UniProtKB - P47890 (OR1G1_HUMAN)
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Protein
Olfactory receptor 1G1
Gene
OR1G1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G-protein coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- detection of chemical stimulus involved in sensory perception Source: GO_Central
- G-protein coupled receptor signaling pathway Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753. Olfactory Signaling Pathway. |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 1G1Alternative name(s): Olfactory receptor 17-209 Short name: OR17-209 Olfactory receptor 1G2 Olfactory receptor OR17-8 |
Gene namesi | Name:OR1G1 Synonyms:OR1G2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183024.3. |
HGNCi | HGNC:8204. OR1G1. |
neXtProti | NX_P47890. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 50 – 57 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 58 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 80 – 100 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 121 – 140 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 141 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 18 | |
Topological domaini | 159 – 196 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 197 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 220 – 236 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 237 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 260 – 272 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 273 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 293 – 313 | CytoplasmicSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000183024. |
PharmGKBi | PA32076. |
Polymorphism and mutation databases
BioMutai | OR1G1. |
DMDMi | 9297118. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150434 | 1 – 313 | Olfactory receptor 1G1Add BLAST | 313 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P47890. |
PRIDEi | P47890. |
Expressioni
Gene expression databases
Bgeei | ENSG00000183024. |
CleanExi | HS_OR1G1. |
ExpressionAtlasi | P47890. baseline and differential. |
Genevisiblei | P47890. HS. |
Structurei
3D structure databases
ProteinModelPortali | P47890. |
SMRi | P47890. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IVEB. Eukaryota. ENOG4111EG1. LUCA. |
GeneTreei | ENSGT00860000133676. |
HOGENOMi | HOG000041364. |
HOVERGENi | HBG017625. |
InParanoidi | P47890. |
KOi | K04257. |
OMAi | ASWIMNA. |
OrthoDBi | EOG091G0B53. |
PhylomeDBi | P47890. |
TreeFami | TF337210. |
Family and domain databases
InterProi | View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. |
Pfami | View protein in Pfam PF13853. 7tm_4. 1 hit. |
PRINTSi | PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR. |
PROSITEi | View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P47890-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII
60 70 80 90 100
TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ
110 120 130 140 150
LYFFMLFVML EAFLLAVMAY DCYVAICHPL HYILIMSPGL CIFLVSASWI
160 170 180 190 200
MNALHSLLHT LLMNSLSFCA NHEIPHFFCD INPLLSLSCT DPFTNELVIF
210 220 230 240 250
ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL
260 270 280 290 300
FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS
310
LRKLIWVRKI HSP
Sequence cautioni
The sequence DAA04641 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 95 | S → L in AAA18352 (PubMed:8004088).Curated | 1 | |
Sequence conflicti | 125 | A → G in AAA18352 (PubMed:8004088).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053122 | 88 | Q → H. Corresponds to variant dbSNP:rs9892491Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087928 Genomic DNA. Translation: AAF37317.1. U53583 Genomic DNA. Translation: AAC99556.1. BC069379 mRNA. Translation: AAH69379.1. BC095520 mRNA. Translation: AAH95520.1. U04689 Genomic DNA. Translation: AAA18352.1. BK004243 Genomic DNA. Translation: DAA04641.1. Different initiation. |
CCDSi | CCDS11020.1. |
PIRi | I38481. |
RefSeqi | NP_003546.1. NM_003555.1. |
UniGenei | Hs.248183. |
Genome annotation databases
Ensembli | ENST00000328890; ENSP00000331545; ENSG00000183024. |
GeneIDi | 8390. |
KEGGi | hsa:8390. |
UCSCi | uc002fvc.2. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | OR1G1_HUMAN | |
Accessioni | P47890Primary (citable) accession number: P47890 Secondary accession number(s): Q4VBM1, Q6IFL9, Q9UM76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 28, 2018 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |