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P47901 (V1BR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin V1b receptor

Short name=V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene names
Name:AVPR1B
Synonyms:AVPR3, VPR3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Vasopressin V1b receptor
PRO_0000070203

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5924Helical; Name=1; Potential
Topological domain60 – 7112Cytoplasmic Potential
Transmembrane72 – 9322Helical; Name=2; Potential
Topological domain94 – 10815Extracellular Potential
Transmembrane109 – 13022Helical; Name=3; Potential
Topological domain131 – 15121Cytoplasmic Potential
Transmembrane152 – 17322Helical; Name=4; Potential
Topological domain174 – 20128Extracellular Potential
Transmembrane202 – 22221Helical; Name=5; Potential
Topological domain223 – 28361Cytoplasmic Potential
Transmembrane284 – 30320Helical; Name=6; Potential
Topological domain304 – 32118Extracellular Potential
Transmembrane322 – 34120Helical; Name=7; Potential
Topological domain342 – 42483Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond107 ↔ 186 By similarity

Natural variations

Natural variant651K → N. Ref.7 Ref.9
Corresponds to variant rs35369693 [ dbSNP | Ensembl ].
VAR_025159
Natural variant1911G → R. Ref.7
Corresponds to variant rs33990840 [ dbSNP | Ensembl ].
VAR_025160
Natural variant2241H → Q.
Corresponds to variant rs3891058 [ dbSNP | Ensembl ].
VAR_061228
Natural variant2671S → G. Ref.7
Corresponds to variant rs36030374 [ dbSNP | Ensembl ].
VAR_025161
Natural variant3641R → H. Ref.7 Ref.9
Corresponds to variant rs28632197 [ dbSNP | Ensembl ].
VAR_025162

Sequences

Sequence LengthMass (Da)Tools
P47901 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 35190281D3EDB6A7

FASTA42446,971
        10         20         30         40         50         60 
MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG 

        70         80         90        100        110        120 
QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA 

       130        140        150        160        170        180 
STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG 

       190        200        210        220        230        240 
SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG 

       250        260        270        280        290        300 
GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV 

       310        320        330        340        350        360 
QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ 

       370        380        390        400        410        420 
PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE 


TIIF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor."
Sugimoto T., Saito M., Mochizuki S., Watanabe Y., Hashimoto S., Kawashima H.
J. Biol. Chem. 269:27088-27092(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[2]"Cloning and characterization of the human V3 pituitary vasopressin receptor."
de Keyzer Y., Auzan C., Lenne F., Beldjord C., Thibonnier M., Bertagna X., Clauser E.
FEBS Lett. 356:215-220(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[3]"Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma."
North W.G., Fay M.J., Longo K.A., Du J.
Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung carcinoma.
[4]"Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
North W.G., Fay M.J., Longo K.A., Du J.
Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene."
Rene P., Lenne F., Ventura M.A., Bertagna X., de Keyzer Y.
Gene 241:57-64(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[7]SeattleSNPs variation discovery resource
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-65; ARG-191; GLY-267 AND HIS-364.
[8]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders."
Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J., Tamas Z., Kennedy J.L., Vetro A., Kovacs M., Barr C.L.
Arch. Gen. Psychiatry 64:1189-1195(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASN-65 AND HIS-364.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D31833 mRNA. Translation: BAA06621.1.
L37112 mRNA. Translation: AAA65687.1.
AF030512 mRNA. Translation: AAB84293.1.
AF101726 mRNA. Translation: AAD17892.1.
AF152238 Genomic DNA. Translation: AAF33681.1.
EU432111 mRNA. Translation: ABY87910.1.
DQ194816 Genomic DNA. Translation: ABA03171.1.
BX571818 Genomic DNA. Translation: CAH73262.1.
PIRA55089.
RefSeqNP_000698.1. NM_000707.3.
UniGeneHs.1372.

3D structure databases

ProteinModelPortalP47901.
SMRP47901. Positions 38-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107034. 1 interaction.
STRING9606.ENSP00000356094.

Chemistry

BindingDBP47901.
ChEMBLCHEMBL1921.
DrugBankDB00035. Desmopressin.
DB02638. Terlipressin.
DB00067. Vasopressin.
GuidetoPHARMACOLOGY367.

Protein family/group databases

TCDB9.A.14.10.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteP47901.

Polymorphism databases

DMDM1351392.

Proteomic databases

PaxDbP47901.
PRIDEP47901.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367126; ENSP00000356094; ENSG00000198049.
ENST00000580826; ENSP00000462301; ENSG00000265027.
GeneID553.
KEGGhsa:553.
UCSCuc001hds.2. human.

Organism-specific databases

CTD553.
GeneCardsGC01P206223.
HGNCHGNC:896. AVPR1B.
HPAHPA017337.
MIM600264. gene.
neXtProtNX_P47901.
PharmGKBPA25188.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299951.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidP47901.
KOK04227.
OMAKVKTQAW.
OrthoDBEOG7Z69CP.
PhylomeDBP47901.
TreeFamTF106499.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP47901.
CleanExHS_AVPR1B.
GenevestigatorP47901.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiArginine_vasopressin_receptor_1B.
GenomeRNAi553.
NextBio2285.
PROP47901.
SOURCESearch...

Entry information

Entry nameV1BR_HUMAN
AccessionPrimary (citable) accession number: P47901
Secondary accession number(s): B0M0J6, Q5TZ00
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries