P47881 (OR3A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 3A1

Alternative name(s):
Olfactory receptor 17-40
Short name=OR17-40
Olfactory receptor OR17-15

Gene names

Name:	OR3A1
Synonyms:	OLFRA03

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Olfactory receptor 3A1		PRO_0000150515
Regions
	Topological domain	1 – 28	28	Extracellular Potential
	Transmembrane	29 – 52	24	Helical; Name=1; Potential
	Topological domain	53 – 60	8	Cytoplasmic Potential
	Transmembrane	61 – 82	22	Helical; Name=2; Potential
	Topological domain	83 – 103	21	Extracellular Potential
	Transmembrane	104 – 123	20	Helical; Name=3; Potential
	Topological domain	124 – 143	20	Cytoplasmic Potential
	Transmembrane	144 – 161	18	Helical; Name=4; Potential
	Topological domain	162 – 199	38	Extracellular Potential
	Transmembrane	200 – 223	24	Helical; Name=5; Potential
	Topological domain	224 – 240	17	Cytoplasmic Potential
	Transmembrane	241 – 264	24	Helical; Name=6; Potential
	Topological domain	265 – 275	11	Extracellular Potential
	Transmembrane	276 – 295	20	Helical; Name=7; Potential
	Topological domain	296 – 315	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Disulfide bond	100 ↔ 192		By similarity
Natural variations
	Natural variant	78	1	S → G. Corresponds to variant rs16952828 [ dbSNP | Ensembl ].		VAR_057542
	Natural variant	125	1	R → Q. Ref.1 Ref.3 Ref.5 Ref.6 Corresponds to variant rs703903 [ dbSNP | Ensembl ].		VAR_012059
Experimental info
	Sequence conflict	120	1	A → D in AAA18347. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P47881 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: DF32977D5EA7D7CA	FASTA	315	34,609
	10 20 30 40 50 60 MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA AVLVEPKLHT 70 80 90 100 110 120 PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC LTQLFFFHLF VGVDCFLLTA 130 140 150 160 170 180 MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNVINHF 190 200 210 220 230 240 YCDLPQLFQL SCSSTQLNEL LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA 250 260 270 280 290 300 FSTCGSHLTV VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV 310 QSAIWRMLTG RRSLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Olfactory receptor-encoding genes and pseudogenes are expressed in humans." Crowe M.L., Perry B.N., Connerton I.F. Gene 169:247-249(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
[2]	"Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity." Glusman G., Clifton S., Roe B., Lancet D. Genomics 37:147-160(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster." Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D. Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-125.
[6]	"Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire." Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A. Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, VARIANT GLN-125.
[7]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80391 Genomic DNA. Translation: CAA56602.1. U58675 Genomic DNA. No translation available. AF087924 Genomic DNA. Translation: AAF37314.1. AC087498 Genomic DNA. No translation available. BC069414 mRNA. Translation: AAH69414.1. BC096187 mRNA. Translation: AAH96187.1. BC096188 mRNA. Translation: AAH96188.1. BC096189 mRNA. Translation: AAH96189.1. BC096190 mRNA. Translation: AAH96190.1. U04683 Genomic DNA. Translation: AAA18347.1. BK004238 Genomic DNA. Translation: DAA04636.1.
IPI	IPI00026651.
PIR	I38476. JC4658.
RefSeq	NP_002541.2. NM_002550.2.
UniGene	Hs.647410.
3D structure databases
ProteinModelPortal	P47881.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7295760.
STRING	9606.ENSP00000313803.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P47881.
Polymorphism databases
DMDM	148880124.
Proteomic databases
PaxDb	P47881.
PRIDE	P47881.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323404; ENSP00000313803; ENSG00000180090.
GeneID	4994.
KEGG	hsa:4994.
UCSC	uc002fvh.1. human.
Organism-specific databases
CTD	4994.
GeneCards	GC17M003194.
H-InvDB	HIX0039208.
HGNC	HGNC:8282. OR3A1.
neXtProt	NX_P47881.
PharmGKB	PA32223.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46142.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	P47881.
KO	K04257.
OMA	RMLTGRR.
OrthoDB	EOG48SGTJ.
PhylomeDB	P47881.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P47881.
CleanEx	HS_OR3A1.
Genevestigator	P47881.
GermOnline	ENSG00000180090. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4994.
NextBio	19232.

Entry information

Entry name

OR3A1_HUMAN

Accession

Primary (citable) accession number: P47881
Secondary accession number(s): Q4VB06, Q6IFM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.