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P47898

- 5HT5A_HUMAN

UniProt

P47898 - 5HT5A_HUMAN

Protein

5-hydroxytryptamine receptor 5A

Gene

HTR5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

    GO - Molecular functioni

    1. serotonin receptor activity Source: MGI

    GO - Biological processi

    1. cAMP-mediated signaling Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: Ensembl
    4. hippocampus development Source: Ensembl
    5. response to estradiol Source: Ensembl
    6. serotonin receptor signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_17064. Serotonin receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 5A
    Short name:
    5-HT-5
    Short name:
    5-HT-5A
    Short name:
    5-HT5A
    Alternative name(s):
    Serotonin receptor 5A
    Gene namesi
    Name:HTR5A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:5300. HTR5A.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. Golgi apparatus Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. perikaryon Source: Ensembl
    5. plasma membrane Source: Reactome
    6. rough endoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29558.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3573575-hydroxytryptamine receptor 5APRO_0000068969Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP47898.
    PRIDEiP47898.

    PTM databases

    PhosphoSiteiP47898.

    Expressioni

    Gene expression databases

    ArrayExpressiP47898.
    BgeeiP47898.
    CleanExiHS_HTR5A.
    GenevestigatoriP47898.

    Organism-specific databases

    HPAiCAB017467.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000287907.

    Structurei

    3D structure databases

    ProteinModelPortaliP47898.
    SMRiP47898. Positions 41-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularBy similarityAdd
    BLAST
    Topological domaini64 – 7815CytoplasmicBy similarityAdd
    BLAST
    Topological domaini100 – 11516ExtracellularBy similarityAdd
    BLAST
    Topological domaini138 – 15821CytoplasmicBy similarityAdd
    BLAST
    Topological domaini182 – 19817ExtracellularBy similarityAdd
    BLAST
    Topological domaini220 – 28263CytoplasmicBy similarityAdd
    BLAST
    Topological domaini304 – 32017ExtracellularBy similarityAdd
    BLAST
    Topological domaini342 – 35716CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6323Helical; Name=1By similarityAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2By similarityAdd
    BLAST
    Transmembranei116 – 13722Helical; Name=3By similarityAdd
    BLAST
    Transmembranei159 – 18123Helical; Name=4By similarityAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5By similarityAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=6By similarityAdd
    BLAST
    Transmembranei321 – 34121Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260742.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP47898.
    KOiK04161.
    OMAiNSAFKNF.
    OrthoDBiEOG7SXW3H.
    PhylomeDBiP47898.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001397. 5HT5A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00518. 5HT5ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47898-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL    50
    VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH 100
    ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT 150
    LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY 200
    AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD 250
    SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP 300
    FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK 350
    NFFSRQH 357
    Length:357
    Mass (Da):40,255
    Last modified:February 1, 1996 - v1
    Checksum:i92F8A78C69169790
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621R → C in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035753

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81411, X81412 Genomic DNA. Translation: CAA57168.1.
    AF498985 mRNA. Translation: AAM21132.1.
    BC112021 mRNA. Translation: AAI12022.1.
    CCDSiCCDS5936.1.
    PIRiI37107.
    RefSeqiNP_076917.1. NM_024012.3.
    UniGeneiHs.65791.
    Hs.744621.

    Genome annotation databases

    EnsembliENST00000287907; ENSP00000287907; ENSG00000157219.
    GeneIDi3361.
    KEGGihsa:3361.
    UCSCiuc003wlu.2. human.

    Polymorphism databases

    DMDMi1345607.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81411 , X81412 Genomic DNA. Translation: CAA57168.1 .
    AF498985 mRNA. Translation: AAM21132.1 .
    BC112021 mRNA. Translation: AAI12022.1 .
    CCDSi CCDS5936.1.
    PIRi I37107.
    RefSeqi NP_076917.1. NM_024012.3.
    UniGenei Hs.65791.
    Hs.744621.

    3D structure databases

    ProteinModelPortali P47898.
    SMRi P47898. Positions 41-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000287907.

    Chemistry

    BindingDBi P47898.
    ChEMBLi CHEMBL2096904.
    GuidetoPHARMACOLOGYi 10.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47898.

    Polymorphism databases

    DMDMi 1345607.

    Proteomic databases

    PaxDbi P47898.
    PRIDEi P47898.

    Protocols and materials databases

    DNASUi 3361.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287907 ; ENSP00000287907 ; ENSG00000157219 .
    GeneIDi 3361.
    KEGGi hsa:3361.
    UCSCi uc003wlu.2. human.

    Organism-specific databases

    CTDi 3361.
    GeneCardsi GC07P154862.
    H-InvDB HIX0033634.
    HGNCi HGNC:5300. HTR5A.
    HPAi CAB017467.
    MIMi 601305. gene.
    neXtProti NX_P47898.
    PharmGKBi PA29558.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260742.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P47898.
    KOi K04161.
    OMAi NSAFKNF.
    OrthoDBi EOG7SXW3H.
    PhylomeDBi P47898.
    TreeFami TF316350.

    Enzyme and pathway databases

    Reactomei REACT_17064. Serotonin receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii 5-HT5A_receptor.
    GenomeRNAii 3361.
    NextBioi 13304.
    PROi P47898.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47898.
    Bgeei P47898.
    CleanExi HS_HTR5A.
    Genevestigatori P47898.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001397. 5HT5A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF14. PTHR24247:SF14. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00518. 5HT5ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterisation of the human 5-HT5A serotonin receptor."
      Rees S., den Daas I., Foord S., Goodson S., Bull D., Kilpatrick G., Lee M.
      FEBS Lett. 355:242-246(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-262.

    Entry informationi

    Entry namei5HT5A_HUMAN
    AccessioniPrimary (citable) accession number: P47898
    Secondary accession number(s): Q2M2D2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3