OR1G1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: InterPro
transmembrane signaling receptor activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

detection of chemical stimulus involved in sensory perception Source: GO_Central
G-protein coupled receptor signaling pathway Source: GO_Central
signal transduction
Source: ProtInc
Non-traceable author statementⁱ
- 8004088

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 1G1 Alternative name(s): Olfactory receptor 17-209 Short name: OR17-209 Olfactory receptor 1G2 Olfactory receptor OR17-8
Gene namesⁱ	Name:OR1G1 Synonyms:OR1G2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8204. OR1G1.

HGNCⁱ

HGNC:8204. OR1G1.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 49	Helical; Name=1Sequence analysisAdd BLAST	24
Topological domainⁱ	50 – 57	CytoplasmicSequence analysis	8
Transmembraneⁱ	58 – 79	Helical; Name=2Sequence analysisAdd BLAST	22
Topological domainⁱ	80 – 100	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	101 – 120	Helical; Name=3Sequence analysisAdd BLAST	20
Topological domainⁱ	121 – 140	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	141 – 158	Helical; Name=4Sequence analysisAdd BLAST	18
Topological domainⁱ	159 – 196	ExtracellularSequence analysisAdd BLAST	38
Transmembraneⁱ	197 – 219	Helical; Name=5Sequence analysisAdd BLAST	23
Topological domainⁱ	220 – 236	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	237 – 259	Helical; Name=6Sequence analysisAdd BLAST	23
Topological domainⁱ	260 – 272	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	273 – 292	Helical; Name=7Sequence analysisAdd BLAST	20
Topological domainⁱ	293 – 313	CytoplasmicSequence analysisAdd BLAST	21

GO - Cellular componentⁱ

integral component of membrane Source: GO_Central
plasma membrane Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8390.
Open Targets More...OpenTargetsⁱ	ENSG00000183024.
PharmGKBⁱ	PA32076.

Polymorphism and mutation databases

BioMutaⁱ	OR1G1.
DMDMⁱ	9297118.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150434	1 – 313	Olfactory receptor 1G1Add BLAST		313

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	97 ↔ 189	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P47890.
PRIDEⁱ	P47890.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000183024.
CleanExⁱ	HS_OR1G1.
ExpressionAtlasⁱ	P47890. baseline and differential.
Genevisibleⁱ	P47890. HS.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000331545.

STRINGⁱ

9606.ENSP00000331545.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47890.
SMRⁱ	P47890.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IVEB. Eukaryota. ENOG4111EG1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133676.
HOGENOMⁱ	HOG000041364.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	P47890.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	ASWIMNA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B53.
PhylomeDBⁱ	P47890.
TreeFamⁱ	TF337210.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P47890-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII 
        60         70         80         90        100
TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ 
       110        120        130        140        150
LYFFMLFVML EAFLLAVMAY DCYVAICHPL HYILIMSPGL CIFLVSASWI 
       160        170        180        190        200
MNALHSLLHT LLMNSLSFCA NHEIPHFFCD INPLLSLSCT DPFTNELVIF 
       210        220        230        240        250
ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL 
       260        270        280        290        300
FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS 
       310 
LRKLIWVRKI HSP

Length:313

Mass (Da):34,924

Last modified:December 1, 2000 - v2

Checksum:ⁱ556C28EB731FD003

GO

Sequence cautionⁱ

The sequence DAA04641 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	95	S → L in AAA18352 (PubMed:8004088).Curated		1
Sequence conflictⁱ	125	A → G in AAA18352 (PubMed:8004088).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053122	88	Q → H. Corresponds to variant dbSNP:rs9892491Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087928 Genomic DNA. Translation: AAF37317.1. U53583 Genomic DNA. Translation: AAC99556.1. BC069379 mRNA. Translation: AAH69379.1. BC095520 mRNA. Translation: AAH95520.1. U04689 Genomic DNA. Translation: AAA18352.1. BK004243 Genomic DNA. Translation: DAA04641.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11020.1.
PIRⁱ	I38481.
NCBI Reference Sequences More...RefSeqⁱ	NP_003546.1. NM_003555.1.
UniGeneⁱ	Hs.248183.

Genome annotation databases

Ensemblⁱ	ENST00000328890; ENSP00000331545; ENSG00000183024.
GeneIDⁱ	8390.
KEGGⁱ	hsa:8390.
UCSC genome browser More...UCSCⁱ	uc002fvc.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087928 Genomic DNA. Translation: AAF37317.1. U53583 Genomic DNA. Translation: AAC99556.1. BC069379 mRNA. Translation: AAH69379.1. BC095520 mRNA. Translation: AAH95520.1. U04689 Genomic DNA. Translation: AAA18352.1. BK004243 Genomic DNA. Translation: DAA04641.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11020.1.
PIRⁱ	I38481.
NCBI Reference Sequences More...RefSeqⁱ	NP_003546.1. NM_003555.1.
UniGeneⁱ	Hs.248183.

3D structure databases

ProteinModelPortalⁱ	P47890.
SMRⁱ	P47890.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000331545.

STRINGⁱ

9606.ENSP00000331545.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Polymorphism and mutation databases

BioMutaⁱ	OR1G1.
DMDMⁱ	9297118.

Proteomic databases

PaxDbⁱ	P47890.
PRIDEⁱ	P47890.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000328890; ENSP00000331545; ENSG00000183024.
GeneIDⁱ	8390.
KEGGⁱ	hsa:8390.
UCSC genome browser More...UCSCⁱ	uc002fvc.2. human.

Organism-specific databases

CTDⁱ	8390.
DisGeNET More...DisGeNETⁱ	8390.
GeneCardsⁱ	OR1G1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8204. OR1G1.
neXtProtⁱ	NX_P47890.
Open Targets More...OpenTargetsⁱ	ENSG00000183024.
PharmGKBⁱ	PA32076.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVEB. Eukaryota. ENOG4111EG1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133676.
HOGENOMⁱ	HOG000041364.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	P47890.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	ASWIMNA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B53.
PhylomeDBⁱ	P47890.
TreeFamⁱ	TF337210.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiⁱ	OR1G1.
GenomeRNAiⁱ	8390.
Protein Ontology More...PROⁱ	PR:P47890.

Gene expression databases

Bgeeⁱ	ENSG00000183024.
CleanExⁱ	HS_OR1G1.
ExpressionAtlasⁱ	P47890. baseline and differential.
Genevisibleⁱ	P47890. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OR1G1_HUMAN
Accessionⁱ	P47890Primary (citable) accession number: P47890 Secondary accession number(s): Q4VBM1, Q6IFL9, Q9UM76
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	December 1, 2000
	Last modified:	June 7, 2017
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47890 (OR1G1_HUMAN)

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Olfactory receptor 1G1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