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Protein

Olfactory receptor 1D4

Gene

OR1D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • olfactory receptor activity Source: InterPro

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • sensory perception of chemical stimulus Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33471-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1D4
Alternative name(s):
Olfactory receptor 17-30
Short name:
OR17-30
Gene namesi
Name:OR1D4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8185. OR1D4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 140CytoplasmicSequence analysisAdd BLAST20
Transmembranei141 – 158Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 220Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 271ExtracellularSequence analysisAdd BLAST11
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 311CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi37538298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504211 – 311Olfactory receptor 1D4Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47884.
PRIDEiP47884.

Expressioni

Gene expression databases

CleanExiHS_OR1D4.

Interactioni

Protein-protein interaction databases

IntActiP47884. 1 interactor.
STRINGi9606.ENSP00000459028.

Structurei

3D structure databases

ProteinModelPortaliP47884.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH29. Eukaryota.
ENOG41116CF. LUCA.
HOVERGENiHBG017625.
InParanoidiP47884.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDNQSENS QFLLLGISES PEQQQILFWM FLSMYLVTVL GNVLIILAIS
60 70 80 90 100
SDSHLHTPMY FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ
110 120 130 140 150
LYFLVSLVTL DNLILAVMAY DRYVAICCPL HYVTAMSPGL CVLLLSLCWG
160 170 180 190 200
LSVLYGLLLT FLLTRVTFCG PREIHYLFCD MYILLWLACS NTHIIHTALI
210 220 230 240 250
ATGCFIFLTL LGFMTTSYVR IVRTILQMPS ASKKYKTFST CASHLGVVSL
260 270 280 290 300
FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYS LRNKDMHGAP
310
GRVLWRPFQR P
Length:311
Mass (Da):35,227
Last modified:October 3, 2003 - v3
Checksum:iBACD6DA94E7B4B51
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204C → W in AAF37312 (PubMed:10673334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087922 Genomic DNA. Translation: AAF37312.1.
U04681 Genomic DNA. Translation: AAA18345.1.
AF399534 Genomic DNA. Translation: AAK95019.1.
PIRiI38473.
UniGeneiHs.653087.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087922 Genomic DNA. Translation: AAF37312.1.
U04681 Genomic DNA. Translation: AAA18345.1.
AF399534 Genomic DNA. Translation: AAK95019.1.
PIRiI38473.
UniGeneiHs.653087.

3D structure databases

ProteinModelPortaliP47884.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47884. 1 interactor.
STRINGi9606.ENSP00000459028.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi37538298.

Proteomic databases

PaxDbiP47884.
PRIDEiP47884.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR1D4.
H-InvDBHIX0039272.
HGNCiHGNC:8185. OR1D4.
neXtProtiNX_P47884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH29. Eukaryota.
ENOG41116CF. LUCA.
HOVERGENiHBG017625.
InParanoidiP47884.

Enzyme and pathway databases

BioCyciZFISH:G66-33471-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiP47884.

Gene expression databases

CleanExiHS_OR1D4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1D4_HUMAN
AccessioniPrimary (citable) accession number: P47884
Secondary accession number(s): Q96RA5, Q9UM75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2003
Last modified: November 30, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.