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Protein

Olfactory receptor 1D4

Gene

OR1D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1D4
Alternative name(s):
Olfactory receptor 17-30
Short name:
OR17-30
Gene namesi
Name:OR1D4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8185 OR1D4
neXtProtiNX_P47884

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 140CytoplasmicSequence analysisAdd BLAST20
Transmembranei141 – 158Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 220Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 271ExtracellularSequence analysisAdd BLAST11
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 311CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi37538298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504211 – 311Olfactory receptor 1D4Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP47884
ProteomicsDBi55810

Expressioni

Gene expression databases

CleanExiHS_OR1D4

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGCBQ165854EBI-11988863,EBI-5663627

Protein-protein interaction databases

IntActiP47884, 11 interactors

Structurei

3D structure databases

ProteinModelPortaliP47884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH29 Eukaryota
ENOG41116CF LUCA
HOVERGENiHBG017625
InParanoidiP47884

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDNQSENS QFLLLGISES PEQQQILFWM FLSMYLVTVL GNVLIILAIS
60 70 80 90 100
SDSHLHTPMY FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ
110 120 130 140 150
LYFLVSLVTL DNLILAVMAY DRYVAICCPL HYVTAMSPGL CVLLLSLCWG
160 170 180 190 200
LSVLYGLLLT FLLTRVTFCG PREIHYLFCD MYILLWLACS NTHIIHTALI
210 220 230 240 250
ATGCFIFLTL LGFMTTSYVR IVRTILQMPS ASKKYKTFST CASHLGVVSL
260 270 280 290 300
FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYS LRNKDMHGAP
310
GRVLWRPFQR P
Length:311
Mass (Da):35,227
Last modified:October 3, 2003 - v3
Checksum:iBACD6DA94E7B4B51
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204C → W in AAF37312 (PubMed:10673334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087922 Genomic DNA Translation: AAF37312.1
U04681 Genomic DNA Translation: AAA18345.1
AF399534 Genomic DNA Translation: AAK95019.1
PIRiI38473
UniGeneiHs.653087

Similar proteinsi

Entry informationi

Entry nameiOR1D4_HUMAN
AccessioniPrimary (citable) accession number: P47884
Secondary accession number(s): Q96RA5, Q9UM75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2003
Last modified: June 20, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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