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P47881

- OR3A1_HUMAN

UniProt

P47881 - OR3A1_HUMAN

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Protein

Olfactory receptor 3A1

Gene

OR3A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: ProtInc

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 3A1
Alternative name(s):
Olfactory receptor 17-40
Short name:
OR17-40
Olfactory receptor OR17-15
Gene namesi
Name:OR3A1
Synonyms:OLFRA03
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8282. OR3A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 5224Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence Analysis
Transmembranei61 – 8222Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini83 – 10321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12320Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini124 – 14320CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16118Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19938ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22324Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 24017CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26424Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 27511ExtracellularSequence AnalysisAdd
BLAST
Transmembranei276 – 29520Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini296 – 31520CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 3A1PRO_0000150515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47881.
PRIDEiP47881.

PTM databases

PhosphoSiteiP47881.

Expressioni

Gene expression databases

BgeeiP47881.
CleanExiHS_OR3A1.
GenevestigatoriP47881.

Interactioni

Protein-protein interaction databases

BioGridi111038. 1 interaction.
IntActiP47881. 1 interaction.
MINTiMINT-7295760.
STRINGi9606.ENSP00000313803.

Structurei

3D structure databases

ProteinModelPortaliP47881.
SMRiP47881. Positions 28-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46142.
GeneTreeiENSGT00770000120476.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP47881.
KOiK04257.
OMAiWRMLTGR.
OrthoDBiEOG7B5WWB.
PhylomeDBiP47881.
TreeFamiTF352732.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47881-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA
60 70 80 90 100
AVLVEPKLHT PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC
110 120 130 140 150
LTQLFFFHLF VGVDCFLLTA MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA
160 170 180 190 200
SWACAFTNAL THTVAMSTLN FCGPNVINHF YCDLPQLFQL SCSSTQLNEL
210 220 230 240 250
LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA FSTCGSHLTV
260 270 280 290 300
VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV
310
QSAIWRMLTG RRSLA
Length:315
Mass (Da):34,609
Last modified:May 29, 2007 - v2
Checksum:iDF32977D5EA7D7CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201A → D in AAA18347. (PubMed:8004088)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781S → G.
Corresponds to variant rs16952828 [ dbSNP | Ensembl ].
VAR_057542
Natural varianti125 – 1251R → Q.4 Publications
Corresponds to variant rs703903 [ dbSNP | Ensembl ].
VAR_012059

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80391 Genomic DNA. Translation: CAA56602.1.
U58675 Genomic DNA. No translation available.
AF087924 Genomic DNA. Translation: AAF37314.1.
AC087498 Genomic DNA. No translation available.
BC069414 mRNA. Translation: AAH69414.1.
BC096187 mRNA. Translation: AAH96187.1.
BC096188 mRNA. Translation: AAH96188.1.
BC096189 mRNA. Translation: AAH96189.1.
BC096190 mRNA. Translation: AAH96190.1.
U04683 Genomic DNA. Translation: AAA18347.1.
BK004238 Genomic DNA. Translation: DAA04636.1.
CCDSiCCDS11023.1.
PIRiI38476.
JC4658.
RefSeqiNP_002541.2. NM_002550.2.
UniGeneiHs.647410.

Genome annotation databases

EnsembliENST00000323404; ENSP00000313803; ENSG00000180090.
GeneIDi4994.
KEGGihsa:4994.
UCSCiuc002fvh.1. human.

Polymorphism databases

DMDMi148880124.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80391 Genomic DNA. Translation: CAA56602.1 .
U58675 Genomic DNA. No translation available.
AF087924 Genomic DNA. Translation: AAF37314.1 .
AC087498 Genomic DNA. No translation available.
BC069414 mRNA. Translation: AAH69414.1 .
BC096187 mRNA. Translation: AAH96187.1 .
BC096188 mRNA. Translation: AAH96188.1 .
BC096189 mRNA. Translation: AAH96189.1 .
BC096190 mRNA. Translation: AAH96190.1 .
U04683 Genomic DNA. Translation: AAA18347.1 .
BK004238 Genomic DNA. Translation: DAA04636.1 .
CCDSi CCDS11023.1.
PIRi I38476.
JC4658.
RefSeqi NP_002541.2. NM_002550.2.
UniGenei Hs.647410.

3D structure databases

ProteinModelPortali P47881.
SMRi P47881. Positions 28-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111038. 1 interaction.
IntActi P47881. 1 interaction.
MINTi MINT-7295760.
STRINGi 9606.ENSP00000313803.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P47881.

Polymorphism databases

DMDMi 148880124.

Proteomic databases

PaxDbi P47881.
PRIDEi P47881.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323404 ; ENSP00000313803 ; ENSG00000180090 .
GeneIDi 4994.
KEGGi hsa:4994.
UCSCi uc002fvh.1. human.

Organism-specific databases

CTDi 4994.
GeneCardsi GC17M003194.
H-InvDB HIX0039208.
HGNCi HGNC:8282. OR3A1.
neXtProti NX_P47881.
PharmGKBi PA32223.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46142.
GeneTreei ENSGT00770000120476.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi P47881.
KOi K04257.
OMAi WRMLTGR.
OrthoDBi EOG7B5WWB.
PhylomeDBi P47881.
TreeFami TF352732.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR3A1.
GenomeRNAii 4994.
NextBioi 19232.
PROi P47881.

Gene expression databases

Bgeei P47881.
CleanExi HS_OR3A1.
Genevestigatori P47881.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Olfactory receptor-encoding genes and pseudogenes are expressed in humans."
    Crowe M.L., Perry B.N., Connerton I.F.
    Gene 169:247-249(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
  2. "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity."
    Glusman G., Clifton S., Roe B., Lancet D.
    Genomics 37:147-160(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-125.
  6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, VARIANT GLN-125.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR3A1_HUMAN
AccessioniPrimary (citable) accession number: P47881
Secondary accession number(s): Q4VB06, Q6IFM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3