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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-418592 ADP signalling through P2Y purinoceptor 1

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000169860.6
HGNCiHGNC:8539 P2RY1
MIMi601167 gene
neXtProtiNX_P47900

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 74Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini75 – 87CytoplasmicSequence analysisAdd BLAST13
Transmembranei88 – 109Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini110 – 126ExtracellularSequence analysisAdd BLAST17
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 166CytoplasmicSequence analysisAdd BLAST19
Transmembranei167 – 188Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini189 – 218ExtracellularSequence analysisAdd BLAST30
Transmembranei219 – 238Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini239 – 265CytoplasmicSequence analysisAdd BLAST27
Transmembranei266 – 285Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini286 – 303ExtracellularSequence analysisAdd BLAST18
Transmembranei304 – 328Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini329 – 373CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5028
OpenTargetsiENSG00000169860
PharmGKBiPA32868

Chemistry databases

ChEMBLiCHEMBL4315
GuidetoPHARMACOLOGYi323

Polymorphism and mutation databases

BioMutaiP2RY1
DMDMi1352692

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700061 – 373P2Y purinoceptor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47900
PeptideAtlasiP47900
PRIDEiP47900
TopDownProteomicsiP47900

PTM databases

iPTMnetiP47900
PhosphoSitePlusiP47900

Expressioni

Inductioni

Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.

Gene expression databases

BgeeiENSG00000169860
CleanExiHS_P2RY1
GenevisibleiP47900 HS

Organism-specific databases

HPAiHPA015577

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC9A3R1O147452EBI-8677223,EBI-349787

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111067, 12 interactors
IntActiP47900, 1 interactor
MINTiP47900
STRINGi9606.ENSP00000304767

Chemistry databases

BindingDBiP47900

Structurei

Secondary structure

1373
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi50 – 78Combined sources29
Helixi85 – 112Combined sources28
Turni113 – 115Combined sources3
Helixi121 – 154Combined sources34
Turni156 – 158Combined sources3
Helixi161 – 183Combined sources23
Helixi186 – 189Combined sources4
Beta strandi191 – 194Combined sources4
Beta strandi200 – 205Combined sources6
Turni208 – 210Combined sources3
Helixi211 – 225Combined sources15
Helixi227 – 245Combined sources19
Helixi253 – 271Combined sources19
Helixi273 – 289Combined sources17
Helixi293 – 295Combined sources3
Helixi296 – 319Combined sources24
Helixi321 – 326Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y36model-A1-373[»]
4XNVX-ray2.20A2-247[»]
A253-373[»]
4XNWX-ray2.70A/C2-247[»]
A/C253-373[»]
ProteinModelPortaliP47900
SMRiP47900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX Eukaryota
ENOG410Z2ZK LUCA
GeneTreeiENSGT00910000144002
HOGENOMiHOG000231307
HOVERGENiHBG101120
InParanoidiP47900
KOiK04270
OMAiHRYTGVV
OrthoDBiEOG091G093Y
PhylomeDBiP47900
TreeFamiTF350009

Family and domain databases

CDDicd15377 7tmA_P2Y1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000142 P2Y1_rcpt
PANTHERiPTHR24231:SF2 PTHR24231:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00595 P2Y1PRNOCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV VAISPILFYS GTGVRKNKTI
210 220 230 240 250
TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEDMTLN ILPEFKQNGD TSL
Length:373
Mass (Da):42,072
Last modified:February 1, 1996 - v1
Checksum:i4DC7C668B4145392
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138Missing in CAA89066 (PubMed:8666290).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49205 mRNA Translation: CAA89066.1
U42030 mRNA Translation: AAA97873.1
U42029 mRNA Translation: AAA97872.1
S81950 Genomic DNA Translation: AAB47091.1
AJ006945 Genomic DNA Translation: CAA07339.1
AY136752 mRNA Translation: AAN01278.1
BC074784 mRNA Translation: AAH74784.1
BC074785 mRNA Translation: AAH74785.1
AF018284 mRNA Translation: AAB94556.1
CCDSiCCDS3169.1
PIRiJC4737
RefSeqiNP_002554.1, NM_002563.4
UniGeneiHs.654526
Hs.79881

Genome annotation databases

EnsembliENST00000305097; ENSP00000304767; ENSG00000169860
GeneIDi5028
KEGGihsa:5028
UCSCiuc003ezq.4 human

Similar proteinsi

Entry informationi

Entry nameiP2RY1_HUMAN
AccessioniPrimary (citable) accession number: P47900
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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