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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19140. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8539. P2RY1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7422Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini75 – 8713CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei88 – 10922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini110 – 12617ExtracellularSequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini148 – 16619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei167 – 18822Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini189 – 21830ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 23820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini239 – 26527CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei266 – 28520Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini286 – 30318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei304 – 32825Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini329 – 37345CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32868.

Polymorphism and mutation databases

BioMutaiP2RY1.
DMDMi1352692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373P2Y purinoceptor 1PRO_0000070006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47900.
PRIDEiP47900.

PTM databases

PhosphoSiteiP47900.

Expressioni

Inductioni

Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.

Gene expression databases

BgeeiP47900.
CleanExiHS_P2RY1.
GenevisibleiP47900. HS.

Organism-specific databases

HPAiHPA015577.
HPA017674.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC9A3R1O147452EBI-8677223,EBI-349787

Protein-protein interaction databases

BioGridi111067. 2 interactions.
IntActiP47900. 1 interaction.
MINTiMINT-1796592.
STRINGi9606.ENSP00000304767.

Structurei

Secondary structure

1
373
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi50 – 7829Combined sources
Helixi85 – 11228Combined sources
Turni113 – 1153Combined sources
Helixi121 – 15434Combined sources
Turni156 – 1583Combined sources
Helixi161 – 18323Combined sources
Helixi186 – 1894Combined sources
Beta strandi191 – 1944Combined sources
Beta strandi200 – 2056Combined sources
Turni208 – 2103Combined sources
Helixi211 – 22515Combined sources
Helixi227 – 24519Combined sources
Helixi253 – 27119Combined sources
Helixi273 – 28917Combined sources
Helixi293 – 2953Combined sources
Helixi296 – 31924Combined sources
Helixi321 – 3266Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y36model-A1-373[»]
4XNVX-ray2.20A2-247[»]
A253-373[»]
4XNWX-ray2.70A/C2-247[»]
A/C253-373[»]
ProteinModelPortaliP47900.
SMRiP47900. Positions 53-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146579.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP47900.
KOiK04270.
OMAiQFYYLPT.
OrthoDBiEOG7GFB51.
PhylomeDBiP47900.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV VAISPILFYS GTGVRKNKTI
210 220 230 240 250
TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEDMTLN ILPEFKQNGD TSL
Length:373
Mass (Da):42,072
Last modified:February 1, 1996 - v1
Checksum:i4DC7C668B4145392
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381Missing in CAA89066 (PubMed:8666290).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49205 mRNA. Translation: CAA89066.1.
U42030 mRNA. Translation: AAA97873.1.
U42029 mRNA. Translation: AAA97872.1.
S81950 Genomic DNA. Translation: AAB47091.1.
AJ006945 Genomic DNA. Translation: CAA07339.1.
AY136752 mRNA. Translation: AAN01278.1.
BC074784 mRNA. Translation: AAH74784.1.
BC074785 mRNA. Translation: AAH74785.1.
AF018284 mRNA. Translation: AAB94556.1.
CCDSiCCDS3169.1.
PIRiJC4737.
RefSeqiNP_002554.1. NM_002563.3.
UniGeneiHs.654526.

Genome annotation databases

EnsembliENST00000305097; ENSP00000304767; ENSG00000169860.
GeneIDi5028.
KEGGihsa:5028.
UCSCiuc003ezq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49205 mRNA. Translation: CAA89066.1.
U42030 mRNA. Translation: AAA97873.1.
U42029 mRNA. Translation: AAA97872.1.
S81950 Genomic DNA. Translation: AAB47091.1.
AJ006945 Genomic DNA. Translation: CAA07339.1.
AY136752 mRNA. Translation: AAN01278.1.
BC074784 mRNA. Translation: AAH74784.1.
BC074785 mRNA. Translation: AAH74785.1.
AF018284 mRNA. Translation: AAB94556.1.
CCDSiCCDS3169.1.
PIRiJC4737.
RefSeqiNP_002554.1. NM_002563.3.
UniGeneiHs.654526.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y36model-A1-373[»]
4XNVX-ray2.20A2-247[»]
A253-373[»]
4XNWX-ray2.70A/C2-247[»]
A/C253-373[»]
ProteinModelPortaliP47900.
SMRiP47900. Positions 53-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111067. 2 interactions.
IntActiP47900. 1 interaction.
MINTiMINT-1796592.
STRINGi9606.ENSP00000304767.

Chemistry

BindingDBiP47900.
ChEMBLiCHEMBL4315.
GuidetoPHARMACOLOGYi323.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP47900.

Polymorphism and mutation databases

BioMutaiP2RY1.
DMDMi1352692.

Proteomic databases

PaxDbiP47900.
PRIDEiP47900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305097; ENSP00000304767; ENSG00000169860.
GeneIDi5028.
KEGGihsa:5028.
UCSCiuc003ezq.3. human.

Organism-specific databases

CTDi5028.
GeneCardsiGC03P152552.
HGNCiHGNC:8539. P2RY1.
HPAiHPA015577.
HPA017674.
MIMi601167. gene.
neXtProtiNX_P47900.
PharmGKBiPA32868.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146579.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP47900.
KOiK04270.
OMAiQFYYLPT.
OrthoDBiEOG7GFB51.
PhylomeDBiP47900.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19140. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

GeneWikiiP2RY1.
GenomeRNAii5028.
NextBioi19362.
PROiP47900.
SOURCEiSearch...

Gene expression databases

BgeeiP47900.
CleanExiHS_P2RY1.
GenevisibleiP47900. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor."
    Leon C., Vial C., Cazenave J.-P., Gachet C.
    Gene 171:295-297(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Leon C., Vial C., Weber J., Cazenave J.-P., Gacher C.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets."
    Jin J., Daniel J.L., Kunapuli S.P.
    J. Biol. Chem. 273:2030-2034(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-373, FUNCTION, INHIBITION.
    Tissue: Platelet.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.

Entry informationi

Entry nameiP2RY1_HUMAN
AccessioniPrimary (citable) accession number: P47900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.