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Protein

Vasopressin V1b receptor

Gene

AVPR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

GO - Molecular functioni

  1. peptide binding Source: GO_Central
  2. protein kinase C binding Source: ProtInc
  3. vasopressin receptor activity Source: ProtInc

GO - Biological processi

  1. activation of phospholipase C activity Source: ProtInc
  2. cellular response to hormone stimulus Source: GO_Central
  3. G-protein coupled receptor signaling pathway Source: ProtInc
  4. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  5. positive regulation of vasoconstriction Source: GO_Central
  6. regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  7. response to peptide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Protein family/group databases

TCDBi9.A.14.10.2. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1b receptor
Short name:
V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene namesi
Name:AVPR1B
Synonyms:AVPR3, VPR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:896. AVPR1B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini60 – 7112CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei72 – 9322Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 10815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 15121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17322Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini174 – 20128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini223 – 28361CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei284 – 30320Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini304 – 32118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei322 – 34120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini342 – 42483CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endosome Source: ProtInc
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Vasopressin V1b receptorPRO_0000070203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47901.
PRIDEiP47901.

PTM databases

PhosphoSiteiP47901.

Expressioni

Gene expression databases

BgeeiP47901.
CleanExiHS_AVPR1B.
GenevestigatoriP47901.

Organism-specific databases

HPAiHPA017337.

Interactioni

Protein-protein interaction databases

BioGridi107034. 1 interaction.
STRINGi9606.ENSP00000356094.

Structurei

3D structure databases

ProteinModelPortaliP47901.
SMRiP47901. Positions 33-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP47901.
KOiK04227.
OMAiPLRHLAC.
OrthoDBiEOG7Z69CP.
PhylomeDBiP47901.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG
60 70 80 90 100
GNLAVLLTLG QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF
110 120 130 140 150
QGPDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPGQST
160 170 180 190 200
YLLIAAPWLL AAIFSLPQVF IFSLREVIQG SGVLDCWADF GFPWGPRAYL
210 220 230 240 250
TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG GGGWRTWDRP
260 270 280 290 300
SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV
310 320 330 340 350
QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL
360 370 380 390 400
RHLACCGGPQ PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR
410 420
PRPEESPRDL ELADGEGTAE TIIF
Length:424
Mass (Da):46,971
Last modified:February 1, 1996 - v1
Checksum:i35190281D3EDB6A7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651K → N.2 Publications
Corresponds to variant rs35369693 [ dbSNP | Ensembl ].
VAR_025159
Natural varianti191 – 1911G → R.1 Publication
Corresponds to variant rs33990840 [ dbSNP | Ensembl ].
VAR_025160
Natural varianti224 – 2241H → Q.
Corresponds to variant rs3891058 [ dbSNP | Ensembl ].
VAR_061228
Natural varianti267 – 2671S → G.1 Publication
Corresponds to variant rs36030374 [ dbSNP | Ensembl ].
VAR_025161
Natural varianti364 – 3641R → H.2 Publications
Corresponds to variant rs28632197 [ dbSNP | Ensembl ].
VAR_025162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31833 mRNA. Translation: BAA06621.1.
L37112 mRNA. Translation: AAA65687.1.
AF030512 mRNA. Translation: AAB84293.1.
AF101726 mRNA. Translation: AAD17892.1.
AF152238 Genomic DNA. Translation: AAF33681.1.
EU432111 mRNA. Translation: ABY87910.1.
DQ194816 Genomic DNA. Translation: ABA03171.1.
BX571818 Genomic DNA. Translation: CAH73262.1.
CCDSiCCDS73015.1.
PIRiA55089.
RefSeqiNP_000698.1. NM_000707.3.
UniGeneiHs.1372.

Genome annotation databases

EnsembliENST00000367126; ENSP00000356094; ENSG00000198049.
GeneIDi553.
KEGGihsa:553.
UCSCiuc001hds.2. human.

Polymorphism databases

DMDMi1351392.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31833 mRNA. Translation: BAA06621.1.
L37112 mRNA. Translation: AAA65687.1.
AF030512 mRNA. Translation: AAB84293.1.
AF101726 mRNA. Translation: AAD17892.1.
AF152238 Genomic DNA. Translation: AAF33681.1.
EU432111 mRNA. Translation: ABY87910.1.
DQ194816 Genomic DNA. Translation: ABA03171.1.
BX571818 Genomic DNA. Translation: CAH73262.1.
CCDSiCCDS73015.1.
PIRiA55089.
RefSeqiNP_000698.1. NM_000707.3.
UniGeneiHs.1372.

3D structure databases

ProteinModelPortaliP47901.
SMRiP47901. Positions 33-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107034. 1 interaction.
STRINGi9606.ENSP00000356094.

Chemistry

BindingDBiP47901.
ChEMBLiCHEMBL1921.
DrugBankiDB00035. Desmopressin.
DB02638. Terlipressin.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi367.

Protein family/group databases

TCDBi9.A.14.10.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

PhosphoSiteiP47901.

Polymorphism databases

DMDMi1351392.

Proteomic databases

PaxDbiP47901.
PRIDEiP47901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367126; ENSP00000356094; ENSG00000198049.
GeneIDi553.
KEGGihsa:553.
UCSCiuc001hds.2. human.

Organism-specific databases

CTDi553.
GeneCardsiGC01P206223.
HGNCiHGNC:896. AVPR1B.
HPAiHPA017337.
MIMi600264. gene.
neXtProtiNX_P47901.
PharmGKBiPA25188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP47901.
KOiK04227.
OMAiPLRHLAC.
OrthoDBiEOG7Z69CP.
PhylomeDBiP47901.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiArginine_vasopressin_receptor_1B.
GenomeRNAii553.
NextBioi2285.
PROiP47901.
SOURCEiSearch...

Gene expression databases

BgeeiP47901.
CleanExiHS_AVPR1B.
GenevestigatoriP47901.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor."
    Sugimoto T., Saito M., Mochizuki S., Watanabe Y., Hashimoto S., Kawashima H.
    J. Biol. Chem. 269:27088-27092(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "Cloning and characterization of the human V3 pituitary vasopressin receptor."
    de Keyzer Y., Auzan C., Lenne F., Beldjord C., Thibonnier M., Bertagna X., Clauser E.
    FEBS Lett. 356:215-220(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  3. "Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma."
    North W.G., Fay M.J., Longo K.A., Du J.
    Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung carcinoma.
  4. "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
    North W.G., Fay M.J., Longo K.A., Du J.
    Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene."
    Rene P., Lenne F., Ventura M.A., Bertagna X., de Keyzer Y.
    Gene 241:57-64(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  7. SeattleSNPs variation discovery resource
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-65; ARG-191; GLY-267 AND HIS-364.
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders."
    Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J., Tamas Z., Kennedy J.L., Vetro A., Kovacs M., Barr C.L.
    Arch. Gen. Psychiatry 64:1189-1195(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-65 AND HIS-364.

Entry informationi

Entry nameiV1BR_HUMAN
AccessioniPrimary (citable) accession number: P47901
Secondary accession number(s): B0M0J6, Q5TZ00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 4, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.