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P47881 (OR3A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 3A1
Alternative name(s):
Olfactory receptor 17-40
Short name=OR17-40
Olfactory receptor OR17-15
Gene names
Name:OR3A1
Synonyms:OLFRA03
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 3A1
PRO_0000150515

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 5224Helical; Name=1; Potential
Topological domain53 – 608Cytoplasmic Potential
Transmembrane61 – 8222Helical; Name=2; Potential
Topological domain83 – 10321Extracellular Potential
Transmembrane104 – 12320Helical; Name=3; Potential
Topological domain124 – 14320Cytoplasmic Potential
Transmembrane144 – 16118Helical; Name=4; Potential
Topological domain162 – 19938Extracellular Potential
Transmembrane200 – 22324Helical; Name=5; Potential
Topological domain224 – 24017Cytoplasmic Potential
Transmembrane241 – 26424Helical; Name=6; Potential
Topological domain265 – 27511Extracellular Potential
Transmembrane276 – 29520Helical; Name=7; Potential
Topological domain296 – 31520Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Disulfide bond100 ↔ 192 By similarity

Natural variations

Natural variant781S → G.
Corresponds to variant rs16952828 [ dbSNP | Ensembl ].
VAR_057542
Natural variant1251R → Q. Ref.1 Ref.3 Ref.5 Ref.6
Corresponds to variant rs703903 [ dbSNP | Ensembl ].
VAR_012059

Experimental info

Sequence conflict1201A → D in AAA18347. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P47881 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: DF32977D5EA7D7CA

FASTA31534,609
        10         20         30         40         50         60 
MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA AVLVEPKLHT 

        70         80         90        100        110        120 
PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC LTQLFFFHLF VGVDCFLLTA 

       130        140        150        160        170        180 
MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNVINHF 

       190        200        210        220        230        240 
YCDLPQLFQL SCSSTQLNEL LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA 

       250        260        270        280        290        300 
FSTCGSHLTV VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV 

       310 
QSAIWRMLTG RRSLA 

« Hide

References

« Hide 'large scale' references
[1]"Olfactory receptor-encoding genes and pseudogenes are expressed in humans."
Crowe M.L., Perry B.N., Connerton I.F.
Gene 169:247-249(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
[2]"Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity."
Glusman G., Clifton S., Roe B., Lancet D.
Genomics 37:147-160(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
[4]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-125.
[6]"Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, VARIANT GLN-125.
[7]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80391 Genomic DNA. Translation: CAA56602.1.
U58675 Genomic DNA. No translation available.
AF087924 Genomic DNA. Translation: AAF37314.1.
AC087498 Genomic DNA. No translation available.
BC069414 mRNA. Translation: AAH69414.1.
BC096187 mRNA. Translation: AAH96187.1.
BC096188 mRNA. Translation: AAH96188.1.
BC096189 mRNA. Translation: AAH96189.1.
BC096190 mRNA. Translation: AAH96190.1.
U04683 Genomic DNA. Translation: AAA18347.1.
BK004238 Genomic DNA. Translation: DAA04636.1.
CCDSCCDS11023.1.
PIRI38476.
JC4658.
RefSeqNP_002541.2. NM_002550.2.
UniGeneHs.647410.

3D structure databases

ProteinModelPortalP47881.
SMRP47881. Positions 28-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP47881. 1 interaction.
MINTMINT-7295760.
STRING9606.ENSP00000313803.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP47881.

Polymorphism databases

DMDM148880124.

Proteomic databases

PaxDbP47881.
PRIDEP47881.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323404; ENSP00000313803; ENSG00000180090.
GeneID4994.
KEGGhsa:4994.
UCSCuc002fvh.1. human.

Organism-specific databases

CTD4994.
GeneCardsGC17M003194.
H-InvDBHIX0039208.
HGNCHGNC:8282. OR3A1.
neXtProtNX_P47881.
PharmGKBPA32223.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46142.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidP47881.
KOK04257.
OMAWRMLTGR.
OrthoDBEOG7B5WWB.
PhylomeDBP47881.
TreeFamTF352732.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP47881.
CleanExHS_OR3A1.
GenevestigatorP47881.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR3A1.
GenomeRNAi4994.
NextBio19232.
PROP47881.

Entry information

Entry nameOR3A1_HUMAN
AccessionPrimary (citable) accession number: P47881
Secondary accession number(s): Q4VB06, Q6IFM4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 29, 2007
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries