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Protein

Olfactory receptor 3A3

Gene

OR3A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159961-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 3A3
Alternative name(s):
Olfactory receptor 17-201
Short name:
OR17-201
Olfactory receptor 3A6
Olfactory receptor 3A7
Olfactory receptor 3A8
Olfactory receptor OR17-22
Gene namesi
Name:OR3A3
Synonyms:OR3A6, OR3A7, OR3A8P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8284. OR3A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 58Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini59 – 66CytoplasmicSequence analysis8
Transmembranei67 – 88Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini89 – 109ExtracellularSequence analysisAdd BLAST21
Transmembranei110 – 129Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 167Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini168 – 205ExtracellularSequence analysisAdd BLAST38
Transmembranei206 – 228Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini229 – 245CytoplasmicSequence analysisAdd BLAST17
Transmembranei246 – 268Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini269 – 281ExtracellularSequence analysisAdd BLAST13
Transmembranei282 – 301Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini302 – 321CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8392.
OpenTargetsiENSG00000159961.
PharmGKBiPA32225.

Polymorphism and mutation databases

BioMutaiOR3A3.
DMDMi226694174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505201 – 321Olfactory receptor 3A3Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47888.
PeptideAtlasiP47888.
PRIDEiP47888.

PTM databases

iPTMnetiP47888.
PhosphoSitePlusiP47888.

Expressioni

Gene expression databases

CleanExiHS_OR3A3.
GenevisibleiP47888. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000291231.

Structurei

3D structure databases

ProteinModelPortaliP47888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47888.
KOiK04257.
OMAiDVQGALC.
OrthoDBiEOG091G0AZH.
PhylomeDBiP47888.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG
60 70 80 90 100
NLSILAAVLV EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST
110 120 130 140 150
ISYDACLSQL FFFHLLAGMD CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ
160 170 180 190 200
RMLVAASWAC AFTNALTHTV AMSTLNFCGP NEVNHFYCDL PQLFQLSCSS
210 220 230 240 250
TQLNELLLFV AAAFMAVAPL VFISVSYAHV VAAVLQIRSA EGRKKAFSTC
260 270 280 290 300
GSHLTVVGIF YGTGVFSYMR LGSVESSDKD KGVGVFMTVI NPMLNPLIYS
310 320
LRNTDVQGAL CQLLVGKRSL T
Length:321
Mass (Da):34,963
Last modified:April 14, 2009 - v3
Checksum:iDA67FD99DE730A66
GO

Sequence cautioni

The sequence AAI08922 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48T → I in AAF37316 (PubMed:10673334).Curated1
Sequence conflicti48T → I in AC007194 (PubMed:10673334).Curated1
Sequence conflicti48T → I in AAF03262 (Ref. 2) Curated1
Sequence conflicti48T → I in AAD00250 (Ref. 3) Curated1
Sequence conflicti48T → I in AAD00277 (Ref. 4) Curated1
Sequence conflicti48T → I in AAH69415 (PubMed:15489334).Curated1
Sequence conflicti171A → G in AAA18351 (PubMed:8004088).Curated1
Sequence conflicti189D → E in AAA18351 (PubMed:8004088).Curated1
Sequence conflicti193L → V in AAA18351 (PubMed:8004088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054961132L → F.Corresponds to variant rs769432dbSNPEnsembl.1
Natural variantiVAR_054962158W → L.Corresponds to variant rs916039dbSNPEnsembl.1
Natural variantiVAR_054963287M → V.Corresponds to variant rs12939997dbSNPEnsembl.1
Natural variantiVAR_054964317K → E.6 PublicationsCorresponds to variant rs227787dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007194 Genomic DNA. No translation available.
AF087926 Genomic DNA. Translation: AAF37316.1.
AF095725 Genomic DNA. Translation: AAF03262.1.
U76377 Genomic DNA. Translation: AAD00250.1.
U78308 Genomic DNA. Translation: AAD00277.1.
AC025125 Genomic DNA. No translation available.
BC069415 mRNA. Translation: AAH69415.1.
BC108921 mRNA. Translation: AAI08922.2. Different initiation.
U04688 Genomic DNA. Translation: AAA18351.1.
AF399620 Genomic DNA. Translation: AAK95105.1.
BK004236 Genomic DNA. Translation: DAA04634.1.
CCDSiCCDS11025.1.
PIRiI38480.
RefSeqiNP_036505.2. NM_012373.2.
UniGeneiHs.532689.

Genome annotation databases

EnsembliENST00000291231; ENSP00000291231; ENSG00000159961.
GeneIDi8392.
KEGGihsa:8392.
UCSCiuc010vrd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007194 Genomic DNA. No translation available.
AF087926 Genomic DNA. Translation: AAF37316.1.
AF095725 Genomic DNA. Translation: AAF03262.1.
U76377 Genomic DNA. Translation: AAD00250.1.
U78308 Genomic DNA. Translation: AAD00277.1.
AC025125 Genomic DNA. No translation available.
BC069415 mRNA. Translation: AAH69415.1.
BC108921 mRNA. Translation: AAI08922.2. Different initiation.
U04688 Genomic DNA. Translation: AAA18351.1.
AF399620 Genomic DNA. Translation: AAK95105.1.
BK004236 Genomic DNA. Translation: DAA04634.1.
CCDSiCCDS11025.1.
PIRiI38480.
RefSeqiNP_036505.2. NM_012373.2.
UniGeneiHs.532689.

3D structure databases

ProteinModelPortaliP47888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000291231.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47888.
PhosphoSitePlusiP47888.

Polymorphism and mutation databases

BioMutaiOR3A3.
DMDMi226694174.

Proteomic databases

PaxDbiP47888.
PeptideAtlasiP47888.
PRIDEiP47888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291231; ENSP00000291231; ENSG00000159961.
GeneIDi8392.
KEGGihsa:8392.
UCSCiuc010vrd.2. human.

Organism-specific databases

CTDi8392.
DisGeNETi8392.
GeneCardsiOR3A3.
H-InvDBHIX0039209.
HGNCiHGNC:8284. OR3A3.
neXtProtiNX_P47888.
OpenTargetsiENSG00000159961.
PharmGKBiPA32225.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47888.
KOiK04257.
OMAiDVQGALC.
OrthoDBiEOG091G0AZH.
PhylomeDBiP47888.
TreeFamiTF352732.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159961-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR3A3.
GenomeRNAii8392.
PROiP47888.

Gene expression databases

CleanExiHS_OR3A3.
GenevisibleiP47888. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR3A3_HUMAN
AccessioniPrimary (citable) accession number: P47888
Secondary accession number(s): Q2VPE4
, Q6IFM6, Q9P1Q4, Q9UBE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 14, 2009
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.