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Protein

Olfactory receptor 3A3

Gene

OR3A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 3A3
Alternative name(s):
Olfactory receptor 17-201
Short name:
OR17-201
Olfactory receptor 3A6
Olfactory receptor 3A7
Olfactory receptor 3A8
Olfactory receptor OR17-22
Gene namesi
Name:OR3A3
Synonyms:OR3A6, OR3A7, OR3A8P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8284. OR3A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5824Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 668CytoplasmicSequence analysis
Transmembranei67 – 8822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini89 – 10921ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 12920Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 16718Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 20538ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22823Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini229 – 24517CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini269 – 28113ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini302 – 32120CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32225.

Polymorphism and mutation databases

BioMutaiOR3A3.
DMDMi226694174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 3A3PRO_0000150520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47888.
PeptideAtlasiP47888.
PRIDEiP47888.

PTM databases

iPTMnetiP47888.

Expressioni

Gene expression databases

BgeeiP47888.
CleanExiHS_OR3A3.
GenevisibleiP47888. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000291231.

Structurei

3D structure databases

ProteinModelPortaliP47888.
SMRiP47888. Positions 34-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47888.
KOiK04257.
OMAiDVQGALC.
OrthoDBiEOG7B5WWB.
PhylomeDBiP47888.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG
60 70 80 90 100
NLSILAAVLV EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST
110 120 130 140 150
ISYDACLSQL FFFHLLAGMD CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ
160 170 180 190 200
RMLVAASWAC AFTNALTHTV AMSTLNFCGP NEVNHFYCDL PQLFQLSCSS
210 220 230 240 250
TQLNELLLFV AAAFMAVAPL VFISVSYAHV VAAVLQIRSA EGRKKAFSTC
260 270 280 290 300
GSHLTVVGIF YGTGVFSYMR LGSVESSDKD KGVGVFMTVI NPMLNPLIYS
310 320
LRNTDVQGAL CQLLVGKRSL T
Length:321
Mass (Da):34,963
Last modified:April 14, 2009 - v3
Checksum:iDA67FD99DE730A66
GO

Sequence cautioni

The sequence AAI08922.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481T → I in AAF37316 (PubMed:10673334).Curated
Sequence conflicti48 – 481T → I in AC007194 (PubMed:10673334).Curated
Sequence conflicti48 – 481T → I in AAF03262 (Ref. 2) Curated
Sequence conflicti48 – 481T → I in AAD00250 (Ref. 3) Curated
Sequence conflicti48 – 481T → I in AAD00277 (Ref. 4) Curated
Sequence conflicti48 – 481T → I in AAH69415 (PubMed:15489334).Curated
Sequence conflicti171 – 1711A → G in AAA18351 (PubMed:8004088).Curated
Sequence conflicti189 – 1891D → E in AAA18351 (PubMed:8004088).Curated
Sequence conflicti193 – 1931L → V in AAA18351 (PubMed:8004088).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321L → F.
Corresponds to variant rs769432 [ dbSNP | Ensembl ].
VAR_054961
Natural varianti158 – 1581W → L.
Corresponds to variant rs916039 [ dbSNP | Ensembl ].
VAR_054962
Natural varianti287 – 2871M → V.
Corresponds to variant rs12939997 [ dbSNP | Ensembl ].
VAR_054963
Natural varianti317 – 3171K → E.6 Publications
Corresponds to variant rs227787 [ dbSNP | Ensembl ].
VAR_054964

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007194 Genomic DNA. No translation available.
AF087926 Genomic DNA. Translation: AAF37316.1.
AF095725 Genomic DNA. Translation: AAF03262.1.
U76377 Genomic DNA. Translation: AAD00250.1.
U78308 Genomic DNA. Translation: AAD00277.1.
AC025125 Genomic DNA. No translation available.
BC069415 mRNA. Translation: AAH69415.1.
BC108921 mRNA. Translation: AAI08922.2. Different initiation.
U04688 Genomic DNA. Translation: AAA18351.1.
AF399620 Genomic DNA. Translation: AAK95105.1.
BK004236 Genomic DNA. Translation: DAA04634.1.
CCDSiCCDS11025.1.
PIRiI38480.
RefSeqiNP_036505.2. NM_012373.2.
UniGeneiHs.532689.

Genome annotation databases

EnsembliENST00000291231; ENSP00000291231; ENSG00000159961.
GeneIDi8392.
KEGGihsa:8392.
UCSCiuc010vrd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007194 Genomic DNA. No translation available.
AF087926 Genomic DNA. Translation: AAF37316.1.
AF095725 Genomic DNA. Translation: AAF03262.1.
U76377 Genomic DNA. Translation: AAD00250.1.
U78308 Genomic DNA. Translation: AAD00277.1.
AC025125 Genomic DNA. No translation available.
BC069415 mRNA. Translation: AAH69415.1.
BC108921 mRNA. Translation: AAI08922.2. Different initiation.
U04688 Genomic DNA. Translation: AAA18351.1.
AF399620 Genomic DNA. Translation: AAK95105.1.
BK004236 Genomic DNA. Translation: DAA04634.1.
CCDSiCCDS11025.1.
PIRiI38480.
RefSeqiNP_036505.2. NM_012373.2.
UniGeneiHs.532689.

3D structure databases

ProteinModelPortaliP47888.
SMRiP47888. Positions 34-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000291231.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47888.

Polymorphism and mutation databases

BioMutaiOR3A3.
DMDMi226694174.

Proteomic databases

PaxDbiP47888.
PeptideAtlasiP47888.
PRIDEiP47888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291231; ENSP00000291231; ENSG00000159961.
GeneIDi8392.
KEGGihsa:8392.
UCSCiuc010vrd.2. human.

Organism-specific databases

CTDi8392.
GeneCardsiOR3A3.
H-InvDBHIX0039209.
HGNCiHGNC:8284. OR3A3.
neXtProtiNX_P47888.
PharmGKBiPA32225.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP47888.
KOiK04257.
OMAiDVQGALC.
OrthoDBiEOG7B5WWB.
PhylomeDBiP47888.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR3A3.
GenomeRNAii8392.
PROiP47888.

Gene expression databases

BgeeiP47888.
CleanExiHS_OR3A3.
GenevisibleiP47888. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-317.
  2. "DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory receptor gene cluster of human chromosome 17p13.3, containing OR genes 2, 201, 93 and pseudogene 1."
    Ferraz C., Vidal S., Brun C., Demaille J.G.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-317.
  3. "Sequence of cosmid ICRF105cH07155 of the olfactory receptor gene cluster of human chromosome 17p13.3."
    Ferraz C., Demaille J.G.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-317.
  4. "Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory receptor gene cluster, containing genes OR17-32 and OR17-201-1, and pseudogene OR17-01."
    Ferraz C., Demaille J.G.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-317.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-317.
  7. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-292.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-292.
  9. Cited for: IDENTIFICATION, VARIANT GLU-317.
  10. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR3A3_HUMAN
AccessioniPrimary (citable) accession number: P47888
Secondary accession number(s): Q2VPE4
, Q6IFM6, Q9P1Q4, Q9UBE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 14, 2009
Last modified: July 6, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.