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P47901

- V1BR_HUMAN

UniProt

P47901 - V1BR_HUMAN

Protein

Vasopressin V1b receptor

Gene

AVPR1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

    GO - Molecular functioni

    1. protein kinase C binding Source: ProtInc
    2. vasopressin receptor activity Source: ProtInc

    GO - Biological processi

    1. activation of phospholipase C activity Source: ProtInc
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    4. regulation of systemic arterial blood pressure by vasopressin Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.

    Protein family/group databases

    TCDBi9.A.14.10.2. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V1b receptor
    Short name:
    V1bR
    Alternative name(s):
    AVPR V1b
    AVPR V3
    Antidiuretic hormone receptor 1b
    Vasopressin V3 receptor
    Gene namesi
    Name:AVPR1B
    Synonyms:AVPR3, VPR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:896. AVPR1B.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: ProtInc
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25188.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Vasopressin V1b receptorPRO_0000070203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP47901.
    PRIDEiP47901.

    PTM databases

    PhosphoSiteiP47901.

    Expressioni

    Gene expression databases

    BgeeiP47901.
    CleanExiHS_AVPR1B.
    GenevestigatoriP47901.

    Organism-specific databases

    HPAiHPA017337.

    Interactioni

    Protein-protein interaction databases

    BioGridi107034. 1 interaction.
    STRINGi9606.ENSP00000356094.

    Structurei

    3D structure databases

    ProteinModelPortaliP47901.
    SMRiP47901. Positions 33-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini60 – 7112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 10815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 15121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 20128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 28361CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 32118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini342 – 42483CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17322Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei322 – 34120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiP47901.
    KOiK04227.
    OMAiKVKTQAW.
    OrthoDBiEOG7Z69CP.
    PhylomeDBiP47901.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000628. Vprs_rcpt_V1B.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00897. VASOPRSNV1BR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47901-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG    50
    GNLAVLLTLG QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF 100
    QGPDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPGQST 150
    YLLIAAPWLL AAIFSLPQVF IFSLREVIQG SGVLDCWADF GFPWGPRAYL 200
    TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG GGGWRTWDRP 250
    SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV 300
    QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL 350
    RHLACCGGPQ PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR 400
    PRPEESPRDL ELADGEGTAE TIIF 424
    Length:424
    Mass (Da):46,971
    Last modified:February 1, 1996 - v1
    Checksum:i35190281D3EDB6A7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651K → N.2 Publications
    Corresponds to variant rs35369693 [ dbSNP | Ensembl ].
    VAR_025159
    Natural varianti191 – 1911G → R.1 Publication
    Corresponds to variant rs33990840 [ dbSNP | Ensembl ].
    VAR_025160
    Natural varianti224 – 2241H → Q.
    Corresponds to variant rs3891058 [ dbSNP | Ensembl ].
    VAR_061228
    Natural varianti267 – 2671S → G.1 Publication
    Corresponds to variant rs36030374 [ dbSNP | Ensembl ].
    VAR_025161
    Natural varianti364 – 3641R → H.2 Publications
    Corresponds to variant rs28632197 [ dbSNP | Ensembl ].
    VAR_025162

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31833 mRNA. Translation: BAA06621.1.
    L37112 mRNA. Translation: AAA65687.1.
    AF030512 mRNA. Translation: AAB84293.1.
    AF101726 mRNA. Translation: AAD17892.1.
    AF152238 Genomic DNA. Translation: AAF33681.1.
    EU432111 mRNA. Translation: ABY87910.1.
    DQ194816 Genomic DNA. Translation: ABA03171.1.
    BX571818 Genomic DNA. Translation: CAH73262.1.
    CCDSiCCDS30994.1.
    PIRiA55089.
    RefSeqiNP_000698.1. NM_000707.3.
    UniGeneiHs.1372.

    Genome annotation databases

    EnsembliENST00000367126; ENSP00000356094; ENSG00000198049.
    GeneIDi553.
    KEGGihsa:553.
    UCSCiuc001hds.2. human.

    Polymorphism databases

    DMDMi1351392.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31833 mRNA. Translation: BAA06621.1 .
    L37112 mRNA. Translation: AAA65687.1 .
    AF030512 mRNA. Translation: AAB84293.1 .
    AF101726 mRNA. Translation: AAD17892.1 .
    AF152238 Genomic DNA. Translation: AAF33681.1 .
    EU432111 mRNA. Translation: ABY87910.1 .
    DQ194816 Genomic DNA. Translation: ABA03171.1 .
    BX571818 Genomic DNA. Translation: CAH73262.1 .
    CCDSi CCDS30994.1.
    PIRi A55089.
    RefSeqi NP_000698.1. NM_000707.3.
    UniGenei Hs.1372.

    3D structure databases

    ProteinModelPortali P47901.
    SMRi P47901. Positions 33-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107034. 1 interaction.
    STRINGi 9606.ENSP00000356094.

    Chemistry

    BindingDBi P47901.
    ChEMBLi CHEMBL2363078.
    DrugBanki DB00035. Desmopressin.
    DB02638. Terlipressin.
    DB00067. Vasopressin.
    GuidetoPHARMACOLOGYi 367.

    Protein family/group databases

    TCDBi 9.A.14.10.2. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47901.

    Polymorphism databases

    DMDMi 1351392.

    Proteomic databases

    PaxDbi P47901.
    PRIDEi P47901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367126 ; ENSP00000356094 ; ENSG00000198049 .
    GeneIDi 553.
    KEGGi hsa:553.
    UCSCi uc001hds.2. human.

    Organism-specific databases

    CTDi 553.
    GeneCardsi GC01P206223.
    HGNCi HGNC:896. AVPR1B.
    HPAi HPA017337.
    MIMi 600264. gene.
    neXtProti NX_P47901.
    PharmGKBi PA25188.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299951.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi P47901.
    KOi K04227.
    OMAi KVKTQAW.
    OrthoDBi EOG7Z69CP.
    PhylomeDBi P47901.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Arginine_vasopressin_receptor_1B.
    GenomeRNAii 553.
    NextBioi 2285.
    PROi P47901.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47901.
    CleanExi HS_AVPR1B.
    Genevestigatori P47901.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000628. Vprs_rcpt_V1B.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00897. VASOPRSNV1BR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor."
      Sugimoto T., Saito M., Mochizuki S., Watanabe Y., Hashimoto S., Kawashima H.
      J. Biol. Chem. 269:27088-27092(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "Cloning and characterization of the human V3 pituitary vasopressin receptor."
      de Keyzer Y., Auzan C., Lenne F., Beldjord C., Thibonnier M., Bertagna X., Clauser E.
      FEBS Lett. 356:215-220(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    3. "Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma."
      North W.G., Fay M.J., Longo K.A., Du J.
      Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung carcinoma.
    4. "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
      North W.G., Fay M.J., Longo K.A., Du J.
      Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene."
      Rene P., Lenne F., Ventura M.A., Bertagna X., de Keyzer Y.
      Gene 241:57-64(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    7. SeattleSNPs variation discovery resource
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-65; ARG-191; GLY-267 AND HIS-364.
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders."
      Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J., Tamas Z., Kennedy J.L., Vetro A., Kovacs M., Barr C.L.
      Arch. Gen. Psychiatry 64:1189-1195(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASN-65 AND HIS-364.

    Entry informationi

    Entry nameiV1BR_HUMAN
    AccessioniPrimary (citable) accession number: P47901
    Secondary accession number(s): B0M0J6, Q5TZ00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3