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Protein

Olfactory receptor 3A1

Gene

OR3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180090-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 3A1
Alternative name(s):
Olfactory receptor 17-40
Short name:
OR17-40
Olfactory receptor OR17-15
Gene namesi
Name:OR3A1
Synonyms:OLFRA03
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8282. OR3A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 52Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 82Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini83 – 103ExtracellularSequence analysisAdd BLAST21
Transmembranei104 – 123Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini124 – 143CytoplasmicSequence analysisAdd BLAST20
Transmembranei144 – 161Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini162 – 199ExtracellularSequence analysisAdd BLAST38
Transmembranei200 – 223Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini224 – 240CytoplasmicSequence analysisAdd BLAST17
Transmembranei241 – 264Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini265 – 275ExtracellularSequence analysisAdd BLAST11
Transmembranei276 – 295Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini296 – 315CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180090.
PharmGKBiPA32223.

Polymorphism and mutation databases

BioMutaiOR3A1.
DMDMi148880124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505151 – 315Olfactory receptor 3A1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47881.
PeptideAtlasiP47881.
PRIDEiP47881.

PTM databases

iPTMnetiP47881.
PhosphoSitePlusiP47881.

Expressioni

Gene expression databases

BgeeiENSG00000180090.
CleanExiHS_OR3A1.
ExpressionAtlasiP47881. baseline and differential.
GenevisibleiP47881. HS.

Interactioni

Protein-protein interaction databases

IntActiP47881. 1 interactor.
MINTiMINT-7295760.
STRINGi9606.ENSP00000313803.

Structurei

3D structure databases

ProteinModelPortaliP47881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP47881.
KOiK04257.
PhylomeDBiP47881.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA
60 70 80 90 100
AVLVEPKLHT PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC
110 120 130 140 150
LTQLFFFHLF VGVDCFLLTA MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA
160 170 180 190 200
SWACAFTNAL THTVAMSTLN FCGPNVINHF YCDLPQLFQL SCSSTQLNEL
210 220 230 240 250
LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA FSTCGSHLTV
260 270 280 290 300
VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV
310
QSAIWRMLTG RRSLA
Length:315
Mass (Da):34,609
Last modified:May 29, 2007 - v2
Checksum:iDF32977D5EA7D7CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120A → D in AAA18347 (PubMed:8004088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754278S → G.Corresponds to variant rs16952828dbSNPEnsembl.1
Natural variantiVAR_012059125R → Q.4 PublicationsCorresponds to variant rs703903dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80391 Genomic DNA. Translation: CAA56602.1.
U58675 Genomic DNA. No translation available.
AF087924 Genomic DNA. Translation: AAF37314.1.
AC087498 Genomic DNA. No translation available.
BC069414 mRNA. Translation: AAH69414.1.
BC096187 mRNA. Translation: AAH96187.1.
BC096188 mRNA. Translation: AAH96188.1.
BC096189 mRNA. Translation: AAH96189.1.
BC096190 mRNA. Translation: AAH96190.1.
U04683 Genomic DNA. Translation: AAA18347.1.
BK004238 Genomic DNA. Translation: DAA04636.1.
CCDSiCCDS11023.1.
PIRiI38476.
JC4658.
RefSeqiNP_002541.2. NM_002550.2.
XP_016880184.1. XM_017024695.1.
XP_016880185.1. XM_017024696.1.
UniGeneiHs.647410.

Genome annotation databases

EnsembliENST00000323404; ENSP00000313803; ENSG00000180090.
GeneIDi4994.
KEGGihsa:4994.
UCSCiuc002fvh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80391 Genomic DNA. Translation: CAA56602.1.
U58675 Genomic DNA. No translation available.
AF087924 Genomic DNA. Translation: AAF37314.1.
AC087498 Genomic DNA. No translation available.
BC069414 mRNA. Translation: AAH69414.1.
BC096187 mRNA. Translation: AAH96187.1.
BC096188 mRNA. Translation: AAH96188.1.
BC096189 mRNA. Translation: AAH96189.1.
BC096190 mRNA. Translation: AAH96190.1.
U04683 Genomic DNA. Translation: AAA18347.1.
BK004238 Genomic DNA. Translation: DAA04636.1.
CCDSiCCDS11023.1.
PIRiI38476.
JC4658.
RefSeqiNP_002541.2. NM_002550.2.
XP_016880184.1. XM_017024695.1.
XP_016880185.1. XM_017024696.1.
UniGeneiHs.647410.

3D structure databases

ProteinModelPortaliP47881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47881. 1 interactor.
MINTiMINT-7295760.
STRINGi9606.ENSP00000313803.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47881.
PhosphoSitePlusiP47881.

Polymorphism and mutation databases

BioMutaiOR3A1.
DMDMi148880124.

Proteomic databases

PaxDbiP47881.
PeptideAtlasiP47881.
PRIDEiP47881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323404; ENSP00000313803; ENSG00000180090.
GeneIDi4994.
KEGGihsa:4994.
UCSCiuc002fvh.1. human.

Organism-specific databases

CTDi4994.
GeneCardsiOR3A1.
H-InvDBHIX0039208.
HGNCiHGNC:8282. OR3A1.
neXtProtiNX_P47881.
OpenTargetsiENSG00000180090.
PharmGKBiPA32223.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKVP. Eukaryota.
ENOG411141Z. LUCA.
GeneTreeiENSGT00840000129832.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP47881.
KOiK04257.
PhylomeDBiP47881.
TreeFamiTF352732.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180090-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR3A1.
GenomeRNAii4994.
PROiP47881.

Gene expression databases

BgeeiENSG00000180090.
CleanExiHS_OR3A1.
ExpressionAtlasiP47881. baseline and differential.
GenevisibleiP47881. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR3A1_HUMAN
AccessioniPrimary (citable) accession number: P47881
Secondary accession number(s): Q4VB06, Q6IFM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.