P47898 (5HT5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 5A
Short name=5-HT-5
Short name=5-HT-5A
Short name=5-HT5A

Alternative name(s):
Serotonin receptor 5A

Gene names

Name:

HTR5A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Inferred from electronic annotation. Source: Compara cAMP-mediated signaling Inferred from electronic annotation. Source: Compara hippocampus development Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc perikaryon Inferred from electronic annotation. Source: Compara rough endoplasmic reticulum Inferred from electronic annotation. Source: Compara
Molecular_function	serotonin receptor activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	5-hydroxytryptamine receptor 5A		PRO_0000068969
Regions
	Topological domain	1 – 40	40	Extracellular By similarity
	Transmembrane	41 – 63	23	Helical; Name=1; By similarity
	Topological domain	64 – 78	15	Cytoplasmic By similarity
	Transmembrane	79 – 99	21	Helical; Name=2; By similarity
	Topological domain	100 – 115	16	Extracellular By similarity
	Transmembrane	116 – 137	22	Helical; Name=3; By similarity
	Topological domain	138 – 158	21	Cytoplasmic By similarity
	Transmembrane	159 – 181	23	Helical; Name=4; By similarity
	Topological domain	182 – 198	17	Extracellular By similarity
	Transmembrane	199 – 219	21	Helical; Name=5; By similarity
	Topological domain	220 – 282	63	Cytoplasmic By similarity
	Transmembrane	283 – 303	21	Helical; Name=6; By similarity
	Topological domain	304 – 320	17	Extracellular By similarity
	Transmembrane	321 – 341	21	Helical; Name=7; By similarity
	Topological domain	342 – 357	16	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	120 ↔ 192		By similarity
Natural variations
	Natural variant	262	1	R → C in a colorectal cancer sample; somatic mutation. Ref.4		VAR_035753

Sequences

	Sequence		Length	Mass (Da)
	P47898 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 92F8A78C69169790	FASTA	357	40,255
	10 20 30 40 50 60 MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL 70 80 90 100 110 120 VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC 130 140 150 160 170 180 DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG 190 200 210 220 230 240 WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS 250 260 270 280 290 300 PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP 310 320 330 340 350 FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterisation of the human 5-HT5A serotonin receptor." Rees S., den Daas I., Foord S., Goodson S., Bull D., Kilpatrick G., Lee M. FEBS Lett. 355:242-246(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-262.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81411, X81412 Genomic DNA. Translation: CAA57168.1. AF498985 mRNA. Translation: AAM21132.1. BC112021 mRNA. Translation: AAI12022.1.
IPI	IPI00026666.
PIR	I37107.
RefSeq	NP_076917.1. NM_024012.3.
UniGene	Hs.65791. Hs.742158.
3D structure databases
ProteinModelPortal	P47898.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000287907.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P47898.
Polymorphism databases
DMDM	1345607.
Proteomic databases
PaxDb	P47898.
PRIDE	P47898.
Protocols and materials databases
DNASU	3361.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000287907; ENSP00000287907; ENSG00000157219.
GeneID	3361.
KEGG	hsa:3361.
UCSC	uc003wlu.1. human.
Organism-specific databases
CTD	3361.
GeneCards	GC07P154862.
H-InvDB	HIX0033634.
HGNC	HGNC:5300. HTR5A.
HPA	CAB017467.
MIM	601305. gene.
neXtProt	NX_P47898.
PharmGKB	PA29558.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG260742.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
InParanoid	P47898.
KO	K04161.
OMA	NSAFKNF.
OrthoDB	EOG4K6G4Q.
PhylomeDB	P47898.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P47898.
Bgee	P47898.
CleanEx	HS_HTR5A.
Genevestigator	P47898.
GermOnline	ENSG00000157219. Homo sapiens.
Family and domain databases
InterPro	IPR001397. 5HT5A_rcpt. IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00518. 5HT5ARECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P47898.
ChEMBL	CHEMBL3426.
GenomeRNAi	3361.
NextBio	13304.
SOURCE	Search...

Entry information

Entry name

5HT5A_HUMAN

Accession

Primary (citable) accession number: P47898
Secondary accession number(s): Q2M2D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.