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Protein

Olfactory receptor 1E2

Gene

OR1E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of chemical stimulus Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127780-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1E2
Alternative name(s):
Olfactory receptor 17-93/17-135/17-136
Short name:
OR17-135
Short name:
OR17-136
Short name:
OR17-93
Olfactory receptor 1E4
Gene namesi
Name:OR1E2
Synonyms:OR1E4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8190. OR1E2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 148CytoplasmicSequence analysisAdd BLAST28
Transmembranei149 – 167Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini168 – 205ExtracellularSequence analysisAdd BLAST38
Transmembranei206 – 228Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini229 – 245CytoplasmicSequence analysisAdd BLAST17
Transmembranei246 – 269Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini270 – 281ExtracellularSequence analysisAdd BLAST12
Transmembranei282 – 301Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini302 – 323CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127780.
PharmGKBiPA32063.

Polymorphism and mutation databases

BioMutaiOR1E2.
DMDMi9297116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504281 – 323Olfactory receptor 1E2Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 198PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47887.
PRIDEiP47887.

PTM databases

iPTMnetiP47887.
PhosphoSitePlusiP47887.

Expressioni

Gene expression databases

CleanExiHS_OR1E2.
ExpressionAtlasiP47887. differential.
GenevisibleiP47887. HS.

Interactioni

Protein-protein interaction databases

BioGridi113978. 1 interactor.
STRINGi9606.ENSP00000248384.

Structurei

3D structure databases

ProteinModelPortaliP47887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9M4. Eukaryota.
ENOG41113B1. LUCA.
GeneTreeiENSGT00860000133705.
HOVERGENiHBG017625.
InParanoidiP47887.
KOiK04257.
OMAiVPSKGIC.
OrthoDBiEOG091G0EOH.
PhylomeDBiP47887.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR
60 70 80 90 100
LDSHLHTPVY LFLSNLSFSD LCFSSVTMPK LLQNMQNQDP SIPYADCLTQ
110 120 130 140 150
MYFFLYFSDL ESFLLVAMAY DRYVAICFPM HYTAICFLLH YTAIMSPMLC
160 170 180 190 200
LSVVALSWVL TTFHAMLHTL LMARLCFCAD NVIPHFFCDM SALLKLACSD
210 220 230 240 250
TRVNEWVIFI MGGLILVIPF LLILGSYARI VSSILKVPSS KGICKAFSTC
260 270 280 290 300
GSHLSVVSLF YGTVIGLYLC PSANSSTLKD TVMAMMYTVV TPMLTPFIYS
310 320
LRNRDMKGAL ERVICKRKNP FLL
Length:323
Mass (Da):36,391
Last modified:December 1, 2000 - v2
Checksum:i19AADA692BD92D3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95A → E in AAC39621 (PubMed:9500546).Curated1
Sequence conflicti108S → T in AAC39621 (PubMed:9500546).Curated1
Sequence conflicti271P → S in AAC39621 (PubMed:9500546).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02929227C → R.1 PublicationCorresponds to variant rs769431dbSNPEnsembl.1
Natural variantiVAR_036207168H → D in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087925 Genomic DNA. Translation: AAF37315.1.
AF095725 Genomic DNA. Translation: AAF03260.1.
BC121105 mRNA. Translation: AAI21106.1.
BC121106 mRNA. Translation: AAI21107.1.
U04686 Genomic DNA. Translation: AAA18349.1.
U86241 Genomic DNA. Translation: AAC39621.1.
U86242 Genomic DNA. Translation: AAC39622.1.
AF399551 Genomic DNA. Translation: AAK95036.1.
U76377 Genomic DNA. Translation: AAD00249.1.
CCDSiCCDS11026.1.
PIRiI38478.
RefSeqiNP_003545.1. NM_003554.2.
UniGeneiHs.533931.

Genome annotation databases

EnsembliENST00000248384; ENSP00000248384; ENSG00000127780.
GeneIDi8388.
KEGGihsa:8388.
UCSCiuc010vre.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087925 Genomic DNA. Translation: AAF37315.1.
AF095725 Genomic DNA. Translation: AAF03260.1.
BC121105 mRNA. Translation: AAI21106.1.
BC121106 mRNA. Translation: AAI21107.1.
U04686 Genomic DNA. Translation: AAA18349.1.
U86241 Genomic DNA. Translation: AAC39621.1.
U86242 Genomic DNA. Translation: AAC39622.1.
AF399551 Genomic DNA. Translation: AAK95036.1.
U76377 Genomic DNA. Translation: AAD00249.1.
CCDSiCCDS11026.1.
PIRiI38478.
RefSeqiNP_003545.1. NM_003554.2.
UniGeneiHs.533931.

3D structure databases

ProteinModelPortaliP47887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113978. 1 interactor.
STRINGi9606.ENSP00000248384.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47887.
PhosphoSitePlusiP47887.

Polymorphism and mutation databases

BioMutaiOR1E2.
DMDMi9297116.

Proteomic databases

PaxDbiP47887.
PRIDEiP47887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248384; ENSP00000248384; ENSG00000127780.
GeneIDi8388.
KEGGihsa:8388.
UCSCiuc010vre.2. human.

Organism-specific databases

CTDi8388.
GeneCardsiOR1E2.
H-InvDBHIX0173556.
HGNCiHGNC:8190. OR1E2.
neXtProtiNX_P47887.
OpenTargetsiENSG00000127780.
PharmGKBiPA32063.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9M4. Eukaryota.
ENOG41113B1. LUCA.
GeneTreeiENSGT00860000133705.
HOVERGENiHBG017625.
InParanoidiP47887.
KOiK04257.
OMAiVPSKGIC.
OrthoDBiEOG091G0EOH.
PhylomeDBiP47887.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127780-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1E2.
GenomeRNAii8388.
PROiP47887.

Gene expression databases

CleanExiHS_OR1E2.
ExpressionAtlasiP47887. differential.
GenevisibleiP47887. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1E2_HUMAN
AccessioniPrimary (citable) accession number: P47887
Secondary accession number(s): O43877
, O95632, Q0VAD5, Q0VAD6, Q9UL13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.