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P47898 (5HT5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 5A

Short name=5-HT-5
Short name=5-HT-5A
Short name=5-HT5A
Alternative name(s):
Serotonin receptor 5A
Gene names
Name:HTR5A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3573575-hydroxytryptamine receptor 5A
PRO_0000068969

Regions

Topological domain1 – 4040Extracellular By similarity
Transmembrane41 – 6323Helical; Name=1; By similarity
Topological domain64 – 7815Cytoplasmic By similarity
Transmembrane79 – 9921Helical; Name=2; By similarity
Topological domain100 – 11516Extracellular By similarity
Transmembrane116 – 13722Helical; Name=3; By similarity
Topological domain138 – 15821Cytoplasmic By similarity
Transmembrane159 – 18123Helical; Name=4; By similarity
Topological domain182 – 19817Extracellular By similarity
Transmembrane199 – 21921Helical; Name=5; By similarity
Topological domain220 – 28263Cytoplasmic By similarity
Transmembrane283 – 30321Helical; Name=6; By similarity
Topological domain304 – 32017Extracellular By similarity
Transmembrane321 – 34121Helical; Name=7; By similarity
Topological domain342 – 35716Cytoplasmic By similarity

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond120 ↔ 192 By similarity

Natural variations

Natural variant2621R → C in a colorectal cancer sample; somatic mutation. Ref.4
VAR_035753

Sequences

Sequence LengthMass (Da)Tools
P47898 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 92F8A78C69169790

FASTA35740,255
        10         20         30         40         50         60 
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL 

        70         80         90        100        110        120 
VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC 

       130        140        150        160        170        180 
DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG 

       190        200        210        220        230        240 
WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS 

       250        260        270        280        290        300 
PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP 

       310        320        330        340        350 
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterisation of the human 5-HT5A serotonin receptor."
Rees S., den Daas I., Foord S., Goodson S., Bull D., Kilpatrick G., Lee M.
FEBS Lett. 355:242-246(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-262.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81411, X81412 Genomic DNA. Translation: CAA57168.1.
AF498985 mRNA. Translation: AAM21132.1.
BC112021 mRNA. Translation: AAI12022.1.
PIRI37107.
RefSeqNP_076917.1. NM_024012.3.
UniGeneHs.65791.
Hs.744621.

3D structure databases

ProteinModelPortalP47898.
SMRP47898. Positions 41-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000287907.

Chemistry

BindingDBP47898.
ChEMBLCHEMBL2096904.
GuidetoPHARMACOLOGY10.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP47898.

Polymorphism databases

DMDM1345607.

Proteomic databases

PaxDbP47898.
PRIDEP47898.

Protocols and materials databases

DNASU3361.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000287907; ENSP00000287907; ENSG00000157219.
GeneID3361.
KEGGhsa:3361.
UCSCuc003wlu.2. human.

Organism-specific databases

CTD3361.
GeneCardsGC07P154862.
H-InvDBHIX0033634.
HGNCHGNC:5300. HTR5A.
HPACAB017467.
MIM601305. gene.
neXtProtNX_P47898.
PharmGKBPA29558.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260742.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP47898.
KOK04161.
OMANSAFKNF.
OrthoDBEOG7SXW3H.
PhylomeDBP47898.
TreeFamTF316350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP47898.
BgeeP47898.
CleanExHS_HTR5A.
GenevestigatorP47898.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWiki5-HT5A_receptor.
GenomeRNAi3361.
NextBio13304.
PROP47898.
SOURCESearch...

Entry information

Entry name5HT5A_HUMAN
AccessionPrimary (citable) accession number: P47898
Secondary accession number(s): Q2M2D2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries