P47884 (OR1D4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1D4

Alternative name(s):
Olfactory receptor 17-30
Short name=OR17-30

Gene names

Name:

OR1D4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	G-protein coupled receptor activity Traceable author statement. Source: ProtInc olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 1D4		PRO_0000150421
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 140	20	Cytoplasmic Potential
	Transmembrane	141 – 158	18	Helical; Name=4; Potential
	Topological domain	159 – 196	38	Extracellular Potential
	Transmembrane	197 – 220	24	Helical; Name=5; Potential
	Topological domain	221 – 237	17	Cytoplasmic Potential
	Transmembrane	238 – 260	23	Helical; Name=6; Potential
	Topological domain	261 – 271	11	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 311	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Experimental info
	Sequence conflict	204	1	C → W in AAF37312. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P47884 [UniParc]. Last modified October 3, 2003. Version 3. Checksum: BACD6DA94E7B4B51	FASTA	311	35,227
	10 20 30 40 50 60 MDGDNQSENS QFLLLGISES PEQQQILFWM FLSMYLVTVL GNVLIILAIS SDSHLHTPMY 70 80 90 100 110 120 FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ LYFLVSLVTL DNLILAVMAY 130 140 150 160 170 180 DRYVAICCPL HYVTAMSPGL CVLLLSLCWG LSVLYGLLLT FLLTRVTFCG PREIHYLFCD 190 200 210 220 230 240 MYILLWLACS NTHIIHTALI ATGCFIFLTL LGFMTTSYVR IVRTILQMPS ASKKYKTFST 250 260 270 280 290 300 CASHLGVVSL FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYS LRNKDMHGAP 310 GRVLWRPFQR P

References

[1]	"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster." Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D. Genomics 63:227-245(2000) [PubMed: 10673334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire." Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A. Hum. Mol. Genet. 3:229-235(1994) [PubMed: 8004088] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed: 12213199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087922 Genomic DNA. Translation: AAF37312.1. U04681 Genomic DNA. Translation: AAA18345.1. AF399534 Genomic DNA. Translation: AAK95019.1.
IPI	IPI00921019.
PIR	I38473.
UniGene	Hs.653087.
3D structure databases
ProteinModelPortal	P47884.
SMR	P47884. Positions 21-307.
ModBase	Search...
Protein-protein interaction databases
STRING	P47884.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	37538298.
Proteomic databases
PRIDE	P47884.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333466; ENSP00000327564; ENSG00000182880.
Organism-specific databases
GeneCards	GC17P003144.
HGNC	HGNC:8185. OR1D4.
neXtProt	NX_P47884.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG017625.
InParanoid	P47884.
OrthoDB	EOG4C5CJZ.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P47884.
CleanEx	HS_OR1D4.
Genevestigator	P47884.
GermOnline	ENSG00000182880. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OR1D4_HUMAN

Accession

Primary (citable) accession number: P47884
Secondary accession number(s): Q96RA5, Q9UM75

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	October 3, 2003
Last modified:	January 25, 2012
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.