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P47902

- CDX1_HUMAN

UniProt

P47902 - CDX1_HUMAN

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Protein

Homeobox protein CDX-1

Gene
CDX1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Could play a role in the terminal differentiation of the intestine.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi154 – 21360HomeoboxAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. bone morphogenesis Source: Ensembl
  3. organ morphogenesis Source: ProtInc
  4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP47902.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-1
Alternative name(s):
Caudal-type homeobox protein 1
Gene namesi
Name:CDX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1805. CDX1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Homeobox protein CDX-1PRO_0000048846Add
BLAST

Proteomic databases

PaxDbiP47902.
PRIDEiP47902.

PTM databases

PhosphoSiteiP47902.

Expressioni

Tissue specificityi

Intestinal epithelium.

Gene expression databases

BgeeiP47902.
CleanExiHS_CDX1.
GenevestigatoriP47902.

Organism-specific databases

HPAiHPA055196.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEBPAP497153EBI-8514176,EBI-1172054

Protein-protein interaction databases

BioGridi107474. 3 interactions.
IntActiP47902. 1 interaction.
MINTiMINT-6800278.
STRINGi9606.ENSP00000231656.

Structurei

3D structure databases

ProteinModelPortaliP47902.
SMRiP47902. Positions 130-214.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi143 – 1497Poly-Gly
Compositional biasi217 – 2215Poly-Gln

Sequence similaritiesi

Belongs to the Caudal homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG291290.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiP47902.
KOiK09312.
OMAiYSHVEPG.
OrthoDBiEOG71P2BK.
PhylomeDBiP47902.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P47902-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYVGYVLDKD SPVYPGPARP ASLGLGPQAY GPPAPPPAPP QYPDFSSYSH    50
VEPAPAPPTA WGAPFPAPKD DWAAAYGPGP AAPAASPASL AFGPPPDFSP 100
VPAPPGPGPG LLAQPLGGPG TPSSPGAQRP TPYEWMRRSV AAGGGGGSGK 150
TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI 200
WFQNRRAKER KVNKKKQQQQ QPPQPPMAHD ITATPAGPSL GGLCPSNTSL 250
LATSSPMPVK EEFLP 265
Length:265
Mass (Da):28,138
Last modified:October 17, 2006 - v2
Checksum:i484CB284E3357BC6
GO
Isoform 2 (identifier: P47902-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:130
Mass (Da):14,661
Checksum:i12D213E8A3BB7CFE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301P → R.
Corresponds to variant rs2302275 [ dbSNP | Ensembl ].
VAR_020149

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 135135Missing in isoform 2. VSP_021030Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 292QA → AN in AAA80284. 1 Publication
Sequence conflicti28 – 292QA → AN in AAC50237. 1 Publication
Sequence conflicti28 – 292QA → AN in AAB40602. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16360 Genomic DNA. Translation: AAA80284.1.
U15212 mRNA. Translation: AAC50237.1.
U51095 mRNA. Translation: AAB40602.1.
AF239666 mRNA. Translation: AAF61234.1.
BC096251 mRNA. Translation: AAH96251.1.
CCDSiCCDS4304.1. [P47902-1]
PIRiI38868.
I38881.
RefSeqiNP_001795.2. NM_001804.2. [P47902-1]
UniGeneiHs.1545.

Genome annotation databases

EnsembliENST00000231656; ENSP00000231656; ENSG00000113722. [P47902-1]
GeneIDi1044.
KEGGihsa:1044.
UCSCiuc003lrq.3. human. [P47902-1]

Polymorphism databases

DMDMi116241291.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16360 Genomic DNA. Translation: AAA80284.1 .
U15212 mRNA. Translation: AAC50237.1 .
U51095 mRNA. Translation: AAB40602.1 .
AF239666 mRNA. Translation: AAF61234.1 .
BC096251 mRNA. Translation: AAH96251.1 .
CCDSi CCDS4304.1. [P47902-1 ]
PIRi I38868.
I38881.
RefSeqi NP_001795.2. NM_001804.2. [P47902-1 ]
UniGenei Hs.1545.

3D structure databases

ProteinModelPortali P47902.
SMRi P47902. Positions 130-214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107474. 3 interactions.
IntActi P47902. 1 interaction.
MINTi MINT-6800278.
STRINGi 9606.ENSP00000231656.

PTM databases

PhosphoSitei P47902.

Polymorphism databases

DMDMi 116241291.

Proteomic databases

PaxDbi P47902.
PRIDEi P47902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000231656 ; ENSP00000231656 ; ENSG00000113722 . [P47902-1 ]
GeneIDi 1044.
KEGGi hsa:1044.
UCSCi uc003lrq.3. human. [P47902-1 ]

Organism-specific databases

CTDi 1044.
GeneCardsi GC05P149526.
HGNCi HGNC:1805. CDX1.
HPAi HPA055196.
MIMi 600746. gene.
neXtProti NX_P47902.
PharmGKBi PA26351.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291290.
HOGENOMi HOG000115975.
HOVERGENi HBG005302.
InParanoidi P47902.
KOi K09312.
OMAi YSHVEPG.
OrthoDBi EOG71P2BK.
PhylomeDBi P47902.
TreeFami TF351605.

Enzyme and pathway databases

SignaLinki P47902.

Miscellaneous databases

GeneWikii CDX1.
GenomeRNAii 1044.
NextBioi 4377.
PROi P47902.
SOURCEi Search...

Gene expression databases

Bgeei P47902.
CleanExi HS_CDX1.
Genevestigatori P47902.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene."
    Bonner C.A., Lofus S.K., Wasmuth J.J.
    Genomics 28:206-211(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  2. "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis."
    Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L.
    Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Colon carcinoma.
  3. "Molecular cloning and sequencing of the human CDX1 homeobox gene."
    Malakooti J.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiCDX1_HUMAN
AccessioniPrimary (citable) accession number: P47902
Secondary accession number(s): Q4VAU4, Q9NYK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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