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P47900

- P2RY1_HUMAN

UniProt

P47900 - P2RY1_HUMAN

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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.1 Publication

GO - Molecular functioni

  1. ADP-activated nucleotide receptor activity Source: Ensembl
  2. ADP binding Source: Ensembl
  3. ATP-activated nucleotide receptor activity Source: BHF-UCL
  4. ATP binding Source: Ensembl
  5. G-protein coupled purinergic nucleotide receptor activity Source: BHF-UCL
  6. receptor activity Source: ProtInc
  7. scaffold protein binding Source: BHF-UCL

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. aging Source: Ensembl
  3. blood coagulation Source: Reactome
  4. brain development Source: Ensembl
  5. cell surface receptor signaling pathway Source: ProtInc
  6. eating behavior Source: Ensembl
  7. G-protein coupled receptor signaling pathway Source: BHF-UCL
  8. negative regulation of binding Source: Ensembl
  9. negative regulation of norepinephrine secretion Source: Ensembl
  10. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  11. platelet activation Source: Reactome
  12. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  13. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  14. positive regulation of hormone secretion Source: Ensembl
  15. positive regulation of inositol trisphosphate biosynthetic process Source: Ensembl
  16. positive regulation of ion transport Source: Ensembl
  17. positive regulation of penile erection Source: Ensembl
  18. positive regulation of protein phosphorylation Source: BHF-UCL
  19. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  20. protein localization to plasma membrane Source: BHF-UCL
  21. regulation of receptor activity Source: Ensembl
  22. regulation of vasodilation Source: Ensembl
  23. relaxation of muscle Source: InterPro
  24. response to growth factor Source: Ensembl
  25. response to mechanical stimulus Source: Ensembl
  26. sensory perception of pain Source: Ensembl
  27. signal transduction involved in regulation of gene expression Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19140. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:8539. P2RY1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cell body Source: BHF-UCL
  4. cell surface Source: UniProtKB
  5. dendrite Source: BHF-UCL
  6. integral component of plasma membrane Source: ProtInc
  7. neuronal postsynaptic density Source: BHF-UCL
  8. plasma membrane Source: BHF-UCL
  9. postsynaptic membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373P2Y purinoceptor 1PRO_0000070006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47900.
PRIDEiP47900.

PTM databases

PhosphoSiteiP47900.

Expressioni

Inductioni

Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.

Gene expression databases

BgeeiP47900.
CleanExiHS_P2RY1.
GenevestigatoriP47900.

Organism-specific databases

HPAiHPA015577.
HPA017674.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC9A3R1O147452EBI-8677223,EBI-349787

Protein-protein interaction databases

BioGridi111067. 2 interactions.
IntActiP47900. 1 interaction.
MINTiMINT-1796592.
STRINGi9606.ENSP00000304767.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y36model-A1-373[»]
ProteinModelPortaliP47900.
SMRiP47900. Positions 23-340.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
BLAST
Topological domaini75 – 8713CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini110 – 12617ExtracellularSequence AnalysisAdd
BLAST
Topological domaini148 – 16619CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini189 – 21830ExtracellularSequence AnalysisAdd
BLAST
Topological domaini239 – 26527CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini286 – 30318ExtracellularSequence AnalysisAdd
BLAST
Topological domaini329 – 37345CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7422Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei88 – 10922Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei167 – 18822Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei219 – 23820Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei266 – 28520Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei304 – 32825Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146579.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP47900.
KOiK04270.
OMAiKKNAVYI.
OrthoDBiEOG7GFB51.
PhylomeDBiP47900.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47900 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV VAISPILFYS GTGVRKNKTI
210 220 230 240 250
TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEDMTLN ILPEFKQNGD TSL
Length:373
Mass (Da):42,072
Last modified:February 1, 1996 - v1
Checksum:i4DC7C668B4145392
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381Missing in CAA89066. (PubMed:8666290)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49205 mRNA. Translation: CAA89066.1.
U42030 mRNA. Translation: AAA97873.1.
U42029 mRNA. Translation: AAA97872.1.
S81950 Genomic DNA. Translation: AAB47091.1.
AJ006945 Genomic DNA. Translation: CAA07339.1.
AY136752 mRNA. Translation: AAN01278.1.
BC074784 mRNA. Translation: AAH74784.1.
BC074785 mRNA. Translation: AAH74785.1.
AF018284 mRNA. Translation: AAB94556.1.
CCDSiCCDS3169.1.
PIRiJC4737.
RefSeqiNP_002554.1. NM_002563.3.
UniGeneiHs.654526.

Genome annotation databases

EnsembliENST00000305097; ENSP00000304767; ENSG00000169860.
GeneIDi5028.
KEGGihsa:5028.
UCSCiuc003ezq.3. human.

Polymorphism databases

DMDMi1352692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49205 mRNA. Translation: CAA89066.1 .
U42030 mRNA. Translation: AAA97873.1 .
U42029 mRNA. Translation: AAA97872.1 .
S81950 Genomic DNA. Translation: AAB47091.1 .
AJ006945 Genomic DNA. Translation: CAA07339.1 .
AY136752 mRNA. Translation: AAN01278.1 .
BC074784 mRNA. Translation: AAH74784.1 .
BC074785 mRNA. Translation: AAH74785.1 .
AF018284 mRNA. Translation: AAB94556.1 .
CCDSi CCDS3169.1.
PIRi JC4737.
RefSeqi NP_002554.1. NM_002563.3.
UniGenei Hs.654526.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Y36 model - A 1-373 [» ]
ProteinModelPortali P47900.
SMRi P47900. Positions 23-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111067. 2 interactions.
IntActi P47900. 1 interaction.
MINTi MINT-1796592.
STRINGi 9606.ENSP00000304767.

Chemistry

BindingDBi P47900.
ChEMBLi CHEMBL4315.
GuidetoPHARMACOLOGYi 323.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P47900.

Polymorphism databases

DMDMi 1352692.

Proteomic databases

PaxDbi P47900.
PRIDEi P47900.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305097 ; ENSP00000304767 ; ENSG00000169860 .
GeneIDi 5028.
KEGGi hsa:5028.
UCSCi uc003ezq.3. human.

Organism-specific databases

CTDi 5028.
GeneCardsi GC03P152552.
HGNCi HGNC:8539. P2RY1.
HPAi HPA015577.
HPA017674.
MIMi 601167. gene.
neXtProti NX_P47900.
PharmGKBi PA32868.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146579.
GeneTreei ENSGT00760000118784.
HOGENOMi HOG000231307.
HOVERGENi HBG101120.
InParanoidi P47900.
KOi K04270.
OMAi KKNAVYI.
OrthoDBi EOG7GFB51.
PhylomeDBi P47900.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19140. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

GeneWikii P2RY1.
GenomeRNAii 5028.
NextBioi 19362.
PROi P47900.
SOURCEi Search...

Gene expression databases

Bgeei P47900.
CleanExi HS_P2RY1.
Genevestigatori P47900.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view ]
PANTHERi PTHR24231:SF2. PTHR24231:SF2. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor."
    Leon C., Vial C., Cazenave J.-P., Gachet C.
    Gene 171:295-297(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Leon C., Vial C., Weber J., Cazenave J.-P., Gacher C.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets."
    Jin J., Daniel J.L., Kunapuli S.P.
    J. Biol. Chem. 273:2030-2034(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-373, FUNCTION, INHIBITION.
    Tissue: Platelet.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.

Entry informationi

Entry nameiP2RY1_HUMAN
AccessioniPrimary (citable) accession number: P47900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3