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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169860-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8539. P2RY1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 74Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini75 – 87CytoplasmicSequence analysisAdd BLAST13
Transmembranei88 – 109Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini110 – 126ExtracellularSequence analysisAdd BLAST17
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 166CytoplasmicSequence analysisAdd BLAST19
Transmembranei167 – 188Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini189 – 218ExtracellularSequence analysisAdd BLAST30
Transmembranei219 – 238Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini239 – 265CytoplasmicSequence analysisAdd BLAST27
Transmembranei266 – 285Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini286 – 303ExtracellularSequence analysisAdd BLAST18
Transmembranei304 – 328Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini329 – 373CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: Ensembl
  • cell body Source: BHF-UCL
  • cell surface Source: UniProtKB
  • dendrite Source: BHF-UCL
  • integral component of plasma membrane Source: ProtInc
  • mitochondrion Source: Ensembl
  • plasma membrane Source: BHF-UCL
  • postsynaptic density Source: BHF-UCL
  • postsynaptic membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5028.
OpenTargetsiENSG00000169860.
PharmGKBiPA32868.

Chemistry databases

ChEMBLiCHEMBL4315.
GuidetoPHARMACOLOGYi323.

Polymorphism and mutation databases

BioMutaiP2RY1.
DMDMi1352692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700061 – 373P2Y purinoceptor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47900.
PeptideAtlasiP47900.
PRIDEiP47900.
TopDownProteomicsiP47900.

PTM databases

iPTMnetiP47900.
PhosphoSitePlusiP47900.

Expressioni

Inductioni

Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.

Gene expression databases

BgeeiENSG00000169860.
CleanExiHS_P2RY1.
GenevisibleiP47900. HS.

Organism-specific databases

HPAiHPA015577.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC9A3R1O147452EBI-8677223,EBI-349787

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111067. 9 interactors.
IntActiP47900. 1 interactor.
MINTiMINT-1796592.
STRINGi9606.ENSP00000304767.

Chemistry databases

BindingDBiP47900.

Structurei

Secondary structure

1373
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi50 – 78Combined sources29
Helixi85 – 112Combined sources28
Turni113 – 115Combined sources3
Helixi121 – 154Combined sources34
Turni156 – 158Combined sources3
Helixi161 – 183Combined sources23
Helixi186 – 189Combined sources4
Beta strandi191 – 194Combined sources4
Beta strandi200 – 205Combined sources6
Turni208 – 210Combined sources3
Helixi211 – 225Combined sources15
Helixi227 – 245Combined sources19
Helixi253 – 271Combined sources19
Helixi273 – 289Combined sources17
Helixi293 – 295Combined sources3
Helixi296 – 319Combined sources24
Helixi321 – 326Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y36model-A1-373[»]
4XNVX-ray2.20A2-247[»]
A253-373[»]
4XNWX-ray2.70A/C2-247[»]
A/C253-373[»]
ProteinModelPortaliP47900.
SMRiP47900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP47900.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
PhylomeDBiP47900.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV VAISPILFYS GTGVRKNKTI
210 220 230 240 250
TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEDMTLN ILPEFKQNGD TSL
Length:373
Mass (Da):42,072
Last modified:February 1, 1996 - v1
Checksum:i4DC7C668B4145392
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138Missing in CAA89066 (PubMed:8666290).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49205 mRNA. Translation: CAA89066.1.
U42030 mRNA. Translation: AAA97873.1.
U42029 mRNA. Translation: AAA97872.1.
S81950 Genomic DNA. Translation: AAB47091.1.
AJ006945 Genomic DNA. Translation: CAA07339.1.
AY136752 mRNA. Translation: AAN01278.1.
BC074784 mRNA. Translation: AAH74784.1.
BC074785 mRNA. Translation: AAH74785.1.
AF018284 mRNA. Translation: AAB94556.1.
CCDSiCCDS3169.1.
PIRiJC4737.
RefSeqiNP_002554.1. NM_002563.4.
UniGeneiHs.654526.
Hs.79881.

Genome annotation databases

EnsembliENST00000305097; ENSP00000304767; ENSG00000169860.
GeneIDi5028.
KEGGihsa:5028.
UCSCiuc003ezq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49205 mRNA. Translation: CAA89066.1.
U42030 mRNA. Translation: AAA97873.1.
U42029 mRNA. Translation: AAA97872.1.
S81950 Genomic DNA. Translation: AAB47091.1.
AJ006945 Genomic DNA. Translation: CAA07339.1.
AY136752 mRNA. Translation: AAN01278.1.
BC074784 mRNA. Translation: AAH74784.1.
BC074785 mRNA. Translation: AAH74785.1.
AF018284 mRNA. Translation: AAB94556.1.
CCDSiCCDS3169.1.
PIRiJC4737.
RefSeqiNP_002554.1. NM_002563.4.
UniGeneiHs.654526.
Hs.79881.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y36model-A1-373[»]
4XNVX-ray2.20A2-247[»]
A253-373[»]
4XNWX-ray2.70A/C2-247[»]
A/C253-373[»]
ProteinModelPortaliP47900.
SMRiP47900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111067. 9 interactors.
IntActiP47900. 1 interactor.
MINTiMINT-1796592.
STRINGi9606.ENSP00000304767.

Chemistry databases

BindingDBiP47900.
ChEMBLiCHEMBL4315.
GuidetoPHARMACOLOGYi323.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47900.
PhosphoSitePlusiP47900.

Polymorphism and mutation databases

BioMutaiP2RY1.
DMDMi1352692.

Proteomic databases

PaxDbiP47900.
PeptideAtlasiP47900.
PRIDEiP47900.
TopDownProteomicsiP47900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305097; ENSP00000304767; ENSG00000169860.
GeneIDi5028.
KEGGihsa:5028.
UCSCiuc003ezq.4. human.

Organism-specific databases

CTDi5028.
DisGeNETi5028.
GeneCardsiP2RY1.
HGNCiHGNC:8539. P2RY1.
HPAiHPA015577.
MIMi601167. gene.
neXtProtiNX_P47900.
OpenTargetsiENSG00000169860.
PharmGKBiPA32868.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP47900.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
PhylomeDBiP47900.
TreeFamiTF350009.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169860-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

GeneWikiiP2RY1.
GenomeRNAii5028.
PROiP47900.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169860.
CleanExiHS_P2RY1.
GenevisibleiP47900. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY1_HUMAN
AccessioniPrimary (citable) accession number: P47900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.