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Protein

5-hydroxytryptamine receptor 5A

Gene

HTR5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functioni

  1. serotonin receptor activity Source: MGI

GO - Biological processi

  1. cAMP-mediated signaling Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: Ensembl
  4. hippocampus development Source: Ensembl
  5. response to estradiol Source: Ensembl
  6. serotonin receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5A
Short name:
5-HT-5
Short name:
5-HT-5A
Short name:
5-HT5A
Alternative name(s):
Serotonin receptor 5A
Gene namesi
Name:HTR5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:5300. HTR5A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularBy similarityAdd
BLAST
Transmembranei41 – 6323Helical; Name=1By similarityAdd
BLAST
Topological domaini64 – 7815CytoplasmicBy similarityAdd
BLAST
Transmembranei79 – 9921Helical; Name=2By similarityAdd
BLAST
Topological domaini100 – 11516ExtracellularBy similarityAdd
BLAST
Transmembranei116 – 13722Helical; Name=3By similarityAdd
BLAST
Topological domaini138 – 15821CytoplasmicBy similarityAdd
BLAST
Transmembranei159 – 18123Helical; Name=4By similarityAdd
BLAST
Topological domaini182 – 19817ExtracellularBy similarityAdd
BLAST
Transmembranei199 – 21921Helical; Name=5By similarityAdd
BLAST
Topological domaini220 – 28263CytoplasmicBy similarityAdd
BLAST
Transmembranei283 – 30321Helical; Name=6By similarityAdd
BLAST
Topological domaini304 – 32017ExtracellularBy similarityAdd
BLAST
Transmembranei321 – 34121Helical; Name=7By similarityAdd
BLAST
Topological domaini342 – 35716CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. perikaryon Source: Ensembl
  5. plasma membrane Source: Reactome
  6. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29558.

Chemistry

DrugBankiDB06216. Asenapine.
DB00408. Loxapine.
DB00334. Olanzapine.

Polymorphism and mutation databases

BioMutaiHTR5A.
DMDMi1345607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3573575-hydroxytryptamine receptor 5APRO_0000068969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47898.
PRIDEiP47898.

PTM databases

PhosphoSiteiP47898.

Expressioni

Gene expression databases

BgeeiP47898.
CleanExiHS_HTR5A.
ExpressionAtlasiP47898. baseline.
GenevestigatoriP47898.

Organism-specific databases

HPAiCAB017467.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287907.

Structurei

3D structure databases

ProteinModelPortaliP47898.
SMRiP47898. Positions 41-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260742.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP47898.
KOiK04161.
OMAiNSAFKNF.
OrthoDBiEOG7SXW3H.
PhylomeDBiP47898.
TreeFamiTF316350.

Family and domain databases

InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL
60 70 80 90 100
VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH
110 120 130 140 150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT
160 170 180 190 200
LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY
210 220 230 240 250
AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD
260 270 280 290 300
SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP
310 320 330 340 350
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK

NFFSRQH
Length:357
Mass (Da):40,255
Last modified:February 1, 1996 - v1
Checksum:i92F8A78C69169790
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti262 – 2621R → C in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035753

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81411, X81412 Genomic DNA. Translation: CAA57168.1.
AF498985 mRNA. Translation: AAM21132.1.
BC112021 mRNA. Translation: AAI12022.1.
CCDSiCCDS5936.1.
PIRiI37107.
RefSeqiNP_076917.1. NM_024012.3.
UniGeneiHs.65791.
Hs.744621.

Genome annotation databases

EnsembliENST00000287907; ENSP00000287907; ENSG00000157219.
GeneIDi3361.
KEGGihsa:3361.
UCSCiuc003wlu.2. human.

Polymorphism and mutation databases

BioMutaiHTR5A.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81411, X81412 Genomic DNA. Translation: CAA57168.1.
AF498985 mRNA. Translation: AAM21132.1.
BC112021 mRNA. Translation: AAI12022.1.
CCDSiCCDS5936.1.
PIRiI37107.
RefSeqiNP_076917.1. NM_024012.3.
UniGeneiHs.65791.
Hs.744621.

3D structure databases

ProteinModelPortaliP47898.
SMRiP47898. Positions 41-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287907.

Chemistry

BindingDBiP47898.
ChEMBLiCHEMBL2096904.
DrugBankiDB06216. Asenapine.
DB00408. Loxapine.
DB00334. Olanzapine.
GuidetoPHARMACOLOGYi10.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP47898.

Polymorphism and mutation databases

BioMutaiHTR5A.
DMDMi1345607.

Proteomic databases

PaxDbiP47898.
PRIDEiP47898.

Protocols and materials databases

DNASUi3361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287907; ENSP00000287907; ENSG00000157219.
GeneIDi3361.
KEGGihsa:3361.
UCSCiuc003wlu.2. human.

Organism-specific databases

CTDi3361.
GeneCardsiGC07P154862.
H-InvDBHIX0033634.
HGNCiHGNC:5300. HTR5A.
HPAiCAB017467.
MIMi601305. gene.
neXtProtiNX_P47898.
PharmGKBiPA29558.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG260742.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP47898.
KOiK04161.
OMAiNSAFKNF.
OrthoDBiEOG7SXW3H.
PhylomeDBiP47898.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii5-HT5A_receptor.
GenomeRNAii3361.
NextBioi13304.
PROiP47898.
SOURCEiSearch...

Gene expression databases

BgeeiP47898.
CleanExiHS_HTR5A.
ExpressionAtlasiP47898. baseline.
GenevestigatoriP47898.

Family and domain databases

InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterisation of the human 5-HT5A serotonin receptor."
    Rees S., den Daas I., Foord S., Goodson S., Bull D., Kilpatrick G., Lee M.
    FEBS Lett. 355:242-246(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-262.

Entry informationi

Entry namei5HT5A_HUMAN
AccessioniPrimary (citable) accession number: P47898
Secondary accession number(s): Q2M2D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 29, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.