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Protein

5-hydroxytryptamine receptor 5A

Gene

HTR5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157219-MONOMER.
ReactomeiR-HSA-390666. Serotonin receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5A
Short name:
5-HT-5
Short name:
5-HT-5A
Short name:
5-HT5A
Alternative name(s):
Serotonin receptor 5A
Gene namesi
Name:HTR5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:5300. HTR5A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularBy similarityAdd BLAST40
Transmembranei41 – 63Helical; Name=1By similarityAdd BLAST23
Topological domaini64 – 78CytoplasmicBy similarityAdd BLAST15
Transmembranei79 – 99Helical; Name=2By similarityAdd BLAST21
Topological domaini100 – 115ExtracellularBy similarityAdd BLAST16
Transmembranei116 – 137Helical; Name=3By similarityAdd BLAST22
Topological domaini138 – 158CytoplasmicBy similarityAdd BLAST21
Transmembranei159 – 181Helical; Name=4By similarityAdd BLAST23
Topological domaini182 – 198ExtracellularBy similarityAdd BLAST17
Transmembranei199 – 219Helical; Name=5By similarityAdd BLAST21
Topological domaini220 – 282CytoplasmicBy similarityAdd BLAST63
Transmembranei283 – 303Helical; Name=6By similarityAdd BLAST21
Topological domaini304 – 320ExtracellularBy similarityAdd BLAST17
Transmembranei321 – 341Helical; Name=7By similarityAdd BLAST21
Topological domaini342 – 357CytoplasmicBy similarityAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3361.
OpenTargetsiENSG00000157219.
PharmGKBiPA29558.

Chemistry databases

ChEMBLiCHEMBL3426.
DrugBankiDB06216. Asenapine.
DB00408. Loxapine.
DB00334. Olanzapine.
GuidetoPHARMACOLOGYi10.

Polymorphism and mutation databases

BioMutaiHTR5A.
DMDMi1345607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689691 – 3575-hydroxytryptamine receptor 5AAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47898.
PeptideAtlasiP47898.
PRIDEiP47898.

PTM databases

iPTMnetiP47898.
PhosphoSitePlusiP47898.

Expressioni

Gene expression databases

BgeeiENSG00000157219.
CleanExiHS_HTR5A.
ExpressionAtlasiP47898. baseline and differential.
GenevisibleiP47898. HS.

Organism-specific databases

HPAiCAB017467.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287907.

Chemistry databases

BindingDBiP47898.

Structurei

3D structure databases

ProteinModelPortaliP47898.
SMRiP47898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP47898.
KOiK04161.
OMAiQKAALMV.
OrthoDBiEOG091G06VI.
PhylomeDBiP47898.
TreeFamiTF316350.

Family and domain databases

InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF108. PTHR24247:SF108. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL
60 70 80 90 100
VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH
110 120 130 140 150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT
160 170 180 190 200
LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY
210 220 230 240 250
AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD
260 270 280 290 300
SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP
310 320 330 340 350
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK

NFFSRQH
Length:357
Mass (Da):40,255
Last modified:February 1, 1996 - v1
Checksum:i92F8A78C69169790
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035753262R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs746290830dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81411, X81412 Genomic DNA. Translation: CAA57168.1.
AF498985 mRNA. Translation: AAM21132.1.
BC112021 mRNA. Translation: AAI12022.1.
CCDSiCCDS5936.1.
PIRiI37107.
RefSeqiNP_076917.1. NM_024012.3.
UniGeneiHs.65791.
Hs.744621.

Genome annotation databases

EnsembliENST00000287907; ENSP00000287907; ENSG00000157219.
GeneIDi3361.
KEGGihsa:3361.
UCSCiuc003wlu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81411, X81412 Genomic DNA. Translation: CAA57168.1.
AF498985 mRNA. Translation: AAM21132.1.
BC112021 mRNA. Translation: AAI12022.1.
CCDSiCCDS5936.1.
PIRiI37107.
RefSeqiNP_076917.1. NM_024012.3.
UniGeneiHs.65791.
Hs.744621.

3D structure databases

ProteinModelPortaliP47898.
SMRiP47898.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287907.

Chemistry databases

BindingDBiP47898.
ChEMBLiCHEMBL3426.
DrugBankiDB06216. Asenapine.
DB00408. Loxapine.
DB00334. Olanzapine.
GuidetoPHARMACOLOGYi10.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47898.
PhosphoSitePlusiP47898.

Polymorphism and mutation databases

BioMutaiHTR5A.
DMDMi1345607.

Proteomic databases

PaxDbiP47898.
PeptideAtlasiP47898.
PRIDEiP47898.

Protocols and materials databases

DNASUi3361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287907; ENSP00000287907; ENSG00000157219.
GeneIDi3361.
KEGGihsa:3361.
UCSCiuc003wlu.3. human.

Organism-specific databases

CTDi3361.
DisGeNETi3361.
GeneCardsiHTR5A.
H-InvDBHIX0033634.
HGNCiHGNC:5300. HTR5A.
HPAiCAB017467.
MIMi601305. gene.
neXtProtiNX_P47898.
OpenTargetsiENSG00000157219.
PharmGKBiPA29558.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP47898.
KOiK04161.
OMAiQKAALMV.
OrthoDBiEOG091G06VI.
PhylomeDBiP47898.
TreeFamiTF316350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157219-MONOMER.
ReactomeiR-HSA-390666. Serotonin receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii5-HT5A_receptor.
GenomeRNAii3361.
PROiP47898.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157219.
CleanExiHS_HTR5A.
ExpressionAtlasiP47898. baseline and differential.
GenevisibleiP47898. HS.

Family and domain databases

InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF108. PTHR24247:SF108. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT5A_HUMAN
AccessioniPrimary (citable) accession number: P47898
Secondary accession number(s): Q2M2D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.