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Protein

Vasopressin V1b receptor

Gene

AVPR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

GO - Molecular functioni

  • peptide binding Source: GO_Central
  • protein kinase C binding Source: ProtInc
  • vasopressin receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).

Protein family/group databases

TCDBi9.A.14.10.2. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1b receptor
Short name:
V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene namesi
Name:AVPR1B
Synonyms:AVPR3, VPR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198049.6.
HGNCiHGNC:896. AVPR1B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 59Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 93Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini94 – 108ExtracellularSequence analysisAdd BLAST15
Transmembranei109 – 130Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini131 – 151CytoplasmicSequence analysisAdd BLAST21
Transmembranei152 – 173Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini174 – 201ExtracellularSequence analysisAdd BLAST28
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 283CytoplasmicSequence analysisAdd BLAST61
Transmembranei284 – 303Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini304 – 321ExtracellularSequence analysisAdd BLAST18
Transmembranei322 – 341Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini342 – 424CytoplasmicSequence analysisAdd BLAST83

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi553.
OpenTargetsiENSG00000198049.
PharmGKBiPA25188.

Chemistry databases

ChEMBLiCHEMBL1921.
DrugBankiDB00035. Desmopressin.
DB05452. PH-284.
DB05455. SR 121463.
DB02638. Terlipressin.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi367.

Polymorphism and mutation databases

BioMutaiAVPR1B.
DMDMi1351392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702031 – 424Vasopressin V1b receptorAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47901.
PRIDEiP47901.

PTM databases

iPTMnetiP47901.
PhosphoSitePlusiP47901.

Expressioni

Gene expression databases

BgeeiENSG00000198049.
CleanExiHS_AVPR1B.
GenevisibleiP47901. HS.

Interactioni

GO - Molecular functioni

  • protein kinase C binding Source: ProtInc

Protein-protein interaction databases

BioGridi107034. 1 interactor.
STRINGi9606.ENSP00000356094.

Chemistry databases

BindingDBiP47901.

Structurei

3D structure databases

ProteinModelPortaliP47901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP47901.
KOiK04227.
OMAiKVKTQAW.
OrthoDBiEOG091G0DB6.
PhylomeDBiP47901.
TreeFamiTF106499.

Family and domain databases

CDDicd15386. 7tmA_V1bR. 1 hit.
InterProiView protein in InterPro
IPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
SMARTiView protein in SMART
SM01164. DUF1856. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P47901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG
60 70 80 90 100
GNLAVLLTLG QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF
110 120 130 140 150
QGPDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPGQST
160 170 180 190 200
YLLIAAPWLL AAIFSLPQVF IFSLREVIQG SGVLDCWADF GFPWGPRAYL
210 220 230 240 250
TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG GGGWRTWDRP
260 270 280 290 300
SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV
310 320 330 340 350
QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL
360 370 380 390 400
RHLACCGGPQ PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR
410 420
PRPEESPRDL ELADGEGTAE TIIF
Length:424
Mass (Da):46,971
Last modified:February 1, 1996 - v1
Checksum:i35190281D3EDB6A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02515965K → N2 PublicationsCorresponds to variant dbSNP:rs35369693Ensembl.1
Natural variantiVAR_025160191G → R1 PublicationCorresponds to variant dbSNP:rs33990840Ensembl.1
Natural variantiVAR_061228224H → Q. Corresponds to variant dbSNP:rs3891058Ensembl.1
Natural variantiVAR_025161267S → G1 PublicationCorresponds to variant dbSNP:rs36030374Ensembl.1
Natural variantiVAR_025162364R → H2 PublicationsCorresponds to variant dbSNP:rs28632197Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31833 mRNA. Translation: BAA06621.1.
L37112 mRNA. Translation: AAA65687.1.
AF030512 mRNA. Translation: AAB84293.1.
AF101726 mRNA. Translation: AAD17892.1.
AF152238 Genomic DNA. Translation: AAF33681.1.
EU432111 mRNA. Translation: ABY87910.1.
DQ194816 Genomic DNA. Translation: ABA03171.1.
BX571818 Genomic DNA. No translation available.
CCDSiCCDS73015.1.
PIRiA55089.
RefSeqiNP_000698.1. NM_000707.3.
UniGeneiHs.1372.

Genome annotation databases

EnsembliENST00000367126; ENSP00000356094; ENSG00000198049.
GeneIDi553.
KEGGihsa:553.
UCSCiuc001hds.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiV1BR_HUMAN
AccessioniPrimary (citable) accession number: P47901
Secondary accession number(s): B0M0J6, Q5TZ00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families