P47902 (CDX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein CDX-1

Alternative name(s):
Caudal-type homeobox protein 1

Gene names

Name:

CDX1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could play a role in the terminal differentiation of the intestine.
Subcellular location	Nucleus.
Tissue specificity	Intestinal epithelium.
Sequence similarities	Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara bone morphogenesis Inferred from electronic annotation. Source: Compara organ morphogenesis Traceable author statement Ref.1. Source: ProtInc positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P47902-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P47902-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Homeobox protein CDX-1		PRO_0000048846
Regions
	DNA binding	154 – 213	60	Homeobox
	Compositional bias	143 – 149	7	Poly-Gly
	Compositional bias	217 – 221	5	Poly-Gln
Natural variations
	Alternative sequence	1 – 135	135	Missing in isoform 2.		VSP_021030
	Natural variant	130	1	P → R. Corresponds to variant rs2302275 [ dbSNP | Ensembl ].		VAR_020149
Experimental info
	Sequence conflict	28 – 29	2	QA → AN in AAA80284. Ref.1
	Sequence conflict	28 – 29	2	QA → AN in AAC50237. Ref.1
	Sequence conflict	28 – 29	2	QA → AN in AAB40602. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 484CB284E3357BC6	FASTA	265	28,138
	10 20 30 40 50 60 MYVGYVLDKD SPVYPGPARP ASLGLGPQAY GPPAPPPAPP QYPDFSSYSH VEPAPAPPTA 70 80 90 100 110 120 WGAPFPAPKD DWAAAYGPGP AAPAASPASL AFGPPPDFSP VPAPPGPGPG LLAQPLGGPG 130 140 150 160 170 180 TPSSPGAQRP TPYEWMRRSV AAGGGGGSGK TRTKDKYRVV YTDHQRLELE KEFHYSRYIT 190 200 210 220 230 240 IRRKSELAAN LGLTERQVKI WFQNRRAKER KVNKKKQQQQ QPPQPPMAHD ITATPAGPSL 250 260 GGLCPSNTSL LATSSPMPVK EEFLP
	Isoform 2 [UniParc]. Checksum: 12D213E8A3BB7CFE	FASTA	130	14,661
	10 20 30 40 50 60 MRRSVAAGGG GGSGKTRTKD KYRVVYTDHQ RLELEKEFHY SRYITIRRKS ELAANLGLTE 70 80 90 100 110 120 RQVKIWFQNR RAKERKVNKK KQQQQQPPQP PMAHDITATP AGPSLGGLCP SNTSLLATSS 130 PMPVKEEFLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene." Bonner C.A., Lofus S.K., Wasmuth J.J. Genomics 28:206-211(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). Tissue: Small intestine.
[2]	"Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis." Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L. Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Colon carcinoma.
[3]	"Molecular cloning and sequencing of the human CDX1 homeobox gene." Malakooti J. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U16360 Genomic DNA. Translation: AAA80284.1. U15212 mRNA. Translation: AAC50237.1. U51095 mRNA. Translation: AAB40602.1. AF239666 mRNA. Translation: AAF61234.1. BC096251 mRNA. Translation: AAH96251.1.
IPI	IPI00790637. IPI00795021.
PIR	I38868. I38881.
RefSeq	NP_001795.2. NM_001804.2.
UniGene	Hs.1545.
3D structure databases
ProteinModelPortal	P47902.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6800278.
STRING	9606.ENSP00000231656.
PTM databases
PhosphoSite	P47902.
Polymorphism databases
DMDM	116241291.
Proteomic databases
PaxDb	P47902.
PRIDE	P47902.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000231656; ENSP00000231656; ENSG00000113722.
GeneID	1044.
KEGG	hsa:1044.
UCSC	uc003lrq.3. human.
Organism-specific databases
CTD	1044.
GeneCards	GC05P149526.
HGNC	HGNC:1805. CDX1.
HPA	HPA055196.
MIM	600746. gene.
neXtProt	NX_P47902.
PharmGKB	PA26351.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG291290.
HOGENOM	HOG000115975.
HOVERGEN	HBG005302.
InParanoid	P47902.
KO	K09312.
OMA	YSHVEPG.
OrthoDB	EOG42FSK7.
PhylomeDB	P47902.
Gene expression databases
Bgee	P47902.
CleanEx	HS_CDX1.
Genevestigator	P47902.
GermOnline	ENSG00000113722. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR006820. Caudal_activation_dom. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF04731. Caudal_act. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1044.
NextBio	4377.
SOURCE	Search...

Entry information

Entry name

CDX1_HUMAN

Accession

Primary (citable) accession number: P47902
Secondary accession number(s): Q4VAU4, Q9NYK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.