ID   OR3A1_HUMAN             Reviewed;         315 AA.
AC   P47881; Q4VB06; Q6IFM4;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   27-MAR-2024, entry version 186.
DE   RecName: Full=Olfactory receptor 3A1;
DE   AltName: Full=Olfactory receptor 17-40;
DE            Short=OR17-40;
DE   AltName: Full=Olfactory receptor OR17-15;
GN   Name=OR3A1; Synonyms=OLFRA03;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-125.
RX   PubMed=8647456; DOI=10.1016/0378-1119(95)00849-7;
RA   Crowe M.L., Perry B.N., Connerton I.F.;
RT   "Olfactory receptor-encoding genes and pseudogenes are expressed in
RT   humans.";
RL   Gene 169:247-249(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8921386; DOI=10.1006/geno.1996.0536;
RA   Glusman G., Clifton S., Roe B., Lancet D.;
RT   "Sequence analysis in the olfactory receptor gene cluster on human
RT   chromosome 17: recombinatorial events affecting receptor diversity.";
RL   Genomics 37:147-160(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-125.
RX   PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA   Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA   Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT   "Sequence, structure, and evolution of a complete human olfactory receptor
RT   gene cluster.";
RL   Genomics 63:227-245(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-125.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, AND VARIANT GLN-125.
RX   PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA   Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA   Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT   "Olfactory receptor gene cluster on human chromosome 17: possible
RT   duplication of an ancestral receptor repertoire.";
RL   Hum. Mol. Genet. 3:229-235(1994).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [8]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR3A1/term:OR3A1/type:keyword";
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DR   EMBL; X80391; CAA56602.1; -; Genomic_DNA.
DR   EMBL; U58675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF087924; AAF37314.1; -; Genomic_DNA.
DR   EMBL; AC087498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069414; AAH69414.1; -; mRNA.
DR   EMBL; BC096187; AAH96187.1; -; mRNA.
DR   EMBL; BC096188; AAH96188.1; -; mRNA.
DR   EMBL; BC096189; AAH96189.1; -; mRNA.
DR   EMBL; BC096190; AAH96190.1; -; mRNA.
DR   EMBL; U04683; AAA18347.1; -; Genomic_DNA.
DR   EMBL; BK004238; DAA04636.1; -; Genomic_DNA.
DR   CCDS; CCDS11023.1; -.
DR   PIR; I38476; I38476.
DR   PIR; JC4658; JC4658.
DR   RefSeq; NP_002541.2; NM_002550.2.
DR   RefSeq; XP_016880184.1; XM_017024695.1.
DR   RefSeq; XP_016880185.1; XM_017024696.1.
DR   AlphaFoldDB; P47881; -.
DR   SMR; P47881; -.
DR   BioGRID; 111038; 3.
DR   IntAct; P47881; 1.
DR   MINT; P47881; -.
DR   STRING; 9606.ENSP00000313803; -.
DR   GlyCosmos; P47881; 1 site, No reported glycans.
DR   GlyGen; P47881; 1 site.
DR   iPTMnet; P47881; -.
DR   PhosphoSitePlus; P47881; -.
DR   BioMuta; OR3A1; -.
DR   DMDM; 148880124; -.
DR   MassIVE; P47881; -.
DR   PaxDb; 9606-ENSP00000313803; -.
DR   PeptideAtlas; P47881; -.
DR   Antibodypedia; 52931; 61 antibodies from 14 providers.
DR   DNASU; 4994; -.
DR   Ensembl; ENST00000323404.2; ENSP00000313803.1; ENSG00000180090.6.
DR   GeneID; 4994; -.
DR   KEGG; hsa:4994; -.
DR   MANE-Select; ENST00000323404.2; ENSP00000313803.1; NM_002550.3; NP_002541.2.
DR   UCSC; uc002fvh.1; human.
DR   AGR; HGNC:8282; -.
DR   CTD; 4994; -.
DR   GeneCards; OR3A1; -.
DR   HGNC; HGNC:8282; OR3A1.
DR   HPA; ENSG00000180090; Not detected.
DR   neXtProt; NX_P47881; -.
DR   OpenTargets; ENSG00000180090; -.
DR   PharmGKB; PA32223; -.
DR   VEuPathDB; HostDB:ENSG00000180090; -.
DR   eggNOG; ENOG502RU17; Eukaryota.
DR   GeneTree; ENSGT00940000162835; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; P47881; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; P47881; -.
DR   TreeFam; TF352732; -.
DR   PathwayCommons; P47881; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; P47881; -.
DR   BioGRID-ORCS; 4994; 8 hits in 751 CRISPR screens.
DR   GeneWiki; OR3A1; -.
DR   GenomeRNAi; 4994; -.
DR   Pharos; P47881; Tdark.
DR   PRO; PR:P47881; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P47881; Protein.
DR   Bgee; ENSG00000180090; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 10 other cell types or tissues.
DR   ExpressionAtlas; P47881; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26452:SF740; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P47881; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 3A1"
FT                   /id="PRO_0000150515"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..82
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        83..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..123
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..264
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..295
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..192
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         78
FT                   /note="S -> G (in dbSNP:rs16952828)"
FT                   /id="VAR_057542"
FT   VARIANT         125
FT                   /note="R -> Q (in dbSNP:rs703903)"
FT                   /evidence="ECO:0000269|PubMed:10673334,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:8004088,
FT                   ECO:0000269|PubMed:8647456"
FT                   /id="VAR_012059"
FT   CONFLICT        120
FT                   /note="A -> D (in Ref. 6; AAA18347)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   315 AA;  34609 MW;  DF32977D5EA7D7CA CRC64;
     MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA AVLVEPKLHT
     PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC LTQLFFFHLF VGVDCFLLTA
     MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNVINHF
     YCDLPQLFQL SCSSTQLNEL LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA
     FSTCGSHLTV VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV
     QSAIWRMLTG RRSLA
//