllysine By similarity
	Modified residue	247	1	N6-acetyllysine By similarity
Experimental info
	Sequence conflict	5	1	K → R Ref.3
	Sequence conflict	10	1	K → M in CAA57513. Ref.3
	Sequence conflict	75	1	L → F in AAH62880. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P47911 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: D65D5EF517660836	FASTA	296	33,510
	10 20 30 40 50 60 MAGEKAPDTK EKKPAAKKAG SDAAASRPRA AKVAKKVHPK GKKPKKAKPH CSRNPVLVRG 70 80 90 100 110 120 IGRYSRSAMY SRKALYKRKY SAAKTKVEKK KKKEKVLATV TKTVGGDKNG GTRVVKLRKM 130 140 150 160 170 180 PRYYPTEDVP RKLLSHGKKP FSQHVRRLRS SITPGTVLII LTGRHRGKRV VFLKQLDSGL 190 200 210 220 230 240 LLVTGPLVIN RVPLRRTHQK FVIATSTKVD ISDVKIPKHL TDAYFKKKQL RKPRHQEGEI 250 260 270 280 290 FDTEKEKYEI TEQRKADQKA VDLQILPKIK AVPQLQGYLR SQFSLTNGMY PHKLVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wang J.-S., Han H., Yang X., Li R., Zhou P. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[3]	"The mouse homologue of the HTLV-I tax responsive element binding protein TAXREB107 is a highly conserved gene which may regulate some basal cellular functions." Nacken W., Klempt M., Sorg C. Biochim. Biophys. Acta 1261:432-434(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-296.
[4]	"Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains." Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D. EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IPO9.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF374195 Genomic DNA. Translation: AAK56936.1. BC062880 mRNA. Translation: AAH62880.1. X81987 mRNA. Translation: CAA57513.1. Different initiation.
IPI	IPI00313222.
PIR	S55922.
RefSeq	NP_035420.2. NM_011290.5.
UniGene	Mm.262021.
3D structure databases
ProteinModelPortal	P47911.
SMR	P47911. Positions 60-296.
ModBase	Search...
Protein-protein interaction databases
IntAct	P47911. 3 interactions.
PTM databases
PhosphoSite	P47911.
Proteomic databases
PaxDb	P47911.
PRIDE	P47911.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031617; ENSMUSP00000031617; ENSMUSG00000029614.
GeneID	19988.
KEGG	mmu:19988.
Organism-specific databases
CTD	6128.
MGI	MGI:108057. Rpl6.
Phylogenomic databases
eggNOG	COG2163.
HOGENOM	HOG000207317.
HOVERGEN	HBG002565.
InParanoid	P47911.
KO	K02934.
OMA	KYELTEQ.
OrthoDB	EOG4W0XDZ.
Gene expression databases
ArrayExpress	P47911.
Bgee	P47911.
CleanEx	MM_RPL6.
Genevestigator	P47911.
GermOnline	ENSMUSG00000029614. Mus musculus.
Family and domain databases
Gene3D	2.30.30.30. 1 hit.
InterPro	IPR014722. Rib_L2_dom2. IPR005568. Ribosomal_L6_N. IPR000915. Ribosomal_L6E. [Graphical view]
PANTHER	PTHR10715. PTHR10715. 1 hit.
Pfam	PF01159. Ribosomal_L6e. 1 hit. PF03868. Ribosomal_L6e_N. 1 hit. [Graphical view]
PROSITE	PS01170. RIBOSOMAL_L6E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297499.
SOURCE	Search...

Entry information

Entry name

RL6_MOUSE

Accession

Primary (citable) accession number: P47911
Secondary accession number(s): Q6P5I2, Q925C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program