P47901 (V1BR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vasopressin V1b receptor
Short name=V1bR

Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor

Gene names

Name:	AVPR1B
Synonyms:	AVPR3, VPR3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Traceable author statement Ref.2. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement Ref.1. Source: ProtInc regulation of systemic arterial blood pressure by vasopressin Inferred from electronic annotation. Source: Compara
Cellular_component	endosome Traceable author statement PubMed 10858434. Source: ProtInc integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	protein kinase C binding Traceable author statement PubMed 10858434. Source: ProtInc vasopressin receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Vasopressin V1b receptor		PRO_0000070203
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 59	24	Helical; Name=1; Potential
	Topological domain	60 – 71	12	Cytoplasmic Potential
	Transmembrane	72 – 93	22	Helical; Name=2; Potential
	Topological domain	94 – 108	15	Extracellular Potential
	Transmembrane	109 – 130	22	Helical; Name=3; Potential
	Topological domain	131 – 151	21	Cytoplasmic Potential
	Transmembrane	152 – 173	22	Helical; Name=4; Potential
	Topological domain	174 – 201	28	Extracellular Potential
	Transmembrane	202 – 222	21	Helical; Name=5; Potential
	Topological domain	223 – 283	61	Cytoplasmic Potential
	Transmembrane	284 – 303	20	Helical; Name=6; Potential
	Topological domain	304 – 321	18	Extracellular Potential
	Transmembrane	322 – 341	20	Helical; Name=7; Potential
	Topological domain	342 – 424	83	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	107 ↔ 186		By similarity
Natural variations
	Natural variant	65	1	K → N. Ref.7 Ref.9 Corresponds to variant rs35369693 [ dbSNP | Ensembl ].		VAR_025159
	Natural variant	191	1	G → R. Ref.7 Corresponds to variant rs33990840 [ dbSNP | Ensembl ].		VAR_025160
	Natural variant	224	1	H → Q. Corresponds to variant rs3891058 [ dbSNP | Ensembl ].		VAR_061228
	Natural variant	267	1	S → G. Ref.7		VAR_025161
	Natural variant	364	1	R → H. Ref.7 Ref.9 Corresponds to variant rs28632197 [ dbSNP | Ensembl ].		VAR_025162

Sequences

	Sequence		Length	Mass (Da)
	P47901 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 35190281D3EDB6A7	FASTA	424	46,971
	10 20 30 40 50 60 MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG 70 80 90 100 110 120 QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA 130 140 150 160 170 180 STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG 190 200 210 220 230 240 SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG 250 260 270 280 290 300 GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV 310 320 330 340 350 360 QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ 370 380 390 400 410 420 PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE TIIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor." Sugimoto T., Saito M., Mochizuki S., Watanabe Y., Hashimoto S., Kawashima H. J. Biol. Chem. 269:27088-27092(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.
[2]	"Cloning and characterization of the human V3 pituitary vasopressin receptor." de Keyzer Y., Auzan C., Lenne F., Beldjord C., Thibonnier M., Bertagna X., Clauser E. FEBS Lett. 356:215-220(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.
[3]	"Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma." North W.G., Fay M.J., Longo K.A., Du J. Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung carcinoma.
[4]	"Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide." North W.G., Fay M.J., Longo K.A., Du J. Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene." Rene P., Lenne F., Ventura M.A., Bertagna X., de Keyzer Y. Gene 241:57-64(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[7]	SeattleSNPs variation discovery resource Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-65; ARG-191; GLY-267 AND HIS-364.
[8]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders." Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J., Tamas Z., Kennedy J.L., Vetro A., Kovacs M., Barr C.L. Arch. Gen. Psychiatry 64:1189-1195(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ASN-65 AND HIS-364.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	D31833 mRNA. Translation: BAA06621.1. L37112 mRNA. Translation: AAA65687.1. AF030512 mRNA. Translation: AAB84293.1. AF101726 mRNA. Translation: AAD17892.1. AF152238 Genomic DNA. Translation: AAF33681.1. EU432111 mRNA. Translation: ABY87910.1. DQ194816 Genomic DNA. Translation: ABA03171.1. BX571818 Genomic DNA. Translation: CAH73262.1.
IPI	IPI00026826.
PIR	A55089.
RefSeq	NP_000698.1. NM_000707.3.
UniGene	Hs.1372.
3D structure databases
ProteinModelPortal	P47901.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000356094.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P47901.
Polymorphism databases
DMDM	1351392.
Proteomic databases
PaxDb	P47901.
PRIDE	P47901.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367126; ENSP00000356094; ENSG00000198049. ENST00000580826; ENSP00000462301; ENSG00000265027.
GeneID	553.
KEGG	hsa:553.
UCSC	uc001hds.2. human.
Organism-specific databases
CTD	553.
GeneCards	GC01P206223.
HGNC	HGNC:896. AVPR1B.
HPA	HPA017337.
MIM	600264. gene.
neXtProt	NX_P47901.
PharmGKB	PA25188.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299951.
HOGENOM	HOG000237331.
HOVERGEN	HBG105710.
InParanoid	P47901.
KO	K04227.
OMA	HLACCGG.
OrthoDB	EOG4640C2.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P47901.
CleanEx	HS_AVPR1B.
Genevestigator	P47901.
GermOnline	ENSG00000198049. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001817. Vasoprsn_rcpt. IPR000628. Vprs_rcpt_V1B. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR. PR00897. VASOPRSNV1BR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P47901.
ChEMBL	CHEMBL1921.
DrugBank	DB00035. Desmopressin. DB02638. Terlipressin. DB00067. Vasopressin.
GenomeRNAi	553.
NextBio	2285.
SOURCE	Search...

Entry information

Entry name

V1BR_HUMAN

Accession

Primary (citable) accession number: P47901
Secondary accession number(s): B0M0J6, Q5TZ00

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.