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Protein

60S ribosomal protein L6

Gene

Rpl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
TAX-responsive enhancer element-binding protein 107
Short name:
TAXREB107
Gene namesi
Name:Rpl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108057. Rpl6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001710102 – 29660S ribosomal protein L6Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineBy similarity1
Modified residuei247N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP47911.
PaxDbiP47911.
PeptideAtlasiP47911.
PRIDEiP47911.

PTM databases

iPTMnetiP47911.
PhosphoSitePlusiP47911.
SwissPalmiP47911.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029614.
CleanExiMM_RPL6.
ExpressionAtlasiP47911. baseline and differential.
GenevisibleiP47911. MM.

Interactioni

Subunit structurei

May bind IPO9 with low affinity.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202987. 4 interactors.
IntActiP47911. 8 interactors.
MINTiMINT-1857899.
STRINGi10090.ENSMUSP00000031617.

Structurei

3D structure databases

ProteinModelPortaliP47911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
HOVERGENiHBG002565.
InParanoidiP47911.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
PhylomeDBiP47911.
TreeFamiTF300115.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKAPDTK EKKPAAKKAG SDAAASRPRA AKVAKKVHPK GKKPKKAKPH
60 70 80 90 100
CSRNPVLVRG IGRYSRSAMY SRKALYKRKY SAAKTKVEKK KKKEKVLATV
110 120 130 140 150
TKTVGGDKNG GTRVVKLRKM PRYYPTEDVP RKLLSHGKKP FSQHVRRLRS
160 170 180 190 200
SITPGTVLII LTGRHRGKRV VFLKQLDSGL LLVTGPLVIN RVPLRRTHQK
210 220 230 240 250
FVIATSTKVD ISDVKIPKHL TDAYFKKKQL RKPRHQEGEI FDTEKEKYEI
260 270 280 290
TEQRKADQKA VDLQILPKIK AVPQLQGYLR SQFSLTNGMY PHKLVF
Length:296
Mass (Da):33,510
Last modified:January 23, 2007 - v3
Checksum:iD65D5EF517660836
GO

Sequence cautioni

The sequence CAA57513 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → R (PubMed:7537974).Curated1
Sequence conflicti10K → M in CAA57513 (PubMed:7537974).Curated1
Sequence conflicti75L → F in AAH62880 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF374195 Genomic DNA. Translation: AAK56936.1.
BC062880 mRNA. Translation: AAH62880.1.
X81987 mRNA. Translation: CAA57513.1. Different initiation.
CCDSiCCDS19632.1.
PIRiS55922.
RefSeqiNP_035420.2. NM_011290.5.
XP_006530290.1. XM_006530227.1.
UniGeneiMm.262021.

Genome annotation databases

EnsembliENSMUST00000031617; ENSMUSP00000031617; ENSMUSG00000029614.
GeneIDi19988.
KEGGimmu:19988.
UCSCiuc008ziq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF374195 Genomic DNA. Translation: AAK56936.1.
BC062880 mRNA. Translation: AAH62880.1.
X81987 mRNA. Translation: CAA57513.1. Different initiation.
CCDSiCCDS19632.1.
PIRiS55922.
RefSeqiNP_035420.2. NM_011290.5.
XP_006530290.1. XM_006530227.1.
UniGeneiMm.262021.

3D structure databases

ProteinModelPortaliP47911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202987. 4 interactors.
IntActiP47911. 8 interactors.
MINTiMINT-1857899.
STRINGi10090.ENSMUSP00000031617.

PTM databases

iPTMnetiP47911.
PhosphoSitePlusiP47911.
SwissPalmiP47911.

Proteomic databases

EPDiP47911.
PaxDbiP47911.
PeptideAtlasiP47911.
PRIDEiP47911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031617; ENSMUSP00000031617; ENSMUSG00000029614.
GeneIDi19988.
KEGGimmu:19988.
UCSCiuc008ziq.3. mouse.

Organism-specific databases

CTDi6128.
MGIiMGI:108057. Rpl6.

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
HOVERGENiHBG002565.
InParanoidiP47911.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
PhylomeDBiP47911.
TreeFamiTF300115.

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP47911.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029614.
CleanExiMM_RPL6.
ExpressionAtlasiP47911. baseline and differential.
GenevisibleiP47911. MM.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL6_MOUSE
AccessioniPrimary (citable) accession number: P47911
Secondary accession number(s): Q6P5I2, Q925C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.