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P47881

- OR3A1_HUMAN

UniProt

P47881 - OR3A1_HUMAN

Protein

Olfactory receptor 3A1

Gene

OR3A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: ProtInc

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 3A1
    Alternative name(s):
    Olfactory receptor 17-40
    Short name:
    OR17-40
    Olfactory receptor OR17-15
    Gene namesi
    Name:OR3A1
    Synonyms:OLFRA03
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8282. OR3A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32223.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 3A1PRO_0000150515Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP47881.
    PRIDEiP47881.

    PTM databases

    PhosphoSiteiP47881.

    Expressioni

    Gene expression databases

    BgeeiP47881.
    CleanExiHS_OR3A1.
    GenevestigatoriP47881.

    Interactioni

    Protein-protein interaction databases

    IntActiP47881. 1 interaction.
    MINTiMINT-7295760.
    STRINGi9606.ENSP00000313803.

    Structurei

    3D structure databases

    ProteinModelPortaliP47881.
    SMRiP47881. Positions 28-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 608CytoplasmicSequence Analysis
    Topological domaini83 – 10321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19938ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 24017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 27511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 31520CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5224Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12320Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16118Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22324Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26424Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29520Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46142.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiP47881.
    KOiK04257.
    OMAiWRMLTGR.
    OrthoDBiEOG7B5WWB.
    PhylomeDBiP47881.
    TreeFamiTF352732.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47881-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA    50
    AVLVEPKLHT PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC 100
    LTQLFFFHLF VGVDCFLLTA MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA 150
    SWACAFTNAL THTVAMSTLN FCGPNVINHF YCDLPQLFQL SCSSTQLNEL 200
    LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA FSTCGSHLTV 250
    VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV 300
    QSAIWRMLTG RRSLA 315
    Length:315
    Mass (Da):34,609
    Last modified:May 29, 2007 - v2
    Checksum:iDF32977D5EA7D7CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201A → D in AAA18347. (PubMed:8004088)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781S → G.
    Corresponds to variant rs16952828 [ dbSNP | Ensembl ].
    VAR_057542
    Natural varianti125 – 1251R → Q.4 Publications
    Corresponds to variant rs703903 [ dbSNP | Ensembl ].
    VAR_012059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80391 Genomic DNA. Translation: CAA56602.1.
    U58675 Genomic DNA. No translation available.
    AF087924 Genomic DNA. Translation: AAF37314.1.
    AC087498 Genomic DNA. No translation available.
    BC069414 mRNA. Translation: AAH69414.1.
    BC096187 mRNA. Translation: AAH96187.1.
    BC096188 mRNA. Translation: AAH96188.1.
    BC096189 mRNA. Translation: AAH96189.1.
    BC096190 mRNA. Translation: AAH96190.1.
    U04683 Genomic DNA. Translation: AAA18347.1.
    BK004238 Genomic DNA. Translation: DAA04636.1.
    CCDSiCCDS11023.1.
    PIRiI38476.
    JC4658.
    RefSeqiNP_002541.2. NM_002550.2.
    UniGeneiHs.647410.

    Genome annotation databases

    EnsembliENST00000323404; ENSP00000313803; ENSG00000180090.
    GeneIDi4994.
    KEGGihsa:4994.
    UCSCiuc002fvh.1. human.

    Polymorphism databases

    DMDMi148880124.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80391 Genomic DNA. Translation: CAA56602.1 .
    U58675 Genomic DNA. No translation available.
    AF087924 Genomic DNA. Translation: AAF37314.1 .
    AC087498 Genomic DNA. No translation available.
    BC069414 mRNA. Translation: AAH69414.1 .
    BC096187 mRNA. Translation: AAH96187.1 .
    BC096188 mRNA. Translation: AAH96188.1 .
    BC096189 mRNA. Translation: AAH96189.1 .
    BC096190 mRNA. Translation: AAH96190.1 .
    U04683 Genomic DNA. Translation: AAA18347.1 .
    BK004238 Genomic DNA. Translation: DAA04636.1 .
    CCDSi CCDS11023.1.
    PIRi I38476.
    JC4658.
    RefSeqi NP_002541.2. NM_002550.2.
    UniGenei Hs.647410.

    3D structure databases

    ProteinModelPortali P47881.
    SMRi P47881. Positions 28-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P47881. 1 interaction.
    MINTi MINT-7295760.
    STRINGi 9606.ENSP00000313803.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47881.

    Polymorphism databases

    DMDMi 148880124.

    Proteomic databases

    PaxDbi P47881.
    PRIDEi P47881.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323404 ; ENSP00000313803 ; ENSG00000180090 .
    GeneIDi 4994.
    KEGGi hsa:4994.
    UCSCi uc002fvh.1. human.

    Organism-specific databases

    CTDi 4994.
    GeneCardsi GC17M003194.
    H-InvDB HIX0039208.
    HGNCi HGNC:8282. OR3A1.
    neXtProti NX_P47881.
    PharmGKBi PA32223.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46142.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi P47881.
    KOi K04257.
    OMAi WRMLTGR.
    OrthoDBi EOG7B5WWB.
    PhylomeDBi P47881.
    TreeFami TF352732.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR3A1.
    GenomeRNAii 4994.
    NextBioi 19232.
    PROi P47881.

    Gene expression databases

    Bgeei P47881.
    CleanExi HS_OR3A1.
    Genevestigatori P47881.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Olfactory receptor-encoding genes and pseudogenes are expressed in humans."
      Crowe M.L., Perry B.N., Connerton I.F.
      Gene 169:247-249(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
    2. "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity."
      Glusman G., Clifton S., Roe B., Lancet D.
      Genomics 37:147-160(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
      Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
      Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-125.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-125.
    6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
      Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
      Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, VARIANT GLN-125.
    7. Cited for: IDENTIFICATION.
    8. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR3A1_HUMAN
    AccessioniPrimary (citable) accession number: P47881
    Secondary accession number(s): Q4VB06, Q6IFM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3