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P47900

- P2RY1_HUMAN

UniProt

P47900 - P2RY1_HUMAN

Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.1 Publication

    GO - Molecular functioni

    1. ADP-activated nucleotide receptor activity Source: Ensembl
    2. ADP binding Source: Ensembl
    3. ATP-activated nucleotide receptor activity Source: BHF-UCL
    4. ATP binding Source: Ensembl
    5. G-protein coupled purinergic nucleotide receptor activity Source: BHF-UCL
    6. protein binding Source: IntAct
    7. receptor activity Source: ProtInc
    8. scaffold protein binding Source: BHF-UCL

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
    2. aging Source: Ensembl
    3. blood coagulation Source: Reactome
    4. brain development Source: Ensembl
    5. cell surface receptor signaling pathway Source: ProtInc
    6. eating behavior Source: Ensembl
    7. G-protein coupled receptor signaling pathway Source: BHF-UCL
    8. negative regulation of binding Source: Ensembl
    9. negative regulation of norepinephrine secretion Source: Ensembl
    10. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
    11. platelet activation Source: Reactome
    12. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
    13. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    14. positive regulation of hormone secretion Source: Ensembl
    15. positive regulation of inositol trisphosphate biosynthetic process Source: Ensembl
    16. positive regulation of ion transport Source: Ensembl
    17. positive regulation of penile erection Source: Ensembl
    18. positive regulation of protein phosphorylation Source: BHF-UCL
    19. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    20. protein localization to plasma membrane Source: BHF-UCL
    21. regulation of receptor activity Source: Ensembl
    22. regulation of vasodilation Source: Ensembl
    23. relaxation of muscle Source: InterPro
    24. response to growth factor Source: Ensembl
    25. response to mechanical stimulus Source: Ensembl
    26. sensory perception of pain Source: Ensembl
    27. signal transduction involved in regulation of gene expression Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 1
    Short name:
    P2Y1
    Alternative name(s):
    ATP receptor
    Purinergic receptor
    Gene namesi
    Name:P2RY1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:8539. P2RY1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cell body Source: BHF-UCL
    4. dendrite Source: BHF-UCL
    5. integral component of plasma membrane Source: ProtInc
    6. neuronal postsynaptic density Source: BHF-UCL
    7. plasma membrane Source: BHF-UCL
    8. postsynaptic membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32868.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373P2Y purinoceptor 1PRO_0000070006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP47900.
    PRIDEiP47900.

    PTM databases

    PhosphoSiteiP47900.

    Expressioni

    Inductioni

    Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.

    Gene expression databases

    BgeeiP47900.
    CleanExiHS_P2RY1.
    GenevestigatoriP47900.

    Organism-specific databases

    HPAiHPA015577.
    HPA017674.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SLC9A3R1O147452EBI-8677223,EBI-349787

    Protein-protein interaction databases

    BioGridi111067. 2 interactions.
    IntActiP47900. 1 interaction.
    MINTiMINT-1796592.
    STRINGi9606.ENSP00000304767.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Y36model-A1-373[»]
    ProteinModelPortaliP47900.
    SMRiP47900. Positions 52-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini75 – 8713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 16619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 21830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini239 – 26527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini286 – 30318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 37345CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7422Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei167 – 18822Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 23820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 28520Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32825Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146579.
    HOGENOMiHOG000231307.
    HOVERGENiHBG101120.
    InParanoidiP47900.
    KOiK04270.
    OMAiKKNAVYI.
    OrthoDBiEOG7GFB51.
    PhylomeDBiP47900.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000142. P2Y1_rcpt.
    [Graphical view]
    PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00595. P2Y1PRNOCPTR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ    50
    FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY 100
    VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY 150
    SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV VAISPILFYS GTGVRKNKTI 200
    TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD 250
    NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND 300
    RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL 350
    QSKSEDMTLN ILPEFKQNGD TSL 373
    Length:373
    Mass (Da):42,072
    Last modified:February 1, 1996 - v1
    Checksum:i4DC7C668B4145392
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381Missing in CAA89066. (PubMed:8666290)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49205 mRNA. Translation: CAA89066.1.
    U42030 mRNA. Translation: AAA97873.1.
    U42029 mRNA. Translation: AAA97872.1.
    S81950 Genomic DNA. Translation: AAB47091.1.
    AJ006945 Genomic DNA. Translation: CAA07339.1.
    AY136752 mRNA. Translation: AAN01278.1.
    BC074784 mRNA. Translation: AAH74784.1.
    BC074785 mRNA. Translation: AAH74785.1.
    AF018284 mRNA. Translation: AAB94556.1.
    CCDSiCCDS3169.1.
    PIRiJC4737.
    RefSeqiNP_002554.1. NM_002563.3.
    UniGeneiHs.654526.

