P2Y purinoceptor 1 - Homo sapiens (Human)

Contribute

Send feedback

Read comments (?) or add your own

P47900 (P2RY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
P2Y purinoceptor 1
Short name=P2Y1

Alternative name(s):
ATP receptor
Purinergic receptor

Gene names

Name:

P2RY1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. Ref.7
Subcellular location	Cell membrane; Multi-pass membrane protein.
Induction	Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Blood coagulation
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger Traceable author statement. Source: ProtInc platelet activation Traceable author statement. Source: Reactome
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 373

373

P2Y purinoceptor 1

PRO_0000070006

Regions

Topological domain

1 – 52

Extracellular Potential

Transmembrane

53 – 74

Helical; Name=1; Potential

Topological domain

75 – 87

Cytoplasmic Potential

Transmembrane

88 – 109

Helical; Name=2; Potential

Topological domain

110 – 126

Extracellular Potential

Transmembrane

127 – 147

Helical; Name=3; Potential

Topological domain

148 – 166

Cytoplasmic Potential

Transmembrane

167 – 188

Helical; Name=4; Potential

Topological domain

189 – 218

Extracellular Potential

Transmembrane

219 – 238

Helical; Name=5; Potential

Topological domain

239 – 265

Cytoplasmic Potential

Transmembrane

266 – 285

Helical; Name=6; Potential

Topological domain

286 – 303

Extracellular Potential

Transmembrane

304 – 328

Helical; Name=7; Potential

Topological domain

329 – 373

Cytoplasmic Potential

Amino acid modifications

Modified residue

352

Phosphoserine Ref.8

Modified residue

354

Phosphoserine Ref.8

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

113

N-linked (GlcNAc...) Potential

Glycosylation

197

N-linked (GlcNAc...) Potential

Disulfide bond

124 ↔ 202

By similarity

Experimental info

Sequence conflict

138

Missing in CAA89066. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P47900 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 4DC7C668B4145392
Show »

FASTA

373

42,072

        10         20         30         40         50         60 
MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ FYYLPAVYIL 

        70         80         90        100        110        120 
VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY VLTLPALIFY YFNKTDWIFG 

       130        140        150        160        170        180 
DAMCKLQRFI FHVNLYGSIL FLTCISAHRY SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV 

       190        200        210        220        230        240 
VAISPILFYS GTGVRKNKTI TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI 

       250        260        270        280        290        300 
VRALIYKDLD NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND 

       310        320        330        340        350        360 
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL QSKSEDMTLN 

       370 
ILPEFKQNGD TSL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor." Leon C., Vial C., Cazenave J.-P., Gachet C. Gene 171:295-297(1996) [PubMed: 8666290] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Cloning and chromosomal localization of the human P2Y1 purinoceptor." Ayyanathan K., Tania W., Harbansjit S., Raghbir A.S., Barnard E.A., Kunapuli S.P. Biochem. Biophys. Res. Commun. 218:783-788(1996) [PubMed: 8579591] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and tissue distribution of the human P2Y1 receptor." Janssens R., Communi D., Pirotton S., Samson M., Parmentier M., Boeynaems J.-M. Biochem. Biophys. Res. Commun. 221:588-593(1996) [PubMed: 8630005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Leon C., Vial C., Weber J., Cazenave J.-P., Gacher C. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets." Jin J., Daniel J.L., Kunapuli S.P. J. Biol. Chem. 273:2030-2034(1998) [PubMed: 9442040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-373, FUNCTION, INHIBITION. Tissue: Platelet.
[8]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352 AND SER-354, MASS SPECTROMETRY. Tissue: Platelet.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z49205 mRNA. Translation: CAA89066.1.
U42030 mRNA. Translation: AAA97873.1.
U42029 mRNA. Translation: AAA97872.1.
S81950 Genomic DNA. Translation: AAB47091.1.
AJ006945 Genomic DNA. Translation: CAA07339.1.
AY136752 mRNA. Translation: AAN01278.1.
BC074784 mRNA. Translation: AAH74784.1.
BC074785 mRNA. Translation: AAH74785.1.
AF018284 mRNA. Translation: AAB94556.1.

IPI

IPI00026825.

PIR

JC4737.

RefSeq

NP_002554.1. NM_002563.2.

UniGene

Hs.654526.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Y36	model	-	A	1-373	[»]

ProteinModelPortal

P47900.

SMR

P47900. Positions 136-167, 308-343.

ModBase

Search...

Protein-protein interaction databases

STRING

P47900.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P47900.

Polymorphism databases

DMDM

1352692.

Proteomic databases

PRIDE

P47900.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000305097; ENSP00000304767; ENSG00000169860.

GeneID

5028.

KEGG

hsa:5028.

UCSC

uc003ezq.1. human.

Organism-specific databases

CTD

5028.

GeneCards

GC03P152552.

H-InvDB

HIX0030700.

HGNC

HGNC:8539. P2RY1.

HPA

HPA015577.
HPA017674.

MIM

601167. gene.

neXtProt

NX_P47900.

PharmGKB

PA32868.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG04390.

GeneTree

ENSGT00600000084187.

HOGENOM

HBG714985.

HOVERGEN

HBG101120.

InParanoid

P47900.

OMA

YSMCTTV.

OrthoDB

EOG4MW868.

PhylomeDB

P47900.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpress

P47900.

Bgee

P47900.

CleanEx

HS_P2RY1.

Genevestigator

P47900.

GermOnline

ENSG00000169860. Homo sapiens.

Family and domain databases

InterPro

IPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR002286. P2_purnocptor.
IPR000142. P2Y_purnocptor.
[Graphical view]

K04270.

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PR01157. P2YPURNOCPTR.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

19362.

SOURCE

Search...

Entry information

Entry name

P2RY1_HUMAN

Accession

Primary (citable) accession number: P47900

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents