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Protein

Olfactory receptor 1G1

Gene

OR1G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31914-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1G1
Alternative name(s):
Olfactory receptor 17-209
Short name:
OR17-209
Olfactory receptor 1G2
Olfactory receptor OR17-8
Gene namesi
Name:OR1G1
Synonyms:OR1G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8204. OR1G1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 140CytoplasmicSequence analysisAdd BLAST20
Transmembranei141 – 158Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8390.
OpenTargetsiENSG00000183024.
PharmGKBiPA32076.

Polymorphism and mutation databases

BioMutaiOR1G1.
DMDMi9297118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504341 – 313Olfactory receptor 1G1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47890.
PRIDEiP47890.

Expressioni

Gene expression databases

BgeeiENSG00000183024.
CleanExiHS_OR1G1.
ExpressionAtlasiP47890. baseline.
GenevisibleiP47890. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331545.

Structurei

3D structure databases

ProteinModelPortaliP47890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEB. Eukaryota.
ENOG4111EG1. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47890.
KOiK04257.
OMAiHPLHYIM.
OrthoDBiEOG091G0B53.
PhylomeDBiP47890.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII
60 70 80 90 100
TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ
110 120 130 140 150
LYFFMLFVML EAFLLAVMAY DCYVAICHPL HYILIMSPGL CIFLVSASWI
160 170 180 190 200
MNALHSLLHT LLMNSLSFCA NHEIPHFFCD INPLLSLSCT DPFTNELVIF
210 220 230 240 250
ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL
260 270 280 290 300
FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS
310
LRKLIWVRKI HSP
Length:313
Mass (Da):34,924
Last modified:December 1, 2000 - v2
Checksum:i556C28EB731FD003
GO

Sequence cautioni

The sequence DAA04641 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95S → L in AAA18352 (PubMed:8004088).Curated1
Sequence conflicti125A → G in AAA18352 (PubMed:8004088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05312288Q → H.Corresponds to variant rs9892491dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087928 Genomic DNA. Translation: AAF37317.1.
U53583 Genomic DNA. Translation: AAC99556.1.
BC069379 mRNA. Translation: AAH69379.1.
BC095520 mRNA. Translation: AAH95520.1.
U04689 Genomic DNA. Translation: AAA18352.1.
BK004243 Genomic DNA. Translation: DAA04641.1. Different initiation.
CCDSiCCDS11020.1.
PIRiI38481.
RefSeqiNP_003546.1. NM_003555.1.
UniGeneiHs.248183.

Genome annotation databases

EnsembliENST00000328890; ENSP00000331545; ENSG00000183024.
GeneIDi8390.
KEGGihsa:8390.
UCSCiuc002fvc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087928 Genomic DNA. Translation: AAF37317.1.
U53583 Genomic DNA. Translation: AAC99556.1.
BC069379 mRNA. Translation: AAH69379.1.
BC095520 mRNA. Translation: AAH95520.1.
U04689 Genomic DNA. Translation: AAA18352.1.
BK004243 Genomic DNA. Translation: DAA04641.1. Different initiation.
CCDSiCCDS11020.1.
PIRiI38481.
RefSeqiNP_003546.1. NM_003555.1.
UniGeneiHs.248183.

3D structure databases

ProteinModelPortaliP47890.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331545.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1G1.
DMDMi9297118.

Proteomic databases

PaxDbiP47890.
PRIDEiP47890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328890; ENSP00000331545; ENSG00000183024.
GeneIDi8390.
KEGGihsa:8390.
UCSCiuc002fvc.2. human.

Organism-specific databases

CTDi8390.
DisGeNETi8390.
GeneCardsiOR1G1.
HGNCiHGNC:8204. OR1G1.
neXtProtiNX_P47890.
OpenTargetsiENSG00000183024.
PharmGKBiPA32076.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVEB. Eukaryota.
ENOG4111EG1. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47890.
KOiK04257.
OMAiHPLHYIM.
OrthoDBiEOG091G0B53.
PhylomeDBiP47890.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:G66-31914-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1G1.
GenomeRNAii8390.
PROiP47890.

Gene expression databases

BgeeiENSG00000183024.
CleanExiHS_OR1G1.
ExpressionAtlasiP47890. baseline.
GenevisibleiP47890. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1G1_HUMAN
AccessioniPrimary (citable) accession number: P47890
Secondary accession number(s): Q4VBM1, Q6IFL9, Q9UM76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.