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Protein

Homeobox protein CDX-1

Gene

CDX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi154 – 213HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP47902
SIGNORiP47902

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-1
Alternative name(s):
Caudal-type homeobox protein 1
Gene namesi
Name:CDX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113722.16
HGNCiHGNC:1805 CDX1
MIMi600746 gene
neXtProtiNX_P47902

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1044
OpenTargetsiENSG00000113722
PharmGKBiPA26351

Polymorphism and mutation databases

BioMutaiCDX1
DMDMi116241291

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488461 – 265Homeobox protein CDX-1Add BLAST265

Proteomic databases

MaxQBiP47902
PaxDbiP47902
PeptideAtlasiP47902
PRIDEiP47902
ProteomicsDBi55820
55821 [P47902-2]

PTM databases

iPTMnetiP47902
PhosphoSitePlusiP47902

Expressioni

Tissue specificityi

Intestinal epithelium.

Gene expression databases

BgeeiENSG00000113722
CleanExiHS_CDX1
ExpressionAtlasiP47902 baseline and differential
GenevisibleiP47902 HS

Organism-specific databases

HPAiHPA055196

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEBPAP497153EBI-8514176,EBI-1172054

Protein-protein interaction databases

BioGridi107474, 77 interactors
ELMiP47902
IntActiP47902, 1 interactor
MINTiP47902
STRINGi9606.ENSP00000231656

Structurei

Secondary structure

1265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi163 – 175Combined sources13
Helixi181 – 191Combined sources11
Helixi195 – 214Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LUXX-ray3.23K/L153-215[»]
ProteinModelPortaliP47902
SMRiP47902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 178Interaction with DNA1 PublicationAdd BLAST22
Regioni196 – 207Interaction with 5-mCpG DNA1 PublicationAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi143 – 149Poly-Gly7
Compositional biasi217 – 221Poly-Gln5

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0848 Eukaryota
ENOG4111W2J LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000115975
HOVERGENiHBG005302
InParanoidiP47902
KOiK09312
OMAiEDWHSYG
OrthoDBiEOG091G0LXJ
PhylomeDBiP47902
TreeFamiTF351605

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P47902-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYVGYVLDKD SPVYPGPARP ASLGLGPQAY GPPAPPPAPP QYPDFSSYSH
60 70 80 90 100
VEPAPAPPTA WGAPFPAPKD DWAAAYGPGP AAPAASPASL AFGPPPDFSP
110 120 130 140 150
VPAPPGPGPG LLAQPLGGPG TPSSPGAQRP TPYEWMRRSV AAGGGGGSGK
160 170 180 190 200
TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI
210 220 230 240 250
WFQNRRAKER KVNKKKQQQQ QPPQPPMAHD ITATPAGPSL GGLCPSNTSL
260
LATSSPMPVK EEFLP
Length:265
Mass (Da):28,138
Last modified:October 17, 2006 - v2
Checksum:i484CB284E3357BC6
GO
Isoform 2 (identifier: P47902-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:130
Mass (Da):14,661
Checksum:i12D213E8A3BB7CFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29QA → AN in AAA80284 (PubMed:8530027).Curated2
Sequence conflicti28 – 29QA → AN in AAC50237 (PubMed:8530027).Curated2
Sequence conflicti28 – 29QA → AN in AAB40602 (PubMed:9036867).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020149130P → R. Corresponds to variant dbSNP:rs2302275Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0210301 – 135Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16360 Genomic DNA Translation: AAA80284.1
U15212 mRNA Translation: AAC50237.1
U51095 mRNA Translation: AAB40602.1
AF239666 mRNA Translation: AAF61234.1
BC096251 mRNA Translation: AAH96251.1
CCDSiCCDS4304.1 [P47902-1]
PIRiI38868
I38881
RefSeqiNP_001795.2, NM_001804.2 [P47902-1]
UniGeneiHs.1545

Genome annotation databases

EnsembliENST00000231656; ENSP00000231656; ENSG00000113722 [P47902-1]
GeneIDi1044
KEGGihsa:1044
UCSCiuc003lrq.4 human [P47902-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDX1_HUMAN
AccessioniPrimary (citable) accession number: P47902
Secondary accession number(s): Q4VAU4, Q9NYK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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