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P47911

- RL6_MOUSE

UniProt

P47911 - RL6_MOUSE

Protein

60S ribosomal protein L6

Gene

Rpl6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L6
    Alternative name(s):
    TAX-responsive enhancer element-binding protein 107
    Short name:
    TAXREB107
    Gene namesi
    Name:Rpl6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:108057. Rpl6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleolus Source: MGI
    3. nucleus Source: MGI
    4. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 29629560S ribosomal protein L6PRO_0000171010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei135 – 1351PhosphoserineBy similarity
    Modified residuei226 – 2261N6-acetyllysineBy similarity
    Modified residuei247 – 2471N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP47911.
    PaxDbiP47911.
    PRIDEiP47911.

    PTM databases

    PhosphoSiteiP47911.

    Expressioni

    Gene expression databases

    BgeeiP47911.
    CleanExiMM_RPL6.
    GenevestigatoriP47911.

    Interactioni

    Subunit structurei

    May bind IPO9 with low affinity.

    Protein-protein interaction databases

    BioGridi202987. 11 interactions.
    IntActiP47911. 7 interactions.
    MINTiMINT-1857899.

    Structurei

    3D structure databases

    ProteinModelPortaliP47911.
    SMRiP47911. Positions 50-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L6e family.Curated

    Phylogenomic databases

    eggNOGiCOG2163.
    HOGENOMiHOG000207317.
    HOVERGENiHBG002565.
    InParanoidiP47911.
    KOiK02934.
    OMAiYELTEQR.
    OrthoDBiEOG78D7MH.
    PhylomeDBiP47911.
    TreeFamiTF300115.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    InterProiIPR000915. 60S_ribosomal_L6E.
    IPR014722. Rib_L2_dom2.
    IPR005568. Ribosomal_L6_N.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR10715. PTHR10715. 1 hit.
    PfamiPF01159. Ribosomal_L6e. 1 hit.
    PF03868. Ribosomal_L6e_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47911-1 [UniParc]FASTAAdd to Basket

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    MAGEKAPDTK EKKPAAKKAG SDAAASRPRA AKVAKKVHPK GKKPKKAKPH    50
    CSRNPVLVRG IGRYSRSAMY SRKALYKRKY SAAKTKVEKK KKKEKVLATV 100
    TKTVGGDKNG GTRVVKLRKM PRYYPTEDVP RKLLSHGKKP FSQHVRRLRS 150
    SITPGTVLII LTGRHRGKRV VFLKQLDSGL LLVTGPLVIN RVPLRRTHQK 200
    FVIATSTKVD ISDVKIPKHL TDAYFKKKQL RKPRHQEGEI FDTEKEKYEI 250
    TEQRKADQKA VDLQILPKIK AVPQLQGYLR SQFSLTNGMY PHKLVF 296
    Length:296
    Mass (Da):33,510
    Last modified:January 23, 2007 - v3
    Checksum:iD65D5EF517660836
    GO

    Sequence cautioni

    The sequence CAA57513.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51K → R(PubMed:7537974)Curated
    Sequence conflicti10 – 101K → M in CAA57513. (PubMed:7537974)Curated
    Sequence conflicti75 – 751L → F in AAH62880. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF374195 Genomic DNA. Translation: AAK56936.1.
    BC062880 mRNA. Translation: AAH62880.1.
    X81987 mRNA. Translation: CAA57513.1. Different initiation.
    CCDSiCCDS19632.1.
    PIRiS55922.
    RefSeqiNP_035420.2. NM_011290.5.
    XP_006530290.1. XM_006530227.1.
    UniGeneiMm.262021.

    Genome annotation databases

    EnsembliENSMUST00000031617; ENSMUSP00000031617; ENSMUSG00000029614.
    GeneIDi19988.
    KEGGimmu:19988.
    UCSCiuc008ziq.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF374195 Genomic DNA. Translation: AAK56936.1 .
    BC062880 mRNA. Translation: AAH62880.1 .
    X81987 mRNA. Translation: CAA57513.1 . Different initiation.
    CCDSi CCDS19632.1.
    PIRi S55922.
    RefSeqi NP_035420.2. NM_011290.5.
    XP_006530290.1. XM_006530227.1.
    UniGenei Mm.262021.

    3D structure databases

    ProteinModelPortali P47911.
    SMRi P47911. Positions 50-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202987. 11 interactions.
    IntActi P47911. 7 interactions.
    MINTi MINT-1857899.

    PTM databases

    PhosphoSitei P47911.

    Proteomic databases

    MaxQBi P47911.
    PaxDbi P47911.
    PRIDEi P47911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031617 ; ENSMUSP00000031617 ; ENSMUSG00000029614 .
    GeneIDi 19988.
    KEGGi mmu:19988.
    UCSCi uc008ziq.3. mouse.

    Organism-specific databases

    CTDi 6128.
    MGIi MGI:108057. Rpl6.

    Phylogenomic databases

    eggNOGi COG2163.
    HOGENOMi HOG000207317.
    HOVERGENi HBG002565.
    InParanoidi P47911.
    KOi K02934.
    OMAi YELTEQR.
    OrthoDBi EOG78D7MH.
    PhylomeDBi P47911.
    TreeFami TF300115.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    NextBioi 297499.
    PROi P47911.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47911.
    CleanExi MM_RPL6.
    Genevestigatori P47911.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    InterProi IPR000915. 60S_ribosomal_L6E.
    IPR014722. Rib_L2_dom2.
    IPR005568. Ribosomal_L6_N.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR10715. PTHR10715. 1 hit.
    Pfami PF01159. Ribosomal_L6e. 1 hit.
    PF03868. Ribosomal_L6e_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    PROSITEi PS01170. RIBOSOMAL_L6E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Wang J.-S., Han H., Yang X., Li R., Zhou P.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The mouse homologue of the HTLV-I tax responsive element binding protein TAXREB107 is a highly conserved gene which may regulate some basal cellular functions."
      Nacken W., Klempt M., Sorg C.
      Biochim. Biophys. Acta 1261:432-434(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-296.
    4. "Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
      Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
      EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IPO9.

    Entry informationi

    Entry nameiRL6_MOUSE
    AccessioniPrimary (citable) accession number: P47911
    Secondary accession number(s): Q6P5I2, Q925C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3