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Protein

Olfactory receptor 3A2

Gene

OR3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central
  • receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of chemical stimulus Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 3A2
Alternative name(s):
Olfactory receptor 17-228
Short name:
OR17-228
Olfactory receptor OR17-14
Gene namesi
Name:OR3A2
Synonyms:OLFRA04
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8283. OR3A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence analysisAdd
BLAST
Transmembranei36 – 5823Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 668CytoplasmicSequence analysis
Transmembranei67 – 8822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini89 – 10921ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 12920Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 16718Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 20538ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini230 – 24617CytoplasmicSequence analysisAdd
BLAST
Transmembranei247 – 27024Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini271 – 28111ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini302 – 32120CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32224.

Polymorphism and mutation databases

BioMutaiOR3A2.
DMDMi226694173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 3A2PRO_0000150518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47893.
PRIDEiP47893.

PTM databases

iPTMnetiP47893.

Expressioni

Gene expression databases

BgeeiP47893.
CleanExiHS_OR3A2.
GenevisibleiP47893. HS.

Interactioni

Protein-protein interaction databases

BioGridi111039. 1 interaction.
IntActiP47893. 1 interaction.
STRINGi9606.ENSP00000386180.

Structurei

3D structure databases

ProteinModelPortaliP47893.
SMRiP47893. Positions 34-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP47893.
KOiK04257.
OMAiALWRIFL.
OrthoDBiEOG7B5WWB.
PhylomeDBiP47893.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG
60 70 80 90 100
NLSILAAVLV EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST
110 120 130 140 150
ISYDACLSQL FFFHLLAGMD CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ
160 170 180 190 200
RMLVAASLAC AFTNALTHTV AMSTLNFCGP NEVNHFYCDL PQLFQLSCSS
210 220 230 240 250
TQLNELLLFA VGFIMAGTPL VLIITAYSHV AAAVLRIRSV EGRKKAFSTC
260 270 280 290 300
GSHLTVVCLF FGRGIFNYMR LGSEEASDKD KGVGVFNTVI NPMLNPLIYS
310 320
LRNPDVQGAL WQIFLGRRSL T
Length:321
Mass (Da):35,207
Last modified:April 14, 2009 - v3
Checksum:i642FCD0CC1660F8A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281A → G in AAA17448 (PubMed:8004088).Curated
Sequence conflicti134 – 1341A → G in AAA17448 (PubMed:8004088).Curated
Sequence conflicti142 – 1421S → R in AAA17448 (PubMed:8004088).Curated
Sequence conflicti171 – 1711A → G in AAA17448 (PubMed:8004088).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901L → V.
Corresponds to variant rs9901356 [ dbSNP | Ensembl ].
VAR_062032

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087498 Genomic DNA. No translation available.
BC095517 mRNA. Translation: AAH95517.1.
AF087930 Genomic DNA. Translation: AAF37318.1.
U04713 Genomic DNA. Translation: AAA17448.1.
BK004239 Genomic DNA. Translation: DAA04637.1.
CCDSiCCDS42233.1.
PIRiI38484.
RefSeqiNP_002542.3. NM_002551.3.
UniGeneiHs.647414.

Genome annotation databases

EnsembliENST00000408891; ENSP00000386180; ENSG00000221882.
GeneIDi4995.
KEGGihsa:4995.
UCSCiuc002fvg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087498 Genomic DNA. No translation available.
BC095517 mRNA. Translation: AAH95517.1.
AF087930 Genomic DNA. Translation: AAF37318.1.
U04713 Genomic DNA. Translation: AAA17448.1.
BK004239 Genomic DNA. Translation: DAA04637.1.
CCDSiCCDS42233.1.
PIRiI38484.
RefSeqiNP_002542.3. NM_002551.3.
UniGeneiHs.647414.

3D structure databases

ProteinModelPortaliP47893.
SMRiP47893. Positions 34-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111039. 1 interaction.
IntActiP47893. 1 interaction.
STRINGi9606.ENSP00000386180.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47893.

Polymorphism and mutation databases

BioMutaiOR3A2.
DMDMi226694173.

Proteomic databases

PaxDbiP47893.
PRIDEiP47893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408891; ENSP00000386180; ENSG00000221882.
GeneIDi4995.
KEGGihsa:4995.
UCSCiuc002fvg.4. human.

Organism-specific databases

CTDi4995.
GeneCardsiOR3A2.
HGNCiHGNC:8283. OR3A2.
neXtProtiNX_P47893.
PharmGKBiPA32224.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP47893.
KOiK04257.
OMAiALWRIFL.
OrthoDBiEOG7B5WWB.
PhylomeDBiP47893.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR3A2.
GenomeRNAii4995.
PROiP47893.

Gene expression databases

BgeeiP47893.
CleanExiHS_OR3A2.
GenevisibleiP47893. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-321.
  4. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-321.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR3A2_HUMAN
AccessioniPrimary (citable) accession number: P47893
Secondary accession number(s): Q6IFM3, Q9P1Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 14, 2009
Last modified: July 6, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.