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P47902 (CDX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein CDX-1
Alternative name(s):
Caudal-type homeobox protein 1
Gene names
Name:CDX1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could play a role in the terminal differentiation of the intestine.

Subcellular location

Nucleus.

Tissue specificity

Intestinal epithelium.

Sequence similarities

Belongs to the Caudal homeobox family.

Contains 1 homeobox DNA-binding domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CEBPAP497153EBI-8514176,EBI-1172054

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P47902-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P47902-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Homeobox protein CDX-1
PRO_0000048846

Regions

DNA binding154 – 21360Homeobox
Compositional bias143 – 1497Poly-Gly
Compositional bias217 – 2215Poly-Gln

Natural variations

Alternative sequence1 – 135135Missing in isoform 2.
VSP_021030
Natural variant1301P → R.
Corresponds to variant rs2302275 [ dbSNP | Ensembl ].
VAR_020149

Experimental info

Sequence conflict28 – 292QA → AN in AAA80284. Ref.1
Sequence conflict28 – 292QA → AN in AAC50237. Ref.1
Sequence conflict28 – 292QA → AN in AAB40602. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 484CB284E3357BC6

FASTA26528,138
        10         20         30         40         50         60 
MYVGYVLDKD SPVYPGPARP ASLGLGPQAY GPPAPPPAPP QYPDFSSYSH VEPAPAPPTA 

        70         80         90        100        110        120 
WGAPFPAPKD DWAAAYGPGP AAPAASPASL AFGPPPDFSP VPAPPGPGPG LLAQPLGGPG 

       130        140        150        160        170        180 
TPSSPGAQRP TPYEWMRRSV AAGGGGGSGK TRTKDKYRVV YTDHQRLELE KEFHYSRYIT 

       190        200        210        220        230        240 
IRRKSELAAN LGLTERQVKI WFQNRRAKER KVNKKKQQQQ QPPQPPMAHD ITATPAGPSL 

       250        260 
GGLCPSNTSL LATSSPMPVK EEFLP 

« Hide

Isoform 2 [UniParc].

Checksum: 12D213E8A3BB7CFE
Show »

FASTA13014,661

References

« Hide 'large scale' references
[1]"Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene."
Bonner C.A., Lofus S.K., Wasmuth J.J.
Genomics 28:206-211(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
Tissue: Small intestine.
[2]"Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis."
Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L.
Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Colon carcinoma.
[3]"Molecular cloning and sequencing of the human CDX1 homeobox gene."
Malakooti J.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U16360 Genomic DNA. Translation: AAA80284.1.
U15212 mRNA. Translation: AAC50237.1.
U51095 mRNA. Translation: AAB40602.1.
AF239666 mRNA. Translation: AAF61234.1.
BC096251 mRNA. Translation: AAH96251.1.
PIRI38868.
I38881.
RefSeqNP_001795.2. NM_001804.2.
UniGeneHs.1545.

3D structure databases

ProteinModelPortalP47902.
SMRP47902. Positions 130-214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107474. 2 interactions.
IntActP47902. 1 interaction.
MINTMINT-6800278.
STRING9606.ENSP00000231656.

PTM databases

PhosphoSiteP47902.

Polymorphism databases

DMDM116241291.

Proteomic databases

PaxDbP47902.
PRIDEP47902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231656; ENSP00000231656; ENSG00000113722. [P47902-1]
GeneID1044.
KEGGhsa:1044.
UCSCuc003lrq.3. human. [P47902-1]

Organism-specific databases

CTD1044.
GeneCardsGC05P149526.
HGNCHGNC:1805. CDX1.
HPAHPA055196.
MIM600746. gene.
neXtProtNX_P47902.
PharmGKBPA26351.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291290.
HOGENOMHOG000115975.
HOVERGENHBG005302.
InParanoidP47902.
KOK09312.
OMAYSHVEPG.
OrthoDBEOG71P2BK.
PhylomeDBP47902.
TreeFamTF351605.

Enzyme and pathway databases

SignaLinkP47902.

Gene expression databases

BgeeP47902.
CleanExHS_CDX1.
GenevestigatorP47902.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCDX1.
GenomeRNAi1044.
NextBio4377.
PROP47902.
SOURCESearch...

Entry information

Entry nameCDX1_HUMAN
AccessionPrimary (citable) accession number: P47902
Secondary accession number(s): Q4VAU4, Q9NYK8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM