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Protein

Olfactory receptor 1G1

Gene

OR1G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1G1
Alternative name(s):
Olfactory receptor 17-209
Short name:
OR17-209
Olfactory receptor 1G2
Olfactory receptor OR17-8
Gene namesi
Name:OR1G1
Synonyms:OR1G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8204. OR1G1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 14020CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 15818Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31321CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32076.

Polymorphism and mutation databases

BioMutaiOR1G1.
DMDMi9297118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 1G1PRO_0000150434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47890.

Expressioni

Gene expression databases

BgeeiP47890.
CleanExiHS_OR1G1.
GenevisibleiP47890. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331545.

Structurei

3D structure databases

ProteinModelPortaliP47890.
SMRiP47890. Positions 33-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEB. Eukaryota.
ENOG4111EG1. LUCA.
GeneTreeiENSGT00810000125354.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47890.
KOiK04257.
OMAiHPLHYIM.
OrthoDBiEOG71K63J.
PhylomeDBiP47890.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII
60 70 80 90 100
TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ
110 120 130 140 150
LYFFMLFVML EAFLLAVMAY DCYVAICHPL HYILIMSPGL CIFLVSASWI
160 170 180 190 200
MNALHSLLHT LLMNSLSFCA NHEIPHFFCD INPLLSLSCT DPFTNELVIF
210 220 230 240 250
ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL
260 270 280 290 300
FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS
310
LRKLIWVRKI HSP
Length:313
Mass (Da):34,924
Last modified:December 1, 2000 - v2
Checksum:i556C28EB731FD003
GO

Sequence cautioni

The sequence DAA04641.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951S → L in AAA18352 (PubMed:8004088).Curated
Sequence conflicti125 – 1251A → G in AAA18352 (PubMed:8004088).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti88 – 881Q → H.
Corresponds to variant rs9892491 [ dbSNP | Ensembl ].
VAR_053122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087928 Genomic DNA. Translation: AAF37317.1.
U53583 Genomic DNA. Translation: AAC99556.1.
BC069379 mRNA. Translation: AAH69379.1.
BC095520 mRNA. Translation: AAH95520.1.
U04689 Genomic DNA. Translation: AAA18352.1.
BK004243 Genomic DNA. Translation: DAA04641.1. Different initiation.
CCDSiCCDS11020.1.
PIRiI38481.
RefSeqiNP_003546.1. NM_003555.1.
XP_006721650.1. XM_006721587.2.
UniGeneiHs.248183.

Genome annotation databases

EnsembliENST00000328890; ENSP00000331545; ENSG00000183024.
GeneIDi8390.
KEGGihsa:8390.
UCSCiuc002fvc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087928 Genomic DNA. Translation: AAF37317.1.
U53583 Genomic DNA. Translation: AAC99556.1.
BC069379 mRNA. Translation: AAH69379.1.
BC095520 mRNA. Translation: AAH95520.1.
U04689 Genomic DNA. Translation: AAA18352.1.
BK004243 Genomic DNA. Translation: DAA04641.1. Different initiation.
CCDSiCCDS11020.1.
PIRiI38481.
RefSeqiNP_003546.1. NM_003555.1.
XP_006721650.1. XM_006721587.2.
UniGeneiHs.248183.

3D structure databases

ProteinModelPortaliP47890.
SMRiP47890. Positions 33-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331545.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1G1.
DMDMi9297118.

Proteomic databases

PaxDbiP47890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328890; ENSP00000331545; ENSG00000183024.
GeneIDi8390.
KEGGihsa:8390.
UCSCiuc002fvc.2. human.

Organism-specific databases

CTDi8390.
GeneCardsiOR1G1.
HGNCiHGNC:8204. OR1G1.
neXtProtiNX_P47890.
PharmGKBiPA32076.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVEB. Eukaryota.
ENOG4111EG1. LUCA.
GeneTreeiENSGT00810000125354.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47890.
KOiK04257.
OMAiHPLHYIM.
OrthoDBiEOG71K63J.
PhylomeDBiP47890.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1G1.
GenomeRNAii8390.
PROiP47890.

Gene expression databases

BgeeiP47890.
CleanExiHS_OR1G1.
GenevisibleiP47890. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3 olfactory receptor gene cluster."
    Ferraz C., Demaille J.G.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1G1_HUMAN
AccessioniPrimary (citable) accession number: P47890
Secondary accession number(s): Q4VBM1, Q6IFL9, Q9UM76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: June 8, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.