    Genome annotation databases

    EnsembliENST00000305097; ENSP00000304767; ENSG00000169860.
    GeneIDi5028.
    KEGGihsa:5028.
    UCSCiuc003ezq.3. human.

    Polymorphism databases

    DMDMi1352692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49205 mRNA. Translation: CAA89066.1 .
    U42030 mRNA. Translation: AAA97873.1 .
    U42029 mRNA. Translation: AAA97872.1 .
    S81950 Genomic DNA. Translation: AAB47091.1 .
    AJ006945 Genomic DNA. Translation: CAA07339.1 .
    AY136752 mRNA. Translation: AAN01278.1 .
    BC074784 mRNA. Translation: AAH74784.1 .
    BC074785 mRNA. Translation: AAH74785.1 .
    AF018284 mRNA. Translation: AAB94556.1 .
    CCDSi CCDS3169.1.
    PIRi JC4737.
    RefSeqi NP_002554.1. NM_002563.3.
    UniGenei Hs.654526.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Y36 model - A 1-373 [» ]
    ProteinModelPortali P47900.
    SMRi P47900. Positions 52-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111067. 2 interactions.
    IntActi P47900. 1 interaction.
    MINTi MINT-1796592.
    STRINGi 9606.ENSP00000304767.

    Chemistry

    BindingDBi P47900.
    ChEMBLi CHEMBL4315.
    GuidetoPHARMACOLOGYi 323.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47900.

    Polymorphism databases

    DMDMi 1352692.

    Proteomic databases

    PaxDbi P47900.
    PRIDEi P47900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305097 ; ENSP00000304767 ; ENSG00000169860 .
    GeneIDi 5028.
    KEGGi hsa:5028.
    UCSCi uc003ezq.3. human.

    Organism-specific databases

    CTDi 5028.
    GeneCardsi GC03P152552.
    HGNCi HGNC:8539. P2RY1.
    HPAi HPA015577.
    HPA017674.
    MIMi 601167. gene.
    neXtProti NX_P47900.
    PharmGKBi PA32868.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146579.
    HOGENOMi HOG000231307.
    HOVERGENi HBG101120.
    InParanoidi P47900.
    KOi K04270.
    OMAi KKNAVYI.
    OrthoDBi EOG7GFB51.
    PhylomeDBi P47900.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.

    Miscellaneous databases

    GeneWikii P2RY1.
    GenomeRNAii 5028.
    NextBioi 19362.
    PROi P47900.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47900.
    CleanExi HS_P2RY1.
    Genevestigatori P47900.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000142. P2Y1_rcpt.
    [Graphical view ]
    PANTHERi PTHR24231:SF2. PTHR24231:SF2. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00595. P2Y1PRNOCPTR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor."
      Leon C., Vial C., Cazenave J.-P., Gachet C.
      Gene 171:295-297(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Leon C., Vial C., Weber J., Cazenave J.-P., Gacher C.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets."
      Jin J., Daniel J.L., Kunapuli S.P.
      J. Biol. Chem. 273:2030-2034(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-373, FUNCTION, INHIBITION.
      Tissue: Platelet.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.

    Entry informationi

    Entry nameiP2RY1_HUMAN
    AccessioniPrimary (citable) accession number: P47900
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3